Inhibitory effects of resveratrol on orthodontic tooth movement and associated root resorption in rats.

Abstract:

OBJECTIVE:To investigate the effect of resveratrol (RSV) on orthodontic tooth movement (OTM) and orthodontic induced root resorption (OIRR) in rats. METHODS:Thirty-six male Wistar rats used in this study were randomly divided into three groups of 12 animals each. All test subjects underwent a 50 g orthodontic force each, generated from a nickel-titanium closed-coil spring. The control group were fed carboxymethylcellulose (CMC) while rats in other two groups were fed 5 mg/kg/d RSV or 10 mg/kg/d RSV (dissolved in CMC). After 14 days of OTM, all rats were sacrificed, after which each group was randomly divided into two subgroups (6 test subjects in each subgroup). One subgroup was used to measure the amount of OTM and assessed by hematoxylin and eosin (HE) staining, tartrate-resistant acid phosphatase (TRAP) staining, and immunohistochemistry staining of Receptor Activator of Nuclear Factor-κ B Ligand (RANKL), Osteoprotegerin (OPG), Runt-related transcription factor 2 (RUNX2), as well as Osteocalcin (OCN). The second subgroup was used to analyze OIRR via scanning electron microscopy. RESULTS:Compared with the control group, the RSV groups showed a significant decrease in the distance of OTM and the OIRR ratio (p<0.05). The number of TRAP positive osteoclasts and the expression of RANKL in periodontal tissue of the RSV groups were significantly inhibited (p<0.01) while the expression of OPG, RUNX2, and OCN were remarkably promoted (p<0.05). The effect of 10 mg/kg/d RSV group was more obvious than that of 5 mg/kg/d RSV group (p<0.05). CONCLUSIONS:RSV could reduce the extent of OTM and root resorption areas.

journal_name

Arch Oral Biol

journal_title

Archives of oral biology

authors

Liu XC,Wang XX,Zhang LN,Yang F,Nie FJ,Zhang J

doi

10.1016/j.archoralbio.2019.104642

subject

Has Abstract

pub_date

2020-03-01 00:00:00

pages

104642

eissn

0003-9969

issn

1879-1506

pii

S0003-9969(19)30764-2

journal_volume

111

pub_type

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