Gene expression based evidence of innate immune response activation in the epithelium with oral lichen planus.


OBJECTIVE:Oral lichen planus (OLP) is a disease of the oral mucosa of unknown cause producing lesions with an intense band-like inflammatory infiltrate of T cells to the subepithelium and keratinocyte cell death. We performed gene expression analysis of the oral epithelium of lesions in subjects with OLP and its sister disease, oral lichenoid reaction (OLR), in order to better understand the role of the keratinocytes in these diseases. DESIGN:Fourteen patients with OLP or OLR were included in the study, along with a control group of 23 subjects with a variety of oral diseases and a normal group of 17 subjects with no clinically visible mucosal abnormalities. Various proteins have been associated with OLP, based on detection of secreted proteins or changes in RNA levels in tissue samples consisting of epithelium, stroma, and immune cells. The mRNA level of twelve of these genes expressed in the epithelium was tested in the three groups. RESULTS:Four genes showed increased expression in the epithelium of OLP patients: CD14, CXCL1, IL8, and TLR1, and at least two of these proteins, TLR1 and CXCL1, were expressed at substantial levels in oral keratinocytes. CONCLUSIONS:Because of the large accumulation of T cells in lesions of OLP it has long been thought to be an adaptive immunity malfunction. We provide evidence that there is increased expression of innate immune genes in the epithelium with this illness, suggesting a role for this process in the disease and a possible target for treatment.


Arch Oral Biol


Archives of oral biology


Adami GR,Yeung AC,Stucki G,Kolokythas A,Sroussi HY,Cabay RJ,Kuzin I,Schwartz JL




Has Abstract


2014-03-01 00:00:00














  • Measurement of root surface area of permanent teeth in a Chinese population.

    abstract:OBJECTIVES:The aim of this study was to investigate the relation between the remaining area of periodontal attachment and the attachment levels for each type of permanent teeth in a Chinese population by using micro-computed tomography (micro-CT) scans. DESIGN:A total of 440 extracted permanent teeth (including each t...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Gu Y,Zhu Q,Tang Y,Zhang Y,Feng X

    更新日期:2017-09-01 00:00:00

  • Connective tissue growth factor expressed in rat alveolar bone regeneration sites after tooth extraction.

    abstract:OBJECTIVE:To understand bone regeneration process after tooth extraction could be a clue to develop a new strategy for alveolar bone reconstruction. Recently, accumulated evidences support that connective tissue growth factor (CTGF) is implicated in tissue repair of many tissues. In this study, we investigated the spat...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Kanyama M,Kuboki T,Akiyama K,Nawachi K,Miyauchi FM,Yatani H,Kubota S,Nakanishi T,Takigawa M

    更新日期:2003-10-01 00:00:00

  • The secretory characteristics of epidermal growth factor in human saliva.

    abstract::A series of unstimulated and stimulated saliva samples from healthy volunteers was tested for EGF by radioimmunoassay. Salivary EGF, like other salivary constituents, was secreted in a diurnal pattern. On stimulation the rate of EGF secretion doubled but the concentration fell by 70% because of dilution by salivary fl...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: McGurk M,Hanford L,Justice S,Metcalfe RA

    更新日期:1990-01-01 00:00:00

  • Diagnostic potential and future directions of biomarkers in gingival crevicular fluid and saliva of periodontal diseases: Review of the current evidence.

    abstract:OBJECTIVES:The holy grail of biomarker research in periodontology is to develop a high impact diagnostics which have a significant impact on clinical decision-making, patient outcomes and healthcare providers. In the field of periodontal diagnostics, oral fluid-based biomarkers have been studied mainly in the gingival ...

    journal_title:Archives of oral biology

    pub_type: 杂志文章,评审


    authors: Ghallab NA

    更新日期:2018-03-01 00:00:00

  • Efficacy of enzymatic toothpastes for immobilisation of protective enzymes in the in situ pellicle.

    abstract:AIM:Different enzyme-containing toothpastes are available on the market. The aim of the present in situ study was to investigate their efficacy for immobilisation of protective enzymes in the pellicle layer. METHODS:Pellicle formation took place in situ on bovine enamel slabs fixed to individual upper jaw splints carr...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Hannig C,Spitzmüller B,Lux HC,Altenburger M,Al-Ahmad A,Hannig M

    更新日期:2010-07-01 00:00:00

  • Evocation of either excitatory or inhibitory reflex responses in human masseter muscle by electrical stimulation of the lip at varying intensities.

    abstract::Electrical stimuli at 1 Hz with pulse widths of 0.05, 0.1 and 1 ms with intensities from two to six times sensory threshold (2-6 T) were delivered to the lower lip. The reflex responses were monitored by surface electromyography of the ipsilateral masseter muscle. An excitatory response that was not preceded or follow...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Brodin P,Türker KS

    更新日期:1994-08-01 00:00:00

  • A histological study of the developing condylar cartilage of the fetal mouse mandible using coronal sections.

    abstract::The first indication of cartilage formation was detected on day 14.5 of pregnancy in close connection to the ossifying mandible. A separated blastema was never observed. Thus the findings support the concept that the condylar cartilage develops from already differentiated cells, not from primary undifferentiated mesen...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Shibata S,Suzuki S,Tengan T,Ishii M,Kuroda T

    更新日期:1996-01-01 00:00:00

  • Effect of cavity depth on dentine sensitivity in man.

    abstract:OBJECTIVE:To determine if dentine at the enamel-dentine junction (EDJ) in man is more sensitive to hydrostatic pressure stimuli then deeper dentine. DESIGN:Cavities (1mm diam.) were cut at the tips of the buccal and lingual cusps of 8 premolars in 3 subjects (ages: 22-25 years). Both cavities were initially deepened t...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Wanachantararak S,Ajcharanukul O,Vongsavan N,Matthews B

    更新日期:2016-06-01 00:00:00

  • Relationship of vitamin D with calbindin D9k and D28k expression in ameloblasts.

    abstract:OBJECTIVE:Calbindin D9k (CB9k) and D28k (CB28k) are intracellular soluble calcium-binding proteins, whose expressions are considered to be regulated by vitamin D. However, the amount of CB28k expression in the kidneys of vitamin D receptor-null mice was reported to be similar to that in wild type mice, suggesting no de...

    journal_title:Archives of oral biology

    pub_type: 杂志文章,评审


    authors: Onishi T,Shintani S,Wakisaka S,Ooshima T

    更新日期:2008-02-01 00:00:00

  • The small molecular weight, gamma-carboxyglutamic acid-containing protein of rabbit bone tissue.

    abstract::The major gamma-carboxyglutamic acid-containing protein of rabbit cortical bone isolated and purified from near-neutral (pH 7.5) EDTA-extracts by DEAE-cellulose and Sephadex G 75 column chromatography had a molecular weight of about 5600 based on integral amino-acid composition; this was confirmed by high-performance ...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Triffitt JT,Wilson JM

    更新日期:1984-01-01 00:00:00

  • Age-related changes in human sublingual glands: a post mortem study.

    abstract:OBJECTIVES:To analyse age- and gender-related microscopic changes in sublingual glands obtained from human cadavers. STUDY DESIGN:One hundred eighty six human sublingual glands were obtained from 93 autopsies. Approximately five individuals of each gender per decade of life were allocated to three age groups: group I ...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Azevedo LR,Damante JH,Lara VS,Lauris JR

    更新日期:2005-06-01 00:00:00

  • Inhibitory effects of β-caryophyllene on Streptococcus mutans biofilm.

    abstract:OBJECTIVE:The biofilm of Streptococcus mutans is associated with induction of dental caries. Also, they produce glucan as an extracellular polysaccharide through glucosyltransferases and help the formation of cariogenic biofilm. β-caryophyllene has been used for therapeutic agent in traditional medicine and has antimic...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Yoo HJ,Jwa SK

    更新日期:2018-04-01 00:00:00

  • Neural form of voltage-dependent sodium current in human cultured dental pulp cells.

    abstract::Intradental, i.e. pulpal, cells may play an important part in sensory transduction in teeth, although the cellular mechanisms and the identity of the specific cell types involved are still unclear. Because the majority of cells in dental pulp are derived from neural crest, it seemed likely that these might have the me...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Davidson RM

    更新日期:1994-07-01 00:00:00

  • Pathogenic mechanisms of cariogenic Propionibacterium acidifaciens.

    abstract:OBJECTIVE:Dental caries is one of the most common infectious diseases in humans. Older adults retain more teeth than did earlier generations and thus are at high risk of root caries. The root surface is covered by cementum, which facilitates the spread of caries lesions into dentinal tissues. Propionibacterium acidifac...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Obata J,Fujishima K,Nagata E,Oho T

    更新日期:2019-09-01 00:00:00

  • Can salivary activity predict periodontal breakdown in A. actinomycetemcomitans infected adolescents?

    abstract:OBJECTIVE:While Aggregatibacter actinomycetemcomitans (Aa) is highly associated with localised aggressive periodontitis (LAP) many Aa-carriers do not develop LAP. This study was designed to determine whether specific salivary factors could distinguish between subjects who have Aa initially and remain healthy (H/AA) as ...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Fine DH,Furgang D,McKiernan M,Rubin M

    更新日期:2013-06-01 00:00:00

  • The oxytalan fibre network in the periodontium and its possible mechanical function.

    abstract::The biomechanical character of the periodontal ligament (PDL) is crucial in its response to functional and orthodontic forces. Collagen has been the primary subject of investigations in this field. Several studies, however, indicate that oxytalan fibres, which belong to the elastic fibre family, also contribute to the...

    journal_title:Archives of oral biology

    pub_type: 杂志文章,评审


    authors: Strydom H,Maltha JC,Kuijpers-Jagtman AM,Von den Hoff JW

    更新日期:2012-08-01 00:00:00

  • Oral biofilm uptake of mineral ions released from experimental toothpaste containing surface pre-reacted glass-ionomer (S-PRG) filler.

    abstract:OBJECTIVE:To clarify the fluoride/mineral kinetics in an oral biofilm following concurrent application of fluoride and other mineral ions released from experimental toothpaste containing S-PRG filler using depth-specific analysis. STUDY DESIGN:Twenty subjects wore in situ plaque-generating devices, comprised of a pair...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Kato K,Tamura K,Shimazaki Y

    更新日期:2020-09-01 00:00:00

  • The effects of dental wear on third molar eruption and on the curve of Spee in human archaeological dentitions.

    abstract::The abrasiveness of food is a key determinant in the rate of physiological attrition (dental wear) in humans. With increasing food processing through time, the rate of physiological dental wear in human teeth has decreased markedly. Many consider such wear to be beneficial to oral health and that insufficient wear may...

    journal_title:Archives of oral biology

    pub_type: 历史文章,杂志文章


    authors: Sengupta A,Whittaker DK,Barber G,Rogers J,Musgrave JH

    更新日期:1999-11-01 00:00:00

  • Effect of gels containing chlorhexidine or epigallocatechin-3-gallate on the protein composition of the acquired enamel pellicle.

    abstract:OBJECTIVE:This study evaluated changes in protein profile of the acquired enamel pellicle (AEP) formed in vivo, after application of gels containing chlorhexidine or EGCG and further challenge with citric acid. DESIGN:AEP was formed in 9 volunteers for 2h and then treated with one of the following gels: placebo, 400μM...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: de Souza-E-Silva CM,da Silva Ventura TM,de Pau L,la Silva Cassiano,de Lima Leite A,Buzalaf MAR

    更新日期:2017-10-01 00:00:00

  • An in vitro approach for the study of dentinogenesis by organ culture of the dentine-pulp complex from rat incisor teeth.

    abstract::Culture of the developing dental tissues has contributed to understanding of developmental processes during early odontogenesis. However, to understand fully the mechanisms involved during dentinogenesis and tissue repair there is a need to develop culture models for the dentine-pulp complex from more mature dental ti...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Sloan AJ,Shelton RM,Hann AC,Moxham BJ,Smith AJ

    更新日期:1998-06-01 00:00:00

  • A comparison between a conventional optical method and image-analysis for measuring the unimpeded eruption rate of the rat mandibular incisor.

    abstract::The impeded/unimpeded eruption rates of the rat incisor have been much studied. The most commonly used optical microscopic method, which has inherent weaknesses, was compared here with an image-analysis method to measure the eruption rate of the mandibular incisor. The study also evaluated the incisal edge as a refere...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Lee CK,Law KT,King NM,Rabie AB

    更新日期:2002-07-01 00:00:00

  • Antimicrobial activity and inhibition of biofilm formation in vitro and on human dentine by silver nanoparticles/carboxymethyl-cellulose composites.

    abstract:OBJECTIVE:To evaluate the antimicrobial activity of a silver nanoparticles/carboxymethyl-cellulose (AgNPs/CMC) composite on in vitro and dentine disc heterogeneous biofilms. DESIGN:AgNPs/CMC composite effect on normal human gingival fibroblast cells (HGF) viability was determined by the MTT reduction assay. In additio...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Madla-Cruz E,De la Garza-Ramos M,Romo-Sáenz CI,Tamez-Guerra P,Garza-Navarro MA,Urrutia-Baca V,Martínez-Rodríguez MA,Gomez-Flores R

    更新日期:2020-12-01 00:00:00

  • TiF4 and NaF varnishes induce low levels of apoptosis in murine and human fibroblasts through mitochondrial Bcl-2 family and death receptor signalling.

    abstract:OBJECTIVES:This study evaluated the level and mechanism of apoptosis in human gingival fibroblasts (HGF) and murine fibroblasts (NIH/3T3) treated with a titanium tetrafluoride (TiF4) varnish compared those treated with a sodium fluoride (NaF) varnish. METHODS:Cells were treated with a TiF4, NaF (both 2.45%F) or placeb...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Aranda Salomão PM,de Oliveira FA,Dos Santos DMS,Domezi JP,Dionísio TJ,de Oliveira RC,Magalhães AC

    更新日期:2019-01-01 00:00:00

  • Determination of leucocyte subsets in human saliva by flow cytometry.

    abstract:OBJECTIVE:Validation of a flow cytometry-based method for the determination of major leucocyte subsets [polymorphonuclear (PMN) cells, monocytes, T cells and B cells] in paraffin-stimulated whole human saliva. DESIGN:Salivary leucocyte subsets were determined by four-colour flow cytometry in eight healthy volunteers o...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Vidović A,Vidović Juras D,Vučićević Boras V,Lukač J,Grubišić-Ilić M,Rak D,Sabioncello A

    更新日期:2012-05-01 00:00:00

  • MUC1 expression in the oral mucosal epithelial cells of the elderly.

    abstract:OBJECTIVE:MUC1 is primarily involved in the protection of epithelial surfaces. Decreases in oral mucosal defence can be a predisposing factor for the development of oral mucosal diseases in the elderly. The aim of this study was to compare MUC1 expression level in oral mucosal epithelial cells of the elderly with that ...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Chang WI,Chang JY,Kim YY,Lee G,Kho HS

    更新日期:2011-09-01 00:00:00

  • Places in the dental arch that show a greater variability in tooth number, shape and position--a prevalence study.

    abstract:OBJECTIVE:The aim of this study was to assess the frequency of variations in tooth number, shape and position in the dental arch to determine if there are parts of the dental arch that show a higher prevalence of tooth variability. DESIGN:198 randomly selected Caucasian subjects (93 females, 105 males) aged between 10...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Primožič J,Farčnik F,Ovsenik M

    更新日期:2012-06-01 00:00:00

  • Longitudinal evaluation of prostaglandin E2 (PGE2) and periodontal status in HIV+ patients.

    abstract::The study aim was to determine whether prostaglandin E(2) (PGE(2)) in gingival crevicular fluid (GCF) could serve as a risk factor for periodontitis in human immunodeficiency virus-positive (HIV(+)) patients. Clinical measurements, including gingival index (GI), plaque index, bleeding index, probing depth (PD), attach...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Alpagot T,Remien J,Bhattacharyya M,Konopka K,Lundergan W,Duzguneş N

    更新日期:2007-11-01 00:00:00

  • The variation in the size and shape of the human speech pattern with incisor-tooth relation.

    abstract::A mandibular kinesiograph was used to monitor the movement of the lower incisors of young dentate adults reading a standard text. An interface to a microcomputer which recorded and analysed these movements. As the tracings accumulated on the computer monitor, a characteristic pattern was produced. The dimensions of th...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Howell PG

    更新日期:1987-01-01 00:00:00

  • Oral mucosa and salivary findings in non-diabetic patients with chronic kidney disease.

    abstract:INTRODUCTION:Chronic kidney disease (CKD) and dialysis treatment could affect oral mucosa and cause qualitative or quantitative changes of saliva. OBJECTIVE:The aim of the study was to investigate oral manifestations, unstimulated salivary flow rate (USFR), salivary pH value and biochemical composition of saliva in no...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Marinoski J,Bokor-Bratic M,Mitic I,Cankovic M

    更新日期:2019-06-01 00:00:00

  • Oxidative stress indices in COPD--Broncho-alveolar lavage and salivary analysis.

    abstract:OBJECTIVE:It has been suggested that oxidative stress plays a role in the pathogenesis of chronic obstructive pulmonary disease (COPD), though this role has yet to be fully elucidated. The purpose of this study was to further evaluate this role as concomitantly expressed in the saliva and broncho-alveolar lavage (BAL/'...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Yigla M,Berkovich Y,Nagler RM

    更新日期:2007-01-01 00:00:00