Abstract:
:Apoptosis in regressive primary (deciduous) dental primordia was examined in the embryos of Suncus murinus, which is a monophyodont. The primary tooth germs of S. murinus are temporarily formed and disappear during the embryonic period before they are calcified. Most primary tooth germs reach the bell stage and degenerate by embryonic day 22 (E22). Light microscopy on haematoxylin-eosin-stained sections revealed that intensely labelled granular substances are frequently present in the epithelial portion (enamel organs) of the deciduous tooth germs during the period from E18 to E20. The terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate-biotin nick end labelling method, computer-assisted three-dimensional reconstructions, and electron microscopy confirmed that these variable-sized granular substances are similar to apoptotic cells or bodies. Apoptotic structures were mainly found in the primary tooth germ located on the buccal surface of the secondary (successional) tooth germ. These results lead to the conclusion that apoptosis is closely associated with the involution and disappearance of the deciduous tooth germ in S. murinus. A primary tooth germ was observed on the buccal side of all the corresponding successional tooth germs, although the buccal surface of the secondary tooth germ of third upper molar teeth developed only to epithelial thickening without mesenchymal condensation. The findings, therefore, suggest that apoptosis is responsible for disappearance of the primary dental primordia during tooth development in S. murinus.
journal_name
Arch Oral Bioljournal_title
Archives of oral biologyauthors
Sasaki C,Sato T,Kozawa Ydoi
10.1016/s0003-9969(01)00007-3subject
Has Abstractpub_date
2001-07-01 00:00:00pages
649-60issue
7eissn
0003-9969issn
1879-1506pii
S0003-9969(01)00007-3journal_volume
46pub_type
杂志文章abstract::The study examined the glucose clearance (retention) in saliva at different surfaces of these teeth in 23 subjects. The mouth was thoroughly rinsed for 15 s with 20 ml of a 0.5 M glucose solution. The concentrations of glucose absorbed by small pieces of paper, placed on the mesial, distal, labial (buccal), lingual an...
journal_title:Archives of oral biology
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更新日期:1996-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:2000-11-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.archoralbio.2017.01.006
更新日期:2017-04-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2017-06-01 00:00:00
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更新日期:2020-03-01 00:00:00
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更新日期:2002-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:2019-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.archoralbio.2014.04.003
更新日期:2014-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/0003-9969(83)90107-3
更新日期:1983-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/0003-9969(89)90130-1
更新日期:1989-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2021-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.archoralbio.2017.05.023
更新日期:2017-10-01 00:00:00
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journal_title:Archives of oral biology
pub_type: 杂志文章
doi:10.1016/j.archoralbio.2011.11.009
更新日期:2012-06-01 00:00:00
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journal_title:Archives of oral biology
pub_type: 杂志文章
doi:10.1016/j.archoralbio.2014.08.021
更新日期:2015-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:1988-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.archoralbio.2018.05.016
更新日期:2018-09-01 00:00:00
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更新日期:2011-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.archoralbio.2004.02.004
更新日期:2004-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:1988-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:1994-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:2000-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.archoralbio.2014.12.009
更新日期:2015-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/s0003-9969(02)00210-8
更新日期:2003-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:1991-01-01 00:00:00
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journal_title:Archives of oral biology
pub_type: 杂志文章
doi:10.1016/j.archoralbio.2007.10.003
更新日期:2008-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.archoralbio.2016.10.003
更新日期:2017-01-01 00:00:00