Alpha 2 integrin gene (ITGA2) polymorphism in renal transplant recipients with and without drug induced gingival overgrowth.


BACKGROUND:Variances in fibroblasts' α2β1 integrin intensity may lead to altered adhesion to type I collagen and consequently to suppression of phagocytosis which may be one of the mechanisms for drug induced gingival overgrowth. The present study aimed to evaluate the genotype and allele frequencies of α2 integrin +807 gene in renal transplant patients with and without gingival overgrowth. MATERIAL AND METHODS:Seventy renal transplant patients with cyclosporine A (CsA)-induced gingival overgrowth (CsA GO+) were enrolled. Renal transplant patients without GO medicated with CsA (CsA GO-; n=79) and tacrolimus (Tac; n=52) served as controls. DNA was obtained from peripheral blood and ITGA2 +807C/T polymorphism was genotyped by polymerase chain reaction and restriction fragment length polymorphism method. Clinical parameters including probing depth and plaque, papilla bleeding and hyperplasia indexes were recorded. Chi-square, Kruskal-Wallis and Mann-Whitney tests were used in statistical analysis. RESULTS:Clinical parameters of CsA GO+ group were significantly higher than those of the CsA GO- and Tac groups (p<0.05). ITGA2 807C/T genotype and allele frequencies of study groups were similar (p>0.05). CONCLUSION:Within the limits of the present study it can be concluded that ITGA2 +807 gene polymorphism is not associated with susceptibility to CsA-induced GO.


Arch Oral Biol


Archives of oral biology


Gürkan A,Emingil G,Afacan B,Berdeli A,Atilla G




Has Abstract


2014-03-01 00:00:00














  • Influence of orthodontic forces on human dental pulp: a systematic review.

    abstract:AIM:The aim of the present study was to systematically review the influence of orthodontic force on human dental pulp. METHODS AND RESULTS:The addressed focused question was "Do orthodontic forces affect the human dental pulp?" which was based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (...

    journal_title:Archives of oral biology

    pub_type: 杂志文章,评审


    authors: Javed F,Al-Kheraif AA,Romanos EB,Romanos GE

    更新日期:2015-02-01 00:00:00

  • Discrimination of objective kinematic characters in temporomandibular joint displacements.

    abstract::Designing a temporomandibular joint (TMJ) total prosthesis requires the assessment of joint displacements for open/close movements. Current knowledge presents disc-condyle motions as involving both translation and rotation but there may be substantial variations from human to human. The aim of this study is to discrim...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Coutant JC,Mesnard M,Morlier J,Ballu A,Cid M

    更新日期:2008-05-01 00:00:00

  • Variation in alkaline-phosphatase activity with changing load on the mandibular condylar cartilage in the rat.

    abstract::Biomechanical loads were varied by feeding diets of different consistencies. One group was fed hard diet for eight weeks, a second soft diet for eight weeks, and a third soft diet for four weeks followed by four weeks of hard diet. In all groups, alkaline-phosphatase activity was localized primarily in cells and extra...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Bouvier M

    更新日期:1987-01-01 00:00:00

  • Spontaneous periodontitis is associated with metabolic syndrome in rhesus monkeys.

    abstract:OBJECTIVE:The present study was designed to investigate (1) whether the non-human primate would be an appropriate animal model for the study of spontaneous periodontitis and its association with metabolic syndrome (MetS), and (2) whether microRNAs (miRNAs) play roles in the co-development of metabolic disorders and per...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Sun HT,Zhang J,Hou N,Zhang X,Wang J,Bai Y

    更新日期:2014-04-01 00:00:00

  • Sympathectomy-induced increases in calcitonin gene-related peptide (CGRP)-, substance P- and vasoactive intestinal peptide (VIP)-levels in parotid and submandibular glands of the rat.

    abstract::The neuropeptide contents of rat salivary glands were increased four weeks after sympathetic postganglionic denervation (but not after preganglionic denervation): calcitonin gene-related peptide (CGRP) by 400 and 65% in the parotid and submandibular glands, respectively; substance P by 30% in the submandibular gland; ...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Ekström J,Ekman R

    更新日期:2005-10-01 00:00:00

  • Immunohistochemical localization of components of the insulin-like growth factor system in human permanent teeth.

    abstract::There is growing evidence that the insulin-like growth factor (IGF) system plays an important role in the biology of oro-dento-facial tissues and organs, including the development, homeostasis and regeneration of the periodontium. To obtain basic data on the occurrence and distribution of IGF components in human perma...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Götz W,Heinen M,Lossdörfer S,Jäger A

    更新日期:2006-05-01 00:00:00

  • Antimicrobial potential of irrigants based on essential oils of Cymbopogon martinii and Thymus zygis towards in vitro multispecies biofilm cultured in ex vivo root canals.

    abstract:OBJECTIVE:The objective was to determine the antibiofilm efficacy of Cymbopogon martinii and Thymus zygis essential oils and to estimate the disruption potential of oil-based endodontic irrigants on the multispecies biofilm formed in the root canals of extracted teeth. DESIGN:The essential oils were characterized (GC-...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Marinković J,Ćulafić DM,Nikolić B,Đukanović S,Marković T,Tasić G,Ćirić A,Marković D

    更新日期:2020-09-01 00:00:00

  • The approximal bone height and intrabony defects in young adults, related to the salivary buffering capacity and counts of Streptococcus mutans and Lactobacilli.

    abstract::Using a computerized technique the bone height and prevalence of approximal periodontal intrabony defects were assessed on posterior bite-wing radiographs from 151 young adults. The results were related to the buffering capacity and counts of Streptococcus mutans and lactobacilli in whole stimulated saliva. The mean d...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Wikner S,Söder PO,Frithiof L,Wouters F

    更新日期:1990-01-01 00:00:00

  • In-vitro urea-dependent pH-changes by human salivary bacteria and dispersed, artificial-mouth, bacterial plaques.

    abstract::The pH effects of urea metabolism were studied in washed salivary-sediment bacteria from subjects that had up to 10-fold variation in oral ureolytic activity, and in dispersed artificial-mouth plaques. Adequate evaluation required analysis of the [OH-] as well as the pH curve. An initial constant rate of pH-change, la...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Sissons CH,Cutress TW

    更新日期:1987-01-01 00:00:00

  • Lipid accumulation in the major salivary glands of streptozotocin-diabetic rats.

    abstract::Four-five months after the induction of diabetes, salivary tissues of male Wistar rats were preserved by glutaraldehyde fixation or rapid freezing in dry-ice cooled hexane. Fixed tissues were either processed and embedded for light and electron microscopy, or frozen and, together with unfixed tissues, sectioned and st...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Anderson LC,Garrett JR

    更新日期:1986-01-01 00:00:00

  • Identification of a lipoarabinomannan-like lipoglycan in Corynebacterium matruchotii.

    abstract::The oral organism Corynebacterium matruchotii was investigated for the presence of lipoteichoic acid, as this common polyanionic macroamphiphilic component of Gram-positive bacteria has been implicated in phenomena related to calcium binding. Phenol-water extraction followed by a small-scale, hydrophobic-interaction c...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Sutcliffe IC

    更新日期:1995-12-01 00:00:00

  • Mechanisms of increase in amylase activity in rat submandibular and sublingual glands after administration of pilocarpine.

    abstract::The increase in parotid rather than pancreatic-type amylase activity in the submandibular and sublingual glands of rats caused by administration of pilocarpine was abolished or diminished when pilocarpine was injected into rats which had been parotidectomized, sympathectomized by superior cervical ganglionectomy or pr...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Ikeno T,Nasu J,Hashimoto S,Kuzuya H

    更新日期:1982-01-01 00:00:00

  • Expression, localization and developmental regulation of insulin-like growth factor I mRNA in rat submandibular gland.

    abstract::The mRNA for insulin-like growth factor I (IGF-I) in the submandibular gland of mature and developing rats was examined by Northern blotting and in situ hybridization with an oligonucleotide probe. In the mature adult rat, IGF-I mRNA was expressed at a higher level in the submandibular gland than in the liver, and was...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Amano O,Iseki S

    更新日期:1993-08-01 00:00:00

  • Chewing chitosan-containing gum effectively inhibits the growth of cariogenic bacteria.

    abstract:OBJECTIVE:We have already reported that chitosan inhibited the growth of cariogenic bacteria in vitro. This study was designed to evaluate whether chewing gum, containing chitosan, can effectively suppressed the growth of oral bacteria (total bacteria, total Streptococci, mutans streptococci (MS)) in saliva. METHODS:F...

    journal_title:Archives of oral biology

    pub_type: 杂志文章,随机对照试验


    authors: Hayashi Y,Ohara N,Ganno T,Yamaguchi K,Ishizaki T,Nakamura T,Sato M

    更新日期:2007-03-01 00:00:00

  • Porphyromonas gingivalis-induced alveolar bone loss is accelerated in the stroke-prone spontaneously hypertensive rat.

    abstract::Porphyromonas gingivalis (P. gingivalis) is one of the prominent periodontal pathogens and is the most important bacteria involved in the onset and exacerbation of periodontitis. P. gingivalis is an anaerobic, Gram-negative coccobacillus that plays a role in the progression of periodontal disease by promoting alveolar...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Tokutomi F,Wada-Takahashi S,Sugiyama S,Toyama T,Sato T,Hamada N,Tsukinoki K,Takahashi SS,Lee MC

    更新日期:2015-06-01 00:00:00

  • The relationship between IgA antibodies to Streptococcus mutans antigens in human saliva and breast milk and the numbers of indigenous oral Streptococcus mutans.

    abstract::The influence of indigenous Streptococcus mutans on naturally-occurring levels of IgA antibodies was studied in 42 lactating females. Breast milk, parotid and whole-saliva samples were collected and analysed by the ELISA method for IgA antibodies, reacting with antigens from Strep. mutans. All salivas and breast milk ...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Camling E,Gahnberg L,Krasse B

    更新日期:1987-01-01 00:00:00

  • The relationship between water-borne fluoride, dental fluorosis and skeletal development in 11-15 year old Tanzanian girls.

    abstract::Dental fluorosis was evaluated by a classification system, previously shown to be sensitive, and skeletal changes evaluated by bone maturity and structure. Dental fluorosis was more severe in posterior than in anterior teeth in both jaws irrespective of fluoride concentration of the drinking water. There appeared to b...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Wenzel A,Thylstrup A,Melsen B,Fejerskov O

    更新日期:1982-01-01 00:00:00

  • Evaluation of the effect of tacrolimus on periodontitis induced in rats.

    abstract:OBJECTIVE:This study was to investigate the effect of tacrolimus (FK506) on periodontitis induced in rats. DESIGN:Periodontal disease was induced in 30 Wistar rats which were then randomly divided into two groups: treatment with a daily injection of 0.9% saline (1mL/day) and treatment with a daily injection of FK506. ...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Moura Penteado LA,Lucena GM,Brandão Peixoto MO,Barbosa TC,de Souza Leitão Arruda AC,Cimões R

    更新日期:2017-08-01 00:00:00

  • Oral health status of patients with leukemia: a systematic review with meta-analysis.

    abstract:OBJECTIVE:The aim of this study was to systematically review the literature regarding the prevalence of periodontal diseases and dental caries in patients with leukemia. METHODS:An electronic search for observational studies on oral health outcomes in patients with leukemia was performed on Medline/PUBMED, Embase, Web...

    journal_title:Archives of oral biology

    pub_type: 杂志文章,meta分析


    authors: Angst PDM,Maier J,Dos Santos Nogueira R,Manso IS,Tedesco TK

    更新日期:2020-12-01 00:00:00

  • Comparative analysis of blood parameters of the erythrocyte lineage between patients with chronic periodontitis and healthy patients: Results obtained from a meta-analysis.

    abstract::Objective Quantitatively evaluate blood parameters of the erythrocyte lineage in patients with chronic periodontitis and healthy controls by means of a meta-analysis. Material and methods A review of literature was performed in the scientific databases for studies published before September 2016. The abstracts were ev...

    journal_title:Archives of oral biology

    pub_type: 杂志文章,meta分析,评审


    authors: França LFC,da Silva FRP,di Lenardo D,Alves EHP,Nascimento HMS,da Silva IAT,Vasconcelos ACCG,Vasconcelos DFP

    更新日期:2019-01-01 00:00:00

  • In vitro effect of a resin infiltrant on different artificial caries-like enamel lesions.

    abstract:OBJECTIVES:A resin infiltrant was employed for the treatment of active white spot lesions due to its ability to penetrate into the enamel pores and prevent the progression of the lesion. However, limited information is available about its mechanical effect on different artificial enamel lesions as well as on its resist...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Freitas MCCA,Nunes LV,Comar LP,Rios D,Magalhães AC,Honório HM,Wang L

    更新日期:2018-11-01 00:00:00

  • Efficacy of enzymatic toothpastes for immobilisation of protective enzymes in the in situ pellicle.

    abstract:AIM:Different enzyme-containing toothpastes are available on the market. The aim of the present in situ study was to investigate their efficacy for immobilisation of protective enzymes in the pellicle layer. METHODS:Pellicle formation took place in situ on bovine enamel slabs fixed to individual upper jaw splints carr...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Hannig C,Spitzmüller B,Lux HC,Altenburger M,Al-Ahmad A,Hannig M

    更新日期:2010-07-01 00:00:00

  • The roles of histidine residues at the starch-binding site in streptococcal-binding activities of human salivary amylase.

    abstract::Human salivary alpha-amylase participates in the initial digestion of starch and may be involved in the colonization of viridans streptococci in the mouth. To elucidate the role of histidine residues located near the starch-binding site on the streptococcal-binding activity, the wild type and three histidine mutants, ...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Tseng CC,Miyamoto M,Ramalingam K,Hemavathy KC,Levine MJ,Ramasubbu N

    更新日期:1999-02-01 00:00:00

  • Epithelial to mesenchymal transition in Cyclosporine A-induced rat gingival overgrowth.

    abstract:BACKGROUND AND OBJECTIVE:Epithelial-mesenchymal transition (EMT) has been proved to occur in drug-induced gingival overgrowth. However, the specific pathogenic mechanism remains uncertain. The aim of this study is to examine the expression of EMT markers in cyclosporine A (CsA)-induced gingival overgrowth in rat models...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Yang F,Lu J,Yu Y,Gong Y

    更新日期:2017-09-01 00:00:00

  • Some factors affecting the diffusion of [14C]-lactate in human dental plaque.

    abstract::The apparent diffusion rate, D, of lactate was significantly retarded in dental plaque fluid and a simulated plaque fluid consisting of a chemically-defined solution of salts, amino acids and albumin in phosphate buffer at pH 6.5. Metabolic utilization of lactate in live plaque residue reduced D for lactate into such ...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Tatevossian A

    更新日期:1985-01-01 00:00:00

  • The effect of cholera toxin and epidermal growth factor on the in-vitro growth of human oral epithelial cells.

    abstract::Human epithelial cells isolated from adult gingival and infant palatal biopsies were cultured using 3T3 feeder cells. The colony-forming efficiency was about 0.8 per cent with cholera toxin and epidermal growth factor (EGF). The cell yield of cultures from infant palates depended on the concentration of cholera toxin ...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Müller-Glauser W,Preisig E

    更新日期:1983-01-01 00:00:00

  • Optimization of poly (lactic-co-glycolic acid)-bioactive glass composite scaffold for bone tissue engineering using stem cells from human exfoliated deciduous teeth.

    abstract:OBJECTIVE:The aim of this study was to develop a composite scaffold with the optimal poly(lactic-co-glycolic acid) (PLGA) and bioactive glass proportions to provide an environment for bone tissue regeneration and repair. DESIGN:PLGA-bioactive glass composite scaffolds were prepared using a salt-leaching technique with...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Kunwong N,Tangjit N,Rattanapinyopituk K,Dechkunakorn S,Anuwongnukroh N,Arayapisit T,Sritanaudomchai H

    更新日期:2021-01-08 00:00:00

  • Effects of hyaluronan oligosaccharide on the expression of MMP-1 in periodontal ligament cells.

    abstract::It is well known that low-molecular weight hyaluronan (HA) is detected in human periodontal tissue under inflammatory conditions. HA oligosaccharide (HAoligo) has been demonstrated to induce matrix metalloproteinase (MMP)-1 expression in dendritic cells and chondrocytes, however, the bioactivities of HAoligo in period...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Nakatani Y,Tanimoto K,Tanaka N,Tanne Y,Kamiya T,Kunimatsu R,Tanaka E,Tanne K

    更新日期:2009-08-01 00:00:00

  • A technique for the study of endocytosis in human oral epithelial cells.

    abstract::Fluorescently labelled latex microspheres (0.01, 0.1 and 1.0 micron dia.) were used to establish whether oral epithelial cells could exhibit an endocytic function. Oral mucosa biopsies were incubated in organ culture at 37 degrees C for 20 h with one of the three sizes of fluorescent microspheres in the medium. Tissue...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Innes NP,Ogden GR

    更新日期:1999-06-01 00:00:00

  • Crevicular fluid levels of TGFbeta1 in drug-induced gingival overgrowth.

    abstract:OBJECTIVE:To determine if local, gingival crevicular fluid (GCF) levels of TGFbeta1 were altered in drug-induced gingival overgrowth. PATIENTS AND METHODS:GCF samples were collected on Periopaper strips from 45 renal transplant recipients who had been medicated with cyclosporin or cyclosporin in combination with other...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Wright HJ,Chapple IL,Blair F,Matthews JB

    更新日期:2004-05-01 00:00:00