Abstract:
:To assess the effect of intravitreal dexamethasone implant (Ozurdex) for the treatment of macular edema secondary to retinal vein occlusion (RVO) resistant to repeated intravitreal ranibizumab injection. Retrospective review of 11 patients (11 eyes) with ranibizumab-resistant macular edema secondary to RVO. Macular edema was considered refractory to ranibizumab if no change of the pattern of macular fluid on optical coherence tomography and no change of best-corrected visual acuity (BCVA) was observed after at least three consecutive monthly injections, excluding the loading dose. A single Ozurdex injection was performed and BCVA and central foveal thickness (CFT) were reviewed 2, 3, and 6 months after treatment. Mean BCVA improved significantly from 0.51 logarithm of the minimal angle of resolution (log MAR) at baseline to 0.3 log MAR (p = 0.03) at 2 months and 0.29 log MAR (p = 0.003) at 3 months. There was no significant difference in the BCVA between baseline at 6 months (p = 0.62). Mean CFT reduced significantly from 538 µm at baseline to 281 µm at 2 months (p = 0.00003), 281 µm at 3 months (p = 0.00003), and 445 µm at 6 months (p = 0.03). Treatment with Ozurdex results in improvement of BCVA and reduction of CFT in patients with ranibizumab refractory macular edema due to RVO at 3 months. However, it seems that the visual acuity gain may not last up to 6 months, so that a re-injection before this time point could be considered.
journal_name
Int Ophthalmoljournal_title
International ophthalmologyauthors
Manousaridis K,Peter S,Mennel Sdoi
10.1007/s10792-016-0226-3subject
Has Abstractpub_date
2017-02-01 00:00:00pages
47-53issue
1eissn
0165-5701issn
1573-2630pii
10.1007/s10792-016-0226-3journal_volume
37pub_type
杂志文章abstract::The unifying principle underlying this classification system is: The more posterior the disease and the greater the amount of involved retinal vascular tissue, the more serious the disease. The staging of the disease at any given location expresses the natural history and evolution of events at the border between vasc...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/BF00136454
更新日期:1985-04-01 00:00:00
abstract:PURPOSE:To compare the outcome of penetrating keratoplasty (PKP) and deep anterior lamellar keratoplasty (DALK) in the surgical management of keratoconus (KC). PATIENT AND METHODS:A retrospective review was conducted of the medical records of all patients treated with PKP or DALK for KC at University of Iowa Hospitals...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-010-9393-9
更新日期:2010-12-01 00:00:00
abstract:UNLABELLED:The purpose of this study is to evaluate the effect of trephination with free scleral auto-implant plug exposed to Mitomycin-C out of the eye, in surgical treatment of primary open-angle glaucoma (POAG), in comparison with efficacy of trabeculectomy with MMC (32 eyes with POAG of patients, younger than 55 ye...
journal_title:International ophthalmology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF00212952
更新日期:1996-01-01 00:00:00
abstract::To investigate the correlation between the perifoveal capillary blood flow velocity (BFV) and the vitreous level of pigment epithelium-derived factor (PEDF) in patients with branch retinal vein occlusion (BRVO) and macular edema. In a retrospective interventional study of patients with BRVO and macular edema, undilute...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-012-9584-7
更新日期:2012-10-01 00:00:00
abstract:PURPOSE:To report a case with acute endophthalmitis as a postoperative complication of 25-gauge transconjunctival sutureless vitrectomy. METHODS:A 65-year-old gentleman, who underwent 25-gauge sutureless vitrectomy for an idiopathic epiretinal membrane at Beyoğlu Eye Research and Training Hospital, presented with pain...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-007-9081-6
更新日期:2007-12-01 00:00:00
abstract::We report on two cases of bilateral chorioretinal colobomas with ocular anomalies in patients with CHARGE syndrome. In the first case, a female infant was born at 36 + 5 weeks gestation. At birth, the patient demonstrated a small left eye. Slit-lamp examination revealed colobomas of both irises. Fundus examination sho...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-013-9817-4
更新日期:2014-06-01 00:00:00
abstract::We compared uveitis patients who attended a general eye clinic (n = 183) with those who attended the ophthalmology department of a university hospital (n = 550) to examine factors that affect the clinical statistics of uveitis outpatients. We observed that diabetic iritis and herpetic iritis were significantly more fr...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-009-9336-5
更新日期:2010-06-01 00:00:00
abstract:PURPOSE:To assess the outcomes and analyze complication rates following primary iris claw IOL retrofixation with intravitreal triamcinolone acetonide. METHODS:This is a retrospective interventional case series. Patients with poor capsular support-diagnosed preoperatively or owing to intraoperative complications-were t...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-017-0467-9
更新日期:2018-02-01 00:00:00
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journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/BF00212942
更新日期:1996-01-01 00:00:00
abstract:PURPOSE:To describe the incidence of, and risk factors associated with, diabetic retinopathy in diabetic persons assessed at a Saudi diabetes centre. METHODS:Five hundred and two patients with diabetes mellitus assessed by our service were studied. There were 174 patients (34.7%) with insulin-dependent diabetes mellit...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1023/a:1006240928938
更新日期:1998-01-01 00:00:00
abstract::To determine changes in choroidal thickness in patients with central serous chorioretinopathy (CSCR) during the first 3 months after initial diagnosis and assess variable therapeutic interventions via enhanced depth imaging spectral-domain optical coherence tomography (EDI-OCT). In this prospective study, choroidal th...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-013-9774-y
更新日期:2014-02-01 00:00:00
abstract::Dear editor and readers, this letter is written to make you aware that the original version of this article unfortunately contained a mistake. ...
journal_title:International ophthalmology
pub_type: 杂志文章,已发布勘误
doi:10.1007/s10792-018-0981-4
更新日期:2019-01-01 00:00:00
abstract::Preliminary results of a larger investigation on correlation between Retinal Nerve Fiber Layer Defects (RNFL) and Automated Perimetry (AP) are presented. A group of ocular hypertensive patients was recruited and a cross-section, randomized study was carried out. The group was composed of 54 eyes from 28 patients; 15 m...
journal_title:International ophthalmology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF00917968
更新日期:1992-09-01 00:00:00
abstract:PURPOSE:The objective of this study is to examine the morphometry of the lacrimal drainage system with reference to bony landmarks in the vicinity. METHODS:Twenty midsaggitalized heads obtained from sixteen preserved cadavers were studied. Measurements involved detailed morphometry of anterior and posterior lacrimal c...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-017-0753-6
更新日期:2018-12-01 00:00:00
abstract:PURPOSE:To evaluate the performance of full-thickness (FT) versus partial-thickness (PT) sutures in a full-thickness corneal wound in an animal model. METHODS:This is a prospective, experimental, comparative, longitudinal study. A 6-mm linear, full-thickness corneal incision was performed on the right eye of eight dom...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-020-01585-0
更新日期:2021-01-01 00:00:00
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journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/BF00155628
更新日期:1987-08-01 00:00:00
abstract:PURPOSE:To assess variability in the coefficient of variation (COV) in cell area estimates when using different numbers of cells for endothelial morphometry. METHODS:Using non-contact specular microscopy images of the corneal endothelium, 4 sets of 20 cases were selected that included 200 cells and had overall (global...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-017-0765-2
更新日期:2018-12-01 00:00:00
abstract:PURPOSE:To evaluate the importance of "en toto" globe submission in the assessment of high-risk pathological findings in retinoblastoma cases, aiming at identifying the additional value from full globe examination of enucleated eyes (including the calottes). METHODS:Retrospective histopathological case series of eight...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-016-0410-5
更新日期:2018-02-01 00:00:00
abstract::The retinal toxicity of vancomycin in infusion solution used in vitrectomy and lensectomy was investigated in rabbit eyes by means of electroretinography and histologic study (light microscopy). Concentrations of 8 micrograms/ml, 16 micrograms/ml, and 32 micrograms/ml of vancomycin in balanced salt solution caused no ...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/BF00942780
更新日期:1993-04-01 00:00:00
abstract::The purpose of this study was to report on two novel missense mutations of the cornea-specific TGFBI gene in one single patient and in two generations of a family diagnosed with unique corneal dystrophy (CD) phenotypes. Ophthalmologic examination, in several cases ocular coherence tomography of the anterior segment (A...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-016-0216-5
更新日期:2016-12-01 00:00:00
abstract:AIM:To evaluate the effect of acute anaerobic exercise on macular perfusion measured by swept-source optical coherence tomography angiography (SS-OCTA) in young football players. MATERIALS AND METHODS:Football players with ages between 18 and 20 years were included into the study. After a detailed ophthalmological exa...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-020-01303-w
更新日期:2020-06-01 00:00:00
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journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-014-9974-0
更新日期:2015-08-01 00:00:00
abstract:PURPOSE:To compare corneal graft survival rates after penetrating keratoplasty (PK) and Descemet's stripping endothelial keratoplasty (DSEK) in patients with a glaucoma drainage device (GDD) or medically managed glaucoma. METHODS:A retrospective chart review was conducted on consecutive patients who underwent primary ...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-017-0451-4
更新日期:2018-02-01 00:00:00
abstract::Onchocerciasis is a major blinding disease affecting at least 28 million people in Africa and Latin America. Although a large-scale vector control program has been highly successful in limiting transmission of infection in West Africa, there has not been a satisfactory form of treatment available for those already inf...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/BF00136735
更新日期:1987-12-01 00:00:00
abstract::We constructed a contact lens with an integrated pressure-sensing device. It is housed in a container with three force-sensing elements, each 120 degrees apart, enabling measurement of the appositional force, i.e., the force with which the instrument is held against the eye. In part 1 of the study, the lens' precision...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1023/a:1006292102204
更新日期:1998-01-01 00:00:00
abstract::Ocular tuberculosis is difficult to diagnose but should be suspected when uveitis fails to respond to inflammation suppressive therapy. Interferon-gamma release assays (IGRAs) represent a substantial help to diagnose suspected ocular tuberculosis especially in non-endemic areas. Indocyanine green angiography (ICGA) is...
journal_title:International ophthalmology
pub_type: 杂志文章,评审
doi:10.1007/s10792-012-9588-3
更新日期:2012-10-01 00:00:00
abstract::The main visual field indices of Flammer and the analogous ones of Heijl have been compared based on a population of 113 glaucomatous visual fields. It is shown that for the population studied, the differences between the two sets of indices are negligible for Octopus G1 program results and that they may thus be used ...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/BF00128955
更新日期:1991-09-01 00:00:00
abstract:PURPOSE:To compare differences in the endothelial cells before and after photorefractive keratectomy (PRK) for myopia with refractive error graded mitomycin C (MMC) application. METHODS:In a prospective randomized clinical trial, forty-eight myopic patients referred to Khatam-al-Anbia Eye Hospital, Mashhad, Iran, for ...
journal_title:International ophthalmology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s10792-017-0584-5
更新日期:2018-06-01 00:00:00
abstract::Acute and invasive fungal infections are usually seen in immunocompromised and debilitated patients. We report a young immunocompetent 28-year-old Indian male who presented with unilateral endogenous endophthalmitis in the left eye and was managed with pars plana vitreous surgery. The polymerase chain reaction from th...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-008-9235-1
更新日期:2009-08-01 00:00:00
abstract:PURPOSE:To report a case of DUSN from the Indian subcontinent and emphasize the importance of immediate photocoagulation. METHOD:Review of case record. RESULT:The referring ophthalmologist had photographed the subretinal worm but had not undertaken laser photocoagulation. On presentation to us the patient had feature...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-007-9045-x
更新日期:2005-12-01 00:00:00