Abstract：
:Internal derangement (ID) in the temporomandibular joint (TMJ) comprises a group of clinical problems with relatively high prevalence. However, the temporal changes in gene expression of condylar cartilage during continuous ID remain unclear. The aim of the current study is to investigate by microarray analysis, the differentially-expressed gene pattern in condylar cartilage of rabbits with ID from one to eight weeks of ID progression. Histological results (hematoxylin and eosin staining) indicated that abnormal collagen fiber arrangements, fragmentation of fibrils, and inflammatory cell-infiltration were detected from one to four weeks in joint disc specimens, while newly formed vessels, mucoid degeneration, meniscal tears, and the presence of osteoclasts and osteoblasts were observed at later time points. The microarray analysis revealed 6478 genes among all tested transcripts, to have a greater than two-fold expression change compared to controls. The inflammation-associated gene group including ace and il1β increased rapidly in the early stage of disease and decreased later. In contrast, bone construction-related genes showed low expression levels at first and increased at later period in the ID progression. The current study also found some genes such as hla2g, which have not been previously reported, to be potentially relevant within ID. Our findings provide useful insights into the pathological mechanism of ID in TMJ.
journal_name
Arch Oral Bioljournal_title
Archives of oral biologyauthors
Wang S,Deng L,Li Y,Wu H,Gu Zdoi
10.1016/j.archoralbio.2016.11.006subject
Has Abstractpub_date
2017-02-01 00:00:00pages
92-100eissn
0003-9969issn
1879-1506pii
S0003-9969(16)30329-6journal_volume
74pub_type
杂志文章abstract：OBJECTIVES:brain-derived neurotrophic factor (BDNF), which is produced in rat submandibular gland, is one of the most abundant neurotrophins in the central nervous system. It is generally accepted that occlusal disharmony causes stress. The purpose of the present study was to investigate whether occlusal disharmony-ind...
journal_title：Archives of oral biology
pub_type： 杂志文章
doi：10.1016/j.archoralbio.2010.09.001
更新日期：2011-01-01 00:00:00
abstract：:Previous studies have reported that the abnormal development of the second deciduous molar in Down syndrome and cerebral palsy begins before birth. In view of these results we have turned our attention to the earlier stages of dental development in utero, represented by the primary canine, in order to see if we can id...
journal_title：Archives of oral biology
pub_type： 杂志文章
doi：10.1016/j.archoralbio.2007.04.011
更新日期：2007-10-01 00:00:00
abstract：:Apatite crystal growth rate and morphology in mineralized tissues are considered to be controlled by surface interaction with extracellular matrix proteins. During enamel maturation where protein is finally removed from crystal surfaces to permit massive crystal growth, pH oscillates between approximately 5.8 and appr...
journal_title：Archives of oral biology
pub_type： 杂志文章
doi：10.1016/j.archoralbio.2004.11.017
更新日期：2005-02-01 00:00:00
abstract：:The morphology and distribution of various types of intercellular junctions were investigated in young odontoblasts. Gap junctions were found between odontoblasts as well as between odontoblasts and fibroblasts in the dental pulp. The junctions between odontoblasts were larger and more numerous than those between odon...
journal_title：Archives of oral biology
pub_type： 杂志文章
doi：10.1016/0003-9969(84)90068-2
更新日期：1984-01-01 00:00:00
abstract：:Transmitted and polarized light microscopy of unerupted and erupted teeth affected by a pigmented anomaly found in two geographically isolated Polynesian populations, the New Zealand Maori and the French Polynesian Marquesas Islander, showed similar histological characteristics. Mounted in water, the pigmented areas w...
journal_title：Archives of oral biology
pub_type： 杂志文章
doi：10.1016/0003-9969(89)90127-1
更新日期：1989-01-01 00:00:00
abstract：OBJECTIVE:The present study evaluated the nociceptive response induced by dentin hypersensitivity after dental erosion in rats that were exhibited to unpredictable chronic mild stress (UCMS)-induced depressive-like behavior. DESIGN:Adult male rats were subjected to UCMS (depression [D] group) or not (no depression [ND...
journal_title：Archives of oral biology
pub_type： 杂志文章
doi：10.1016/j.archoralbio.2017.04.005
更新日期：2017-08-01 00:00:00
abstract：:The proteolytic activity of N-benzoyl-D,L-arginine-p-nitroanilide hydrochloride, a trypsin-like protease, was weak, whereas strong glucose-6-phosphate dehydrogenase activity was found in all subjects. The enzyme activities of males and females were similar. ...
journal_title：Archives of oral biology
pub_type： 杂志文章
doi：10.1016/0003-9969(87)90124-5
更新日期：1987-01-01 00:00:00
abstract：OBJECTIVE:Respiratory epithelial cells are the first natural barrier against bacteria and viruses; hence, the interactions among epithelial cells, bacteria, and viruses are associated with disease occurrence and development. The effect of co-infection by P. gingivalis and influenza A virus (IAV) on respiratory epitheli...
journal_title：Archives of oral biology
pub_type： 杂志文章
doi：10.1016/j.archoralbio.2018.04.003
更新日期：2018-11-01 00:00:00
abstract：:Non-invasive imaging techniques such as computerized tomography, magnetic resonance imaging (MRI), and ultrasonography enable measurements of the cross-section and thickness of human jaw muscles in vivo, providing an indication of the maximal force a muscle can exert. In 15 adult Caucasian men the thickness of the mas...
journal_title：Archives of oral biology
pub_type： 杂志文章
doi：10.1016/0003-9969(94)90061-2
更新日期：1994-12-01 00:00:00
abstract：:Streptococcus mutans GS5, Lactobacillus casei DSM20011 and Actinomyces viscosus T14 produce artificial caries in the roots of extracted teeth. Roots were coated with wax leaving an 8 mm2 window exposed on the buccal surfaces, and then incubated for 8 days in the presence of the test organism, the synthetic medium bein...
journal_title：Archives of oral biology
pub_type： 杂志文章
doi：10.1016/0003-9969(88)90031-3
更新日期：1988-01-01 00:00:00
abstract：:In adult miniature pigs (Sus scrofa) fibres of the masseter contract differentially, helping to produce the successive movements of the mandible during the chewing cycle. In infant pigs, however, most fibres of the masseter contract simultaneously. One hypothesis to explain the ontogenetic change in contraction patter...
journal_title：Archives of oral biology
pub_type： 杂志文章
doi：10.1016/0003-9969(91)90116-c
更新日期：1991-01-01 00:00:00
abstract：:Lymphocytes isolated from chronically-inflamed tissues were assessed for their ability to produce lymphokines without further stimulation in vitro. Cells were extracted from tissue obtained from 42 patients undergoing periodontal surgery. Cultures were set up in triplicate and supernatants collected after 48 h were as...
journal_title：Archives of oral biology
pub_type： 杂志文章
doi：10.1016/0003-9969(85)90094-9
更新日期：1985-01-01 00:00:00
abstract：:The discharge of albumin, IgG and fibrinogen in dentinal fluid released from freshly exposed dentine was determined by enzyme-linked immunosorbent assay. Data were compared with the relative concentrations of these proteins in the interstitial fluid of the pulp. The sampling procedure involved retrieval of phosphate-b...
journal_title：Archives of oral biology
pub_type： 杂志文章
doi：10.1016/0003-9969(94)90043-4
更新日期：1994-03-01 00:00:00
abstract：:Periodontal mechanosensitive (PM) primary afferent neurones were recorded from the rat trigeminal ganglion and their response to mechanical tooth stimulation studied. The majority (95%) of PM afferents were single-tooth units and most were sensitive to mechanical stimulation of the incisor. They had a sustained respon...
journal_title：Archives of oral biology
pub_type： 杂志文章
doi：10.1016/0003-9969(94)90167-8
更新日期：1994-05-01 00:00:00
abstract：OBJECTIVE:The objective was to determine the antibiofilm efficacy of Cymbopogon martinii and Thymus zygis essential oils and to estimate the disruption potential of oil-based endodontic irrigants on the multispecies biofilm formed in the root canals of extracted teeth. DESIGN:The essential oils were characterized (GC-...
journal_title：Archives of oral biology
pub_type： 杂志文章
doi：10.1016/j.archoralbio.2020.104842
更新日期：2020-09-01 00:00:00
abstract：:The 10,000 g supernatant of wax-stimulated whole saliva was fractionated by gel filtration and its components were tested along with amino acids, small peptides and urea for their ability to stimulate this oxygen uptake, and for their effects on pH. Fractions containing the larger components, the proteins and large pe...
journal_title：Archives of oral biology
pub_type： 杂志文章
doi：10.1016/0003-9969(90)90176-b
更新日期：1990-01-01 00:00:00
abstract：OBJECTIVES:Radiographic dental age estimation methods are viable in the living and deceased. One such method [Kvaal et al. Forensic Sci Int 1995;74:175-85] quantified secondary dentinal deposition indirectly through measurements of tooth and pulp lengths and widths. The method is untested on non-European populations an...
journal_title：Archives of oral biology
pub_type： 杂志文章
doi：10.1016/j.archoralbio.2011.08.020
更新日期：2012-03-01 00:00:00
abstract：:Non-specific cholinesterase (ChE) activity was demonstrated in lamellated sensory corpuscles of the rat lip by light and electron microscopy using Karnovsky and Roots' method. ChE activity was present in the interlamellar spaces between neighbouring lamellae as well as in the peri-axonal space between axon terminals a...
journal_title：Archives of oral biology
pub_type： 杂志文章
doi：10.1016/0003-9969(87)90056-2
更新日期：1987-01-01 00:00:00
abstract：:After an initial demineralisation, an intensive fluoridation is capable of inhibiting the erosive mineral loss in dentine completely, which might be related to the presence of the exposed organic dentine matrix. Aim of the present study was, therefore, to evaluate whether fluoride is also effective when the organic ma...
journal_title：Archives of oral biology
pub_type： 杂志文章
doi：10.1016/j.archoralbio.2004.05.010
更新日期：2004-11-01 00:00:00
abstract：OBJECTIVES:The influence of carotid artery occlusion (10, 30 and 60 min) on regulatory mechanisms implicated in the vasorelaxant responses of isolated glandular branch of rabbit facial artery to acetylcholine (ACh) and vasoactive intestinal polypeptide (VIP) was examined. DESIGN:In organ bath studies with arterial rin...
journal_title：Archives of oral biology
pub_type： 杂志文章
doi：10.1016/j.archoralbio.2010.03.006
更新日期：2010-05-01 00:00:00
abstract：OBJECTIVE:Accumulating evidence suggests an association between periodontitis and several systemic diseases, such as atherosclerosis. In the lesions of these diseases, nucleotide-binding domain leucine-rich repeat-containing protein 3 (NLRP3), apoptosis-associated speck-like protein containing a caspase activation and ...
journal_title：Archives of oral biology
pub_type： 杂志文章
doi：10.1016/j.archoralbio.2019.104625
更新日期：2020-02-01 00:00:00
abstract：OBJECTIVES:To analyse age- and gender-related microscopic changes in sublingual glands obtained from human cadavers. STUDY DESIGN:One hundred eighty six human sublingual glands were obtained from 93 autopsies. Approximately five individuals of each gender per decade of life were allocated to three age groups: group I ...
journal_title：Archives of oral biology
pub_type： 杂志文章
doi：10.1016/j.archoralbio.2004.10.019
更新日期：2005-06-01 00:00:00
abstract：:Autoantibodies directed against nucleic acid and protein complexes present in cell nuclei characterize autoimmune diseases and are employed in diagnosis. The mechanisms by which these autoantigens escape immunological tolerance are largely unknown, but a number of recent observations suggest that modified self-protein...
journal_title：Archives of oral biology
pub_type： 杂志文章
doi：10.1016/s0003-9969(02)00025-0
更新日期：2002-06-01 00:00:00
abstract：OBJECTIVE:Consumption of acidic food and drinks is considered as important risk factor for development of dental erosion. There are several in vitro and in situ studies focusing on the risk indicators and preventive treatment, however, the need for a standardized animal model has been emphasised for many years. The aim...
journal_title：Archives of oral biology
pub_type： 杂志文章
doi：10.1016/j.archoralbio.2018.08.013
更新日期：2018-12-01 00:00:00
abstract：OBJECTIVE:To identify the genetic risk markers of aggressive periodontitis (AgP), researchers focus on genetic components that regulate the immune response. Therefore the purpose of this study was to investigate genetic impact of monocyte chemoattractant protein (MCP)-1-2518A/G and CC chemokine receptor 2 (CCR2) -190G/...
journal_title：Archives of oral biology
pub_type： 杂志文章
doi：10.1016/j.archoralbio.2017.04.016
更新日期：2017-08-01 00:00:00
abstract：:The rate of synthesis of secretory proteins increases significantly in rat parotid glands after stimulated discharge of stored proteins. How any difference in the amount of secretory protein discharge affects the rate of subsequent protein synthesis, and whether this post-secretory synthesis is regulated at the level ...
journal_title：Archives of oral biology
pub_type： 杂志文章
doi：10.1016/0003-9969(89)90147-7
更新日期：1989-01-01 00:00:00
abstract：:The transforming growth factor (TGF)-beta superfamily comprises more than 35 structurally related genes that have been implicated in embryonic induction and morphogenesis. Different superfamily members may have distinct regulatory roles in tooth development and maintenance. Degenerate primer sets derived from the high...
journal_title：Archives of oral biology
pub_type： 杂志文章
doi：10.1016/s0003-9969(98)00046-6
更新日期：1998-09-01 00:00:00
abstract：:Previous studies of the sympathetic nerve supply of the rat mandibular incisor pulp have shown conflicting results. Here, the neurovascular control of the rat lower incisor pulp was investigated by stimulating the tooth crown and the cervical sympathetic trunk electrically and monitoring blood-flow changes in the pulp...
journal_title：Archives of oral biology
pub_type： 杂志文章
doi：10.1016/0003-9969(92)90033-5
更新日期：1992-12-01 00:00:00
abstract：OBJECTIVE:To investigate the role of the histone 3 lysine 27 trimethylation (H3K27me3) demethylase Jumonji domain-containing protein 3 (Jmjd3) in the epigenetic regulation of the inflammatory response in human periodontal ligament cells (HPDLs). DESIGN:HPDLs were stimulated with lipopolysaccharide from E. coli. The ex...
journal_title：Archives of oral biology
pub_type： 杂志文章
doi：10.1016/j.archoralbio.2018.05.007
更新日期：2018-09-01 00:00:00
abstract：OBJECTIVE:Eight commercially available resins, Epoxy Embedding Medium ("Epon"), Spurr, Epofix, Epo-Kwick, Epo-Thin, Technovit 9100 New, Unicryl, and Vestopal W, all intended for embedding specimens for microscopy, were tested and compared for binding and adaptation to the enamel surface of human third molar crowns that...
journal_title：Archives of oral biology
pub_type： 杂志文章
doi：10.1016/s0003-9969(03)00194-8
更新日期：2004-01-01 00:00:00
