Abstract：
PURPOSE:To report two cases of ciliochoroidal effusion after the usage of topiramate. CASES:Two middle-aged women experienced sudden onset of acute glaucoma and acquired myopia after taking topiramate. Ultrasound biomicroscopy demonstrated bilateral ciliochoroidal effusion and angle closure. The A-scan ultrasonography revealed shallow anterior chamber and thick lens. After the treatment and drug withdrawal, intraocular pressure, refractive status and angle anatomy returned to normal and there was resolution of ciliochoroidal effusion. During the clinical course, the anterior chamber depth (ACD) increased from 2.02 to 3.30 mm (1.28 mm of changes) OD and from 1.94 to 3.36 mm (1.42 mm of changes) OS. The lens thickness (LT) became thinner from 4.53 to 4.31 mm (0.22 mm of changes) OD and from 4.59 to 4.30 mm (0.29 mm of changes) OS in the first case. In the second case, the ACD increased from 2.33 to 3.07 mm (0.74 mm of changes) OD and from 2.30 to 3.05 mm (0.75 mm of changes) OS. The LT became thinner from 4.42 to 4.27 mm (0.15 mm of changes) OD and from 4.38 to 4.26 mm (0.12 mm of changes) OS. The forward displacement of the lens-iris diaphragm contributed more to the shallowness of the anterior chamber than the thickening of the lens itself (only accounting for 20%). CONCLUSION:Topiramate-induced bilateral acute angle closure glaucoma and myopic shift was due to ciliochoroidal effusion which resulted in thicker lens and shallow anterior chamber. The later was mainly due to anterior displacement of the lens-iris diaphragm.
journal_name
Int Ophthalmoljournal_title
International ophthalmologyauthors
Lan YW,Hsieh JWdoi
10.1007/s10792-017-0740-ysubject
Has Abstractpub_date
2018-12-01 00:00:00pages
2639-2648issue
6eissn
0165-5701issn
1573-2630pii
10.1007/s10792-017-0740-yjournal_volume
38pub_type
杂志文章,评审abstract：PURPOSE:To estimate objective visual acuity in subjects suffering from cataract and age-related macular degeneration via the optokinetic response evoked by a non-conventional induction method (oktotype); in addition, to compare such objective outcome with the subjective acuity based on the ETDRS charts. METHODS:Patien...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-018-1001-4
更新日期：2019-08-01 00:00:00
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journal_title：International ophthalmology
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更新日期：2010-08-01 00:00:00
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journal_title：International ophthalmology
pub_type： 临床试验,杂志文章
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更新日期：1997-01-01 00:00:00
abstract：:Glaucoma after penetrating keratoplasty is a frequently observed post-operative complication and is a risk factor for graft failure. Penetrating keratoplasty performed for aphakic and pseudophakic bullous keratopathy and inflammatory conditions are more likely to cause postoperative glaucoma compared with keratoconus ...
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pub_type： 杂志文章,评审
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更新日期：2008-06-01 00:00:00
abstract：BACKGROUND:Only a few studies have investigated structural and functional changes in monocular blind individuals. Our aim in this study was to segmentally investigate the cerebellar structures of subjects with late-onset monocular blindness (LMB) using a Voxel-based volumetric analysis system. METHODS:The segmental vo...
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更新日期：2017-02-01 00:00:00
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pub_type： 杂志文章
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更新日期：1990-01-01 00:00:00
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journal_title：International ophthalmology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s10792-013-9871-y
更新日期：2014-08-01 00:00:00
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更新日期：2012-04-01 00:00:00
abstract：PURPOSE:Primary ocular adnexal lymphomas are cured by radiotherapy; however, complications are frequent and relapses may occur. In this case, we aimed to report the efficacy and safety of extended systemic rituximab (anti-CD 20 monoclonal antibody) therapy of conjunctival mucosa-associated lymphoid tissue (MALT) lympho...
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doi：10.1007/s10792-018-0844-z
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doi：10.1007/BF00133176
更新日期：1995-01-01 00:00:00
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journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/BF00918866
更新日期：1993-02-01 00:00:00
abstract：:Infants have been known occasionally to stare without blinking for almost a minute. This puts great demands on the stability of their tear-film. To verify the stability of infant tears, we performed biophysical experiments on Meibomian gland secretion, which forms the outermost layer of the tear-film. The secretion wa...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/BF00919408
更新日期：1994-01-01 00:00:00
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journal_title：International ophthalmology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1023/a:1026567912389
更新日期：1999-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：2014-08-01 00:00:00
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更新日期：2008-04-01 00:00:00
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journal_title：International ophthalmology
pub_type： 杂志文章
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pub_type： 杂志文章,评审
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doi：10.1007/s10792-011-9428-x
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更新日期：2012-08-01 00:00:00
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journal_title：International ophthalmology
pub_type： 杂志文章,多中心研究
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更新日期：2017-10-01 00:00:00
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journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-013-9817-4
更新日期：2014-06-01 00:00:00
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journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-015-0148-5
更新日期：2016-06-01 00:00:00
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journal_title：International ophthalmology
pub_type： 杂志文章
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更新日期：2010-10-01 00:00:00
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journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-012-9675-5
更新日期：2013-08-01 00:00:00
abstract：PURPOSE:To describe the outcome of a series of Acanthamoeba keratitis treated with a similar regimen. METHODS:All cases diagnosed with Acanthamoeba keratitis in a referral centre from June 1994 through June 1997 were included. Diagnosis of Acanthamoeba keratitis was based in clinical presentation and laboratory result...
journal_title：International ophthalmology
pub_type： 杂志文章
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更新日期：1997-01-01 00:00:00
