Alpha 2 integrin gene (ITGA2) polymorphism in renal transplant recipients with and without drug induced gingival overgrowth.


BACKGROUND:Variances in fibroblasts' α2β1 integrin intensity may lead to altered adhesion to type I collagen and consequently to suppression of phagocytosis which may be one of the mechanisms for drug induced gingival overgrowth. The present study aimed to evaluate the genotype and allele frequencies of α2 integrin +807 gene in renal transplant patients with and without gingival overgrowth. MATERIAL AND METHODS:Seventy renal transplant patients with cyclosporine A (CsA)-induced gingival overgrowth (CsA GO+) were enrolled. Renal transplant patients without GO medicated with CsA (CsA GO-; n=79) and tacrolimus (Tac; n=52) served as controls. DNA was obtained from peripheral blood and ITGA2 +807C/T polymorphism was genotyped by polymerase chain reaction and restriction fragment length polymorphism method. Clinical parameters including probing depth and plaque, papilla bleeding and hyperplasia indexes were recorded. Chi-square, Kruskal-Wallis and Mann-Whitney tests were used in statistical analysis. RESULTS:Clinical parameters of CsA GO+ group were significantly higher than those of the CsA GO- and Tac groups (p<0.05). ITGA2 807C/T genotype and allele frequencies of study groups were similar (p>0.05). CONCLUSION:Within the limits of the present study it can be concluded that ITGA2 +807 gene polymorphism is not associated with susceptibility to CsA-induced GO.


Arch Oral Biol


Archives of oral biology


Gürkan A,Emingil G,Afacan B,Berdeli A,Atilla G




Has Abstract


2014-03-01 00:00:00














  • Cloning and expression of a Porphyromonas (Bacteroides) gingivalis protease gene in Escherichia coli.

    abstract::A genomic library of Bacteroides gingivalis W83 chromosomal DNA was constructed in the Escherichia coli lambda (lambda) vector EMBL 4. Three recombinant lambda phages expressing a cloned protease were identified in the library. All three lambda phages contained cloned overlapping DNA fragments from the same region of ...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Arnott MA,Rigg G,Shah H,Williams D,Wallace A,Roberts IS

    更新日期:1990-01-01 00:00:00

  • Mineral distribution of artificial dentinal caries lesions after treatment with fluoride agents in combination with saliva substitutes.

    abstract:OBJECTIVE:Some saliva substitutes have been shown to demineralize dentine in vitro. This effect is counteracted by the application of various fluorides. In contrast, remineralizing saliva substitutes might be supported by these treatments, depending on the dynamics during remineralization. The aim of this in vitro stud...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Tschoppe P,Meyer-Lueckel H

    更新日期:2011-08-01 00:00:00

  • Electron microscopy of watery vacuole formation in rat parotid acinar cells during reflex stimulation.

    abstract::Reflex stimulation from eating hard chow caused variable degrees of watery vacuolation, most conspicuously in animals that had eaten the most food; this was accentuated by eating in the cold. Some vacuolation occurred in the absence of sympathetic impulses but there was much more in glands receiving both parasympathet...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Garrett JR,Harrop TJ,Thulin A

    更新日期:1987-01-01 00:00:00

  • Langerin+ versus CD1a+ Langerhans cells in human gingival tissue: a comparative and quantitative immunohistochemical study.

    abstract::Langerhans cells (LC) are dendritic cells of the immune system able to capture intraepithelial pathogens and migrate to regional lymph nodes to present them to naive T cells. Up to now immunohistological studies on human gingival LC have been carried out using antibodies against HLA-DR or CD1a molecules. A new marker ...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Séguier S,Bodineau A,Godeau G,Pellat B,Brousse N

    更新日期:2003-04-01 00:00:00

  • Characterization of the mucosal immune response in breast milk after peroral immunization of chimpanzees (Pan troglodytes) with Streptococcus mutans.

    abstract::The characteristics of the mucosal immune response to Streptococcus mutans cells, antigen A, antigen B, glucosyltransferases and glucan-binding proteins were examined in four pregnant chimpanzees that had been immunized perorally with Strep. mutans. Six pregnant chimpanzees served as non-immunized controls. None of th...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Tyler BM,Cole MF

    更新日期:1999-10-01 00:00:00

  • Effects of gender on serum biomarkers of systemic inflammation coincident to experimentally-induced periapical lesions.

    abstract:OBJECTIVE:The literature suggests that females have less adverse effects to infection than males, due to the protective effects of oestrogen. The purpose of our study is to compare the systemic effects of induced periapical lesions between groups of animals with various serum concentrations of oestrogen. METHODS:To in...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Zhang H,Bain JL,Caskey CP,Sandifer LC,Johnson RB

    更新日期:2011-02-01 00:00:00

  • The effect of propranolol on salivary gland function and dental caries development in young and aged rats.

    abstract::Medications commonly used in elderly people cause hyposalivation and are associated with an enhanced prevalence of dental caries. Propranolol (a beta-adrenergic antagonist) is a commonly used antihypertensive agent that is prescribed for long-term use. The purpose of this investigation was to compare the effects of th...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: O'Connell AC,Van Wuyckhuyse BC,Pearson SK,Bowen WH

    更新日期:1993-10-01 00:00:00

  • The influence of food consistency on chewing rate and muscular work.

    abstract::Food properties influence the parameters of the masticatory process, such as jaw movement, muscle activity and chewing rate. Firm foods will require more muscle activity than softer foods. However, the influence of food hardness on chewing rate is ambiguous as both slower and higher chewing rates have been reported fo...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: van der Bilt A,Abbink JH

    更新日期:2017-11-01 00:00:00

  • The relationship between IgA antibodies to Streptococcus mutans antigens in human saliva and breast milk and the numbers of indigenous oral Streptococcus mutans.

    abstract::The influence of indigenous Streptococcus mutans on naturally-occurring levels of IgA antibodies was studied in 42 lactating females. Breast milk, parotid and whole-saliva samples were collected and analysed by the ELISA method for IgA antibodies, reacting with antigens from Strep. mutans. All salivas and breast milk ...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Camling E,Gahnberg L,Krasse B

    更新日期:1987-01-01 00:00:00

  • Structural variations in the surface zone of human tooth enamel observed by scanning electron microscopy.

    abstract::The surface zone of human deciduous and permanent enamel was examined following sectioning, polishing and etching. Three main types of surface were where prisms reached the surface, where the prisms were not discernible and those formed by a complex of both types. The aprismatic layers were measured and the percentage...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Whittaker DK

    更新日期:1982-01-01 00:00:00

  • Effects of glucose and sucrose variants of the caries-promoting Diet 2000 on the feeding patterns and parotid glands of prematurely weaned rats.

    abstract:OBJECTIVE:The hypothesis of this study was that feeding glucose instead of sucrose in the cariogenic Diet 2000 to rats weaned at age 18 days would result in greater light/dark differences in feeding activity and secretion and storage of parotid salivary enzymes. DESIGN OF STUDY:Diet 2000 and a stock commercial diet (c...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Redman RS

    更新日期:2015-03-01 00:00:00

  • Evidence against a direct role for protein kinase C in rat submandibular salivary mucin secretion.

    abstract::Calcium and protein kinase C may be directly involved in exocytosis. However, in the rat submandibular gland, cAMP-mediated events appear to be required for mucin secretion. Calcium may be involved, but a direct signal-transduction role for calcium and protein kinase C in regulating such secretion has yet to be establ...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Quissell DO,Barzen KA,Deisher LM

    更新日期:1989-01-01 00:00:00

  • Neonatal lines in the enamel of primary teeth--a morphological and scanning electron microscopic investigation.

    abstract:OBJECTIVE:The neonatal line (NNL) is in principle found in all primary teeth and the line represents the time of birth. Earlier findings of the appearance of the NNL in light microscope and in microradiographs have shown not only changes in the prism direction of the enamel, but that the NNL has a hypomineralized chara...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Sabel N,Johansson C,Kühnisch J,Robertson A,Steiniger F,Norén JG,Klingberg G,Nietzsche S

    更新日期:2008-10-01 00:00:00

  • In-vitro urea-dependent pH-changes by human salivary bacteria and dispersed, artificial-mouth, bacterial plaques.

    abstract::The pH effects of urea metabolism were studied in washed salivary-sediment bacteria from subjects that had up to 10-fold variation in oral ureolytic activity, and in dispersed artificial-mouth plaques. Adequate evaluation required analysis of the [OH-] as well as the pH curve. An initial constant rate of pH-change, la...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Sissons CH,Cutress TW

    更新日期:1987-01-01 00:00:00

  • The effect on vertical tooth mobility of extraction and immediate replacement of incisors (Macaca fascicularis).

    abstract::Intrusive displacement of 7 incisors was measured before and within 3 min of extraction. A substantial increase in intrusion with recovery from loads of 4 N followed replacement of the incisors. These changes are taken to indicate that tension is an important mechanism of support in the intact periodontal ligament. ...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Picton DC

    更新日期:1991-01-01 00:00:00

  • Effects of iron deficiency on respiration of hamster cheek-pouch epithelium in vitro.

    abstract::Iron-deficiency anaemia was induced in hamsters by feeding a low-iron diet coupled with weekly bleeding. Respiration, assessed by measuring oxygen uptake, was significantly reduced (p less than 0.002) in cheek-pouch epithelia from iron-deficient animals. To relate data on oxygen consumption to cell numbers, the cell d...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Ranasinghe AW,Johnson NW,Williams RA,Scragg MA

    更新日期:1985-01-01 00:00:00

  • The roles of histidine residues at the starch-binding site in streptococcal-binding activities of human salivary amylase.

    abstract::Human salivary alpha-amylase participates in the initial digestion of starch and may be involved in the colonization of viridans streptococci in the mouth. To elucidate the role of histidine residues located near the starch-binding site on the streptococcal-binding activity, the wild type and three histidine mutants, ...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Tseng CC,Miyamoto M,Ramalingam K,Hemavathy KC,Levine MJ,Ramasubbu N

    更新日期:1999-02-01 00:00:00

  • Biological markers for evaluation of root resorption.

    abstract:BACKGROUND:External apical root resorption is a pathologic consequence of orthodontic tooth movement. Cementum and dentin are removed from the root surface while active force is present. OBJECTIVE:The aim of this study was to identify and quantify extracellular matrix proteins, dentin matrix protein 1 (DMP1), dentin p...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Balducci L,Ramachandran A,Hao J,Narayanan K,Evans C,George A

    更新日期:2007-03-01 00:00:00

  • Distribution of periodontopathic bacterial species in dogs and their owners.

    abstract:OBJECTIVE:Presently, a large number of individuals consider their companion animals as family members and have close contact with them in daily life. The purpose of the present study was to analyze the distribution of periodontopathic bacterial species in oral specimens taken from dogs and their owners. DESIGN:Dental ...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Yamasaki Y,Nomura R,Nakano K,Naka S,Matsumoto-Nakano M,Asai F,Ooshima T

    更新日期:2012-09-01 00:00:00

  • Existence of ATP sensitive potassium currents on human periodontal ligament cells.

    abstract:OBJECTIVE:Potassium channels of the ATP-sensitive family (KATP channel) are inhibited by increase in intracellular ATP. Electrophysiological studies have demonstrated that the kinetics and pharmacological properties of KATP channels vary among different tissues, suggesting structurally and functionally distinct types. ...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Tran PT,Lee YH,Bhattarai JP,Park SJ,Yi HK,Han SK

    更新日期:2017-04-01 00:00:00

  • Recovery of INS-R and ER-alpha expression in the salivary glands of diabetic mice submitted to hormone replacement therapy.

    abstract::The interaction between proteins and cell receptors is related to tissue homeostasis such as in salivary glands. In this respect, alterations in hormone levels caused by hyperglycaemic conditions may interfere with this interaction, intensifying the damage caused by diabetes mellitus. Hormone replacement therapy is an...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Maekawa ET,Maioral EE,Metidieri HT,Picardi PK,Caldeira EJ

    更新日期:2011-10-01 00:00:00

  • Differential expression of long noncoding RNAs from dental pulp stem cells in the microenvironment of the angiogenesis.

    abstract:INTRODUCTION:Angiogenesis is important in pulp-dentin formation. Among the regulatory factors, long noncoding RNA (LncRNA) is a class of functional RNA molecules that are not translated into protein and involved in regulating multiple physiological processes. The different expression of LncRNA and its target gene in de...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Li X,Xu W,Wu J,Lin X,Chen Y,Wen J,Wu B

    更新日期:2020-05-01 00:00:00

  • Confocal laser scanning microscopic study [corrected] of tartrate-resistant acid phosphatase-positive cells in the dental follicle during early morphogenesis of mouse embryonic molar teeth.

    abstract::Tartrate-resistant acid phosphatase (TRAPase)-positive cells were examined during the early morphogenesis of mouse mandibular first molar teeth, using a simultaneous azo dye-coupling technique and confocal laser scanning microscopy (CLSM). CLSM of paraffin-embedded sections revealed that cells exhibiting TRAPase fluor...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Sakakura Y,Yajima T,Tsuruga E

    更新日期:1998-05-01 00:00:00

  • Analysis of human palatine salivary proteins by isoelectric focusing in agarose.

    abstract::An electrophoretic method capable of analysing a small volume (5-10 microliter) of human palatine saliva without prior concentration was developed by combining the high resolution of isoelectric focusing in agarose with a highly sensitive silver protein staining method. Human palatine saliva exhibited 23 protein bands...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Shiba A,Sano K,Nakao M,Kobayashi K,Igarashi Y

    更新日期:1983-01-01 00:00:00

  • Effects of 7S globulin 3 derived from the adzuki bean [Vigna angularis] on the CSP- and eDNA- dependent biofilm formation of Streptococcus mutans.

    abstract:OBJECTIVE:Streptococcus mutans is a principal bacterium that forms pathogenic biofilm involved in the development of dental caries. S. mutans possesses a quorum sensing system (QS) stimulated by competence stimulating peptide (CSP), which is associated with bacteriocin production, genetic competency and biofilm formati...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Senpuku H,Mohri S,Mihara M,Arai T,Suzuki Y,Saeki Y

    更新日期:2019-06-01 00:00:00

  • Effect of cavity depth on dentine sensitivity in man.

    abstract:OBJECTIVE:To determine if dentine at the enamel-dentine junction (EDJ) in man is more sensitive to hydrostatic pressure stimuli then deeper dentine. DESIGN:Cavities (1mm diam.) were cut at the tips of the buccal and lingual cusps of 8 premolars in 3 subjects (ages: 22-25 years). Both cavities were initially deepened t...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Wanachantararak S,Ajcharanukul O,Vongsavan N,Matthews B

    更新日期:2016-06-01 00:00:00

  • Associations of the microRNA gene polymorphisms with the risk of non-syndromic supernumerary teeth in a Chinese population.

    abstract:OBJECTIVE:Non-syndromic supernumerary teeth (NSST) are a common type of dental anomaly. microRNAs (miRNAs) play an important role in craniofacial and tooth development. Therefore, we hypothesized that single nucleotide polymorphisms (SNPs) of miRNAs may be associated with the susceptibility of NSST. MATERIALS AND METH...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Yang F,Yu X,Fan L,Xu Z,Kan S,Zhu G,Gu M,Lou S,Li D,Ma L,Zhang W,Wang L,Pan Y

    更新日期:2020-09-01 00:00:00

  • Host genotype, pathogenic challenge and periodontal bone loss in the mouse.

    abstract::Periodontal bone loss was induced in mice of different genotypes by oral inoculation with Actinomyces viscosus. Relatively high bone loss occurred in the mutant X-linked immune deficiency, implicating the humoral immune system. Maximum bone loss was always associated with inoculations of 1.6 x 10(7) colony forming uni...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Gilbert AD,Sofaer JA

    更新日期:1988-01-01 00:00:00

  • The fracture behaviour of human and pig molar cusps.

    abstract::Masticatory efficiency depends upon the ability of the molar cusps to apply concentrated bite forces to food particles and simultaneously to withstand the dental stresses that may cause enamel fracture. This study investigated how low-crowned molar cusps in omnivorous mammals, specifically humans, Homo sapiens, and pi...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Popowics TE,Rensberger JM,Herring SW

    更新日期:2001-01-01 00:00:00

  • Sympathetic neuronotrophic activity in the pulp of the cat canine tooth.

    abstract::Extracts of these dental pulps from adult cats contained a non-dialysable agent or agents which could support neurone survival and neurite development for at least three days in neurone-enriched cultures of sympathetic ganglion cells from 11-day chick embryos. The neurone survival-promoting activity differed from nerv...

    journal_title:Archives of oral biology

    pub_type: 杂志文章


    authors: Naftel JP

    更新日期:1987-01-01 00:00:00