Full- versus partial-thickness sutures: experimental models of corneal injury repair.

Abstract:

PURPOSE:To evaluate the performance of full-thickness (FT) versus partial-thickness (PT) sutures in a full-thickness corneal wound in an animal model. METHODS:This is a prospective, experimental, comparative, longitudinal study. A 6-mm linear, full-thickness corneal incision was performed on the right eye of eight domestic pigs. Eyes were randomly assigned for repair with interrupted PT (80-90% depth) sutures or FT 10-0 nylon sutures. Anterior segment OCT, corneal pachymetry and clinical photographs were obtained 1, 4 and 8 weeks postoperatively. Corneal thickness, depth of suture placement, perilesional edema, coaptation of wound edges and complications were noted. Histopathologic examination was performed at 8 weeks. RESULTS:100% of the eyes with FT sutures developed a linear, less opaque scar. 100% of the eyes with PT developed a dense, opaque stromal scar (p = 0.02). Vascularization of the cornea was present in 75% of PT group and 25% in the FT group (p = 0.50). As the corneas healed, there was a marked trend toward thicker corneas in the PT group versus FT group with a median difference of - 63 µm at week 1 [median 788 µm vs. 725 µm, (p = 0.11)], - 38 µm at week 4, (724 µm vs. 686 µm, (p = 0.63)) and - 47 µm median difference at week 8 with (670 µm vs. 623 µm, (p = 0.06)). Histopathology showed disorganization of the collagen fibers and the formation of a retrocorneal fibrous membrane in the PT group. CONCLUSIONS:The FT group presented less corneal edema at week 8 with a more linear and less opaque scar. Histopathology showed a better-organized scar and endothelialization without the formation of a fibrous membrane.

journal_name

Int Ophthalmol

authors

Dalma-Weiszhausz J,Galván-Chávez M,Guinto-Arcos EB,Miyake-Martínez DY,Rodríguez-Reyes A,Golzarri MF,Sebastián-Arellano C,Dávila-Ávila NM,Ríos-Elizondo CE

doi

10.1007/s10792-020-01585-0

subject

Has Abstract

pub_date

2021-01-01 00:00:00

pages

325-334

issue

1

eissn

0165-5701

issn

1573-2630

pii

10.1007/s10792-020-01585-0

journal_volume

41

pub_type

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