Abstract:
:To describe the efficacy of intravitreal chemotherapy (IViC) preceded by intra-arterial chemotherapy (IAC) for the treatment of advanced stage retinoblastoma. This non-comparative interventional case series retrospectively reviewed the medical records of six patients who presented within months of each other with unilateral retinoblastoma, Reese-Ellsworth stage Vb/D of ABC classification in the affected eye. After clinical and ophthalmoscopic evaluation, they underwent MRI to exclude local and CNS dissemination. The IAC was given to treat retinal masses and intravitreal injections to treat vitreous seeding. Patients had received two cycles (six infusions) of IAC, and from six up to ten melphalan injections into the vitreous, with an interval of 7-10 days between them. From one to four intravitreal injections were performed for partial remission or consolidation. No permanent complications of procedures have been reported. All patients underwent to bimonthly MRI examination, during treatment and every 3 months for 1 year after last injection, to exclude orbital dissemination. Successful control (100 %) of tumor masses and vitreous seeds was achieved in all cases at 12 months follow-up. Complications were posterior lens opacity, acute ischemic papillitis, partial CVR thrombosis, hypotonia (case 1), partial vitreous hemorrhage (case 4). No complications appeared in cases 2, 3, 5, and 6. No intraocular or orbital tumor recurrence or retinoblastoma metastases (follow-up range, 12-33 months) were observed. Sequential IAC and intravitreal melphalan for advanced retinoblastoma allowed to provide retinal and vitreous seed control.
journal_name
Int Ophthalmoljournal_title
International ophthalmologyauthors
De Francesco S,Galluzzi P,Bracco S,Menicacci F,Motolese E,Hadjistilianou Tdoi
10.1007/s10792-015-0129-8subject
Has Abstractpub_date
2015-12-01 00:00:00pages
887-95issue
6eissn
0165-5701issn
1573-2630pii
10.1007/s10792-015-0129-8journal_volume
35pub_type
杂志文章abstract::To describe a congenital retinal macrovessel with macular thickening. This case was investigated using fundus photography, fluorescein angiography, Spectralis optical coherence tomography and a 10-2 visual field test. A 23-year-old man was referred to our clinic with decreased vision in the right eye. Fundus examinati...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-010-9402-z
更新日期:2011-02-01 00:00:00
abstract::To report a unusual case of an isolated traumatic stellated tarso-conjunctival laceration located in the upper left eyelid without eyelid margin involvement and with normal ocular examination. A 19 year-old male wounded by a bokken (wooden katana) while practicing a sham duel had an isolated eyelid tarso-conjunctival ...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-012-9573-x
更新日期:2012-08-01 00:00:00
abstract:PURPOSE:To report a case of bilateral Terson Syndrome with sub inner limiting membrane hemorrhage associated with a rare finding: perimacular fold. METHODS:The patient, a 34 years old female with aneurysmal subarachnoid hemorrhage and bilateral Terson syndrome was admitted to the Ophthalmology department, complaining ...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-018-0822-5
更新日期:2019-02-01 00:00:00
abstract::The unifying principle underlying this classification system is: The more posterior the disease and the greater the amount of involved retinal vascular tissue, the more serious the disease. The staging of the disease at any given location expresses the natural history and evolution of events at the border between vasc...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/BF00136454
更新日期:1985-04-01 00:00:00
abstract:BACKGROUND:To determine the inflammatory course and level of visual rehabilitation after cataract extraction and posterior chamber lens implantation in patients with Fuchs' heterochromic iridocyclitis complicated by cataract. METHODS:In a clinical trial, 32 eyes (visual acuity of 20/160 or worse) of 30 patients underw...
journal_title:International ophthalmology
pub_type: 临床试验,杂志文章
doi:10.1023/a:1026490902566
更新日期:1997-01-01 00:00:00
abstract::We encountered two cases of Harada's disease in monozygotic twins, and this is the first such report as far as could be determined. Case 1 was a 32-year-old woman who presented a typical clinical picture of Harada's disease. Seven years later, case 2 (the younger sister), also presented with the disease at 39 years of...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/BF00917073
更新日期:1992-01-01 00:00:00
abstract::The purpose of this study was to evaluate the presence of Toxoplasmosis gondii in samples of peripheral blood from patients with varying etiologies of uveitis. Whole blood from patients with different forms of uveitis was tested for the presence of T. gondii using real-time PCR targeting the well-characterized 529 bp ...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-016-0221-8
更新日期:2017-02-01 00:00:00
abstract:PURPOSE:To assess ophthalmic manifestations in patients with stroke and emphasize the importance of a formal screening for visual problems in stroke patients in hospital and rehabilitation settings. METHODS:This was a cross-sectional study of 50 newly diagnosed patients with stroke with Glasgow Coma Scale (GCS) > 8 ex...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-019-01131-7
更新日期:2019-12-01 00:00:00
abstract:PURPOSE:To report a unique case of congenital simple hamartoma of retinal pigment epithelium (CSHRPE) associated with full-thickness macular hole (FTMH). METHODS:A 14-year-old female with a previous diagnosis of simple hamartoma of retinal pigment epithelium in the left eye presented with a 3-week onset of reduced vis...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-017-0676-2
更新日期:2018-10-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to evaluate the effect retrobulbar and topical anesthesia on optic nerve by measuring retinal nerve fiber layer (RNFL) thickness before and after phacoemulsification cataract surgery using optical coherence tomography (OCT). METHODS:A total of 126 eyes of 108 patients were included ...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-020-01338-z
更新日期:2020-07-01 00:00:00
abstract::The purpose of this paper was to describe a patient with pericentral retinitis pigmentosa (RP) and cystoid macular edema (CME) refractory to oral acetazolamide alone who was successfully treated with adjunctive pegaptanib sodium. A 33-year-old man presented with decreased vision and a best-corrected visual acuity (BCV...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-007-9175-1
更新日期:2009-04-01 00:00:00
abstract::The aim of this study is to report the clinical outcome of a diabetic patient with optic nerve head neovascularization treated with an intravitreal injection of triamcinolone acetonide. A 52-year-old patient presented with clinically significant diffuse macular edema and optic nerve head neovascularization due to prol...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1023/b:inte.0000031740.85124.78
更新日期:2004-03-01 00:00:00
abstract:PURPOSE:To evaluate the influence of strong fixation preference on clinical and surgical outcomes, in non-amblyopic patients with basic-type intermittent exotropia (IXT). MATERIALS AND METHODS:The records of patients were retrospectively investigated. Non-amblyopic patients with the diagnosis of basic-type IXT were en...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-020-01603-1
更新日期:2020-10-14 00:00:00
abstract:PURPOSE:To determine whether there are angiographic differences among normal, preperimetric and advanced glaucoma eyes using indocyanine green angiography with SLO. This method was chosen because of its sensibility to detect peripapillary capillary vessels. METHODS:Scanning laser opthalmoscopy was preformed on normal ...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1023/a:1014431404096
更新日期:2001-01-01 00:00:00
abstract:PURPOSE:To evaluate the performance of full-thickness (FT) versus partial-thickness (PT) sutures in a full-thickness corneal wound in an animal model. METHODS:This is a prospective, experimental, comparative, longitudinal study. A 6-mm linear, full-thickness corneal incision was performed on the right eye of eight dom...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-020-01585-0
更新日期:2021-01-01 00:00:00
abstract::This paper builds on results of a previous paper on the prevalence of trachomatous visual impairment as the foundation for assessing the global burden of trachomatous blindness and low vision: approximately 2.9 million cases of trachomatous blindness and 3.8 million low visioned corresponding to a global prevalence of...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/BF00130921
更新日期:1995-01-01 00:00:00
abstract::Various techniques which use monoclonal antibodies to detect Chlamydia trachomatis in clinical specimens are reviewed. An investigation comparing the efficacy of immunofluorescent staining with Giemsa staining in detecting Chlamydia in conjunctival scrapings from cases of active trachoma is presented. Sixty-two eyes o...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/BF00133786
更新日期:1988-01-01 00:00:00
abstract::Onchocerciasis is a devastating blinding disease caused by the parasite Onchocerca volvulus that infects about 80 million people, causing blindness and visual impairment in 1-2 million people. In hyperendemic areas, more than half of the population will become blind from onchocerciasis before they die. Blindness is th...
journal_title:International ophthalmology
pub_type: 杂志文章,评审
doi:10.1007/BF00158317
更新日期:1990-05-01 00:00:00
abstract::A 71-year-old man presented with a large disciform scar in the right eye and hard (nodular) as well as soft (granular) drusen scattered throughout the posterior pole of the left eye. A large serous pigment epithelial detachment was evident in the drusen area of the left fundus. Six months later a tear of the retinal p...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/BF00139344
更新日期:1987-06-01 00:00:00
abstract:PURPOSE:To evaluate the long-term course of primary angle-closure ocular hypertension and primary open-angle ocular hypertension and possible risk factors for progression to glaucoma. METHODS:A total of 109 eyes of 109 ocular hypertension (OHT) patients with a minimum follow-up period of 5 years having complete ocular...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-018-0872-8
更新日期:2019-04-01 00:00:00
abstract:PURPOSE:The objective is to report a rare case of asymptomatic penetrating injury with a copper foreign body found during an examination for cataract surgery. METHOD:A case report. RESULTS:A 73-year-old woman had vision loss. Examination by pupil dilation disclosed a dark-brown metallic mass located under the anterio...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-007-9074-5
更新日期:2007-10-01 00:00:00
abstract::The retinal toxicity of vancomycin in infusion solution used in vitrectomy and lensectomy was investigated in rabbit eyes by means of electroretinography and histologic study (light microscopy). Concentrations of 8 micrograms/ml, 16 micrograms/ml, and 32 micrograms/ml of vancomycin in balanced salt solution caused no ...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/BF00942780
更新日期:1993-04-01 00:00:00
abstract::The association between HLA-A29 and birdshot chorioretinopathy is the strongest of all associations between HLA and disease. Determination of HLA-A29 is even of diagnostic significance. The association between HLA-B27 and acute anterior uveitis (AAU) is much weaker, but B27 positive AAU may be considered as a distinct...
journal_title:International ophthalmology
pub_type: 杂志文章,评审
doi:10.1007/BF00163552
更新日期:1990-10-01 00:00:00
abstract::A series of pathological conditions such as pupillary block glaucoma, angle block glaucoma, acoria, pupillary membranes and goniosynechias of various origins have been treated successfully by means of pulses emitted from a Nd:YAG Q-switched laser above optical breakdown threshold. Since linear absorption is not requir...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/BF00130696
更新日期:1981-05-01 00:00:00
abstract::Acute and invasive fungal infections are usually seen in immunocompromised and debilitated patients. We report a young immunocompetent 28-year-old Indian male who presented with unilateral endogenous endophthalmitis in the left eye and was managed with pars plana vitreous surgery. The polymerase chain reaction from th...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-008-9235-1
更新日期:2009-08-01 00:00:00
abstract:PURPOSE:To compare the outcome of penetrating keratoplasty (PKP) and deep anterior lamellar keratoplasty (DALK) in the surgical management of keratoconus (KC). PATIENT AND METHODS:A retrospective review was conducted of the medical records of all patients treated with PKP or DALK for KC at University of Iowa Hospitals...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-010-9393-9
更新日期:2010-12-01 00:00:00
abstract:PURPOSE:To assess the comparative efficacy and the long-term cost-utility of alternative minimally invasive glaucoma surgeries (MIGSs) when combined with cataract surgery in patients with primary open-angle glaucoma (POAG). METHODS:Treatment effects, as measured by the 1-year reduction in intraocular pressure (IOP), w...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-020-01314-7
更新日期:2020-06-01 00:00:00
abstract::The Acuityscope projects an image of a three bar resolution test target onto the patient's retina, where it is viewed and read by an observer. The test target consists of a series of three bar targets varying in size on a logarithmic scale. Individual targets are identified in the projected image by Bailey-Lovie log v...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/BF00224470
更新日期:1991-03-01 00:00:00
abstract::To investigate subconjunctival bevacizumab as an adjuvant in first-time glaucoma filtration surgery, we conducted a non-comparative, interventional case series, enrolling consecutive patients with uncontrolled primary glaucomas. All patients underwent trabeculectomy with mitomycin C and received a 1.25 mg subconjuncti...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-012-9704-4
更新日期:2013-12-01 00:00:00
abstract::The purpose of this study was to investigate the incidence and risk factors associated with retinal redetachment after silicone oil (SO) removal in the African population. A retrospective cohort study was performed on patients undergoing SO removal over a period of 4 years. The risk factors assessed were (1) character...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-016-0309-1
更新日期:2017-06-01 00:00:00