Spontaneous periodontitis is associated with metabolic syndrome in rhesus monkeys.

Abstract:

OBJECTIVE:The present study was designed to investigate (1) whether the non-human primate would be an appropriate animal model for the study of spontaneous periodontitis and its association with metabolic syndrome (MetS), and (2) whether microRNAs (miRNAs) play roles in the co-development of metabolic disorders and periodontitis. DESIGN:Rhesus monkeys (aged 12-29 years) with or without MetS were analyzed for the prevalence of periodontitis. The potential mechanisms underlying the association between MetS and periodontitis were explored using miRNA profiling of the gingival tissues from the MetS monkey groups with or without periodontitis as well as the age-matched controls. RESULTS:Among the 57 rhesus monkeys examined, 18 were diagnosed with periodontitis according to the inclusion criteria, with an overall prevalence of 31.6%. Moreover, the prevalence of periodontitis was 8.3% in the control group, 18.2% in the at-risk group, and 44.1% in the MetS group. The C-reactive protein level was doubled in the MetS periodontitis group, compared to the non-periodontitis sub-groups. Most importantly, only 3 miRNAs were confirmed to be differentially expressed between the MetS periodontitis and non-periodontitis subgroups while other miRNAs showed similar expression profiles. CONCLUSIONS:The results indicate that the monkey with MetS is an ideal model for studies of spontaneous periodontitis and its association with MetS. miRNA profiling using this unique model showed that miRNAs play roles in the co-development of MetS and periodontitis.

journal_name

Arch Oral Biol

journal_title

Archives of oral biology

authors

Sun HT,Zhang J,Hou N,Zhang X,Wang J,Bai Y

doi

10.1016/j.archoralbio.2014.01.004

subject

Has Abstract

pub_date

2014-04-01 00:00:00

pages

386-92

issue

4

eissn

0003-9969

issn

1879-1506

pii

S0003-9969(14)00005-3

journal_volume

59

pub_type

杂志文章
  • T helper 1 and 2 stimuli induce distinct phenotypes in gingival fibroblasts.

    abstract:OBJECTIVE:Gingival fibroblasts (GFs) can participate in the immune response and play an immune-regulatory role. This study was to evaluate whether GFs can be differently activated and polarized into distinct functional subtypes in response to T helper type 1 (Th1), or Th2 stimuli. DESIGN:Human GFs were stimulated by t...

    journal_title:Archives of oral biology

    pub_type: 杂志文章

    doi:10.1016/j.archoralbio.2019.04.019

    authors: Jang JY,Baek KJ,Choi Y,Ji S

    更新日期:2019-06-01 00:00:00

  • Morphometric study of length and grooves of maxillary lateral incisor roots.

    abstract:OBJECTIVE:Root grooves are considered a risk factor for periodontal disease. The purpose of this study was to measure the length of the root of maxillary lateral incisors (MLI), as well as the width and depth of the concavities of their proximal surfaces, and also to determine the prevalence of palato-gingival grooves....

    journal_title:Archives of oral biology

    pub_type: 杂志文章

    doi:10.1016/j.archoralbio.2006.02.008

    authors: Storrer CM,Sanchez PL,Romito GA,Pustiglioni FE

    更新日期:2006-08-01 00:00:00

  • Gene-gene interaction for nonsyndromic cleft lip with or without cleft palate in Chilean case-parent trios.

    abstract:OBJECTIVE:Nonsyndromic cleft lip with or without cleft palate (NSCL/P) is a birth defect for which several genes susceptibility genes been proposed. Consequently, it has been suggested that many of these genes belong to common inter-related pathways during craniofacial development gene-gene interaction. We evaluated th...

    journal_title:Archives of oral biology

    pub_type: 杂志文章

    doi:10.1016/j.archoralbio.2018.04.009

    authors: Suazo J,Santos JL,Colombo A,Pardo R

    更新日期:2018-07-01 00:00:00

  • The case of an insular molarless black rat: Effects on lifestyle and mandible morphology.

    abstract::We report a specimen of an insular black rat (Rattus rattus) from Illa den Colom (Menorca, Western Mediterranean) displaying a singular dental characteristic. It has no molar teeth but displays regular incisors. Its mere occurrence as a regular adult rat is puzzling and we attempted to evaluate what diet and morpholog...

    journal_title:Archives of oral biology

    pub_type: 杂志文章

    doi:10.1016/j.archoralbio.2010.05.004

    authors: Bover P,Alcover JA,Michaux J,Renaud S

    更新日期:2010-08-01 00:00:00

  • The effects of sodium lauryl sulphate and its oxidative breakdown products on calcium phosphate precipitation and transformation.

    abstract::Most commercial dentifrices contain sodium lauryl sulphate, which oxidizes upon storage. The effects of aged sodium lauryl sulphate and its oxidative breakdown products on the conversion of amorphous calcium phosphate to hydroxyapatite were studied in vitro by a pH drop method. Hydroxyapatite was identified from its X...

    journal_title:Archives of oral biology

    pub_type: 杂志文章

    doi:10.1016/0003-9969(92)90085-m

    authors: Hidaka S,Abe K

    更新日期:1992-03-01 00:00:00

  • Interferential effect of the over-erupted third molar on chewing movement.

    abstract:OBJECTIVE:To clarify whether over-eruption of the mandibular third molar can disturb chewing movement. METHODS:Eighteen patients with a unilateral mandibular over-erupted third molar confirmed by both study cast observation and T-scan occlusal detection were selected from a sample of patients with complaints of tempor...

    journal_title:Archives of oral biology

    pub_type: 杂志文章

    doi:10.1016/j.archoralbio.2017.06.012

    authors: Guo S,Li B,Qi K,Zhang M,Zhang H,Guo D,Liu X,Wang M

    更新日期:2017-10-01 00:00:00

  • Morphometric analysis of developing crowns of maxillary primary second molars and permanent first molars in humans.

    abstract::The purpose of this study was firstly to characterize the changes occurring in size and form of the mineralizing maxillary second primary molar and first permanent molar crowns, and secondly to determine if similar changes in size and form characterize enamel apposition in the crowns of these teeth. Twenty-five primar...

    journal_title:Archives of oral biology

    pub_type: 杂志文章

    doi:10.1016/s0003-9969(98)00034-x

    authors: Peretz B,Nevis N,Smith P

    更新日期:1998-07-01 00:00:00

  • Sclerostin injection enhances orthodontic tooth movement in rats.

    abstract:OBJECTIVE:It was aimed to investigate the in vivo effects of local injection of sclerostin protein on orthodontic tooth movement. DESIGN:A total of 48 rats underwent orthodontic mesialization of the maxillary first molars on both sides. Local injection was given at the compression side in the alveolar bone on both max...

    journal_title:Archives of oral biology

    pub_type: 杂志文章

    doi:10.1016/j.archoralbio.2018.12.011

    authors: Lu W,Zhang X,Firth F,Mei L,Yi J,Gong C,Li H,Zheng W,Li Y

    更新日期:2019-03-01 00:00:00

  • The effect of stimulus intensity and gape on electrically-evoked jaw reflexes in man.

    abstract::The changes in masseter EMG and biting force evoked by electrical stimulation of the lip were measured in normal people. Stimulation at noxious intensities elicited a characteristic, biphasic inhibitory response in the masseter EMG and a transient reduction in the biting force. The pattern of masseter inhibition and f...

    journal_title:Archives of oral biology

    pub_type: 杂志文章

    doi:10.1016/0003-9969(85)90083-4

    authors: Türker KS,Miles TS

    更新日期:1985-01-01 00:00:00

  • Altered phenotype and function of dendritic cells in individuals with chronic periodontitis.

    abstract:OBJECTIVE:To investigate the effects of periodontal bacterial lysates on maturation and function of mature monocyte-derived dendritic cells (m-MDDCs) derived from individuals with chronic periodontitis (CP) or healthy periodontal tissue (HP). DESIGN:m-MDDCs derived from peripheral blood monocytes, cultured for 7 days ...

    journal_title:Archives of oral biology

    pub_type: 杂志文章

    doi:10.1016/j.archoralbio.2013.03.013

    authors: Cury PR,Carmo JP,Horewicz VV,Santos JN,Barbuto JA

    更新日期:2013-09-01 00:00:00

  • Histological and histochemical observations on salivary microliths in ferret.

    abstract::The fortuitous observation of salivary microliths in ferret was pursued in the present investigation. Major salivary glands obtained post-mortem from mature ferrets of either sex were examined with the use of histology and light microscopical histochemistry for calcium, protein, amino acids, mucosubstances and hydroly...

    journal_title:Archives of oral biology

    pub_type: 杂志文章

    doi:10.1016/j.archoralbio.2005.07.009

    authors: Triantafyllou A,Fletcher D,Scott J

    更新日期:2006-03-01 00:00:00

  • High frequency of p16 and p14 promoter hypermethylation and marked telomere instability in salivary gland tumors.

    abstract:OBJECTIVES:to investigate p16(INK4a) and p14(ARF) tumor suppressor gene methylation status, determine telomere length and assess the importance of these epigenetic and genetic parameters in the development of pleomorphic adenoma and carcinoma ex pleomorphic adenoma of the parotid salivary glands. MATERIALS AND METHODS...

    journal_title:Archives of oral biology

    pub_type: 杂志文章

    doi:10.1016/j.archoralbio.2015.08.011

    authors: Nikolic N,Anicic B,Carkic J,Simonovic J,Toljic B,Tanic N,Tepavcevic Z,Vukadinovic M,Konstantinovic VS,Milasin J

    更新日期:2015-11-01 00:00:00

  • The effect of honey on human tooth enamel in vitro observed by electron microscopy and microhardness measurements.

    abstract::Various fruit juices with relatively low pH are known to have erosive effects on human tooth enamel in a reasonably short time. Honey, also with a relatively low pH, could do the same, but scanning electron microscopy showed no erosion of enamel by honey over a period of 30 min, neither did Knoop microhardness tests s...

    journal_title:Archives of oral biology

    pub_type: 杂志文章

    doi:10.1016/0003-9969(94)90110-4

    authors: Grobler SR,du Toit IJ,Basson NJ

    更新日期:1994-02-01 00:00:00

  • A comparison of electromyography recorded parallel and transverse to the fibres of the anterior and posterior temporalis muscle in man.

    abstract::Electrical activity recorded during voluntary clenching by platinum hook intra-cutaneous electrodes was significantly higher (p less than 0.01) when the electrodes were placed parallel to the muscle fibres than across the fibres. The correlation between the parallel and transverse EMG recordings was highly significant...

    journal_title:Archives of oral biology

    pub_type: 杂志文章

    doi:10.1016/0003-9969(87)90110-5

    authors: Ahlgren J,Henrikson T

    更新日期:1987-01-01 00:00:00

  • Development of multi-species consortia biofilms of oral bacteria as an enamel and root caries model system.

    abstract::The aim was to establish defined-species consortium plaque biofilms to investigate enamel and root caries in an artificial mouth. Strains of the putative enamel and root caries pathogens, Streptococcus mutans, Strep. sobrinus, Actinomyces naeslundii and Lactobacillus rhamnosus, were screened in batch culture for poten...

    journal_title:Archives of oral biology

    pub_type: 杂志文章

    doi:10.1016/s0003-9969(99)00111-9

    authors: Shu M,Wong L,Miller JH,Sissons CH

    更新日期:2000-01-01 00:00:00

  • The approximal bone height and intrabony defects in young adults, related to the salivary buffering capacity and counts of Streptococcus mutans and Lactobacilli.

    abstract::Using a computerized technique the bone height and prevalence of approximal periodontal intrabony defects were assessed on posterior bite-wing radiographs from 151 young adults. The results were related to the buffering capacity and counts of Streptococcus mutans and lactobacilli in whole stimulated saliva. The mean d...

    journal_title:Archives of oral biology

    pub_type: 杂志文章

    doi:10.1016/0003-9969(90)90161-3

    authors: Wikner S,Söder PO,Frithiof L,Wouters F

    更新日期:1990-01-01 00:00:00

  • Intercellular junctions in odontoblasts of the rat incisor studied with freeze-fracture.

    abstract::The morphology and distribution of various types of intercellular junctions were investigated in young odontoblasts. Gap junctions were found between odontoblasts as well as between odontoblasts and fibroblasts in the dental pulp. The junctions between odontoblasts were larger and more numerous than those between odon...

    journal_title:Archives of oral biology

    pub_type: 杂志文章

    doi:10.1016/0003-9969(84)90068-2

    authors: Iguchi Y,Yamamura T,Ichikawa T,Hashimoto S,Horiuchi T,Shimono M

    更新日期:1984-01-01 00:00:00

  • Initial periodontal treatment affects nucleotide-binding domain leucine-rich repeat-containing protein 3 inflammasome priming in peripheral blood mononuclear cells.

    abstract:OBJECTIVE:Accumulating evidence suggests an association between periodontitis and several systemic diseases, such as atherosclerosis. In the lesions of these diseases, nucleotide-binding domain leucine-rich repeat-containing protein 3 (NLRP3), apoptosis-associated speck-like protein containing a caspase activation and ...

    journal_title:Archives of oral biology

    pub_type: 杂志文章

    doi:10.1016/j.archoralbio.2019.104625

    authors: Higuchi K,Sm Z,Yamashita Y,Ozaki Y,Yoshimura A

    更新日期:2020-02-01 00:00:00

  • Antibacterial and cytotoxic evaluation of copper and zinc oxide nanoparticles as a potential disinfectant material of connections in implant provisional abutments: An in-vitro study.

    abstract:OBJECTIVE:This study evaluates the antibacterial activity against mono and multispecies bacterial models and the cytotoxic effects of zinc oxide and copper nanoparticles(ZnO-NPs/Cu-NPs) in cell cultures of human gingival fibroblasts(HGFs). DESIGN:The antibacterial activities of ZnO-NPs and Cu-NPs against 4 bacteria sp...

    journal_title:Archives of oral biology

    pub_type: 杂志文章

    doi:10.1016/j.archoralbio.2020.105031

    authors: Vergara-Llanos D,Koning T,Pavicic MF,Bello-Toledo H,Díaz-Gómez A,Jaramillo A,Melendrez-Castro M,Ehrenfeld P,Sánchez-Sanhueza G

    更新日期:2021-02-01 00:00:00

  • Determination of leucocyte subsets in human saliva by flow cytometry.

    abstract:OBJECTIVE:Validation of a flow cytometry-based method for the determination of major leucocyte subsets [polymorphonuclear (PMN) cells, monocytes, T cells and B cells] in paraffin-stimulated whole human saliva. DESIGN:Salivary leucocyte subsets were determined by four-colour flow cytometry in eight healthy volunteers o...

    journal_title:Archives of oral biology

    pub_type: 杂志文章

    doi:10.1016/j.archoralbio.2011.10.015

    authors: Vidović A,Vidović Juras D,Vučićević Boras V,Lukač J,Grubišić-Ilić M,Rak D,Sabioncello A

    更新日期:2012-05-01 00:00:00

  • Differential gene expression in the condylar cartilage of growing rabbits with temporomandibular joint anterior disk displacement-A transcriptomic study.

    abstract::Internal derangement (ID) in the temporomandibular joint (TMJ) comprises a group of clinical problems with relatively high prevalence. However, the temporal changes in gene expression of condylar cartilage during continuous ID remain unclear. The aim of the current study is to investigate by microarray analysis, the d...

    journal_title:Archives of oral biology

    pub_type: 杂志文章

    doi:10.1016/j.archoralbio.2016.11.006

    authors: Wang S,Deng L,Li Y,Wu H,Gu Z

    更新日期:2017-02-01 00:00:00

  • Dentine permeability and its role in the pathobiology of dentine sensitivity.

    abstract::The classical hydrodynamic theory implicated fluid movement as a transducing mechanism in the production of dental sensitivity. This theory assumes that sensitive dentine must be permeable. Various measurements of dentine permeability are discussed, including: (1) factors that influence diffusive permeation across den...

    journal_title:Archives of oral biology

    pub_type: 杂志文章,评审

    doi:10.1016/0003-9969(94)90191-0

    authors: Pashley DH

    更新日期:1994-01-01 00:00:00

  • Effect of estrogen receptor beta on the osteoblastic differentiation function of human periodontal ligament cells.

    abstract:OBJECTIVE:To investigate the effect of estrogen receptor beta (ERbeta) on osteoblastic differentiation function of human periodontal ligament (hPDL) cells by measuring the alkaline phosphatase (ALP) activity and the production of osteocalcin (OCN) in vitro. DESIGN:We employed a short interfering RNA (siRNA) technique ...

    journal_title:Archives of oral biology

    pub_type: 杂志文章

    doi:10.1016/j.archoralbio.2007.12.011

    authors: Liang L,Yu JF,Wang Y,Wang G,Ding Y

    更新日期:2008-06-01 00:00:00

  • The roles of histidine residues at the starch-binding site in streptococcal-binding activities of human salivary amylase.

    abstract::Human salivary alpha-amylase participates in the initial digestion of starch and may be involved in the colonization of viridans streptococci in the mouth. To elucidate the role of histidine residues located near the starch-binding site on the streptococcal-binding activity, the wild type and three histidine mutants, ...

    journal_title:Archives of oral biology

    pub_type: 杂志文章

    doi:10.1016/s0003-9969(98)00112-5

    authors: Tseng CC,Miyamoto M,Ramalingam K,Hemavathy KC,Levine MJ,Ramasubbu N

    更新日期:1999-02-01 00:00:00

  • Inhibitory properties of Coffea canephora extract against oral bacteria and its effect on demineralisation of deciduous teeth.

    abstract:OBJECTIVES:The antibacterial activity of Coffea canephora extract was evaluated in vitro against Streptococcus mutans and Streptococcus sobrinus. The viability of planktonic cells was analysed by susceptibility tests (MIC and MBC) and time-kill assays. The effect of the extract on dental demineralisation was also inves...

    journal_title:Archives of oral biology

    pub_type: 杂志文章

    doi:10.1016/j.archoralbio.2010.12.001

    authors: Antonio AG,Iorio NL,Pierro VS,Candreva MS,Farah A,dos Santos KR,Maia LC

    更新日期:2011-06-01 00:00:00

  • Human lateral pterygoid muscle activity on the return phase of contralateral and protrusive jaw movements.

    abstract::Normal function of the lateral pterygoid muscle is not well understood. The principal aim of this study was to determine whether there is a progressive decrease in lateral pterygoid activity as the condyle moves posteriorly and superiorly during the return phase of a contralateral or protrusive jaw movement, as would ...

    journal_title:Archives of oral biology

    pub_type: 杂志文章

    doi:10.1016/s0003-9969(00)00011-x

    authors: Phanachet I,Murray GM

    更新日期:2000-06-01 00:00:00

  • A review of in-vitro fibrocartilage tissue engineered therapies with a focus on the temporomandibular joint.

    abstract::The inability of fibrocartilage, specifically the temporomandibular joint (TMJ) disc, to regenerate and remodel following injury presents a unique problem for clinicians. Tissue engineering then offers a potential regenerative therapy. In vitro testing provides a valuable screening tool for potential tissue engineered...

    journal_title:Archives of oral biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.archoralbio.2017.07.013

    authors: Lowe J,Almarza AJ

    更新日期:2017-11-01 00:00:00

  • Biodistribution of GB-10 (Na(2)(10)B10H10 compound for boron neutron capture therapy (BNCT) in an experimental model of oral cancer in the hamster cheek pouch.

    abstract:OBJECTIVE:We previously proposed the hamster cheek pouch model of oral cancer for BNCT studies. We herein present the biodistribution of a non-toxic boron compound, GB-10 (Na(2)(10)B10H10), in this model to assess its potential for BNCT or BNCT enhanced Fast Neutron Therapy. MATERIALS AND METHODS:We evaluated the upta...

    journal_title:Archives of oral biology

    pub_type: 杂志文章

    doi:10.1016/j.archoralbio.2003.10.003

    authors: Heber E,Trivillin VA,Nigg D,Kreimann EL,Itoiz ME,Rebagliati RJ,Batistoni D,Schwint AE

    更新日期:2004-04-01 00:00:00

  • Degradation of insoluble bovine collagen and human dentine collagen pretreated in vitro with lactic acid, pH 4.0 and 5.5.

    abstract::The purpose of the study was to test the hypothesis that both insoluble pure type I collagen from bovine Achilles tendon and dentine collagen in root dentine powder from human teeth required acid pretreatment for subsequent degradation by trypsin, a non-specific protease. Pure type I collagen or dentine powder was tre...

    journal_title:Archives of oral biology

    pub_type: 杂志文章

    doi:10.1016/0003-9969(94)90022-1

    authors: Dung SZ,Li Y,Dunipace AJ,Stookey GK

    更新日期:1994-10-01 00:00:00

  • Haemodynamic changes induced by submaximal isometric contraction in painful and non-painful human masseter using near-infra-red spectroscopy.

    abstract::Although mechanisms underlying chronic muscle pain are poorly understood, one prevalent theory is that it is due, in part, to localized hypoxia. The purpose of this study was to evaluate this theory using non-invasive near-infra-red spectroscopy that monitors relative changes in intramuscular haemoglobin (Hb) concentr...

    journal_title:Archives of oral biology

    pub_type: 杂志文章

    doi:10.1016/0003-9969(96)00009-x

    authors: Delcanho RE,Kim YJ,Clark GT

    更新日期:1996-06-01 00:00:00