Abstract:
PURPOSE:To determine the cytokine levels in vitreous samples of diabetic macular edema (DME) patients in comparison with nondiabetic patients, and to evaluate the effect of subretinal fluid on the cytokine levels of vitreous samples. METHODS:In this prospective case-control study, 11 eyes of 11 patients with DME and subretinal fluid, 11 eyes of 11 patients with DME without subretinal fluid, and 14 eyes of 14 patients who had undergone vitreoretinal surgery for the epiretinal membrane or a macular hole (control group) were evaluated. The blood glycated hemoglobin (HbA1c) level, vitreous vascular endothelial growth factor (VEGF), and interleukin-8 (IL-8) levels were determined. RESULTS:The vitreous VEGF level of patients in DME groups was significantly higher than the control group (p < 0.001) without significant difference between DME patients with and without subretinal fluid (p = 0.796). The vitreous IL-8 level of DME patients with subretinal fluid was significantly higher than both control (p = 0.002) and DME without subretinal fluid groups (p = 0.019). The blood HbA1c level was significantly higher in DME group with subretinal fluid than those without subretinal fluid (8.7 ± 1.32 and 7.1 ± 1.13%, respectively, p = 0.010). The only significant correlation was between vitreous VEGF level and blood HbA1c level in DME patients without subretinal fluid (r = 0.813, p = 0.002). CONCLUSIONS:IL-8 level in vitreous samples was higher in DME patients with subretinal fluid than those without subretinal fluid, suggesting that inflammation is an important factor in the progression of DME leading to the subretinal fluid formation in diabetic patients.
journal_name
Int Ophthalmoljournal_title
International ophthalmologyauthors
Yenihayat F,Özkan B,Kasap M,Karabaş VL,Güzel N,Akpınar G,Pirhan Ddoi
10.1007/s10792-018-0874-6subject
Has Abstractpub_date
2019-04-01 00:00:00pages
821-828issue
4eissn
0165-5701issn
1573-2630pii
10.1007/s10792-018-0874-6journal_volume
39pub_type
杂志文章abstract:PURPOSE:To evaluate the effects of epiretinal membrane (ERM) formation on the anatomic and functional results of subjects with diabetic macular edema (DME) who are receiving intravitreal aflibercept injections (IAIs). MATERIALS AND METHODS:This retrospective comparative study includes 29 eyes with DME (Group 1) and 43...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-020-01444-y
更新日期:2020-10-01 00:00:00
abstract:BACKGROUND:A study of the characteristics and the results obtained in 99 consecutive eyes operated on for rhegmatogenous retinal detachment associated with aphakia or pseudophakia in order to find the predictive factors of poor anatomical and functional results. METHODS:The authors retrospectively reviewed the files o...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/BF00176882
更新日期:1996-01-01 00:00:00
abstract::Using a direct immunofluorescent technique and monoclonal antibody, chlamydia trachomatis was detected in the conjunctival smears of 13 out of 47 patients presenting with conjunctivitis or keratoconjunctivitis (an incidence of 28%). Two patients presented with acute symptoms of few days duration, whereas the condition...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/BF00133933
更新日期:1988-01-01 00:00:00
abstract::Long-term use of topical drugs can induce changes in the conjunctiva and ocular surface. To determine the conjunctival changes resulting from topical glaucoma medication, patients with glaucoma were selected and classified into seven groups, according to the medication received: 24 eyes were treated with betaxolol, 20...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1023/a:1005892426045
更新日期:1997-01-01 00:00:00
abstract::Invasive aspergillosis is a rare disease and is often misdiagnosed. The clinical course is quite aggressive and it is a potentially fatal disease. We report a case of invasive aspergillosis involving the dura mater and optic nerves which was successfully treated with voriconazole, even though the patient had residual ...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-013-9730-x
更新日期:2014-02-01 00:00:00
abstract::We examined nine patients who presented cilioretinal artery occlusion (CLRAO) associated with retinal vein occlusion (RVO). CLRAO was probably secondary to the raised intraluminal resistance consequent to the RVO in patients showing initially a delayed filling of the cilioretinal artery in fluorescein angiography. Int...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/BF01007789
更新日期:1993-10-01 00:00:00
abstract::To evaluate the potential benefit of intraocular pressure (IOP) reduction in normal-tension glaucoma (NTG) patients in South Korea. A retrospective, multi-center analysis of Korean NTG patients with 5-years follow-up, typical glaucomatous optic disc and/or visual field changes and no recorded IOP >21 mmHg. Progression...
journal_title:International ophthalmology
pub_type: 杂志文章,多中心研究
doi:10.1007/s10792-011-9463-7
更新日期:2011-10-01 00:00:00
abstract:BACKGROUND:With the increasing prevalence of electronic readers (e-readers) for vocational and professional uses, it is important to discover if there are visual consequences in the use of these products. There are no studies in the literature quantifying the incidence or severity of eyestrain, nor are there clinical c...
journal_title:International ophthalmology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s10792-016-0281-9
更新日期:2017-04-01 00:00:00
abstract:PURPOSE:To report a case of toxic optic neuropathy caused by an ocular bee sting. METHODS:Case report and literature review. RESULTS:A 44-year-old female presented with no light perception vision 2 days after a corneal bee sting in her right eye. She was found to have diffuse cornea edema with overlying epithelial de...
journal_title:International ophthalmology
pub_type: 杂志文章,评审
doi:10.1007/s10792-018-0978-z
更新日期:2019-07-01 00:00:00
abstract:PURPOSE:To present the long-term results of therapeutic keratoplasty for microbial keratitis in moderate to advanced phases. METHODS:The medical records of 44 patients who underwent therapeutic keratoplasty for microbial keratitis at the ophthalmology clinic of a training and research hospital between June 2012 and Ma...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-020-01538-7
更新日期:2020-12-01 00:00:00
abstract:PURPOSE:To introduce a case of ciliary detachment with primary pulmonary hypertension (PPH). METHODS:The clinical manifestations of a case of ciliary detachment with PPH were addressed by comprehensive examination including ultrasound biological microscope (UBM), intraocular pressure, color fundus photographs, fluores...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-017-0443-4
更新日期:2018-02-01 00:00:00
abstract::This study evaluates the efficiency of fluid-air exchange on the reattachment of the retina and clarifies the possibility that a posterior retinotomy is a cause for intra- and postoperative complications. A consecutive series of 211 eyes with retinal detachments due to P.V.R. (47%), diabetic traction, perforating trau...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/BF00951805
更新日期:1994-01-01 00:00:00
abstract::To investigate long-term clinical outcomes after acute angle closure in the Chinese population. A 10-year retrospective review of primary acute angle closure in Hong Kong Chinese to document patient demographics, treatment, and pre- and post-acute angle closure intraocular pressure (IOP) and visual acuity (VA). The ye...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-013-9806-7
更新日期:2014-04-01 00:00:00
abstract::To evaluate the clinical efficacy of transcutaneous everting sutures for lower eyelid involutional entropion in Chinese patients. A retrospective, non-comparative, interventional case series. This retrospective study consecutively reviewed the medical records of all patients with involutional lower eyelid entropion wh...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-013-9893-5
更新日期:2014-08-01 00:00:00
abstract::The appearance of a hypopyon is an extremely uncommon finding in acute angle-closure glaucoma and only a few cases have been previously reported in the literature. We report a fifty-year-old female who, following a recent bereavement, presented with classical features of acute angle-closure glaucoma and a hypopyon. Th...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/BF00942925
更新日期:1993-06-01 00:00:00
abstract:INTRODUCTION:The aim of this prospective study is to verify, in terms of both early postoperative complications and intraocular pressure (IOP) outcomes, the performance of a scleral flap removable suture. MATERIALS AND METHODS:Sixty-six patients that underwent trabeculectomy were randomly divided into two groups: in t...
journal_title:International ophthalmology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s10792-008-9245-z
更新日期:2009-10-01 00:00:00
abstract::In order to evaluate possible etiological factors and the natural course of 'idiopathic' preretinal fibrosis in young persons, nine consecutive patients with macular pucker diagnosed under the age of 50 years were examined. There were six women and three men with the mean age of 27.2 years (range 15-50) and the mean f...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/BF00202776
更新日期:1987-02-01 00:00:00
abstract:PURPOSE:To report a case of retinal pigment epithelial tear following intravitreal ranibizumab injection for subfoveal choroidal neovascularization. METHODS:Retrospective single case review. RESULTS:A 78-year-old Caucasian female was treated with intravitreal ranibizumab for occult subfoveal choroidal neovascularizat...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-007-9066-5
更新日期:2007-02-01 00:00:00
abstract::The purpose of this paper was to describe a patient with pericentral retinitis pigmentosa (RP) and cystoid macular edema (CME) refractory to oral acetazolamide alone who was successfully treated with adjunctive pegaptanib sodium. A 33-year-old man presented with decreased vision and a best-corrected visual acuity (BCV...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-007-9175-1
更新日期:2009-04-01 00:00:00
abstract:PURPOSE:To explore the protective effect of probucol on human retinal Müller cells cultured in high glucose. METHODS:Primary Müller cells from human retinas were cultured in complete DMEM. Third-generation Müller cells were identified using glutamine synthetase (GS) antibody and randomly divided into three groups: nor...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-019-01130-8
更新日期:2019-12-01 00:00:00
abstract:BACKGROUND:The surgical management of macular holes has been a subject of controversy in recent years. Various techniques such as vitrectomy, membrane peeling, and gas tamponade with or without transforming growth factor-beta 2, and recently the use of autologous platelets have produced closure rates from 58% to 96%, d...
journal_title:International ophthalmology
pub_type: 临床试验,杂志文章
doi:10.1023/a:1005866002930
更新日期:1997-01-01 00:00:00
abstract::A 32-year-old lady presented with bilateral painful proptosis and left infranuclear facial palsy. She was mildly anemic. Ocular examination revealed a firm non-tender mass in the super lateral quadrant of both orbits. Fine-needle aspiration cytology from the orbital mass showed the presence of lymphoplasmacytoid cells...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-007-9037-x
更新日期:2005-12-01 00:00:00
abstract:BACKGROUND:To evaluate the preliminary effects of treating the half of high latent hyperopia on refractive and visual outcomes of femtosecond laser-assisted in situ keratomileusis (LASIK) in young subjects with hyperopia. METHODS:This non-randomized comparative study includes 120 eyes of 60 subjects who underwent femt...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-020-01421-5
更新日期:2020-09-01 00:00:00
abstract::Preliminary results of a larger investigation on correlation between Retinal Nerve Fiber Layer Defects (RNFL) and Automated Perimetry (AP) are presented. A group of ocular hypertensive patients was recruited and a cross-section, randomized study was carried out. The group was composed of 54 eyes from 28 patients; 15 m...
journal_title:International ophthalmology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF00917968
更新日期:1992-09-01 00:00:00
abstract:PURPOSE:To review the multimodal imaging patterns of posterior syphilitic uveitis. METHODS:A systematic review. RESULTS:The percentage of syphilis has started to increase again: The World Health Organization has reported 12 million new cases of syphilis each year. In addition, syphilis was responsible for 0.3% of dea...
journal_title:International ophthalmology
pub_type: 杂志文章,评审
doi:10.1007/s10792-020-01285-9
更新日期:2020-05-01 00:00:00
abstract::XPERT NCT advanced logic pneumotonometer (Reichert) was studied for its reliability and use in glaucoma screening. The evaluated 2400 NCT measurements on 300 eyes were compared to the results of Goldmann applanation tonometry (GAT) from the same eyes. Repeated NCT tonometry had no significant effect on IOP. Local anes...
journal_title:International ophthalmology
pub_type: 临床试验,杂志文章
doi:10.1007/BF00917978
更新日期:1992-09-01 00:00:00
abstract:BACKGROUND:Cyclocryotherapy and transscleral cyclophotocoagulation are commonly used procedures for the treatment of refractory glaucoma, but still with many complications. Ultrasound cyclo plasty (UCP) is a novel technique that determines a selective and more precise coagulation necrosis of the ciliary body to reduce ...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-020-01606-y
更新日期:2020-10-18 00:00:00
abstract::To report an unusual case of primary paranasal sinus lymphoma associated with intraocular secondary uveal involvement. Retrospective case report emphasizing the histopathologic diagnosis as well as imaging studies, and review of the pertinent literature. The diagnosis of ophthalmologic lymphoma can be difficult due to...
journal_title:International ophthalmology
pub_type: 杂志文章,评审
doi:10.1007/s10792-012-9570-0
更新日期:2012-08-01 00:00:00
abstract:PURPOSE:Proliferative vitreoretinopathy (PVR) is characterized by the formation of cellular membranes on the detached retina and also in the vitreous. Glial cells can be found in epiretinal and subretinal membranes from eyes with PVR, proliferative diabetic retinopathy (PDR), idiopathic macular pucker, uveitis and othe...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1023/a:1022509614815
更新日期:2001-01-01 00:00:00
abstract::Retinal astrocytic hamartomas are benign tumors of the retinal nerve fiber layer (NFL) that may be found in association with tuberous sclerosis (TS). We describe the spectral-domain optical coherence tomography (SD-OCT) features of type 1 astrocytic hamartomas in a child with TS that may aid in the diagnosis and follo...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-012-9586-5
更新日期:2012-10-01 00:00:00