Platelet aggregation induced by uncommon serotypes of Streptococcus sanguis isolated from patients with Behçet's disease.

Abstract:

:Uncommon serotypes were tested for their ability to induce aggregation in platelet-rich plasma. Both uncommon and common serotypes induced platelet aggregation in rabbit platelet-rich plasma, but serotonin release was higher with the uncommon serotypes. Aggregation at ATP release varied between uncommon and common serotypes. With human platelet-rich plasma, only uncommon serotypes showed aggregation. Differences in serotype selectivity and the rate of aggregation were noted among platelet donors. About half of the patients with Behçet's disease and 30% of health controls showed platelet aggregation. Plasma from non-responder patients with Behçet's disease inhibited aggregation of healthy responder platelets within 20 min. Thus selective binding of uncommon serotypes of Strep. sanguis to platelets might cause the vasculitis in Behçet's disease.

journal_name

Arch Oral Biol

journal_title

Archives of oral biology

authors

Isogai E,Isogai H,Yokota K,Hayashi S,Fujii N,Oguma K,Yoshikawa K,Sasamoto Y,Kotake S,Ohno S

doi

10.1016/0003-9969(91)90132-e

subject

Has Abstract

pub_date

1991-01-01 00:00:00

pages

425-9

issue

6

eissn

0003-9969

issn

1879-1506

pii

0003-9969(91)90132-E

journal_volume

36

pub_type

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