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Relaxin 2 fails to lower intraocular pressure and to dilate retinal vessels in rats.

Abstract：

PURPOSE:Recently, the vasodilator relaxin 2 has been introduced as a treatment for acute heart failure. However, its role on vessels of the eye and intraocular pressure (IOP) remains unclear though it has been hypothesized to induce a decrease IOP after intramuscular injection in humans. We aimed to test whether the hormone relaxin 2 lowers IOP and dilates retinal vessels in animals. METHODS:The IOP of female Sprague-Dawley rats before and after application of relaxin 2 was measured using an Icare Tonolab device calibrated for rats. Recombinant human relaxin 2 in phosphate-buffered saline with 0.1% bovine serum albumin was either applied as eye drops (1000, 2000 or 3000 ng/ml), injected intravitreally (500 ng/ml) or intravenously (13.3 μg/kg body weight). Retinal vessel thickness was monitored using infrared fundus images compiled with optical coherence tomography (Heidelberg Engineering) before and several time points after application of relaxin 2. RESULTS:Neither topical nor intravitreous or intravenous application of relaxin 2 lowered the IOP or changed the arterial or venous vessel diameter after 1 or 3 h after application. DISCUSSION:Now that relaxin 2 is more easily available, the hormone came again into focus as a potential glaucoma therapeutic. However, our study in rats could not support the hypothesis that relaxin 2 lowers IOP or dilates retinal vessels.

journal_name

Int Ophthalmol

journal_title

International ophthalmology

authors

Hampel U,Träger K,Liu H,Teister J,Grus F,Prokosch-Willing V

doi

10.1007/s10792-018-0884-4

subject

Has Abstract

pub_date

2019-04-01 00:00:00

pages

847-851

issue

4

eissn

0165-5701

issn

1573-2630

pii

10.1007/s10792-018-0884-4

journal_volume

39

pub_type

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