Enhancement by cyclosporin A of metastasis from hamster cheek pouch carcinoma.


:Daily intravenous administration of 50 mg/kg cyclosporin A (CsA), after excision of cheek pouch tumors induced with 9,10-dimethyl-1,2-benzanthracene (DMBA), enhanced the incidence of cervical lymph node metastasis to 93%, a significant increase over the rates observed for animals receiving a dosage of 25 mg/kg (43%), and for control animals receiving no CsA (40%). No significant effect was evident on the growth rates of the metastasized tumour cells in the lymph node.


Arch Oral Biol


Archives of oral biology


Yamada T,Mogi M,Kage T,Ueda A,Nakajima J,Chino T




Has Abstract


1992-01-01 00:00:00














  • Anti-inflammatory and antioxidant activity of hydroethanolic extract of Spondias mombin leaf in an oral mucositis experimental model.

    abstract:BACKGROUND:Spondias mombin has been used in folk medicine to treat inflammation in the oral cavity. This study aimed to evaluate the antioxidant and anti-inflammatory activity of S. mombin extract in an oral mucositis experimental model. METHODS:Male hamsters were orally pre-treated with hydroethanolic extract of S. m...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Sousa Gomes M,Diógenes Alves Uchoa Lins R,Zucolotto Langassner SM,Dantas da Silveira ÉJ,Gomes de Carvalho T,Diniz de Sousa Lopes ML,de Souza Araújo L,Addison Carvalho Xavier de Medeiros C,Ferreira de Carvalho Leitão R,Coelho Bernardo G

    更新日期:2020-03-01 00:00:00

  • The effect of honey on human tooth enamel in vitro observed by electron microscopy and microhardness measurements.

    abstract::Various fruit juices with relatively low pH are known to have erosive effects on human tooth enamel in a reasonably short time. Honey, also with a relatively low pH, could do the same, but scanning electron microscopy showed no erosion of enamel by honey over a period of 30 min, neither did Knoop microhardness tests s...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Grobler SR,du Toit IJ,Basson NJ

    更新日期:1994-02-01 00:00:00

  • Antisense inhibition of transglutaminase 2 affects development of mouse embryo submandibular gland in organ culture.

    abstract::Tissue transglutaminase (TGase 2) has been implicated in numerous cellular functions, i.e., apoptosis, differentiation, extracellular matrix protein cross-linking and organogenesis. Earlier report of the strong transient expression of TGase 2 localized at the anchoring sites of muscle bundles of human embryo and recen...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Lee SK,Kim YS,Lee SS,Lee YJ,Song IS,Park SC,Chi JG,Chung SI

    更新日期:2005-09-01 00:00:00

  • A study in 47,XYY men of the expression of sex-chromosome anomalies in dental occlusion.

    abstract::Occlusal traits were determined for 47,XYY men and compared with previous determinations of occlusal morphology in other sex-chromosome anomalies and in normal women and men. The 47,XYY men, like 47,XXY men, tended to have a mesial molar occlusion and a mandibular overjet more often than did other groups, while 45,X w...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Laine T,Alvesalo L,Lammi S

    更新日期:1992-11-01 00:00:00

  • Purification and characterization of Porphyromonas gingivalis outer membrane antigens.

    abstract::Porphyromonas gingivalis is strongly associated with periodontal disease. Significant titres of specific IgG antibodies to P. gingivalis can be found in healthy individuals and those with periodontitis. In this study, 22 outer membrane antigens ranging from 15.5 to 107.6 kDa were recognized by sera from persons with p...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Polak B,Peck MA,Dyer JK,Bird PS,Reinhardt RA,Seymour GJ

    更新日期:1995-10-01 00:00:00

  • Tooth type as indicator of exposure to lead of adults and children.

    abstract::One hundred and forty-two teeth of children and adults were analysed for lead content by graphite furnace atomic absorption spectrophotometry. The results showed that, for children, tooth age is an important factor that has to be taken into consideration when lead levels are evaluated. In adults tooth type may be igno...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Bercovitz K,Laufer D

    更新日期:1990-01-01 00:00:00

  • Risk factors of oral candidosis: a twofold approach of study by fuzzy logic and traditional statistic.

    abstract:OBJECTIVE:To assess a panel of risk factors associated to oral candidosis (OC) onset and its chronic maintenance by means of fuzzy logic (FL) approach and statistical traditional methodology (STM); to investigate their casual relationship within a multifactorial framework. DESIGN:Case-control study. SETTING:One hospi...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Campisi G,Panzarella V,Matranga D,Calvino F,Pizzo G,Lo Muzio L,Porter S

    更新日期:2008-04-01 00:00:00

  • Tea catechin epigallocatechin gallate inhibits Streptococcus mutans biofilm formation by suppressing gtf genes.

    abstract:OBJECTIVE:The anti-cariogenic properties of tea have been suggested for decades. Tea polyphenols, especially epigallocatechin gallate (EGCG), have been shown to inhibit dental plaque accumulation, but the exact mechanisms are not clear at present. We hypothesise that EGCG suppresses gtf genes in Streptococcus mutans at...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Xu X,Zhou XD,Wu CD

    更新日期:2012-06-01 00:00:00

  • Neural form of voltage-dependent sodium current in human cultured dental pulp cells.

    abstract::Intradental, i.e. pulpal, cells may play an important part in sensory transduction in teeth, although the cellular mechanisms and the identity of the specific cell types involved are still unclear. Because the majority of cells in dental pulp are derived from neural crest, it seemed likely that these might have the me...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Davidson RM

    更新日期:1994-07-01 00:00:00

  • RhoE regulates actin cytoskeleton organization in human periodontal ligament cells under mechanical stress.

    abstract:OBJECTIVES:RhoE and regulator of G-proteins signalling (RGS) 2 were identified as the up-regulated genes in human periodontal ligament (PDL) cells under compression. RhoE belongs to the Rho GTPase family, and RGS2, a novel family of GTPase-activating proteins, turns off the G-protein signalling. Rho family proteins hav...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: de Araujo RM,Oba Y,Kuroda S,Tanaka E,Moriyama K

    更新日期:2014-02-01 00:00:00

  • Inhibition of bovine gingival laminin receptor by bacterial lipopolysaccharide.

    abstract::A laminin receptor was isolated from bovine gingival epithelial-cell membrane. After solubilization with octylglucoside, the receptor was subjected to affinity chromatography on laminin-coupled Sepharose and eluted with cation-free EDTA buffer yielding on SDS-PAGE a 67 kDa protein band. After radioiodination, the prot...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Slomiany BL,Sengupta S,Piotrowski J,Shovlin FS,Slomiany A

    更新日期:1991-01-01 00:00:00

  • Effects of iron deficiency on respiration of hamster cheek-pouch epithelium in vitro.

    abstract::Iron-deficiency anaemia was induced in hamsters by feeding a low-iron diet coupled with weekly bleeding. Respiration, assessed by measuring oxygen uptake, was significantly reduced (p less than 0.002) in cheek-pouch epithelia from iron-deficient animals. To relate data on oxygen consumption to cell numbers, the cell d...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Ranasinghe AW,Johnson NW,Williams RA,Scragg MA

    更新日期:1985-01-01 00:00:00

  • Characterization of cyclic AMP phosphodiesterase isozymes in rat parotid gland.

    abstract::Cyclic AMP phosphodiesterase (PDE) isozymes were isolated and characterized from the soluble fraction of rat parotid gland. Four main peaks containing PDE activity were obtained by Q-Sepharose Fast Flow column chromatography. The four peaks were identified as PDEs I-IV by kinetic properties, molecular-weight analysis ...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Imai A,Nashida T,Shimomura H

    更新日期:1995-02-01 00:00:00

  • Initial periodontal treatment affects nucleotide-binding domain leucine-rich repeat-containing protein 3 inflammasome priming in peripheral blood mononuclear cells.

    abstract:OBJECTIVE:Accumulating evidence suggests an association between periodontitis and several systemic diseases, such as atherosclerosis. In the lesions of these diseases, nucleotide-binding domain leucine-rich repeat-containing protein 3 (NLRP3), apoptosis-associated speck-like protein containing a caspase activation and ...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Higuchi K,Sm Z,Yamashita Y,Ozaki Y,Yoshimura A

    更新日期:2020-02-01 00:00:00

  • Bilateral effect of a unilateral occlusal splint on the expression of myosin heavy-chain isoforms in rat deep masseter muscle.

    abstract::Many studies have shown that various myosin isoforms are involved in muscle contraction. A search for specific antibodies directed against the myosin heavy chain (MHC) resulted in the identification of at least two main classes, referred to as MHC type I and type II. In this study, immunohistology and gel electrophore...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Muller J,Vayssiere N,Muller A,Marti-Mestres G,Mornet D

    更新日期:2000-12-01 00:00:00

  • Chewing chitosan-containing gum effectively inhibits the growth of cariogenic bacteria.

    abstract:OBJECTIVE:We have already reported that chitosan inhibited the growth of cariogenic bacteria in vitro. This study was designed to evaluate whether chewing gum, containing chitosan, can effectively suppressed the growth of oral bacteria (total bacteria, total Streptococci, mutans streptococci (MS)) in saliva. METHODS:F...

    journal_title:Archives of oral biology

    pub_type: 杂志文章,随机对照试验


    authors: Hayashi Y,Ohara N,Ganno T,Yamaguchi K,Ishizaki T,Nakamura T,Sato M

    更新日期:2007-03-01 00:00:00

  • Comparisons of chewing rhythm, craniomandibular morphology, body mass and height between mothers and their biological daughters.

    abstract:OBJECTIVE:To study and compare the relationships between mean chewing cycle duration, selected cephalometric variables representing mandibular length, face height, etc., measured in women and in their teenage or young-adult biological daughters. DESIGN:Daughters were recruited from local high schools and the Universit...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Cho C,Louie K,Maawadh A,Gerstner GE

    更新日期:2015-11-01 00:00:00

  • Characterization of dental follicle cells in developing mouse molar.

    abstract::Dental follicle has been implicated as the origin of alveolar bone, cementum and periodontal ligament, but there is no direct evidence of their cellular lineage. The present pilot study was designed to characterize the phenotype of cultured cells obtained from the dental follicle of neonatal mouse molars. Developing m...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Hou LT,Liu CM,Chen YJ,Wong MY,Chen KC,Chen J,Thomas HF

    更新日期:1999-09-01 00:00:00

  • Selective inhibition of collagen biosynthesis in the dental pulps of glucocorticoid-treated rabbits.

    abstract::Prednisolone (2 mg/kg) was injected daily for 14 days. Collagen and protein biosynthesis were measured in isolated molar and incisor pulps by the incorporation of [14C]-proline into protein and collagen in vitro. Collagen solubility, free proline content, prolyl hydroxylase activity, collagenolytic activity and DNA an...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Uitto VJ,Manthorpe R

    更新日期:1983-01-01 00:00:00

  • An in-vitro study of the role of sucrose and interactions between oral bacteria in possible mechanisms of dental plaque formation.

    abstract::The adherence of streptococci to hydroxyapatite spheroids (HAS) depended upon the strain used, the fermentable carbon source available during bacterial growth, the number of times a clinical isolate had been subcultured on laboratory media and the pre-treatment of the HAS. Sucrose greatly stimulated the secondary colo...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Adshead VM,Parke JM,Chambers PJ,Davies RM,Cole JA

    更新日期:1983-01-01 00:00:00

  • Prenatal growth acceleration in maxillary deciduous canines of children with Down syndrome: histological and chemical composition study.

    abstract::Previous studies have reported that the abnormal development of the second deciduous molar in Down syndrome and cerebral palsy begins before birth. In view of these results we have turned our attention to the earlier stages of dental development in utero, represented by the primary canine, in order to see if we can id...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Keinan D,Smith P,Zilberman U

    更新日期:2007-10-01 00:00:00

  • The approximal bone height and intrabony defects in young adults, related to the salivary buffering capacity and counts of Streptococcus mutans and Lactobacilli.

    abstract::Using a computerized technique the bone height and prevalence of approximal periodontal intrabony defects were assessed on posterior bite-wing radiographs from 151 young adults. The results were related to the buffering capacity and counts of Streptococcus mutans and lactobacilli in whole stimulated saliva. The mean d...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Wikner S,Söder PO,Frithiof L,Wouters F

    更新日期:1990-01-01 00:00:00

  • The effect of intraperitoneal N-methyl-N-nitrosourea on hamster palatal gingiva and intermolar mucosa.

    abstract::Fifty 4- to 6-week-old male random-bred golden hamsters were injected intraperitoneally with a weight-related dose (12.5 mg/kg body weight) of N-methyl-N-nitrosourea (NMU) three times a week for 4 weeks. Groups of seven animals were killed 10, 16 and 22 weeks after the first injection. The palatal gingiva from six ani...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: McMillan MD,Smith CJ,Ramirez V

    更新日期:1994-06-01 00:00:00

  • Gene therapy in dentistry: tool of genetic engineering. Revisited.

    abstract::Advances in biotechnology have brought gene therapy to the forefront of medical research. The concept of transferring genes to tissues for clinical applications has been discussed nearly half a century, but the ability to manipulate genetic material via recombinant DNA technology has brought this goal to reality. The ...

    journal_title:Archives of oral biology

    pub_type: 杂志文章,评审


    authors: Gupta K,Singh S,Garg KN

    更新日期:2015-03-01 00:00:00

  • Roles of hypoxia inducible factor-1α in the temporomandibular joint.

    abstract:OBJECTIVE:Temporomandibular joint osteoarthritis (TMJ-OA) is a degenerative disease characterized by permanent cartilage loss. Articular cartilage is maintained in a low-oxygen environment. The chondrocyte response to hypoxic conditions involves expression of hypoxia inducible factor 1α (HIF-1α), which induces chondroc...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Mino-Oka A,Izawa T,Shinohara T,Mori H,Yasue A,Tomita S,Tanaka E

    更新日期:2017-01-01 00:00:00

  • Dentine permeability and its role in the pathobiology of dentine sensitivity.

    abstract::The classical hydrodynamic theory implicated fluid movement as a transducing mechanism in the production of dental sensitivity. This theory assumes that sensitive dentine must be permeable. Various measurements of dentine permeability are discussed, including: (1) factors that influence diffusive permeation across den...

    journal_title:Archives of oral biology

    pub_type: 杂志文章,评审


    authors: Pashley DH

    更新日期:1994-01-01 00:00:00

  • The incidence and distribution of branched pulpal axons in the adult ferret.

    abstract::Previous laboratory studies have revealed that some axons branch to supply the pulps of two teeth, but the incidence of such fibres in different regions of the jaws has not been investigated. The present study has used electrophysiological techniques to determine the incidence and distribution of branched pulpal axons...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Foster E,Robinson PP

    更新日期:1993-11-01 00:00:00

  • Immunocytochemical localization of laminin in the epithelial rests of Malassez of immature rat molars.

    abstract::Immediately after disruption of Hertwig's root sheath, epithelial cells were found near the root apex, singly or in groups of two or three cells. They were irregular in shape with only a partial lining of basal lamina. Immunoreactivity for laminin was intense in the basal lamina and weak between projections of the epi...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Hamamoto Y,Suzuki I,Nakajima T,Ozawa H

    更新日期:1991-01-01 00:00:00

  • Polymorphisms in genes involved in enamel development are associated with dental fluorosis.

    abstract:OBJECTIVE:To evaluate the association between polymorphisms in DLX1, DLX2, MMP13, TIMP1 and TIMP2 genes with dental fluorosis (DF) phenotype. DESIGN:Four hundred and eighty one subjects (108 with DF and 373 DF free) from 6 to 18 years of age were recruited. This population lived in Rio de Janeiro, a city with fluorida...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Küchler EC,Tannure PN,Oliveira DS,Charone S,Nelson-Filho P,Silva RA,Costa MC,Antunes LS,Calasans Maia MD,Antunes LA

    更新日期:2017-04-01 00:00:00

  • Salivary aldehyde dehydrogenase--reversible oxidation of the enzyme and its inhibition by caffeine, investigated using fluorimetric method.

    abstract:OBJECTIVE:We have applied fluorimetric method to monitor aldehyde dehydrogenase (ALDH*) activity in human saliva samples to study inactivation, reactivation and inhibition of the enzyme. DESIGN:Saliva samples were collected to buffer stock solution, containing various thiols, and assayed in the presence of the fluorog...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Wierzchowski J,Pietrzak M,Szelag M,Wroczyński P

    更新日期:2008-05-01 00:00:00