Abstract：
PURPOSE:To compare differences in the endothelial cells before and after photorefractive keratectomy (PRK) for myopia with refractive error graded mitomycin C (MMC) application. METHODS:In a prospective randomized clinical trial, forty-eight myopic patients referred to Khatam-al-Anbia Eye Hospital, Mashhad, Iran, for PRK. Patients were treated with PRK by a Bausch and Lomb Technolas 217z excimer laser (Bausch and Lomb, Rochester, NY). MMC was applied after PRK 5 s for each diopter of spherical equivalent myopic refractive error corrected. The manifest refraction, visual acuity, MMC treatment length, corneal pachymetry and specular microscopy were evaluated preoperatively and at 1 and 6 months postoperatively. RESULTS:A total of 48 cases (96 eyes, 68.75% female) were treated, with a mean age of 26.70 ± 4.89 years (range, 18-34 years). Postoperative cell density, cell size and polymegathism did not significantly change. On the other hand, standard deviation (SD) of cell size (P = 0.008), pleomorphism (P = 0.003) and coefficient of variation (CV) (P = 0.016) were significantly increased. None of these parameters was related to the length of MMC application. Corneal thickness decreased significantly after the operation but it increased 6 months postoperatively compared with the first month (P < 0.001). CONCLUSION:MMC application for PRK in myopia can affect the endothelial cells, but in early follow-ups, it does not affect the cell density or size. Cell size was changed but it was obvious not in mean cell size, but in SD and CV. MMC time below the 30 s was not significant on endothelial cell changes.
journal_name
Int Ophthalmoljournal_title
International ophthalmologyauthors
Gharaee H,Zarei-Ghanavati S,Alizadeh R,Abrishami Mdoi
10.1007/s10792-017-0584-5subject
Has Abstractpub_date
2018-06-01 00:00:00pages
1211-1217issue
3eissn
0165-5701issn
1573-2630pii
10.1007/s10792-017-0584-5journal_volume
38pub_type
杂志文章,随机对照试验abstract：PURPOSE:To review the multimodal imaging patterns of posterior syphilitic uveitis. METHODS:A systematic review. RESULTS:The percentage of syphilis has started to increase again: The World Health Organization has reported 12 million new cases of syphilis each year. In addition, syphilis was responsible for 0.3% of dea...
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pub_type： 临床试验,杂志文章
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journal_title：International ophthalmology
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journal_title：International ophthalmology
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更新日期：2019-10-01 00:00:00
