Abstract:
OBJECTIVES:To compare the intraocular pressure (IOP)-lowering effects of ripasudil, a rho-kinase inhibitor, and selective laser trabeculoplasty (SLT) as adjuvant therapy in Japanese glaucoma patients and to identify the factors associated with treatment success. METHODS:We performed a retrospective medical chart review of patients with glaucoma who received ripasudil or SLT as an adjuvant therapy. We collected data on 65 eyes (65 patients) with primary open-angle glaucoma, normal-tension glaucoma, or exfoliation glaucoma with at least 12 months of follow-up. IOP and number of glaucoma medications at 0, 1, 3, 6, 9, and 12 months were compared between and within groups. A repeated-measures mixed model was used to perform statistical analysis. We also investigated factors associated with treatment success, which was defined as ≥ 20% reduction in IOP at all follow-up periods, using univariate and multivariate logistic regression analysis. RESULTS:Significant IOP reduction was observed at all time-points after treatment in the ripasudil group (n = 33) and in the SLT group (n = 32), with no statistically significant difference between the groups before or after treatment. Patients in the SLT group used more anti-glaucoma medications before treatment, but fewer during follow-up, than those in the ripasudil group. Regardless of treatment, higher baseline IOP was associated with treatment success [crude odds ratio: 1.21 (95% confidence interval: 1.06-1.38), adjusted odds ratio: 1.37 (95% confidence interval: 1.06-1.77)]. CONCLUSIONS:Adjuvant SLT or ripasudil in patients with inadequately controlled glaucoma both reduced IOP to a similar degree, but SLT contributed to reducing the number of medications used.
journal_name
Int Ophthalmoljournal_title
International ophthalmologyauthors
Ono K,Sakemi F,Marumoto Tdoi
10.1007/s10792-020-01615-xsubject
Has Abstractpub_date
2020-10-20 00:00:00eissn
0165-5701issn
1573-2630pii
10.1007/s10792-020-01615-xpub_type
杂志文章abstract:PURPOSE:To determine the visual outcome and incidence of complications after posterior capsule rupture during phacoemulsification surgery. METHODS:Forty-four eyes of 43 patients which sustained posterior capsule rupture or zonulysis during phacoemulsification surgery between April 1993 and May 1996 were retrospectivel...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1023/a:1006462928542
更新日期:1999-01-01 00:00:00
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journal_title:International ophthalmology
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更新日期:2010-08-01 00:00:00
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journal_title:International ophthalmology
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:1984-01-01 00:00:00
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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更新日期:1991-11-01 00:00:00
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更新日期:2018-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s10792-016-0278-4
更新日期:2017-04-01 00:00:00
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journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/BF00161902
更新日期:1982-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/BF00915963
更新日期:1994-01-01 00:00:00
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journal_title:International ophthalmology
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更新日期:2015-12-01 00:00:00
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更新日期:2014-10-01 00:00:00
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journal_title:International ophthalmology
pub_type: 杂志文章,多中心研究
doi:10.1007/s10792-016-0383-4
更新日期:2017-10-01 00:00:00
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journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/BF01007789
更新日期:1993-10-01 00:00:00
abstract::To evaluate the role of brimonidine (BMD), an alpha-2 agonist, in the management of clinically significant macular edema (CSME) in diabetic maculopathy with ischemic changes. A prospective, randomized controlled trial including 30 eyes of 30 metabolically stable diabetic patients with CSME showing fundus fluorescein a...
journal_title:International ophthalmology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s10792-013-9871-y
更新日期:2014-08-01 00:00:00
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更新日期:2019-11-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2018-06-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2018-04-01 00:00:00
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journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-006-9027-4
更新日期:2007-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:2018-08-01 00:00:00