Abstract：
PURPOSE:To evaluate the long-term course of primary angle-closure ocular hypertension and primary open-angle ocular hypertension and possible risk factors for progression to glaucoma. METHODS:A total of 109 eyes of 109 ocular hypertension (OHT) patients with a minimum follow-up period of 5 years having complete ocular/medical records were evaluated. They were classified into primary angle closure or primary open angle based on gonioscopy at baseline. Baseline and review data of Humphrey field analyser, HFA, and Heidelberg retinal tomography, HRT, were recorded. Guided progression analysis (GPA) and univariate Cox regression were used for time to event analysis in identifying progression to glaucoma. RESULTS:Over a mean follow-up of 12.18 ± 4.8 years, progression to glaucoma was 17.43% (19 eyes), out of whom 5.5% (6 eyes) showed ≥ 3 loci on GPA. Sub-classifying them, progression to primary angle-closure glaucoma was 19.72%, and that of primary open-angle glaucoma was 13.16%. The mean time to progression was 9.34 ± 3.6 years. Significant risk factors included small disc area (≤ 1.99 sq.mm on HRT), requirement of ≥ 2 drugs to maintain target IOP and those engaged in activities yielding a Valsalva effect in daily life. Coronary artery disease (CAD) and systemic use of steroids were associated with increased severity. CONCLUSION:Overall progression of OHT to glaucoma was 17.43% over a mean of 9 years, with target IOP of ≤ 18 mm Hg. Patients with smaller discs, CAD, exercising Valsalva type activities and using ≥ 2 glaucoma medications or systemic steroids should be closely monitored.
journal_name
Int Ophthalmoljournal_title
International ophthalmologyauthors
Sihota R,Selvan H,Sharma A,Gupta A,Gupta V,Dada T,Upadhyay ADdoi
10.1007/s10792-018-0872-8subject
Has Abstractpub_date
2019-04-01 00:00:00pages
803-812issue
4eissn
0165-5701issn
1573-2630pii
10.1007/s10792-018-0872-8journal_volume
39pub_type
杂志文章abstract：PURPOSE:Retinal vascular abnormalities are associated with choroidal melanoma. Although tumor ischemia, resulting in soluble angiogenic factor production, is a proposed etiology of these abnormalities, other sources of ischemia may also contribute. Mushroom-shaped choroidal melanomas have increased loss of the overlyin...
journal_title：International ophthalmology
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doi：10.1023/a:1021170402679
更新日期：2001-01-01 00:00:00
abstract：:Thirty-three cases of aphakic retinal detachment have been treated by pars plana vitrectomy and retinopexy. This procedure allowed us to lower the incidence of postoperative massive periretinal proliferation from 15,4%, in a series that was performed by a classical method, to 6% in the pars plana treated group. ...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/BF00138265
更新日期：1984-01-01 00:00:00
abstract：:Onchocerciasis is a devastating blinding disease caused by the parasite Onchocerca volvulus that infects about 80 million people, causing blindness and visual impairment in 1-2 million people. In hyperendemic areas, more than half of the population will become blind from onchocerciasis before they die. Blindness is th...
journal_title：International ophthalmology
pub_type： 杂志文章,评审
doi：10.1007/BF00158317
更新日期：1990-05-01 00:00:00
abstract：:Transvitreal pars plana sclerotomy using the contact Nd:YAG laser with a sapphire probe was performed on a group of rabbit eyes and compared with a similar procedure performed with a Ziegler knife. Although the intraocular pressure (IOP) was lowered in both groups of animals, the reduction was greater and more lasting...
journal_title：International ophthalmology
pub_type： 杂志文章
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更新日期：1988-01-01 00:00:00
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journal_title：International ophthalmology
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abstract：:Carotid cavernous fistulas (CCFs) can be classified as direct and indirect, depending on their flow rates and their etiology. Both forms can cause the same characteristic ophthalmological symptoms and signs. We analyzed these ocular characteristics and determined the prognostics factors associated with treatment outco...
journal_title：International ophthalmology
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abstract：:17 patients with intraretinal magnetic foreign bodies and vitreous hemorrhage are reported. 15 patients underwent a primary surgical repair consisting of a watertight wound closure and removal of the already swelling cataractous lens in 5 cases. All patients had vitrectomy during the second postinjury week. The foreig...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/BF02279868
更新日期：1989-09-01 00:00:00
abstract：:The purpose of this study was to evaluate the dynamic reality of the corneal transplant (CT) waiting list and if the CT candidates are really eager to operation. We evaluated the response of consecutive 96 CT candidates to call for operation. The age, functional visual acuity, CT indication, waiting period, and the ex...
journal_title：International ophthalmology
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journal_title：International ophthalmology
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doi：10.1007/s10792-020-01446-w
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journal_title：International ophthalmology
pub_type： 杂志文章
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更新日期：2001-01-01 00:00:00
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journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/BF00133274
更新日期：1978-09-01 00:00:00
abstract：:A 22-year-old male presented to us with complaints of sudden painful loss of vision in left eye 10 days ago along with inward deviation of the left eye. Best-corrected visual acuity (BCVA) in right eye was 20/20 and 20/50 in left eye. Left eye showed limitation of abduction, a relative afferent pupillary defect, norma...
journal_title：International ophthalmology
pub_type： 杂志文章
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更新日期：2019-05-01 00:00:00
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journal_title：International ophthalmology
pub_type： 杂志文章
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journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-020-01615-x
更新日期：2020-10-20 00:00:00
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更新日期：2017-06-01 00:00:00
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pub_type： 杂志文章
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更新日期：2020-10-14 00:00:00
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pub_type： 杂志文章
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doi：10.1007/s10792-013-9836-1
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更新日期：2019-08-01 00:00:00
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journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/BF00917990
更新日期：1992-09-01 00:00:00
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journal_title：International ophthalmology
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journal_title：International ophthalmology
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更新日期：1990-10-01 00:00:00
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journal_title：International ophthalmology
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更新日期：1990-10-01 00:00:00
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更新日期：2012-12-01 00:00:00
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journal_title：International ophthalmology
pub_type： 杂志文章,评审
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更新日期：2015-08-01 00:00:00
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journal_title：International ophthalmology
pub_type： 杂志文章,多中心研究
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更新日期：2017-06-01 00:00:00
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journal_title：International ophthalmology
pub_type： 杂志文章
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更新日期：1990-07-01 00:00:00
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更新日期：2016-10-01 00:00:00
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journal_title：International ophthalmology
pub_type： 杂志文章
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更新日期：1978-09-01 00:00:00
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journal_title：International ophthalmology
pub_type： 杂志文章
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更新日期：2015-04-01 00:00:00
