当前位置： SCI文献检索 > ARCHIVES OF ORAL BIOLOGY期刊下所有文献 > Biodistribution of GB-10 (Na(2)(10)B10H10 compound for boron neutron capture therapy (BNCT) in an experimental model of oral cancer in the hamster cheek pouch.

Biodistribution of GB-10 (Na(2)(10)B10H10 compound for boron neutron capture therapy (BNCT) in an experimental model of oral cancer in the hamster cheek pouch.

Abstract：

OBJECTIVE:We previously proposed the hamster cheek pouch model of oral cancer for BNCT studies. We herein present the biodistribution of a non-toxic boron compound, GB-10 (Na(2)(10)B10H10), in this model to assess its potential for BNCT or BNCT enhanced Fast Neutron Therapy. MATERIALS AND METHODS:We evaluated the uptake and retention of GB-10 in tumour and precancerous tissue and in potentially dose-limiting, clinically relevant normal tissues. RESULTS:Mean tumour boron concentration delivered by GB-10 (50mgB/kg) peaked to 77.7+/-28.0 ppm at 20min post-administration and remained at therapeutically useful values of 31.9+/-21.4 ppm at 3h. The clearance rate for normal tissues was faster than for tumour tissue. The consistently low brain and spinal cord values would preclude normal tissue toxicity. The uptake of GB-10 by precancerous tissue may be of potential use in the treatment of field cancerized areas. GB-10 was deposited homogeneously in different tumour areas, an asset when treating heterogenous tumours. The data suggests that the joint administration of BPA and GB-10 may improve the therapeutic efficacy of BNCT. CONCLUSIONS:GB-10 is a potential boron carrier for BNCT of head and neck tumours and for BNCT-FNT.

journal_name

Arch Oral Biol

journal_title

Archives of oral biology

authors

Heber E,Trivillin VA,Nigg D,Kreimann EL,Itoiz ME,Rebagliati RJ,Batistoni D,Schwint AE

doi

10.1016/j.archoralbio.2003.10.003

subject

Has Abstract

pub_date

2004-04-01 00:00:00

pages

313-24

issue

4

eissn

0003-9969

issn

1879-1506

pii

S0003996903002632

journal_volume

49

pub_type

杂志文章

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