Abstract：
OBJECTIVE:To evaluate the effect of sympathetic nervous system hyperactivity on craniofacial skeletal growth in growing spontaneously hypertensive rats (SHRs). DESIGN:Craniofacial skeletal growth was compared between male SHR and Wistar-Kyoto rats (WKR) using linear measurements on lateral and transverse cephalometric radiographs at the age of 12 weeks. Tibia length was measured as an index of whole body growth. Body weight and blood pressure were measured from 3 to 12 weeks of age. Bone microstructure in the mandibular condyle and tibia between the two groups was compared at the age of 12 weeks using microcomputed tomography. RESULTS:The SHRs had a significantly lower body weight than WKRs from 7 weeks of age, and tibial length was significantly smaller in the SHRs than in the WKR at 12 weeks of age. In all SHRs, blood pressure was significantly higher than in WKRs from 3 to 12 weeks of age. Cephalometric analyses revealed decreased measurements of the neurocranium, viscerocranium, and mandible in SHRs, and mandibular growth was most negatively affected in this group. Lastly, in SHRs, microcomputed tomography analyses revealed decreased bone mineral density and bone volume/tissue volume in the mandibular condyle but not in the tibia. CONCLUSION:In growing SHRs, hypertension related to the hyperactivity of the sympathetic nervous system reduced craniofacial skeletal growth more than the growth of the tibia.
journal_name
Arch Oral Bioljournal_title
Archives of oral biologyauthors
Uchikawa Y,Hosomichi J,Suzuki JI,Yamaguchi H,Ishida Y,Hatano K,Usumi-Fujita R,Shimizu Y,Kaneko S,Uesugi S,Ono Tdoi
10.1016/j.archoralbio.2019.01.001subject
Has Abstractpub_date
2019-03-01 00:00:00pages
73-81eissn
0003-9969issn
1879-1506pii
S0003-9969(18)30709-Xjournal_volume
99pub_type
杂志文章abstract：OBJECTIVE:Some saliva substitutes have been shown to demineralize dentine in vitro. This effect is counteracted by the application of various fluorides. In contrast, remineralizing saliva substitutes might be supported by these treatments, depending on the dynamics during remineralization. The aim of this in vitro stud...
journal_title：Archives of oral biology
pub_type： 杂志文章
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更新日期：2016-08-01 00:00:00
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journal_title：Archives of oral biology
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更新日期：2014-12-01 00:00:00
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pub_type： 杂志文章
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更新日期：2017-03-01 00:00:00
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journal_title：Archives of oral biology
pub_type： 杂志文章
doi：10.1016/j.archoralbio.2010.08.007
更新日期：2010-12-01 00:00:00
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journal_title：Archives of oral biology
pub_type： 杂志文章
doi：10.1016/j.archoralbio.2003.08.004
更新日期：2004-02-01 00:00:00
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pub_type： 杂志文章
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更新日期：2000-11-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/0003-9969(85)90050-0
更新日期：1985-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.archoralbio.2014.05.021
更新日期：2014-09-01 00:00:00
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pub_type： 杂志文章,随机对照试验
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更新日期：2014-05-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.archoralbio.2013.07.003
更新日期：2013-10-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.archoralbio.2016.10.028
更新日期：2017-01-01 00:00:00
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journal_title：Archives of oral biology
pub_type： 杂志文章
doi：10.1016/0003-9969(91)90082-6
更新日期：1991-01-01 00:00:00
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journal_title：Archives of oral biology
pub_type： 杂志文章
doi：10.1016/0003-9969(83)90090-0
更新日期：1983-01-01 00:00:00
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journal_title：Archives of oral biology
pub_type： 杂志文章
doi：10.1016/0003-9969(91)90150-s
更新日期：1991-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：1988-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.archoralbio.2003.10.003
更新日期：2004-04-01 00:00:00
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更新日期：2017-01-01 00:00:00
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journal_title：Archives of oral biology
pub_type： 杂志文章
doi：10.1016/0003-9969(89)90044-7
更新日期：1989-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：1987-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.archoralbio.2019.04.021
更新日期：2019-06-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/0003-9969(85)90135-9
更新日期：1985-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/s0003-9969(98)00112-5
更新日期：1999-02-01 00:00:00
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pub_type： 杂志文章
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更新日期：2017-07-01 00:00:00
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pub_type： 杂志文章
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更新日期：1989-01-01 00:00:00
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journal_title：Archives of oral biology
pub_type： 杂志文章
doi：10.1016/s0003-9969(02)00173-5
更新日期：2003-04-01 00:00:00
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pub_type： 杂志文章
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更新日期：1999-10-01 00:00:00
abstract：:The structure of human dentine affected by familial hypophosphataemic rickets was investigated by polarized light and electron microscopy. Within the calcospherites both radially-orientated and collagen-orientated crystals were present, in approximately equal numbers. This was so, but less distinctly, in the calcosphe...
journal_title：Archives of oral biology
pub_type： 杂志文章
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更新日期：1983-01-01 00:00:00
