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Association between the promoter region of serotonin transporter polymorphisms and recurrent aphthous stomatitis: A meta-analysis.

Abstract：

OBJECTIVES:To assess the association between the promoter region of serotonin transporter (5-HTTLPR) gene polymorphism and recurrent aphthous stomatitis (RAS) occurrence. DESIGNS:We performed the meta-analysis to determine the potential association between 5-HTTLPR polymorphism and RAS. We retrieved revelant studies from the PubMed, Scopus, Embase, Web of Science and Cochrane Library databases up to January 2019. Data were analyzed for odd ratios with 95% confidence intervals using Revman 5.3 software. RESULTS:There were 4 studies in the meta-analysis, which included 291 RAS cases and 286 controls. It indicated a substantially augmented threat of RAS with respect to S vs. L (P =  0.005), SS vs. LL+LS (P ＜ 0.0001) and SS vs. LL models (P ＜ 0.00001), respectively. No heterogeneity was found between studies in all comparisons. CONCLUSIONS:The current meta-analysis provides evidence to prove the association between 5-HTTLPR polymorphism and RAS. Further studies should be performed to clarify the biochemical function and pathological role of 5-HTTLPR in the risk of RAS.

journal_name

Arch Oral Biol

journal_title

Archives of oral biology

authors

Lu Y,Wang W,Ding X,Shi X

doi

10.1016/j.archoralbio.2019.104555

subject

Has Abstract

pub_date

2020-01-01 00:00:00

pages

104555

eissn

0003-9969

issn

1879-1506

pii

S0003-9969(19)30382-6

journal_volume

109

pub_type

杂志文章,meta分析

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