Immunohistochemical localization of inducible nitric oxide synthase in synovial tissue of human temporomandibular joints with internal derangement.

Abstract:

:The expression and distribution of inducible nitric oxide synthase (iNOS) was examined in 12 samples of human temporomandibular joint (TMJ) with internal derangement (ID) and four control specimens. In the diseased joints, strong or definite iNOS reactivity was expressed in synovial lining and endothelial cells; weaker activity was present in synovial fibroblasts. In contrast, although there was weak expression of iNOS in synovial fibroblasts and endothelial cells in the two control specimens, there was no iNOS staining in the synovial lining cell layers. This original report that iNOS is expressed in the synovial tissue of the temporomandibular joint indicates that nitric oxide is produced locally at least in the synovial lining in these joints when affected by internal derangement.

journal_name

Arch Oral Biol

journal_title

Archives of oral biology

authors

Homma H,Takahashi T,Seki H,Ohtani M,Kondoh T,Fukuda M

doi

10.1016/s0003-9969(00)00086-8

subject

Has Abstract

pub_date

2001-01-01 00:00:00

pages

93-7

issue

1

eissn

0003-9969

issn

1879-1506

pii

S0003-9969(00)00086-8

journal_volume

46

pub_type

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