Abstract:
INTRODUCTION:Chronic kidney disease (CKD) and dialysis treatment could affect oral mucosa and cause qualitative or quantitative changes of saliva. OBJECTIVE:The aim of the study was to investigate oral manifestations, unstimulated salivary flow rate (USFR), salivary pH value and biochemical composition of saliva in non-diabetic patients with CKD. DESIGN:The study group (PD) consisted of 50 pre-dialysis patients diagnosed with CKD, positive control group (HD) of 25 haemodialysis patients and negative control (H) of 25 age and gender-matched healthy persons. Creatinine clearance rate (CrCl) was calculated from the blood creatinine using the Cockcroft-Gault formula. After a detailed intraoral examination, whole unstimulated saliva samples were collected to determine salivary pH value, and biochemical composition using a spectrophotometric method. RESULTS:Statistical analysis revealed that PD subjects had more oral lesions (p < 0.05) and symptoms (p < 0.001) than controls. The mean CrCl was significantly lower (p < 0.05) in CKD subjects with pale mucosa, xerostomia, dysgeusia, and uremic odour, comparing to those without listed symptoms. PD subjects had significantly decreased USFR and increased pH, urea and creatinine than H controls (p < 0.05). A moderately strong positive correlation between serum and salivary creatinine in both PD (p < 0.05) and HD (p < 0.05) groups was found. CONCLUSION:This study confirmed that xerostomia and dysgeusia are major symptoms among pre-dialysis patients. Their presence along with uremic odour and pale mucosa is directly related to decreased kidney function. On the diagnostic point, decreased USFR, especially hyposalivation and increased salivary creatinine, should be considered a significant indicator of CKD in stages before dialysis therapy.
journal_name
Arch Oral Bioljournal_title
Archives of oral biologyauthors
Marinoski J,Bokor-Bratic M,Mitic I,Cankovic Mdoi
10.1016/j.archoralbio.2019.04.021subject
Has Abstractpub_date
2019-06-01 00:00:00pages
205-211eissn
0003-9969issn
1879-1506pii
S0003-9969(18)30868-9journal_volume
102pub_type
杂志文章abstract:OBJECTIVE:The existence of extra-pineal melatonin has been observed in various tissues. No prior studies of melatonin in human oral mucosal tissue under the condition of chronic inflammation have been reported. The aim of this study was to investigate the presence of melatonin in oral mucosal tissue of patients with or...
journal_title:Archives of oral biology
pub_type: 杂志文章
doi:10.1016/j.archoralbio.2017.02.007
更新日期:2017-06-01 00:00:00
abstract::The secretions (HPS) contained an arylamidase-like enzyme discovered by chromatography on Sephadex G-100 Superfine columns using N-L-alanyl-2-naphthylamine (2NA) as substrate. The enzyme was fractionated in the void volume, suggesting that its molecular weight was 150,000 or higher. It hydrolysed, with decreasing rate...
journal_title:Archives of oral biology
pub_type: 杂志文章
doi:10.1016/0003-9969(85)90050-0
更新日期:1985-01-01 00:00:00
abstract::High-speed, high-resolution data (frontal plane) were collected from 6 Sprague-Dawley rats by opto-electronic mandibular tracking (OMT), followed by microcomputer analysis of individual chew cycles. Mastication comprised rapidly alternating, unilateral cycles with variable degrees of lateral translation. There was no ...
journal_title:Archives of oral biology
pub_type: 杂志文章
doi:10.1016/0003-9969(88)90047-7
更新日期:1988-01-01 00:00:00
abstract:OBJECTIVES:Radiographic dental age estimation methods are viable in the living and deceased. One such method [Kvaal et al. Forensic Sci Int 1995;74:175-85] quantified secondary dentinal deposition indirectly through measurements of tooth and pulp lengths and widths. The method is untested on non-European populations an...
journal_title:Archives of oral biology
pub_type: 杂志文章
doi:10.1016/j.archoralbio.2011.08.020
更新日期:2012-03-01 00:00:00
abstract:OBJECTIVES:Lemon essential oil (LEO) is a kind of secondary metabolite from lemon peels and has been found to inhibit cariogenic bacteria for decades. However, its effects on main cariogenic virulence factors are rarely reported. The present study aimed to investigate the effects of sub-minimum inhibitory concentration...
journal_title:Archives of oral biology
pub_type: 杂志文章
doi:10.1016/j.archoralbio.2017.12.028
更新日期:2018-03-01 00:00:00
abstract::These mechanoreceptors were studied with particular regard to their type and the distribution. In both species they were concentrated in the crests of transverse palatine rugae. In the mouse, Meissner corpuscles, glomerular corpuscles, and Merkel cell nerve endings were seen in every palatine ruga, though the first an...
journal_title:Archives of oral biology
pub_type: 杂志文章
doi:10.1016/0003-9969(90)90014-2
更新日期:1990-01-01 00:00:00
abstract::Substituting ferrets for rats and dogs as animal models for craniofacial research is favourable because of the similarity of many of the ferret's anatomical, metabolic and physiological features to those of man. Other advantages are cost-effectiveness and possibly less ethical controversy. However, information on the ...
journal_title:Archives of oral biology
pub_type: 杂志文章
doi:10.1016/s0003-9969(02)00043-2
更新日期:2002-08-01 00:00:00
abstract::In a previous study, it was shown that tooth germs of neonatal homozygous parathyroid hormone-related protein (PTHrP)-knockout mice are penetrated or compressed by the surrounding alveolar bone, suggesting an important role for PTHrP in the formation and activation of osteoclasts around growing tooth germs. In order t...
journal_title:Archives of oral biology
pub_type: 杂志文章
doi:10.1016/s0003-9969(02)00026-2
更新日期:2002-09-01 00:00:00
abstract::Dispersed salivary acini isolated from the rat submandibular gland were incubated in a HEPES-buffered Krebs-Ringer solution or in the same buffer containing 20 mM NH4Cl and the accumulation and efflux of K+ were measured with the radiotracer 86Rb+, in the presence and absence of acetylcholine and of transport inhibito...
journal_title:Archives of oral biology
pub_type: 杂志文章
doi:10.1016/0003-9969(92)90135-u
更新日期:1992-01-01 00:00:00
abstract::Intradental, i.e. pulpal, cells may play an important part in sensory transduction in teeth, although the cellular mechanisms and the identity of the specific cell types involved are still unclear. Because the majority of cells in dental pulp are derived from neural crest, it seemed likely that these might have the me...
journal_title:Archives of oral biology
pub_type: 杂志文章
doi:10.1016/0003-9969(94)90137-6
更新日期:1994-07-01 00:00:00
abstract:OBJECTIVES:To explore the role of rostral ventromedial medulla (RVM) orexin 1 receptors (OX1R) on orofacial nociception -induced anxiety and locomotion in rats. DESIGN:Forty two adult male Wistar rats (220-270 gr) were randomly divided into 7 groups (n = 6) as follows: untreated control, capsaicin, capsaicin vehicle-t...
journal_title:Archives of oral biology
pub_type: 杂志文章
doi:10.1016/j.archoralbio.2020.104778
更新日期:2020-08-01 00:00:00
abstract::The interactions between low (MG2) and high (MG1) molecular-weight human submandibular-sublingual mucin and hydroxyapatite (OHAp) were compared using a quantitative assay. Data obtained appeared to empirically fit the Langmuir adsorption isotherm. Apparent affinity constants derived from this isotherm indicated that M...
journal_title:Archives of oral biology
pub_type: 杂志文章
doi:10.1016/0003-9969(85)90070-6
更新日期:1985-01-01 00:00:00
abstract::Cell migration and replication associated with odontoblast replacement occurring soon after pulp exposure in primate teeth were studied. Class 5 cavity preparations resulting in pulp exposures were restored with a calcium hydroxide-containing capping agent and amalgam. Eighty-four and 96 h after this the animals were ...
journal_title:Archives of oral biology
pub_type: 杂志文章
doi:10.1016/0003-9969(90)90093-p
更新日期:1990-01-01 00:00:00
abstract::A large earthquake (8-9 on the Richter scale) and a series of aftershocks took place on 2 March 1985 in Santiago, Chile. The characteristics of over 22,000 births registered in three public hospitals in the same year were reviewed. A significant increase in the rate of facial clefts was found; 2.01 per 1000 births in ...
journal_title:Archives of oral biology
pub_type: 杂志文章
doi:10.1016/0003-9969(94)00146-3
更新日期:1995-01-01 00:00:00
abstract:OBJECTIVE:To provide a systematic review of the effects of the bite-raised condition in animal models, a widespread technique in modern orthodontics. DESIGN:A systematic review of the literature was conducted. Original articles were searched through Pubmed, Cochrane Central database and Embase until December 2018. RE...
journal_title:Archives of oral biology
pub_type: 杂志文章
doi:10.1016/j.archoralbio.2019.104516
更新日期:2019-11-01 00:00:00
abstract:OBJECTIVES:The objective of this study was to evaluate the effect of platelet-rich plasma (PRP), platelet-rich fibrin (PRF), and concentrated growth factor (CGF) on bone healing. STUDY DESIGN:Twelve rabbits were included in this randomized, blinded, prospective study. 15-mm×10-mm-sized defects were created in the pari...
journal_title:Archives of oral biology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.archoralbio.2014.02.004
更新日期:2014-05-01 00:00:00
abstract:OBJECTIVE:To evaluate the effect of toothpaste treatments on levels of oral volatile sulphur compounds (VSCs) measured by gas chromatography in two clinical studies. METHODS:These were blinded, randomised, controlled, crossover studies with 16 (study A) or 20 (study B) healthy volunteers between the ages of 19-54. Stu...
journal_title:Archives of oral biology
pub_type: 杂志文章
doi:10.1016/S0003-9969(08)70005-0
更新日期:2008-04-01 00:00:00
abstract::Candidal adherence to mucosal surfaces is considered as the first step in the pathogenesis of oral candidiasis. We examined the effect of antifungal polyenes, amphotericin B, nystatin and natamycin, at sublethal and minimum inhibitory concentrations (MICs) on the adherence of Candida albicans and Candida glabrata to H...
journal_title:Archives of oral biology
pub_type: 杂志文章
doi:10.1016/s0003-9969(03)00174-2
更新日期:2003-12-01 00:00:00
abstract::Cheek pouches were removed from 9 BIO 87.20 adult-male hamsters, pinned out on cork sheets and fixed, then divided into segments and processed. Mallory stain showed complete orthokeratinization of the pouch epithelium with regular keratohyaline granules. With scanning electron microscopy, the morphology of the walls w...
journal_title:Archives of oral biology
pub_type: 杂志文章
doi:10.1016/0003-9969(82)90185-6
更新日期:1982-01-01 00:00:00
abstract::The cartilage of the mandibular condyle of growing mice was used to monitor changes in the content of protein, DNA, hydroxyproline, hydroxylysine, uronic acid, calcium and phosphate. Protein and DNA increased in a stepwise fashion with one spurt seen during the first 2 weeks of post-natal life a second immediately aft...
journal_title:Archives of oral biology
pub_type: 杂志文章
doi:10.1016/0003-9969(83)90036-5
更新日期:1983-01-01 00:00:00
abstract::Mechanisms of primary fluid formation by macropodine mandibular glands were investigated in anaesthetized red kangaroos using ion-transport and carbonic anhydrase inhibitors. Bumetanide at carotid plasma concentrations of 0.005-0.1 mmol/l progressively reduced a stable, acetylcholine-evoked flow rate of 1.02 +/- 0.024...
journal_title:Archives of oral biology
pub_type: 杂志文章
doi:10.1016/s0003-9969(97)00074-5
更新日期:1997-10-01 00:00:00
abstract::Although mechanisms underlying chronic muscle pain are poorly understood, one prevalent theory is that it is due, in part, to localized hypoxia. The purpose of this study was to evaluate this theory using non-invasive near-infra-red spectroscopy that monitors relative changes in intramuscular haemoglobin (Hb) concentr...
journal_title:Archives of oral biology
pub_type: 杂志文章
doi:10.1016/0003-9969(96)00009-x
更新日期:1996-06-01 00:00:00
abstract::Mesiodistal dimensions of teeth in 59 relatives of 26 patients with oligodontia were evaluated and compared with the size of teeth of a control group (n = 66). It was found that the teeth of relatives do show reductions in size even in relatives with a full permanent dentition. In male relatives with a full permanent ...
journal_title:Archives of oral biology
pub_type: 杂志文章
doi:10.1016/0003-9969(95)00143-3
更新日期:1996-05-01 00:00:00
abstract::The first indication of cartilage formation was detected on day 14.5 of pregnancy in close connection to the ossifying mandible. A separated blastema was never observed. Thus the findings support the concept that the condylar cartilage develops from already differentiated cells, not from primary undifferentiated mesen...
journal_title:Archives of oral biology
pub_type: 杂志文章
doi:10.1016/0003-9969(95)00105-0
更新日期:1996-01-01 00:00:00
abstract:OBJECTIVE:Vanillic acid, also known as 4-hydroxy-3-methoxy benzoic acid has a potent effect on bone metabolism. The purpose of the present study was to specify the effects of vanillic acid (VA) on preventing inflammation and bone destruction in experimental periodontitis as inflammatory bone disease. To evaluate the ef...
journal_title:Archives of oral biology
pub_type: 杂志文章
doi:10.1016/j.archoralbio.2019.05.010
更新日期:2019-07-01 00:00:00
abstract:OBJECTIVE:This study aimed to evaluate the anti-caries effect of a fluoridated milk-based drink on a root caries model by assessing mineral loss and both biofilm microbial viability and acidogenicity under increasing concentrations of fluoride supplementation. DESIGN:Streptococcus mutans UA159 biofilms were grown on r...
journal_title:Archives of oral biology
pub_type: 杂志文章
doi:10.1016/j.archoralbio.2020.104878
更新日期:2020-10-01 00:00:00
abstract::Previous studies using potassium ion-selective microelectrodes have demonstrated that potassium concentrations in dental plaque fluid obtained by centrifugation are identical to whole plaque values determined immediately after collection. Such procedures were now used to examine the variations in potassium concentrati...
journal_title:Archives of oral biology
pub_type: 杂志文章
doi:10.1016/0003-9969(88)90030-1
更新日期:1988-01-01 00:00:00
abstract::Perfusion with a variety of commonly-used fixatives was used. Quality of cell preservation and occurrence of stippled material between the mineralization front and the secretory ameloblasts were compared in normal animals and in ones injected with fluoride. There was no relationship between the formation of stippled m...
journal_title:Archives of oral biology
pub_type: 杂志文章
doi:10.1016/0003-9969(84)90172-9
更新日期:1984-01-01 00:00:00
abstract::Previous studies have reported that the abnormal development of the second deciduous molar in Down syndrome and cerebral palsy begins before birth. In view of these results we have turned our attention to the earlier stages of dental development in utero, represented by the primary canine, in order to see if we can id...
journal_title:Archives of oral biology
pub_type: 杂志文章
doi:10.1016/j.archoralbio.2007.04.011
更新日期:2007-10-01 00:00:00
abstract::The crown and root morphology, and bilateral occurrence of human deciduous lower first molars that exhibited a triangular occlusal outline, taken from excavated samples of Japanese, Jomonese and Iraqi origin, were investigated. The crowns of triangular teeth had smaller mesiodistal and larger buccolingual diameters th...
journal_title:Archives of oral biology
pub_type: 历史文章,杂志文章
doi:10.1016/0003-9969(95)00131-x
更新日期:1996-04-01 00:00:00