The Bewildering Effect of AMPK Activators in Alzheimer's Disease: Review of the Current Evidence.

Abstract:

:Alzheimer's disease is a multifactorial neurodegenerative disease characterized by progressive cognitive dysfunction. It is the most common form of dementia. The pathologic hallmarks of the disease include extracellular amyloid plaque, intracellular neurofibrillary tangles, and oxidative stress, to mention some of them. Despite remarkable progress in the understanding of the pathogenesis of the disease, drugs for cure or disease-modifying therapy remain somewhere in the distance. From recent time, the signaling molecule AMPK is gaining enormous attention in the AD drug research. AMPK is a master regulator of cellular energy metabolism, and recent pieces of evidence show that perturbation of its function is highly ascribed in the pathology of AD. Several drugs are known to activate AMPK, but their effect in AD remains to be controversial. In this review, the current shreds of evidence on the effect of AMPK activators in Aβ accumulation, tau aggregation, and oxidative stress are addressed. Positive and negative effects are reported with regard to Aβ and tauopathy but only positive in oxidative stress. We also tried to dissect the molecular interplays where the bewildering effects arise from.

journal_name

Biomed Res Int

authors

Assefa BT,Tafere GG,Wondafrash DZ,Gidey MT

doi

10.1155/2020/9895121

subject

Has Abstract

pub_date

2020-02-18 00:00:00

pages

9895121

eissn

2314-6133

issn

2314-6141

journal_volume

2020

pub_type

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