Abstract：
:Sarcoidosis is a multisystem disease characterized by enhanced immune responses at sites of involvement. To elucidate the immunopathogenesis of ophthalmic lesions, cell infiltrates in biopsies from conjunctiva and other tissues involved (lungs, lymph nodes, skin) were studied in 26 patients with active sarcoidosis in order to define the surface phenotype and the distribution of cells in granulomatous lesions. Biopsy specimens were also stained for detection of immunoglobulins, complement and fibrinogen deposits. The data demonstrate a lymphocytes/macrophages interaction in the central core of granulomatous areas as the crucial event that initiates the maintains the state of inflammation: at all sites of disease activity is present a compartmentalization of T-cells expressing a helper-related phenotype which account for the great majority of infiltrating cells both in the early lesions (aggregate of macrophages surrounded by lymphocytic infiltrate) and in well-organized sarcoid granulomata. The presence of plasma cells and immunoglobulin deposits may represent an epiphenomenon in line with the helper infiltration, suggesting a local hyper-reactivity of the B-cells immune system. This study suggests some immunopathogenetic mechanisms leading to the formation and growth of conjunctival sarcoid granulomata.
journal_name
Int Ophthalmoljournal_title
International ophthalmologyauthors
Angi MR,Forattini F,Chilosi M,Cipriani A,De Caro G,Semenzato Gdoi
10.1007/BF00131162subject
Has Abstractpub_date
1990-01-01 00:00:00pages
1-11issue
1eissn
0165-5701issn
1573-2630journal_volume
14pub_type
杂志文章abstract：:Current theories for macular hole formation implicate antero-posterior and tractional forces at the vitreofoveal interface. It is thought that localized perifoveal defects enlarge from centrifugal forces acting about the axis of ocular rotation. If this is true, eyes with longer axial lengths should have an increased ...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-012-9568-7
更新日期：2012-08-01 00:00:00
abstract：:The purpose of this study was to evaluate the presence of Toxoplasmosis gondii in samples of peripheral blood from patients with varying etiologies of uveitis. Whole blood from patients with different forms of uveitis was tested for the presence of T. gondii using real-time PCR targeting the well-characterized 529 bp ...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-016-0221-8
更新日期：2017-02-01 00:00:00
abstract：PURPOSE:This study aims to evaluate the efficacy and safety of XEN45 gel stent (Allergan plc, Dublin, Ireland) in East Asian patients with glaucoma. METHODS:A retrospective study of consecutive XEN45 gel stent implantation surgeries with or without concurrent cataract surgery from May 2017 to August 2018 was performed...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-020-01284-w
更新日期：2020-05-01 00:00:00
abstract：BACKGROUND:To investigate the efficacy of intravitreal injection of triamcinolone acetonide in the management of papillophlebitis and associated cystoid macular edema. METHODS:This study was a retrospective medical records review of four eyes of four patients (three males and one female) who had approximately 2-4 mont...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-007-9128-8
更新日期：2008-08-01 00:00:00
abstract：PURPOSE:Growth factors are considered as key molecules that participating in fibrosis formation. This research aimed to clarify potential effects of p53 on regulation of transforming growth factor β (TGF-β) and fibrosis formation and investigate the associated mechanisms. METHODS:Vimentin was examined to identify huma...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-020-01320-9
更新日期：2020-06-01 00:00:00
abstract：PURPOSE:To investigate the antibacterial effect of topical anesthetic proparacaine on conjunctival flora. METHODS:One hundred and forty-four eyes of 72 patients awaiting cataract surgery were included in the study. A commercially available solution of proparacaine, preserved with benzalkonium chloride 0.01%, was insti...
journal_title：International ophthalmology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1023/a:1026567912389
更新日期：1999-01-01 00:00:00
abstract：:A 61-year-old male developed recurrent anterior uveitis over a period of 8 months after an uncomplicated phacoemulsification and posterior chamber intraocular lens implantation surgery. This was subsequently found to be due to a retained lens fragment in the anterior segment, with complete resolution following surgica...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-008-9279-2
更新日期：2010-02-01 00:00:00
abstract：PURPOSE:To investigate the longitudinal changes in refractive errors in preterm children with and without retinopathy of prematurity (ROP) in the first 6 years of life. METHODS:We included 226 preterm children with a gestational age of ≤34 weeks: 222 eyes with no ROP, 73 eyes with mild ROP and 145 eyes with severe ROP...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-017-0642-z
更新日期：2018-08-01 00:00:00
abstract：:The purpose of this study was to determine the penetration of itraconazole, a type of azole antifungal agent, into the aqueous humor and vitreous after repeated oral administrations. Fungal endophthalmitis developed bilaterally in a 21-year-old man who had a history of intravenous hyperalimentation following abdominal...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-012-9696-0
更新日期：2013-10-01 00:00:00
abstract：BACKGROUND:We carried out a study by in-vivo confocal microscopy to investigate the appearance of iridocorneal endothelial (ICE) syndrome, and discuss its diagnostic potential. METHODS:Twelve patients, each with unilateral ICE syndrome, had both their eyes examined by in-vivo confocal microscopy. The images were recor...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-007-9187-x
更新日期：2009-02-01 00:00:00
abstract：PURPOSE:The aim of the study reported here was to assess the influence of serum HbA1c levels on foveal choroidal thickness in diabetic patients. METHODS:A total of 122 eyes from 122 patients who had type 2 DM were studied in this prospective, cross-sectional study. Patients were divided into three groups: 43 patients ...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-017-0668-2
更新日期：2018-10-01 00:00:00
abstract：PURPOSE:The objective of this study is to examine the morphometry of the lacrimal drainage system with reference to bony landmarks in the vicinity. METHODS:Twenty midsaggitalized heads obtained from sixteen preserved cadavers were studied. Measurements involved detailed morphometry of anterior and posterior lacrimal c...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-017-0753-6
更新日期：2018-12-01 00:00:00
abstract：:Central serous chorioretinopathy (CSCR) is characterized by neurosensory retinal detachment. Because the retina pigment epithelium and choroidal pathology is the current mechanism in CSCR, many studies in the literature focused on the outer retinal layers. There is little information about the functional or histologic...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-016-0278-4
更新日期：2017-04-01 00:00:00
abstract：BACKGROUND/AIMS:To study the observer-related variability of optic nerve head (ONH) measurements using confocal laser scanning tomography (HRT I) in a screening setting. METHODS:Six experienced glaucoma specialists independently evaluated 50 ONH topographies from 25 adults using HRT software ver. 2.01 in a masked fash...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-006-9022-9
更新日期：2005-08-01 00:00:00
abstract：PURPOSE:Numerous studies suggest that reactive oxygen species play a crucial role in the development of glaucoma. Since glaucoma patients exhibit posterior vitreous detachment earlier than controls, it has been suggested that reactive oxygen species-increased in glaucoma-also affect the vitreous. In the present study w...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-019-01268-5
更新日期：2020-04-01 00:00:00
abstract：PURPOSE:The aim of this study was to evaluate the corneal biomechanical parameters in patients with ankylosing spondylitis (AS) and to compare them with the healthy subjects. METHODS:Sixty patients with AS (study group) and 60 healthy subjects (control group) were enrolled in this prospective study. The study group wa...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-016-0368-3
更新日期：2017-08-01 00:00:00
abstract：:The purpose of this study was to compare the keratometry (K) values obtained by the Scheimpflug camera combined with placido-disk corneal topography (Sirius) and optical biometry (Lenstar) for intraocular lens (IOL) power calculation before the cataract surgery, and to evaluate the accuracy of postoperative refraction...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-016-0330-4
更新日期：2017-08-01 00:00:00
abstract：PURPOSE:This study investigated postoperative visual acuity and corneal higher-order aberrations following EX-PRESS or trabeculectomy. METHODS:Out of 56 eyes of 56 patients analyzed, 30 eyes were treated using trabeculectomy, while 26 eyes were treated with EX-PRESS. Visual acuity and corneal higher-order aberrations ...
journal_title：International ophthalmology
pub_type： 临床试验,杂志文章
doi：10.1007/s10792-017-0685-1
更新日期：2018-10-01 00:00:00
abstract：:Melanoma-associated retinopathy is a paraneoplastic retinopathy associated mostly with cutaneous melanoma. In most cases it presents months to years after diagnosis of primary cutaneous melanoma was made or after recurrence. We describe a 55-year-old male patient who presented with symptoms of decreased vision and pho...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-012-9564-y
更新日期：2012-08-01 00:00:00
abstract：:Management of retinoblastoma (Rb), the most common intraocular malignant tumor in childhood, is tailored to each individual case and based on the overall situation. We present a case of bilateral Rbs in a 4-month-old girl, referred to our center for bilateral leukocoria. In the right eye, the optic disc was partially ...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-012-9703-5
更新日期：2013-10-01 00:00:00
abstract：:The association between HLA-A29 and birdshot chorioretinopathy is the strongest of all associations between HLA and disease. Determination of HLA-A29 is even of diagnostic significance. The association between HLA-B27 and acute anterior uveitis (AAU) is much weaker, but B27 positive AAU may be considered as a distinct...
journal_title：International ophthalmology
pub_type： 杂志文章,评审
doi：10.1007/BF00163552
更新日期：1990-10-01 00:00:00
abstract：:In serial experiments on cats, intravenous digital subtraction angiography (DSA) was utilized to observe orbital and ocular circulation. Images of the orbital arterial system as well as normal ocular vasculature were obtained, utilizing dosage of contrast material acceptable for human study. Images obtained after intr...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/BF00136492
更新日期：1985-09-01 00:00:00
abstract：PURPOSE:To investigate the diurnal fluctuations of macular vessel density (VD) in primary open-angle glaucoma (POAG) and healthy subjects using optical coherence tomography angiography. METHODS:A total of 22 POAG eyes and 15 healthy eyes were included in this study. Macular VD, intraocular pressure, and blood pressure...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-020-01408-2
更新日期：2020-09-01 00:00:00
abstract：PURPOSE:To determine the cytokine levels in vitreous samples of diabetic macular edema (DME) patients in comparison with nondiabetic patients, and to evaluate the effect of subretinal fluid on the cytokine levels of vitreous samples. METHODS:In this prospective case-control study, 11 eyes of 11 patients with DME and s...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-018-0874-6
更新日期：2019-04-01 00:00:00
abstract：:Ewing's sarcoma is a small, blue, round-cell tumor of mesenchymal origin which typically presents itself during the first and the second decades of life. Typically, it is noticed in the long bones of the limbs, pelvis, or ribs. There have been few reports worldwide with none in Pakistan of this rare phenomenon. We rep...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-014-9937-5
更新日期：2014-10-01 00:00:00
abstract：:Roussel and Fankhauser have proposed contact glasses with a collecting front surface centred on the bundle focus for use with high power lasers. We demonstrate here that the main contribution to the gain in energy density within the focus spot must be attributed to the front surface of the glass. This is at variance w...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/BF00165111
更新日期：1984-06-01 00:00:00
abstract：PURPOSE:To examine the retinal layers' changes and alterations in retinal microvasculature in patients with rhegmatogenous retinal detachment (RRD) treated with pars plana vitrectomy (PPV). METHODS:Participants in this study were 103 patients with RRD, 85 macula off and 18 macula on, who were treated with PPV and gas ...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-020-01521-2
更新日期：2020-12-01 00:00:00
abstract：PURPOSE:Proliferative vitreoretinopathy in the inferior retina remains clinically challenging. Heavier-than-water intraocular tamponades have been developed to improve inferior tamponading properties, and their chemical compositions have been substantially improved over the years, in parallel with developments in vitre...
journal_title：International ophthalmology
pub_type： 杂志文章,评审
doi：10.1007/s10792-017-0489-3
更新日期：2018-04-01 00:00:00
abstract：:To describe the efficacy of intravitreal chemotherapy (IViC) preceded by intra-arterial chemotherapy (IAC) for the treatment of advanced stage retinoblastoma. This non-comparative interventional case series retrospectively reviewed the medical records of six patients who presented within months of each other with unil...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-015-0129-8
更新日期：2015-12-01 00:00:00
abstract：:Several different sets of criteria have been proposed to establish the diagnosis of Vogt-Koyanagi-Harada disease (VKH). Various investigators have used the criteria proposed by Sugiura, those proposed by by the American Uveitis Society as well as the revised diagnostic criteria proposed by the First VKH International ...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-006-9021-x
更新日期：2007-04-01 00:00:00
