Abstract:
:This study explored protective effects of Houshiheisan and its compound prescription of wind-dispelling drugs and deficiency-nourishing drugs on cerebral ischemia in terms of astrocyte activation and inflammatory factor expression. Results suggested that Houshiheisan lessened neuronal degeneration in the corpus striatum on the ischemic side of rats following cerebral ischemia/reperfusion injury, contributed to astrocyte activation and glial fibrillary acidic protein expression in the corpus striatum and decreased the levels of interleukin-2, interleukin-6, interleukin-1β and tumor necrosis factor-α. Factor analysis results demonstrated that deficiency-nourishing drugs were more beneficial in protecting neurons and upregulating glial fibrillary acidic protein expression than wind-dispelling drugs. However, wind-dispelling drugs were more effective in increasing the number of glial fibrillary acidic protein-positive cells and reducing inflammatory factor expression than deficiency-nourishing drugs. These indicate that different ingredients of Houshiheisan suppress cerebral ischemic injury by promoting astrocyte activation and diminishing inflammatory factor expression.
journal_name
Neural Regen Resjournal_title
Neural regeneration researchauthors
Zhang Q,Zhao H,Wang L,Zhang Q,Wang Hdoi
10.3969/j.issn.1673-5374.2012.24.002subject
Has Abstractpub_date
2012-08-25 00:00:00pages
1851-7issue
24eissn
1673-5374issn
1876-7958pii
NRR-7-1851journal_volume
7pub_type
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journal_title:Neural regeneration research
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abstract::Several studies have demonstrated that the Chinese herb Gastrodia elata Blume can protect against amyloid beta-peptide (Aβ)-induced cell death. To investigate the possible therapeutic effects of Gastrodia elata Blume on Alzheimer's disease, we established a rat model of Alzheimer's disease by injecting Aβ25-35 into bi...
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doi:10.3969/j.issn.1673-5374.2013.12.001
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journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.3969/j.issn.1673-5374.2012.08.006
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更新日期:2018-09-01 00:00:00
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journal_title:Neural regeneration research
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pub_type: 杂志文章,评审
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