Abstract:
:This study aimed to present precancerous and cancerous epithelial eyelid lesions, their histopathological features, and possible correlations with clinical parameters. The retrospective study included 147 formalin-fixed, paraffin-embedded samples. We studied precancerous and cancerous epithelial eyelid lesions. Preneoplastic tumors were represented by 12 actinic keratoses and 6 in situ squamous cell carcinomas (Bowen disease) and skin epithelial tumors by 119 basal and 10 squamous cell carcinomas. We recorded the clinicomorphological and histopathological features of the specimens and investigated possible correlations. In our study, the vast majority of pre-malignant and malignant tumors occurred in advanced age (mean age of occurrence: 70.18 years). The data analysis showed that inflammation in patients with basal cell carcinoma (BCC) positively correlated with advanced age (p < 0.01), tumor diameter (p < 0.05), and the appearance of ulceration (p < 0.001). A prevalence of female sex was noted in the BCC group. We also found that inflammation with or without the presence of ulceration was more commonly seen in carcinomatous lesions than in preneoplastic lesions (p < 0.05). Inflammation occurrence is present in high proportions in the tumors studied and correlates with some clinicopathological parameters such as the age of patients, the mean tumor diameter, and the presence of ulceration. The comparison between premalignant and malignant conditions showed that inflammation probability increases as we move toward the more aggressive tumor phenotypes.
journal_name
Int Ophthalmoljournal_title
International ophthalmologyauthors
Tzoutzos K,Batistatou A,Kitsos G,Liasko R,Stefanou Ddoi
10.1007/s10792-016-0258-8subject
Has Abstractpub_date
2017-02-01 00:00:00pages
203-208issue
1eissn
0165-5701issn
1573-2630pii
10.1007/s10792-016-0258-8journal_volume
37pub_type
杂志文章abstract::A solitary fibrous tumor is a neoplasm generally arising from the mesothelial surfaces of the pleura and mesothelium. In this paper, we describe three cases of rare solitary fibrous tumors arising from the orbit and discuss the management of the tumors, including diagnosis and treatment. All three cases were treated b...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-016-0421-2
更新日期:2018-02-01 00:00:00
abstract::One hundred cases of clinically acceptable sympathetic ophthalmia (SO) were evaluated histologically to determine the incidence of atypical features and correlate them with the severity of choroidal inflammation. The inflammatory response in the choroid varied from a focal non-granulomatous to a diffuse non-necrotizin...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/BF00161902
更新日期:1982-02-01 00:00:00
abstract:BACKGROUND:To describe the clinical characteristics of active ocular toxoplasmosis in a large population of Turkish patients. METHODS:A retrospective study of 109 consecutive patients with active ocular toxoplasmosis seen at the Department of Ophthalmology, Istanbul Faculty of Medicine, from 1995 to 2005. RESULTS:Fif...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-007-9047-8
更新日期:2005-12-01 00:00:00
abstract:PURPOSE:To evaluate superficial capillary plexus (SCP) changes occurring after internal limiting membrane (ILM) peeling for the treatment of idiopathic epiretinal membrane (ERM). METHODS:A total of 15 eyes of 15 patients affected by idiopathic ERM (eight males and seven females; mean age 59.8 ± 9.6 years) were enrolle...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-017-0608-1
更新日期:2018-08-01 00:00:00
abstract::We have studied the cholinergic nerve fibers (CNF) of human uveoscleral tissue in normal and pathological conditions (intraocular pressure: (IOP) of various degrees ) and have performed a quantitative image analysis of CNF with the aim of studying an hypothetical association between IOP and the uveoscleral level of ch...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1023/a:1006306812296
更新日期:1998-01-01 00:00:00
abstract::The aim of this study was to evaluate tear osmolarity and ocular comfort with two different types of hydrogel daily disposable lenses. The right eyes of 15 first-time contact lens users were included in this prospective study. All eyes wore hilafilcon B silicone hydrogel contact lenses for 8 h (group 1). After 1 week ...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-012-9556-y
更新日期:2012-06-01 00:00:00
abstract:OBJECTIVE:To observe the effect of sirt1 on retinal ganglion cells (RGC) with high glucose culture and to explore the role of sirt1 in the development of diabetic retinopathy. Method RGC was infected by sirt1 lentivirus overexpression vector pLV5-sirt1 and interference vector pLV3-si-sirt1. The normal control group and...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-020-01638-4
更新日期:2020-11-11 00:00:00
abstract::Diabetes mellitus and pregnancy have reciprocal influences between them, therefore diabetes mellitus may complicate the course of pregnancy as well as pregnancy can worsen the performance of diabetes especially at the fundus oculi. Several factors seem to play a role in retinal neovascularization. Actually it's not po...
journal_title:International ophthalmology
pub_type: 杂志文章,评审
doi:10.1007/s10792-014-9906-z
更新日期:2014-08-01 00:00:00
abstract:PURPOSE:State Gentamicin antibiotic prophylaxis is contraindicated in 25 gauge Transconjunctival Sutureless Vitrectomy. METHODS:A 75-year-old diabetic woman was affected by glaucoma and mild diabetic retinopathy in both eyes, and epiretinal membrane in the left eye. A 25-gauge Transconjunctival Sutureless Vitrectomy (...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-007-9148-4
更新日期:2008-10-01 00:00:00
abstract:PURPOSE:To evaluate whether retrobulbar blood flow and choroidal thickness (CT) are affected in patients with rheumatoid arthritis (RA), and the relationship between these values. METHODS:We evaluated 40 eyes of 20 RA patients and 40 eyes of 20 healthy controls. The enhanced depth imaging optical coherence tomography,...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-017-0656-6
更新日期:2018-10-01 00:00:00
abstract:OBJECTIVE:To evaluate the efficacy and safety of the bilateral simultaneous XEN (BISIXEN) surgery in open-angle glaucoma patients. METHODS:Retrospective analysis of a prospective data base conducted on uncontrolled glaucoma patients who underwent BISIXEN surgery. Primary endpoint measure was the incidence of sight-thr...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-020-01640-w
更新日期:2021-01-02 00:00:00
abstract:PURPOSE:Recently, the vasodilator relaxin 2 has been introduced as a treatment for acute heart failure. However, its role on vessels of the eye and intraocular pressure (IOP) remains unclear though it has been hypothesized to induce a decrease IOP after intramuscular injection in humans. We aimed to test whether the ho...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-018-0884-4
更新日期:2019-04-01 00:00:00
abstract:PURPOSES:This research aimed to investigate effects and risk factors on non-contact tonometer (NCT) readings in healthy myopic subjects by employing cross-sectional study design. METHODS:Totally, sixty otherwise healthy myopic volunteers (mean 28.4 years old) with 90% female were recruited in ophthalmic clinic. The ro...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-019-01203-8
更新日期:2020-02-01 00:00:00
abstract::The purpose of this article is to report an unusual bilateral inferior subluxation of the lens in a patient with Marfan's syndrome. A 14-year-old boy presented with gradual painless diminution of vision in both eyes. His family history showed that his maternal uncle also had similar complaints. Systemic examination of...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-013-9750-6
更新日期:2014-02-01 00:00:00
abstract:PURPOSE:To report a childhood case of tumor necrosis factor receptor-associated periodic syndrome (TRAPS) carrying the R92Q variant with a vision-threatening bilateral panuveitis. METHODS:Case report and review of the literature. RESULTS:A 7-year-old boy presented with an active bilateral panuveitis and a macular ras...
journal_title:International ophthalmology
pub_type: 杂志文章,评审
doi:10.1007/s10792-017-0785-y
更新日期:2019-01-01 00:00:00
abstract::We evaluated the in vitro effects of the 1.3 u wavelength of a Nd:YAG laser using a fiberoptic delivery system, with or without sapphire tips on ocular tissue. Conjunctival and retinal adhesions were achieved best with a noncontact technique compared with a contact method. ...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/BF00155628
更新日期:1987-08-01 00:00:00
abstract::The purpose of this study was to evaluate the impact of intravitreal bevacizumab injections on the management and outcome of patients affected by retinal vein occlusions, their effectiveness on morphological and functional parameters, the modalities of long-term management and the need for additional laser treatment d...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-014-0002-1
更新日期:2014-12-01 00:00:00
abstract:PURPOSE:To develop a new regression formula based on the Gaussian thick lens formula and to verify the accuracy of the regression formula. METHODS:In this prospective study, 207 eyes of 207 myopic subjects and 133 eyes of 67 postoperative subjects were included. For the 133 postoperative eyes, 127 eyes underwent laser...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-019-01089-6
更新日期:2019-11-01 00:00:00
abstract:PURPOSE:Our aim was to summarize key aspects of the pathomechanism and the ocular involvements of rheumatic and systemic autoimmune diseases. METHODS:Apart from a paper in French (Morax V, Ann Oculist 109:368-370, 1893), all papers referred to in this article were published in English. All the materials were peer-revi...
journal_title:International ophthalmology
pub_type: 杂志文章,评审
doi:10.1007/s10792-019-01183-9
更新日期:2020-02-01 00:00:00
abstract::IgG4-related disease is a recently defined inflammatory process characterized by IgG4-bearing plasma cells in the involved tissues. The most common sites of involvement are the pancreas, hepatobiliary tract, salivary glands, lymph nodes, retroperitoneum and orbit, especially the lacrimal glands. Other ocular or ocular...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-015-0070-x
更新日期:2015-08-01 00:00:00
abstract:BACKGROUND:To determine the inflammatory course and level of visual rehabilitation after cataract extraction and posterior chamber lens implantation in patients with Fuchs' heterochromic iridocyclitis complicated by cataract. METHODS:In a clinical trial, 32 eyes (visual acuity of 20/160 or worse) of 30 patients underw...
journal_title:International ophthalmology
pub_type: 临床试验,杂志文章
doi:10.1023/a:1026490902566
更新日期:1997-01-01 00:00:00
abstract:PURPOSE:To provide normal corneal elevation data for a large Caucasian population and to determine the impacts on these data of age, sex, axial length (AXL) and horizontal white-to-white (WW). SETTING:Centro Internacional de Oftalmología Avanzada, Madrid, Spain. DESIGN:Retrospective, cross-sectional, observational. ...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-018-1028-6
更新日期:2019-09-01 00:00:00
abstract::Long-term use of topical drugs can induce changes in the conjunctiva and ocular surface. To determine the conjunctival changes resulting from topical glaucoma medication, patients with glaucoma were selected and classified into seven groups, according to the medication received: 24 eyes were treated with betaxolol, 20...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1023/a:1005892426045
更新日期:1997-01-01 00:00:00
abstract:OBJECTIVES:To evaluate the use of Optical Coherence Tomography (OCT) in the diagnosis of macular edema (ME) in diabetic patients in comparison to indirect ophthalmoscopy (IO) and, in addition, to study the characteristics of these patients. METHODS:165 patients were randomly selected to join the study in 1998. Ophthal...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1023/b:inte.0000006784.52885.e9
更新日期:2001-01-01 00:00:00
abstract::Insulin-like growth factor-1 (IGF-1) is altered in several neurodegenerative diseases, the association between serum IGF-1 levels and glaucoma has not been evaluated. This study was designed to evaluate whether serum IGF-1 levels are different in patients with Pseudoexfoliation (PEX) with or without glaucoma. The stud...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-016-0271-y
更新日期:2017-04-01 00:00:00
abstract:PURPOSE:To analyze the demographic patterns, clinical characteristics, and treatment protocols of optic neuropathies. MATERIALS AND METHODS:The hospital data of patients with optic neuropathy admitted to the Department of Neuro-ophthalmology in a tertiary referral center in Turkey between January 2010 to January 2017 ...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-017-0799-5
更新日期:2019-01-01 00:00:00
abstract:INTRODUCTION:Vogt-Koyanagi-Harada syndrome (VKHS) is an inflammatory systemic autoimmune disease principally affecting pigmented tissues in the ocular, auditory, integumentary and central nervous systems. Patients are generally women in the fourth decade of life. The prognosis is correlated mainly with the time between...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-017-0504-8
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND:We carried out a study by in-vivo confocal microscopy to investigate the appearance of iridocorneal endothelial (ICE) syndrome, and discuss its diagnostic potential. METHODS:Twelve patients, each with unilateral ICE syndrome, had both their eyes examined by in-vivo confocal microscopy. The images were recor...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-007-9187-x
更新日期:2009-02-01 00:00:00
abstract::To describe the efficacy of intravitreal chemotherapy (IViC) preceded by intra-arterial chemotherapy (IAC) for the treatment of advanced stage retinoblastoma. This non-comparative interventional case series retrospectively reviewed the medical records of six patients who presented within months of each other with unil...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-015-0129-8
更新日期:2015-12-01 00:00:00
abstract::The authors reviewed their experience with 429 cases of orbital exenteration between 1963 and 1993. Apart from the 22 cases operated in concert with other physicians, 407 cases were operated by an ophthalmologist and spontaneous granulation technique was used. Total or eyelid-sacrificing exenteration was carried out f...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/BF00133735
更新日期:1995-01-01 00:00:00