Abstract:
OBJECTIVE:To investigate the role of the histone 3 lysine 27 trimethylation (H3K27me3) demethylase Jumonji domain-containing protein 3 (Jmjd3) in the epigenetic regulation of the inflammatory response in human periodontal ligament cells (HPDLs). DESIGN:HPDLs were stimulated with lipopolysaccharide from E. coli. The expression of Jmjd3 in HPDLs was examined by quantitative real-time polymerase chain reaction (Q-PCR), Western Blot and immunofluorescent staining. Potential target genes were selected by silencing Jmjd3 and were confirmed by Chromatin Immunoprecipitation (ChIP). RESULTS:Q-PCR, Western Blot and immunofluorescent staining revealed that the expression of Jmjd3 was increased in inflamed HPDLs. Knockdown of Jmjd3 led to the suppression of inflammation-induced up-regulation of interleukin-6 and interleukin-12. Moreover, ChIP assays demonstrated that Jmjd3 was recruited to the promoters of interleukin-6 and interleukin-12b and this recruitment was associated with decreased levels of trimethylated histone 3 lysine 27 (H3K27). CONCLUSIONS:It was concluded that Jmjd3 regulated the activation of interleukin-6 and interleukin-12b in the early inflammatory response of HPDLs via demethylation of H3K27me3 at promoters. This molecular event may play an important role in the regulation of the inflammatory response in HPDLs.
journal_name
Arch Oral Bioljournal_title
Archives of oral biologyauthors
Wang P,Yue J,Xu W,Chen X,Yi X,Ye L,Zhang L,Huang Ddoi
10.1016/j.archoralbio.2018.05.007subject
Has Abstractpub_date
2018-09-01 00:00:00pages
87-94eissn
0003-9969issn
1879-1506pii
S0003-9969(18)30177-8journal_volume
93pub_type
杂志文章abstract::The fragmentation of foods (breakage function) was measured in five humans on "bagged' single particles of 28 foods from three food groups. The change in the square root of the specific surface of the particles (the specific surface being the area of particle silhouettes, measured by image analysis, divided by origina...
journal_title:Archives of oral biology
pub_type: 杂志文章
doi:10.1016/s0003-9969(96)00102-1
更新日期:1997-01-01 00:00:00
abstract::Although most cases of cleft lip and palate are free of other developmental defects, children with isolated cleft lip/palate are at enhanced risk of delayed growth and reduced final size. Three variables were assessed in the permanent dentition away from the cleft site: congenital absence by tooth type (which ranged f...
journal_title:Archives of oral biology
pub_type: 杂志文章
doi:10.1016/0003-9969(90)90210-2
更新日期:1990-01-01 00:00:00
abstract:OBJECTIVE:The objective of this systematic review was to assess the impact of nicotine administration on orthodontic tooth movement (OTM). METHODS:A systematic search was conducted in PubMed, Scopus, EMBASE, MEDLINE (OVID) and Web of Knowledge databases and the Preferred Reporting Items for Systematic Reviews and Meta...
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pub_type: 杂志文章
doi:10.1016/j.archoralbio.2018.05.016
更新日期:2018-09-01 00:00:00
abstract:OBJECTIVE AND DESIGN:Autopsies of the submandibular gland, the vestibular folds and the soft palate from 65-87 old humans were examined to record the immunohistochemical expression of MUC1 and the simple mucin-type antigens Tn and Sialyl-Tn. RESULTS:(1) The serous acini in the submucosal glands from the larynx and the...
journal_title:Archives of oral biology
pub_type: 杂志文章
doi:10.1016/j.archoralbio.2010.07.007
更新日期:2010-11-01 00:00:00
abstract::Many studies have shown that various myosin isoforms are involved in muscle contraction. A search for specific antibodies directed against the myosin heavy chain (MHC) resulted in the identification of at least two main classes, referred to as MHC type I and type II. In this study, immunohistology and gel electrophore...
journal_title:Archives of oral biology
pub_type: 杂志文章
doi:10.1016/s0003-9969(00)00092-3
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abstract:OBJECTIVE:To determine if dentine at the enamel-dentine junction (EDJ) in man is more sensitive to hydrostatic pressure stimuli then deeper dentine. DESIGN:Cavities (1mm diam.) were cut at the tips of the buccal and lingual cusps of 8 premolars in 3 subjects (ages: 22-25 years). Both cavities were initially deepened t...
journal_title:Archives of oral biology
pub_type: 杂志文章
doi:10.1016/j.archoralbio.2016.02.015
更新日期:2016-06-01 00:00:00
abstract:INTRODUCTION:Intact neural supply is necessary for tooth eruption. Sympathetic denervation accelerates or decelerates the eruption rate depending on the tooth condition (intact or injured). The aim of this study is to reexamine the role of the sympathetic innervation, through the observation of the effects of pre or po...
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doi:10.1016/j.archoralbio.2018.02.003
更新日期:2018-05-01 00:00:00
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journal_title:Archives of oral biology
pub_type: 杂志文章
doi:10.1016/j.archoralbio.2013.04.003
更新日期:2013-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/0003-9969(95)00106-9
更新日期:1996-01-01 00:00:00
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journal_title:Archives of oral biology
pub_type: 历史文章,杂志文章
doi:10.1016/0003-9969(95)00131-x
更新日期:1996-04-01 00:00:00
abstract::The structure of human dentine affected by familial hypophosphataemic rickets was investigated by polarized light and electron microscopy. Within the calcospherites both radially-orientated and collagen-orientated crystals were present, in approximately equal numbers. This was so, but less distinctly, in the calcosphe...
journal_title:Archives of oral biology
pub_type: 杂志文章
doi:10.1016/0003-9969(83)90030-4
更新日期:1983-01-01 00:00:00
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journal_title:Archives of oral biology
pub_type: 杂志文章
doi:10.1016/0003-9969(82)90136-4
更新日期:1982-01-01 00:00:00
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journal_title:Archives of oral biology
pub_type: 杂志文章
doi:10.1016/s0003-9969(01)00039-5
更新日期:2001-09-01 00:00:00
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journal_title:Archives of oral biology
pub_type: 杂志文章
doi:10.1016/0003-9969(95)00018-k
更新日期:1995-07-01 00:00:00
abstract::The EMG patterns of temporalis, masseter and digastric muscles of twenty Wistar white rats were studied as they ate large and small standard food pellets, bread and pudding. Bipolar EMG electrodes were placed in the muscles and led subcutaneously to a connector pedestal on the rat's head. Integrated records of the EMG...
journal_title:Archives of oral biology
pub_type: 杂志文章
doi:10.1016/0003-9969(83)90090-0
更新日期:1983-01-01 00:00:00
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journal_title:Archives of oral biology
pub_type: 杂志文章
doi:10.1016/0003-9969(92)90085-m
更新日期:1992-03-01 00:00:00
abstract:OBJECTIVE:Changes in the masticatory function of ferrets have been shown to cause alterations in their craniofacial morphology. The aim of the present study was to investigate how the functional changes influence the histochemical characteristics of fibres of the masticatory muscles of the animal. DESIGN:Forty five-we...
journal_title:Archives of oral biology
pub_type: 杂志文章
doi:10.1016/j.archoralbio.2004.07.011
更新日期:2004-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.archoralbio.2019.104625
更新日期:2020-02-01 00:00:00
abstract::The changes in masseter EMG and biting force evoked by electrical stimulation of the lip were measured in normal people. Stimulation at noxious intensities elicited a characteristic, biphasic inhibitory response in the masseter EMG and a transient reduction in the biting force. The pattern of masseter inhibition and f...
journal_title:Archives of oral biology
pub_type: 杂志文章
doi:10.1016/0003-9969(85)90083-4
更新日期:1985-01-01 00:00:00
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journal_title:Archives of oral biology
pub_type: 杂志文章
doi:10.1016/j.archoralbio.2018.04.009
更新日期:2018-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.archoralbio.2017.04.024
更新日期:2017-09-01 00:00:00
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journal_title:Archives of oral biology
pub_type: 杂志文章
doi:10.1016/j.archoralbio.2010.08.007
更新日期:2010-12-01 00:00:00
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journal_title:Archives of oral biology
pub_type: 杂志文章
doi:10.1016/j.archoralbio.2020.104851
更新日期:2020-10-01 00:00:00
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journal_title:Archives of oral biology
pub_type: 杂志文章
doi:10.1016/0003-9969(91)90150-s
更新日期:1991-01-01 00:00:00
abstract:OBJECTIVES:Lemon essential oil (LEO) is a kind of secondary metabolite from lemon peels and has been found to inhibit cariogenic bacteria for decades. However, its effects on main cariogenic virulence factors are rarely reported. The present study aimed to investigate the effects of sub-minimum inhibitory concentration...
journal_title:Archives of oral biology
pub_type: 杂志文章
doi:10.1016/j.archoralbio.2017.12.028
更新日期:2018-03-01 00:00:00
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journal_title:Archives of oral biology
pub_type: 杂志文章
doi:10.1016/0003-9969(91)90003-D
更新日期:1991-01-01 00:00:00
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journal_title:Archives of oral biology
pub_type: 杂志文章
doi:10.1016/j.archoralbio.2019.104512
更新日期:2019-11-01 00:00:00
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journal_title:Archives of oral biology
pub_type: 杂志文章
doi:10.1016/0003-9969(85)90116-5
更新日期:1985-01-01 00:00:00
abstract::Intrusive displacement of 7 incisors was measured before and within 3 min of extraction. A substantial increase in intrusion with recovery from loads of 4 N followed replacement of the incisors. These changes are taken to indicate that tension is an important mechanism of support in the intact periodontal ligament. ...
journal_title:Archives of oral biology
pub_type: 杂志文章
doi:10.1016/0003-9969(91)90057-2
更新日期:1991-01-01 00:00:00
abstract::Iron-deficiency anaemia was induced in hamsters by feeding a low-iron diet coupled with weekly bleeding. Respiration, assessed by measuring oxygen uptake, was significantly reduced (p less than 0.002) in cheek-pouch epithelia from iron-deficient animals. To relate data on oxygen consumption to cell numbers, the cell d...
journal_title:Archives of oral biology
pub_type: 杂志文章
doi:10.1016/0003-9969(85)90150-5
更新日期:1985-01-01 00:00:00