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Beta-defensin 1 gene polymorphisms at 5' untranslated region are not associated with a susceptibility to recurrent aphthous stomatitis.

Abstract：

OBJECTIVE:The purpose of this study was to evaluate the possible association between two single nucleotide polymorphisms of the β-defensin 1 gene: -20 G > A and -44 C > G at 5 untranslated region and recurrent aphthous stomatitis in a cohort of Polish patients. DESIGN:One hundred and six patients suffering from recurrent aphthous stomatitis and 96 healthy volunteers were genotyped at β-defensin 1-20 G > A and -44 C > G using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) approach. The results were statistically analysed with the difference test between two proportion and chi-square tests with p < 0.05 as a significance level (Dell Statistica data analysis software system, version 13, Dell Inc. 2016). RESULTS:No statistically significant differences between the tested groups were revealed in the genotype distribution for -20 G > A and -44 C > G polymorphisms of the β-defensin 1 gene. Stratification into carriers and non-carriers of alleles did not unequivocally show the single nucleotide polymorphism recognized as a risk factor for recurrent aphthous stomatitis. However, after gender stratification, statistically significant differences in the distribution of some DEFB1 genotypes were observed. Heterozygotes of G[-20]A and C[-44]G genotypes were found more frequently in males with RAS than in males from the control group. Moreover, a significantly higher rate of carriers of the polymorphic *A[-20] allele was found in males with RAS compared to the controls. CONCLUSIONS:The role of the tested single nucleotide polymorphisms of the β-defensin 1 gene in the aetiology of recurrent aphthous stomatitis has not been confirmed. Further observations are required to clarify this potential association.

journal_name

Arch Oral Biol

journal_title

Archives of oral biology

authors

Kowalska A,Ślebioda Z,Woźniak T,Zasadziński R,Daszkowska M,Dorocka-Bobkowska B

doi

10.1016/j.archoralbio.2019.03.016

subject

Has Abstract

pub_date

2019-05-01 00:00:00

pages

130-134

eissn

0003-9969

issn

1879-1506

pii

S0003-9969(18)30878-1

journal_volume

101

pub_type

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Beta-defensin 1 gene polymorphisms at 5' untranslated region are not associated with a susceptibility to recurrent aphthous stomatitis.