Intraocular penetration of itraconazole in patient with fungal endophthalmitis.

Abstract:

:The purpose of this study was to determine the penetration of itraconazole, a type of azole antifungal agent, into the aqueous humor and vitreous after repeated oral administrations. Fungal endophthalmitis developed bilaterally in a 21-year-old man who had a history of intravenous hyperalimentation following abdominal surgery. Itraconazole capsules (200 mg/day) were taken orally for 12 consecutive days. Vitrectomy was performed on the left eye 30 h after the last oral itraconazole. Samples of blood, aqueous, and vitreous were collected during the vitrectomy. The concentration of itraconazole was determined by high performance liquid chromatography. The concentration of itraconazole was 0.492 μg/mL in the plasma, 0.020 μg/mL in the vitreous, and none in the aqueous of the left eye. Although no fungal organisms were isolated from the plasma and vitreous samples from both eyes, fungal DNA was detected in the vitreous from the left eye. Our findings indicate that oral itraconazole has limited penetration in eyes with fungal endophthalmitis.

journal_name

Int Ophthalmol

authors

Mochizuki K,Niwa Y,Ishida K,Kawakami H

doi

10.1007/s10792-012-9696-0

subject

Has Abstract

pub_date

2013-10-01 00:00:00

pages

579-81

issue

5

eissn

0165-5701

issn

1573-2630

journal_volume

33

pub_type

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