Biomechanical evaluation of cornea in patients with ankylosing spondylitis.

Abstract:

PURPOSE:The aim of this study was to evaluate the corneal biomechanical parameters in patients with ankylosing spondylitis (AS) and to compare them with the healthy subjects. METHODS:Sixty patients with AS (study group) and 60 healthy subjects (control group) were enrolled in this prospective study. The study group was further classified as active (n:30) and inactive (n:30). After detailed ophthalmological examination including intraocular pressure (IOP) measurement with Goldmann applanation tonometer (IOPGAT), corneal hysteresis (CH), corneal resistance factor (CRF), corneal-compensated IOP (IOPcc), and Goldmann-correlated IOP (IOPg) were measured with the Reichert Ocular Response Analyzer (ORA). Central corneal thickness (CCT) was measured with the Spectral-Domain Optical Coherence Tomography (SD-OCT). RESULTS:The study group's mean CH, CCT, IOPg, and IOPGAT values were lower than the control group (p < 0.05 for all variables). The mean CH, CRF, CCT, IOPg, and IOPGAT values were higher in active patients when compared to the inactive ones (p < 0.001, p < 0.001, p = 0.013, p = 0.021, and p = 0.002, respectively). CONCLUSIONS:AS patients have lower CCT, CH, IOPg, and IOPGAT when compared with healthy subjects. In the active stage of AS, patients present with higher levels of corneal biomechanical parameters with thicker corneas. IOPcc is a more accurate measurement than IOPGAT or IOPg in AS patients.

journal_name

Int Ophthalmol

authors

Caglayan M,Sarac O,Kosekahya P,Erten S,Ayan B,Cagil N

doi

10.1007/s10792-016-0368-3

subject

Has Abstract

pub_date

2017-08-01 00:00:00

pages

1017-1024

issue

4

eissn

0165-5701

issn

1573-2630

pii

10.1007/s10792-016-0368-3

journal_volume

37

pub_type

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