Abstract:
:Ezrin, coding protein EZR which cross-links actin filaments, overexpresses and involves invasion, metastasis, and poor prognosis in various cancers including esophageal squamous cell carcinoma (ESCC). In our previous study, Ezrin was knock down and analyzed by mRNA expression profile which has not been fully mined. In this study, we applied protein-protein interactions (PPI) network knowledge and methods to explore our understanding of these differentially expressed genes (DEGs). PPI subnetworks showed that hundreds of DEGs interact with thousands of other proteins. Subcellular localization analyses found that the DEGs and their directly or indirectly interacting proteins distribute in multiple layers, which was applied to analyze the shortest paths between EZR and other DEGs. Gene ontology annotation generated a functional annotation map and found hundreds of significant terms, especially those associated with cytoskeleton organization of Ezrin protein, such as "cytoskeleton organization," "regulation of actin filament-based process," and "regulation of actin cytoskeleton organization." The algorithm of Random Walk with Restart was applied to prioritize the DEGs and identified several cancer related DEGs ranked closest to EZR. These analyses based on PPI network have greatly expanded our comprehension of the mRNA expression profile of Ezrin knockdown for future examination of the roles and mechanisms of Ezrin.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Wu B,Xie J,Du Z,Wu J,Zhang P,Xu L,Li Edoi
10.1155/2014/651954subject
Has Abstractpub_date
2014-01-01 00:00:00pages
651954eissn
2314-6133issn
2314-6141journal_volume
2014pub_type
杂志文章abstract:Background:The present study aims to investigate the incidence and risk factors associated with postoperative delirium in patients undergoing spine surgery. Methods:PubMed, EMBASE, Cochrane Library, and Science Citation Index were searched up to August 2019 for studies examining postoperative delirium following spine ...
journal_title:BioMed research international
pub_type: 杂志文章,meta分析
doi:10.1155/2019/2139834
更新日期:2019-11-26 00:00:00
abstract::Background. Aortic valve calcification (AVC) is a common feature of aging and is related to coronary artery disease. Although abdominal visceral adipose tissue (VAT) plays fundamental roles in coronary artery disease, the relationship between abdominal VAT and AVC is not fully understood. Methods. We investigated 259 ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/2174657
更新日期:2016-01-01 00:00:00
abstract::With the recent advancement in the field of ocular therapy, drug delivery approaches have been elevated to a new concept in terms of nonionic surfactant vesicles (NSVs), that is, the ability to deliver the therapeutic agent to a patient in a staggered profile. However the major drawbacks of the conventional drug deliv...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/263604
更新日期:2014-01-01 00:00:00
abstract::Bacterial biofilms are communities of microorganisms attached to a surface. Biofilm formation is critical not only for environmental survival but also for successful infection. Helicobacter pylori is one of the most common causes of bacterial infection in humans. Some studies demonstrated that this microorganism has b...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/914791
更新日期:2015-01-01 00:00:00
abstract::Freshly ejaculated spermatozoa are incapable or poorly capable of fertilizing an oocyte. The fertilization aptness of spermatozoa depends on the appropriate and time-dependent acquisition of hyperactivation, chemotaxis, capacitation, and the acrosome reaction, where calcium (Ca(2+)) is extensively involved in almost e...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/841615
更新日期:2014-01-01 00:00:00
abstract::Sudden cardiac death is the main cause of mortality in patients affected by chronic heart failure (CHF) and with history of myocardial infarction. No study yet investigated the intra-QT phase spectral coherence as a possible tool in stratifying the arrhythmic susceptibility in patients at risk of sudden cardiac death ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/583035
更新日期:2014-01-01 00:00:00
abstract::Bone integrity abnormality and imbalance between bone formation by osteoblasts and bone resorption by osteoclasts are known to result in metabolic bone diseases such as osteoporosis. Silymarin-rich milk thistle extract (MTE) and its component silibinin enhanced alkaline phosphatase activity of osteoblasts but reduced ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/919374
更新日期:2013-01-01 00:00:00
abstract::Background. High HDL-cholesterol (HDL-C) values are negatively correlated with cardiovascular diseases. This review analyses the effect of the supplementation with various Mediterranean diet products (artichoke, bergamot, and olive oil) and Asian diet products (red yeast rice) on the HDL-C value in dyslipidemic subjec...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2016/2025687
更新日期:2016-01-01 00:00:00
abstract::Introduction. The triangular fibrocartilage complex (TFCC) provides both mobility and stability of the radiocarpal joint. TFCC lesions are difficult to diagnose due to the complex anatomy. The standard treatment for TFCC lesions is arthroscopy, posing surgery-related risks onto the patients. This feasibility study aim...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/5870875
更新日期:2017-01-01 00:00:00
abstract::Induced pluripotent stem cells (iPSC) hold tremendous potential for personalized cell-based therapy for skin regeneration. Aiming to establish human iPSCs as a potential cell source for skin tissue engineering, we expect to obtain an epidermal-like cell line with angiogenic and keratinogenic differentiation potential ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/8459503
更新日期:2018-09-13 00:00:00
abstract::Cutaneous squamous cell carcinoma (cSCC) is one of the most common skin cancers. In the treatment of cSCC, it is necessary to remove it completely, and reconstructive surgery, such as a skin graft or a local or free flap, will be required, depending on the size, with donor-site morbidity posing a burden to the patient...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/3074742
更新日期:2020-03-07 00:00:00
abstract::Morphine is considered a highly potent analgesic agent used to relieve suffering of patients with cancer. Several in vitro and in vivo studies showed that morphine also modulates angiogenesis and regulates tumour cell growth. Unfortunately, the results obtained by these studies are still contradictory. In order to bet...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/161508
更新日期:2015-01-01 00:00:00
abstract:Background:Musculoskeletal disorders (MSDs) are considered one of the most common health issues in working population and have a high social and economic impact. This study is aimed at determining the MSD patterns and associated risk factors among higher education academicians in Saudi Arabia. Methods:A cross-sectiona...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/8930968
更新日期:2020-08-15 00:00:00
abstract::A large number of occupational exposure limit values (OELs) are based on avoiding of sensory irritation of the eyes and the upper respiratory tract. In order to investigate the chemosensory effect range of a chemical, odor and sensory irritation thresholds (lateralization thresholds, LTs) can be assessed. Humidity aff...
journal_title:BioMed research international
pub_type: 杂志文章,随机对照试验
doi:10.1155/2016/6015761
更新日期:2016-01-01 00:00:00
abstract:Background:It is unclear whether computer navigation can improve the accuracy and reliability of targeted lower limb alignment correction following open-wedge high tibial osteotomy (HTO). This meta-analysis was designed to compare the accuracy and reliability of limb alignment correction between computer navigated and ...
journal_title:BioMed research international
pub_type: 杂志文章,meta分析
doi:10.1155/2017/3803457
更新日期:2017-01-01 00:00:00
abstract::A search for novel and more efficient therapeutic modalities of inflammatory bowel disease (IBD) is one of the most important tasks of contemporary medicine. The anti-inflammatory action of nicotine in IBD might be therapeutic, but its toxicity due to off-target and nonreceptor effects limited its use and prompted a s...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/609086
更新日期:2014-01-01 00:00:00
abstract::The myostatin (MSTN) is a known negative growth regulator of skeletal muscle. The mutated myostatin showed a double-muscular phenotype having a positive significance for the farmed animals. Consequently, adequate information is not available in the teleosts, including farmed rohu carp, Labeo rohita. In the absence of ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/7562368
更新日期:2016-01-01 00:00:00
abstract::Diabetic foot ulcers (DFUs) are characterized by an unsatisfactory inflammatory and migratory response. Skin inflammation involves the participation of many cells and particularly macrophages. Macrophage function can be modulated by neuropeptides; however, little is known regarding the role of neurotensin (NT) as a mo...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/941764
更新日期:2013-01-01 00:00:00
abstract::Acute graft-versus-host disease (aGVHD) is a major complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT) and a major cause of nonrelapse mortality after allo-HSCT. A conditioning regimen plays a pivotal role in the development of aGVHD. To provide a platform for studying aGVHD and evaluating t...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/3071214
更新日期:2016-01-01 00:00:00
abstract::Nonlinear contrast-enhanced ultrasound imaging schemes strive to suppress tissue signals in order to better visualize nonlinear signals from blood-pooling ultrasound contrast agents. Because tissue does not generate a subharmonic response (i.e., signal at half the transmit frequency), subharmonic imaging has been prop...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/640397
更新日期:2015-01-01 00:00:00
abstract::Organic pollutants, like phenol, along with heavy metals, like chromium, are present in various industrial effluents that pose serious health hazard to humans. The present study looked at removal of chromium (VI) in presence of phenol in a counter-current continuous packed bed reactor packed with E. coli cells immobil...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/373412
更新日期:2013-01-01 00:00:00
abstract::Stability and mobility in functional motor activities depend on a precise regulation of phasic and tonic muscular activity that is carried out automatically, without conscious awareness. The sensorimotor control of posture involves a complex integration of multisensory inputs that results in a final motor adjustment p...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/434683
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:There is a paucity of a biological large animal model of myocardial infarction (MI). We hypothesized that, using autologous-aggregated platelets, we could create an ovine model that was reproducible and more closely mimicked the pathophysiology of MI. METHODS:Mepacrine stained autologous platelets from male ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/938047
更新日期:2013-01-01 00:00:00
abstract::The recombinant catalase-peroxidase HPI from E. coli was used as an alternative enzyme in polymerization reactions for the production of (-) epicatechin oligomers and their biological activity was characterized. The enzyme was prepared in two forms: a purified and an immobilized form. Both were tested for their activi...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/3828627
更新日期:2018-04-23 00:00:00
abstract::Colorectal cancer, a malignant neoplasm that occurs in the colorectal mucosa, is one of the most common types of gastrointestinal cancer. Colorectal cancer has been studied extensively, but the molecular mechanisms of this malignancy have not been characterized. This study identified and verified core genes associated...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/8082697
更新日期:2020-05-08 00:00:00
abstract::Alzheimer's disease is a multifactorial neurodegenerative disease characterized by progressive cognitive dysfunction. It is the most common form of dementia. The pathologic hallmarks of the disease include extracellular amyloid plaque, intracellular neurofibrillary tangles, and oxidative stress, to mention some of the...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2020/9895121
更新日期:2020-02-18 00:00:00
abstract::We discuss some aspects of the fluid dynamics of vitreous substitutes in the vitreous chamber, focussing on the flow induced by rotations of the eye bulb. We use simple, yet not trivial, theoretical models to highlight mechanical concepts that are relevant to understand the dynamics of vitreous substitutes and also to...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/672926
更新日期:2014-01-01 00:00:00
abstract::Little is known about the clinical value of the Hadlock and INTERGROWTH-21st EFW standards for predicting adverse perinatal outcomes (APOs) in the third trimester. The purpose of this study was to study the association between low estimated fetal weight percentile (EFWc) in the third trimester and the risk of APOs and...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/7698038
更新日期:2019-01-09 00:00:00
abstract:Background:There is little data available on HBV infection and mother-to-child transmission (MTCT) in Vietnam. Objective:This study is aimed at assessing the prevalence of HBV infection and the current situation of MTCT in Haiphong, Vietnam. Methods:A transversal survey of 1721 pregnant women followed by an observati...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/4747965
更新日期:2020-08-20 00:00:00
abstract::Malaria is one of the life-threatening diseases in the world. The spread of resistance to antimalarial drugs is a major challenge, and resistance to artemisinin has been reported in the Southeast Asian region. In the previous study, the active compound of Streptomyces hygroscopicus subsp. Hygroscopicus (S. hygroscopic...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/6135696
更新日期:2020-01-09 00:00:00