Abstract:
:The association between HLA-A29 and birdshot chorioretinopathy is the strongest of all associations between HLA and disease. Determination of HLA-A29 is even of diagnostic significance. The association between HLA-B27 and acute anterior uveitis (AAU) is much weaker, but B27 positive AAU may be considered as a distinct clinical entity. B27 positive patients with AAU should be referred to a rheumatologist, because half of these patients have ankylosing spondylitis or Reiter's syndrome. The determination of HLA-Bw51 is of limited but significant diagnostic value for the diagnosis of Behçet's disease. The present article shows how HLA determinations can serve as diagnostic tests. It is explained how the sensitivity and specificity of such tests can be used to calculate the influence of positive or negative results on the probability of the diagnosis. The structure and function of HLA class I molecules is now known to a great extent. This may lead to a better understanding of the pathogenic role of HLA-A29, HLA-B27, HLA-Bw51 and other HLA molecules which are associated with uveitis.
journal_name
Int Ophthalmoljournal_title
International ophthalmologyauthors
Feltkamp TEdoi
10.1007/BF00163552subject
Has Abstractpub_date
1990-10-01 00:00:00pages
327-33issue
5-6eissn
0165-5701issn
1573-2630journal_volume
14pub_type
杂志文章,评审abstract:PURPOSE:To compare the outcome of penetrating keratoplasty (PKP) and deep anterior lamellar keratoplasty (DALK) in the surgical management of keratoconus (KC). PATIENT AND METHODS:A retrospective review was conducted of the medical records of all patients treated with PKP or DALK for KC at University of Iowa Hospitals...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-010-9393-9
更新日期:2010-12-01 00:00:00
abstract:PURPOSE:The study aims to evaluate changes in neopterin levels and tryptophan degradation which are induced by Th1-type immune response and nitric oxide metabolism which may be involved in allergic inflammation. METHODS:Serum nitrite, kynurenine, tryptophan and neopterin levels were evaluated in 36 patients with seaso...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-017-0669-1
更新日期:2018-10-01 00:00:00
abstract::To evaluate the efficacy of golimumab on severe and frequent recurrent anterior uveitis in patients with HLA-B27-positive ankylosing spondylitis. In this study, 15 eyes of 12 HLA-B27-positive AS patients with resistant anterior uveitis who received 50 mg of subcutaneous golimumab (Gol) per month due to frequent uveiti...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-016-0239-y
更新日期:2017-02-01 00:00:00
abstract:PURPOSE:To compare the actual depth of the tunnel created with femtosecond laser for intracorneal ring segment (ICRS) implantation with the target depth in keratoconus patients. METHODS:In this mix design study, eligible keratoconus patients were identified through chart review. The inclusion criterion was a history o...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-017-0595-2
更新日期:2018-08-01 00:00:00
abstract::17 patients with intraretinal magnetic foreign bodies and vitreous hemorrhage are reported. 15 patients underwent a primary surgical repair consisting of a watertight wound closure and removal of the already swelling cataractous lens in 5 cases. All patients had vitrectomy during the second postinjury week. The foreig...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/BF02279868
更新日期:1989-09-01 00:00:00
abstract:PURPOSE:To evaluate one-year visual, refractive, and topographic outcomes of 58 eyes of 53 keratoconus patients who underwent surgery with a progressive thickness intrastromal corneal ring segment (ICRS). METHODS:This multi-center, retrospective, observational study evaluates the one-year effects of progressive thickn...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-020-01467-5
更新日期:2020-11-01 00:00:00
abstract::The ocular surface is exposed to many chronic inflammatory stimuli, and goblet cell hyperplasia of the conjunctiva occurs in many situations. We report two cases of epithelial goblet cell hyperplasia with nonspecific chronic inflammation which occurred on the internal canthus of elderly people. These cases shared the ...
journal_title:International ophthalmology
pub_type: 杂志文章,评审
doi:10.1007/s10792-015-0083-5
更新日期:2015-08-01 00:00:00
abstract::A 22-year-old male presented to us with complaints of sudden painful loss of vision in left eye 10 days ago along with inward deviation of the left eye. Best-corrected visual acuity (BCVA) in right eye was 20/20 and 20/50 in left eye. Left eye showed limitation of abduction, a relative afferent pupillary defect, norma...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-018-0910-6
更新日期:2019-05-01 00:00:00
abstract:PURPOSE:To describe the incidence of, and risk factors associated with, diabetic retinopathy in diabetic persons assessed at a Saudi diabetes centre. METHODS:Five hundred and two patients with diabetes mellitus assessed by our service were studied. There were 174 patients (34.7%) with insulin-dependent diabetes mellit...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1023/a:1006240928938
更新日期:1998-01-01 00:00:00
abstract:PURPOSE:The aim of the study reported here was to assess the influence of serum HbA1c levels on foveal choroidal thickness in diabetic patients. METHODS:A total of 122 eyes from 122 patients who had type 2 DM were studied in this prospective, cross-sectional study. Patients were divided into three groups: 43 patients ...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-017-0668-2
更新日期:2018-10-01 00:00:00
abstract:PURPOSE:To describe and evaluate the value of nutritional supplements in the management of age-related macular degeneration (AMD) through a review of the current literature. METHODS:An extensive literature search was performed, and key research articles exploring AREDS and AREDS-2 formulations, genetics, omega fatty a...
journal_title:International ophthalmology
pub_type: 杂志文章,评审
doi:10.1007/s10792-019-01140-6
更新日期:2019-12-01 00:00:00
abstract:UNLABELLED:We examined the immunocytochemical features of after cataract tissue and cataractous lens epithelium prior to cataract surgery and at the time of surgery. METHODS:This study included 23 cases. Antibodies against the following antigens were used: epidermal growth factor (EGF), EGF receptor (EGF-R), fibroblas...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1023/a:1010640118852
更新日期:1999-01-01 00:00:00
abstract::Clinical trials are often used to evaluate the efficacy of a given treatment. The results of clinical trials however do not always agree with a clinician's experience or intuition. The merits and demerits of Clinical Trials versus Intuition are discussed by using the laser photocoagulation trials of Proliferative Diab...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/BF00159835
更新日期:1986-05-01 00:00:00
abstract::Ocular wall dimensions (axial eye length, anterior chamber depth, lens thickness, vitreous length, thickness and volume of the ocular wall) were determined by echobiometry on 10 eyes of 10 patients with glaucoma one day before and four days after trabeculectomy. The results showed significant differences: decreased ax...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/BF00917990
更新日期:1992-09-01 00:00:00
abstract::Evaluation of brain cluster activation using the functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) was sought in strabismic amblyopes. In this hospital-based case-control cross-sectional study, fMRI and DTI were conducted in strabismic amblyopes before initiation of any therapy and after ...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-015-0159-2
更新日期:2016-08-01 00:00:00
abstract::To document the rate of self-reported compliance and glaucoma-related knowledge in Swiss patients and to identify risk factors for their poor compliance. This was an observational study, including a total of 200 consecutive patients already under glaucoma medication in two Swiss tertiary glaucoma clinics (Geneva and B...
journal_title:International ophthalmology
pub_type: 杂志文章,多中心研究
doi:10.1007/s10792-011-9468-2
更新日期:2011-10-01 00:00:00
abstract::Onchocerciasis is a major blinding disease affecting at least 28 million people in Africa and Latin America. Although a large-scale vector control program has been highly successful in limiting transmission of infection in West Africa, there has not been a satisfactory form of treatment available for those already inf...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/BF00136735
更新日期:1987-12-01 00:00:00
abstract:PURPOSE:To evaluate the cognitive performance of patients with glaucoma and compare it to individuals with Alzheimer's disease (AD). METHODS:This is a prospective, cross-sectional and case-control study. All subjects were assessed using the Mini-Mental State Examination (MMSE) and its subtests verbal fluency, word lis...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-017-0658-4
更新日期:2018-10-01 00:00:00
abstract:PURPOSE:The authors investigated the use of dapiprazole, an alpha-adrenergic blocking agent, in preventing pigment release and IOP increase after exercise in patients affected with PDS. METHODS:Three young myopic males (31, 34 and 35 years old) affected with pigmentary dispersion syndrome performed 30 minutes of joggi...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/BF00130855
更新日期:1995-01-01 00:00:00
abstract::The purpose of this study was to evaluate the impact of intravitreal bevacizumab injections on the management and outcome of patients affected by retinal vein occlusions, their effectiveness on morphological and functional parameters, the modalities of long-term management and the need for additional laser treatment d...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-014-0002-1
更新日期:2014-12-01 00:00:00
abstract:PURPOSE:To evaluate circular neodymium: YAG laser incision in cases of anterior capsular contraction syndrome (ACCS) by comparing it to radial Neodymium: YAG laser incision as for efficacy and safety. SETTINGS:Ophthalmology Department, Benha University Hospitals. METHODS:The study was done on 74 eyes of 66 patients w...
journal_title:International ophthalmology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s10792-019-01094-9
更新日期:2019-11-01 00:00:00
abstract::We evaluated the in vitro effects of the 1.3 u wavelength of a Nd:YAG laser using a fiberoptic delivery system, with or without sapphire tips on ocular tissue. Conjunctival and retinal adhesions were achieved best with a noncontact technique compared with a contact method. ...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/BF00155628
更新日期:1987-08-01 00:00:00
abstract::Infrequently, vitreomacular traction is released through the spontaneous development of complete posterior vitreous detachment (PVD). PVD caused by laser photocoagulation has also been reported. A 62-year-old woman with ischemic branch retinal vein occlusion showed decreased vision in the affected eye due to vitreomac...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-007-9166-2
更新日期:2009-02-01 00:00:00
abstract::One hundred cases of clinically acceptable sympathetic ophthalmia (SO) were evaluated histologically to determine the incidence of atypical features and correlate them with the severity of choroidal inflammation. The inflammatory response in the choroid varied from a focal non-granulomatous to a diffuse non-necrotizin...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/BF00161902
更新日期:1982-02-01 00:00:00
abstract::Carotid cavernous fistulas (CCFs) can be classified as direct and indirect, depending on their flow rates and their etiology. Both forms can cause the same characteristic ophthalmological symptoms and signs. We analyzed these ocular characteristics and determined the prognostics factors associated with treatment outco...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-012-9550-4
更新日期:2012-04-01 00:00:00
abstract::We compared uveitis patients who attended a general eye clinic (n = 183) with those who attended the ophthalmology department of a university hospital (n = 550) to examine factors that affect the clinical statistics of uveitis outpatients. We observed that diabetic iritis and herpetic iritis were significantly more fr...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-009-9336-5
更新日期:2010-06-01 00:00:00
abstract::To evaluate the efficacy of 25-ga pars plana vitrectomy (PPV) and 25-ga PPV combined with phacoemulsification surgery for managing ciliary block (malignant) glaucoma. The medical records of 11 eyes, in nine consecutive patients with malignant glaucoma were retrospectively reviewed to determine the efficacy of 25-ga PP...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-014-9974-0
更新日期:2015-08-01 00:00:00
abstract:PURPOSE:Retinal vascular abnormalities are associated with choroidal melanoma. Although tumor ischemia, resulting in soluble angiogenic factor production, is a proposed etiology of these abnormalities, other sources of ischemia may also contribute. Mushroom-shaped choroidal melanomas have increased loss of the overlyin...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1023/a:1021170402679
更新日期:2001-01-01 00:00:00
abstract::An animal model of keratomycosis was used to study the interaction between the new enzyme antifungal compound mycolase II and the polyene antifungal antibiotic pimaricin. Well established corneal infection caused by an ocular pathogenic candida albicans on New Zealand white male rabbits were treated with 3% mycolase I...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/BF00149150
更新日期:1982-11-01 00:00:00
abstract::In a prospective study of untreated ocular hypertension 117 eyes were non-exfoliative and 20 eyes exfoliative. The percentage of optic disc pallor was significantly larger in the exfoliative than in the non-exfoliative group, whereas no significant differences were found in IOP or in the visual field. ...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/BF02028632
更新日期:1989-01-01 00:00:00