The effects of epiretinal membranes on the treatment outcomes of intravitreal aflibercept injection in diabetic macular edema: a real-life study.

Abstract:

PURPOSE:To evaluate the effects of epiretinal membrane (ERM) formation on the anatomic and functional results of subjects with diabetic macular edema (DME) who are receiving intravitreal aflibercept injections (IAIs). MATERIALS AND METHODS:This retrospective comparative study includes 29 eyes with DME (Group 1) and 43 eyes with DME and ERM (Group 2). After three consecutive monthly 2.0 mg IAIs, subjects received monthly follow-ups and retreatment was performed if needed. Corrected visual acuity (CVA), central macular thickness (CMT), and central macular volume (CMV) parameters were recorded tri-monthly, and the 36-month follow-up was designated the primary endpoint of the study. RESULTS:There was no significant difference between groups when comparing the mean ages and male-to-female ratios (p > 0.05, for both). At the baseline, the mean CVA value was significantly worse (p = 0.002), and the mean CMT was significantly lower (p = 0.016) in Group 1, while there was no significant difference in terms of the mean CMV (p = 0.625). The mean number of IAIs was similar at the first (p < 0.102), second (p = 0.363), and third year (p = 0.850) follow-ups. The mean CVA was significantly worse, and CMT was significantly lower in Group 1 at most of the visits in the first half of the follow-up period (p < 0.05, for all), while there was no significant difference in the second half of the follow-up period. There was no significant difference between groups in terms of CMV at any visit (p > 0.05, for all). CONCLUSION:Despite a similar number of IAIs needed, worse baseline clinical parameters are associated with poorer early- or mid-term outcomes. At the long-term follow-up, CVA and CMT became similar in DME independent of ERM.

journal_name

Int Ophthalmol

authors

Kocak Altintas AG,Ilhan C,Cankurtaran M

doi

10.1007/s10792-020-01444-y

subject

Has Abstract

pub_date

2020-10-01 00:00:00

pages

2635-2641

issue

10

eissn

0165-5701

issn

1573-2630

pii

10.1007/s10792-020-01444-y

journal_volume

40

pub_type

杂志文章
  • Quantitative analysis of subfoveal choroidal thickness using enhanced depth imaging optical coherence tomography in normal eyes.

    abstract::To evaluate subfoveal choroidal thickness of normal eyes with the use of the enhanced depth imaging technique of optical coherence tomography (EDI-OCT) and correlation of choroidal thickness with patient age. A retrospective analysis of 123 healthy eyes was performed. Age, gender, refractive state and spheric equivale...

    journal_title:International ophthalmology

    pub_type: 杂志文章

    doi:10.1007/s10792-013-9787-6

    authors: Ozdogan Erkul S,Kapran Z,Uyar OM

    更新日期:2014-02-01 00:00:00

  • Epipolis-laser in situ keratomileusis versus photorefractive keratectomy for the correction of myopia: a meta-analysis.

    abstract::It is unclear whether epipolis-laser in situ keratomileusis (Epi-LASIK) has any significant advantage over photorefractive keratectomy (PRK) for correcting myopia. We undertook this meta-analysis of randomized controlled trials and cohort studies to examine possible differences in efficacy, predictability, and side ef...

    journal_title:International ophthalmology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1007/s10792-015-0109-z

    authors: Wu W,Wang Y,Xu L

    更新日期:2015-10-01 00:00:00

  • Mycolase II: an enzyme antifungal agent interacts with the polyene antibiotic pimaricin in the treatment of keratomycosis.

    abstract::An animal model of keratomycosis was used to study the interaction between the new enzyme antifungal compound mycolase II and the polyene antifungal antibiotic pimaricin. Well established corneal infection caused by an ocular pathogenic candida albicans on New Zealand white male rabbits were treated with 3% mycolase I...

    journal_title:International ophthalmology

    pub_type: 杂志文章

    doi:10.1007/BF00149150

    authors: Oji EO

    更新日期:1982-11-01 00:00:00

  • Femtosecond laser-assisted cataract surgery with bimanual technique: learning curve for an experienced cataract surgeon.

    abstract:PURPOSE:To describe the intraoperative complications and the learning curve of microincision cataract surgery assisted by femtosecond laser (FLACS) with bimanual technique performed by an experienced surgeon. METHODS:It is a prospective, observational, comparative case series. A total of 120 eyes which underwent biman...

    journal_title:International ophthalmology

    pub_type: 杂志文章

    doi:10.1007/s10792-017-0776-z

    authors: Cavallini GM,Verdina T,De Maria M,Fornasari E,Volpini E,Campi L

    更新日期:2019-01-01 00:00:00

  • Pars plana vitrectomy in aphakic retinal detachments.

    abstract::Thirty-three cases of aphakic retinal detachment have been treated by pars plana vitrectomy and retinopexy. This procedure allowed us to lower the incidence of postoperative massive periretinal proliferation from 15,4%, in a series that was performed by a classical method, to 6% in the pars plana treated group. ...

    journal_title:International ophthalmology

    pub_type: 杂志文章

    doi:10.1007/BF00138265

    authors: Verbraeken H,Vanhulst L

    更新日期:1984-01-01 00:00:00

  • In-vivo confocal microscopy of iridocorneal endothelial syndrome.

    abstract:BACKGROUND:We carried out a study by in-vivo confocal microscopy to investigate the appearance of iridocorneal endothelial (ICE) syndrome, and discuss its diagnostic potential. METHODS:Twelve patients, each with unilateral ICE syndrome, had both their eyes examined by in-vivo confocal microscopy. The images were recor...

    journal_title:International ophthalmology

    pub_type: 杂志文章

    doi:10.1007/s10792-007-9187-x

    authors: Le QH,Sun XH,Xu JJ

    更新日期:2009-02-01 00:00:00

  • Principles of contact lens tonometry.

    abstract::We constructed a contact lens with an integrated pressure-sensing device. It is housed in a container with three force-sensing elements, each 120 degrees apart, enabling measurement of the appositional force, i.e., the force with which the instrument is held against the eye. In part 1 of the study, the lens' precision...

    journal_title:International ophthalmology

    pub_type: 杂志文章

    doi:10.1023/a:1006292102204

    authors: Dekker PW,Robert YC,Kanngiesser H,Pirani P,Entenmann B

    更新日期:1998-01-01 00:00:00

  • A randomized prospective study comparing trabeculectomy with and without the use of a new removable suture.

    abstract:INTRODUCTION:The aim of this prospective study is to verify, in terms of both early postoperative complications and intraocular pressure (IOP) outcomes, the performance of a scleral flap removable suture. MATERIALS AND METHODS:Sixty-six patients that underwent trabeculectomy were randomly divided into two groups: in t...

    journal_title:International ophthalmology

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s10792-008-9245-z

    authors: Caporossi A,Balestrazzi A,Malandrini A,Tosi GM,Caporossi T,Frezzotti P,Lomurno L

    更新日期:2009-10-01 00:00:00

  • The global burden of trachomatous visual impairment: II. Assessing burden.

    abstract::This paper builds on results of a previous paper on the prevalence of trachomatous visual impairment as the foundation for assessing the global burden of trachomatous blindness and low vision: approximately 2.9 million cases of trachomatous blindness and 3.8 million low visioned corresponding to a global prevalence of...

    journal_title:International ophthalmology

    pub_type: 杂志文章

    doi:10.1007/BF00130921

    authors: Evans TG,Ranson MK

    更新日期:1995-01-01 00:00:00

  • Structural features of eyelid connective tissue in patients with primary open-angle glaucoma.

    abstract:PURPOSE:To study the connective tissue (CT) structure of upper eyelid skin of primary open-angle glaucoma (POAG) patients. PATIENTS AND METHODS:Forty-seven patients aged 47-91 expecting blepharoplasty formed 3 groups: group 1 [16 subjects without POAG, median age 55 years (interquartile range 54-55.5)], group 2 [12 su...

    journal_title:International ophthalmology

    pub_type: 杂志文章

    doi:10.1007/s10792-018-1035-7

    authors: Svetikova LA,Iomdina EN,Ignatyeva NY,Serik AN,Migal SF,Nazarova NA

    更新日期:2019-09-01 00:00:00

  • Management of postequatorial magnetic intraretinal foreign bodies.

    abstract::17 patients with intraretinal magnetic foreign bodies and vitreous hemorrhage are reported. 15 patients underwent a primary surgical repair consisting of a watertight wound closure and removal of the already swelling cataractous lens in 5 cases. All patients had vitrectomy during the second postinjury week. The foreig...

    journal_title:International ophthalmology

    pub_type: 杂志文章

    doi:10.1007/BF02279868

    authors: Kuhn F,Kovacs B

    更新日期:1989-09-01 00:00:00

  • Anti-tuberculous therapy combined with systemic corticosteroids improves retinal sensitivity in patients with active presumed tuberculous choroiditis.

    abstract::To investigate the efficacy of anti-tuberculous therapy and systemic corticosteroids in patients suffering from active presumed tuberculous choroiditis by the assessment of central retinal sensitivity and fixation characteristics. Six patients (six eyes) with active presumed tuberculous choroiditis were treated with a...

    journal_title:International ophthalmology

    pub_type: 杂志文章

    doi:10.1007/s10792-010-9371-2

    authors: Abu El-Asrar AM,Al-Mezaine HS

    更新日期:2010-10-01 00:00:00

  • Correction to: Primary vitrectomy with short-term silicone oil tamponade for uncomplicated rhegmatogenous retinal detachment.

    abstract::Dear editor and readers, this letter is written to make you aware that the original version of this article unfortunately contained a mistake. ...

    journal_title:International ophthalmology

    pub_type: 杂志文章,已发布勘误

    doi:10.1007/s10792-018-0981-4

    authors: Karacorlu M,Hocaoglu M,Sayman Muslubas I,Ersoz MG,Arf S,Uysal O

    更新日期:2019-01-01 00:00:00

  • Visual consequences of electronic reader use: a pilot study.

    abstract:BACKGROUND:With the increasing prevalence of electronic readers (e-readers) for vocational and professional uses, it is important to discover if there are visual consequences in the use of these products. There are no studies in the literature quantifying the incidence or severity of eyestrain, nor are there clinical c...

    journal_title:International ophthalmology

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s10792-016-0281-9

    authors: Maducdoc MM,Haider A,Nalbandian A,Youm JH,Morgan PV,Crow RW

    更新日期:2017-04-01 00:00:00

  • External ophthalmomyiasis: a case series.

    abstract::Oestrus ovis or 'sheep botfly' causes common ophthalmomyiasis in warm climates. It is a self-limited infestation with symptoms such as foreign body sensation and/or tearing. The larvae can be observed in the conjunctiva and should be extracted with forceps. The development of larvae beyond the first stage does not occ...

    journal_title:International ophthalmology

    pub_type: 杂志文章

    doi:10.1007/s10792-012-9644-z

    authors: Carrillo I,Zarratea L,Suárez MJ,Izquierdo C,Garde A,Bengoa A

    更新日期:2013-04-01 00:00:00

  • Physiology of the choroidal vascular bed.

    abstract::The choroidal vascular bed has many interesting features such as relatively wide but flat capillaries, fenestrated capillary walls and an enormous blood flow. The high flow rate results in a high oxygen tension in the tissue and is also of importance in the temperature control of the eye. The capillary wall is permeab...

    journal_title:International ophthalmology

    pub_type: 杂志文章

    doi:10.1007/BF00127638

    authors: Bill A,Sperber G,Ujiie K

    更新日期:1983-02-01 00:00:00

  • Retinal pigment epithelial tear after intravitreal ranibizumab for subfoveal CNV secondary to AMD.

    abstract:PURPOSE:To report a case of retinal pigment epithelial tear following intravitreal ranibizumab injection for subfoveal choroidal neovascularization. METHODS:Retrospective single case review. RESULTS:A 78-year-old Caucasian female was treated with intravitreal ranibizumab for occult subfoveal choroidal neovascularizat...

    journal_title:International ophthalmology

    pub_type: 杂志文章

    doi:10.1007/s10792-007-9066-5

    authors: Apte RS

    更新日期:2007-02-01 00:00:00

  • Trabeculectomy with anterior vitrectomy in aphakic and pseudophakic glaucoma.

    abstract::In 15 eyes with uncontrolled aphakic/pseudophakic glaucoma, trabeculectomy with anterior vitrectomy was performed. Mean pre-operative intraocular pressure (IOP) was 38.2 +/- 6.7 mmHg and mean post operative IOP was 19.3 +/- 5.2 mmHg after follow-up of 11.2 2 months. The anterior chamber maintainer technique during vit...

    journal_title:International ophthalmology

    pub_type: 杂志文章

    doi:10.1007/BF00153920

    authors: Melamed S,Neumann D,Blumenthal M

    更新日期:1991-05-01 00:00:00

  • Peripapillary vessel density in pediatric cases with buried optic disk drusen.

    abstract:BACKGROUND:To evaluate the retinal nerve fiber layer (RNFL) and peripapillary vascular density (VD) changes in the pediatric group with optic disk drusen (ODD). METHODS:Sixty eyes of 30 patients with buried ODD referred by the pediatric or neurology physicians to ophthalmology clinic with a preliminary diagnosis of pa...

    journal_title:International ophthalmology

    pub_type: 杂志文章

    doi:10.1007/s10792-021-01700-9

    authors: Türker IÇ,Doğan CU,Uzun SÜ,Güven D

    更新日期:2021-01-18 00:00:00

  • Regression of optic nerve head neovascularization in proliferative diabetic retinopathy after intravitreal triamcinolone. Regression of diabetic optic disc neovascularization after intravitreal triamcinolone.

    abstract::The aim of this study is to report the clinical outcome of a diabetic patient with optic nerve head neovascularization treated with an intravitreal injection of triamcinolone acetonide. A 52-year-old patient presented with clinically significant diffuse macular edema and optic nerve head neovascularization due to prol...

    journal_title:International ophthalmology

    pub_type: 杂志文章

    doi:10.1023/b:inte.0000031740.85124.78

    authors: Karacorlu M,Ozdemir H,Karacorlu S,Alacali N

    更新日期:2004-03-01 00:00:00

  • Five-slice technique for the explantation of complicated BrightOcular© cosmetic iris implants.

    abstract:PURPOSE:Our purpose is to describe a safe and easy technique for the removal of the BrightOcular cosmetic iris implants. Our technique involves cutting the implant into five parts rather than removal as a whole with less intraocular manipulation and no rotation of the implant. METHODS:We have used this technique in tw...

    journal_title:International ophthalmology

    pub_type: 杂志文章

    doi:10.1007/s10792-020-01328-1

    authors: Shalash A,El Bahrawy M

    更新日期:2020-06-01 00:00:00

  • Laser flare photometry: a noninvasive, objective, and quantitative method to measure intraocular inflammation.

    abstract::Aqueous flare and cells are the two inflammatory parameters of anterior chamber inflammation resulting from disruption of the blood-ocular barriers. When examined with the slit lamp, measurement of intraocular inflammation remains subjective with considerable intra- and interobserver variations. Laser flare cell photo...

    journal_title:International ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1007/s10792-009-9310-2

    authors: Tugal-Tutkun I,Herbort CP

    更新日期:2010-10-01 00:00:00

  • 'Idiopathic' preretinal macular fibrosis in young individuals.

    abstract::In order to evaluate possible etiological factors and the natural course of 'idiopathic' preretinal fibrosis in young persons, nine consecutive patients with macular pucker diagnosed under the age of 50 years were examined. There were six women and three men with the mean age of 27.2 years (range 15-50) and the mean f...

    journal_title:International ophthalmology

    pub_type: 杂志文章

    doi:10.1007/BF00202776

    authors: Laatikainen L,Punnonen E

    更新日期:1987-02-01 00:00:00

  • Investigation of genetic base in the treatment of age-related macular degeneration.

    abstract:PURPOSE:To determine whether gene polymorphisms which are associated with age-related macular degeneration (AMD) influence treatments' response and specifically the antioxidant supplementation in dry AMD patients, as well as the anti-vascular endothelial growth factor (anti-VEGF) therapy in neovascular AMD patients. M...

    journal_title:International ophthalmology

    pub_type: 杂志文章

    doi:10.1007/s10792-019-01274-7

    authors: Gourgouli K,Gourgouli I,Tsaousis G,Spai S,Niskopoulou M,Efthimiopoulos S,Lamnissou K

    更新日期:2020-04-01 00:00:00

  • Changes in the postoperative foveal avascular zone in patients with rhegmatogenous retinal detachment associated with choroidal detachment.

    abstract:BACKGROUND:Rhegmatogenous retinal detachment associated with choroidal detachment (RRDCD) refers to the detachment of the ciliary body and choroid from the sclera along with retinal detachment. The recovery of visual function is often far worse after surgical treatment of RRDCD than following anatomical reduction for c...

    journal_title:International ophthalmology

    pub_type: 杂志文章

    doi:10.1007/s10792-020-01433-1

    authors: Xu C,Wu J,Feng C

    更新日期:2020-10-01 00:00:00

  • Neuroretinitis: a rare feature of tubulointerstitial nephritis and uveitis syndrome.

    abstract::A 17-year-old female presented to our hospital with fatigue, arthralgia and fever associated with non-granulomatous anterior uveitis in the left eye. Blood tests revealed renal failure and a renal biopsy showed acute tubulointerstitial nephritis. Findings were consistent with tubulointerstitial nephritis and uveitis (...

    journal_title:International ophthalmology

    pub_type: 杂志文章

    doi:10.1007/s10792-013-9820-9

    authors: Khochtali S,Harzallah O,Hadhri R,Hamdi C,Zaouali S,Khairallah M

    更新日期:2014-06-01 00:00:00

  • Macular ganglion cell complex thickness in acute and chronic central serous chorioretinopathy.

    abstract::Central serous chorioretinopathy (CSCR) is characterized by neurosensory retinal detachment. Because the retina pigment epithelium and choroidal pathology is the current mechanism in CSCR, many studies in the literature focused on the outer retinal layers. There is little information about the functional or histologic...

    journal_title:International ophthalmology

    pub_type: 杂志文章

    doi:10.1007/s10792-016-0278-4

    authors: Demirok G,Kocamaz F,Topalak Y,Altay Y,Sengun A

    更新日期:2017-04-01 00:00:00

  • Investigating the effects of glaucomatous damage on the multifocal visual evoked potential parameters.

    abstract:PURPOSE:To investigate the effects of glaucomatous damage on the mfVEP parameters of patients suffering from primary open-angle glaucoma (POAG). METHODS:Fifteen healthy subjects and 15 patients with unilateral POAG participated in this study. In addition, routine ophthalmological examinations including visual acuity, ...

    journal_title:International ophthalmology

    pub_type: 杂志文章

    doi:10.1007/s10792-019-01138-0

    authors: Danyaei A,Kasiri A,Latifi SM,Armiun P,Tahmasebi MJ

    更新日期:2019-12-01 00:00:00

  • Retinal function immediately after Nd.YAG-laser treatment.

    abstract::The purpose of this study was to evaluate the effect of Nd.YAG-laser treatment on retinal function. All the patients treated showed a temporary decrease of visual acuity immediately after treatment. The ERG and EOG recordings were identical before and after treatment. The Umazume-Ohta test showed temporary central or ...

    journal_title:International ophthalmology

    pub_type: 杂志文章

    doi:10.1007/BF02027893

    authors: Hendrikse F,Pinckers A

    更新日期:1987-10-01 00:00:00

  • Prospective cohort study of risk factors for choroidal detachment after trabeculectomy.

    abstract:PURPOSE:To investigate risk factors for choroidal detachment after trabeculectomy. METHODS:We prospectively evaluated 97 patients with open-angle glaucoma who underwent primary trabeculectomy to investigate risk factors for choroidal detachment after trabeculectomy. The primary outcome measure was risk factors for the...

    journal_title:International ophthalmology

    pub_type: 杂志文章

    doi:10.1007/s10792-019-01267-6

    authors: Iwasaki K,Kakimoto H,Arimura S,Takamura Y,Inatani M

    更新日期:2020-05-01 00:00:00