Effect of alendronate sodium on tooth movement in ovariectomized rats.

Abstract:

OBJECTIVES:The aim of the present study was to evaluate the effect of two different dosages of alendronate on induced orthodontic movement in an experimental model involving rats with osteoporosis following ovariectomy. DESIGN:Female Wistar rats (Rattus norvegicus) eight weeks of age were divided into four groups (n=12/group): ovariectomized (OVX group); ovariectomized and treated with alendronate sodium at 1mg/kg (Group OVX+ALN1); ovariectomized and treated with alendronate sodium at 2mg/kg (Group OVX+ALN2); and sham operated (control). Three months after ovariectomy, the maxillary right first molar was submitted to movement for five and seven days. After the death of the animals, the maxilla were removed and processed for microscopic evaluation. The maxillary left first molar (without movement) was used for comparison purposes in all groups. The samples were processed for the quantification of alveolar bone and tooth movement. RESULTS:Intragroup comparisons showed significant movement after five and seven days (p<0.05) for all groups. Comparison among groups revealed greater tooth movement in the OVX group (p<0.05), on day 7. CONCLUSIONS:Both alendronate sodium doses similarly decreased tooth movement in ovariectomized rats (p>0.05). Movement in ovariectomized+alendronate groups were also smaller than non-ovariectomized rats, however without statistical difference.

journal_name

Arch Oral Biol

journal_title

Archives of oral biology

authors

Salazar M,Hernandes L,Ramos AL,Salazar Bde O,Micheletti KR,Paranhos LR,de Mendonça MR,Cuoghi OA

doi

10.1016/j.archoralbio.2015.02.003

subject

Has Abstract

pub_date

2015-05-01 00:00:00

pages

776-81

issue

5

eissn

0003-9969

issn

1879-1506

pii

S0003-9969(15)00026-6

journal_volume

60

pub_type

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