Abstract：
PURPOSE:To investigate the feasibility of intrastromal lenticule insertion to restore corneal shape in a model of ectatic human cornea. METHODS:For this experimental ex vivo study on 34 human corneas unsuitable for transplantation, 17 corneas were thinned by decentralized posterior excimer laser ablation to 200 μm thickness and 6.5 mm diameter and then inflated up to 100 mm Hg to expose the ectasias (recipient corneas). Pachimetry and topography were obtained. Stromal lenticules of the same diameter and thickness as the ectasias were shaped with a femtosecond laser from the remaining 17 donor corneas. An intrastromal pocket was created with femtosecond laser within the ectatic recipient corneas and the donor lenticule was inserted inside it. Changes in corneal architecture and profile were evaluated by means of corneal topography and anterior segment optical coherence tomography. RESULTS:All stromal lenticules were successfully implanted. Tomography confirmed regularity of the lenticule profile within the stromal pocket. Corneal thickness was significantly increased after the procedure (P < 0.0001). Maximal posterior elevation from the best-fitted toric ellipsoid was significantly reduced (P < 0.0001). Significant flattening of posterior K1 and K2 was also obtained (P = 0.041 and P = 0.004, respectively). Anterior and posterior astigmatism, anterior and posterior asphericity, and spherical aberration did not differ significantly after the procedure. CONCLUSIONS:Femtosecond laser-assisted stromal lenticule addition is feasible for restoring corneal thickness to an ectatic area and for regularizing posterior corneal elevation. The technique opens new perspectives for the treatment of corneal ectasias.
journal_name
Int Ophthalmoljournal_title
International ophthalmologyauthors
Pedrotti E,Cozzini T,Fasolo A,Bonacci E,Bonetto J,Merz T,Talli P,Marchini Gdoi
10.1007/s10792-019-01106-8subject
Has Abstractpub_date
2019-11-01 00:00:00pages
2575-2581issue
11eissn
0165-5701issn
1573-2630pii
10.1007/s10792-019-01106-8journal_volume
39pub_type
杂志文章abstract：PURPOSE:Primary ocular adnexal lymphomas are cured by radiotherapy; however, complications are frequent and relapses may occur. In this case, we aimed to report the efficacy and safety of extended systemic rituximab (anti-CD 20 monoclonal antibody) therapy of conjunctival mucosa-associated lymphoid tissue (MALT) lympho...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-018-0844-z
更新日期：2019-03-01 00:00:00
abstract：:Thirty-three cases of aphakic retinal detachment have been treated by pars plana vitrectomy and retinopexy. This procedure allowed us to lower the incidence of postoperative massive periretinal proliferation from 15,4%, in a series that was performed by a classical method, to 6% in the pars plana treated group. ...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/BF00138265
更新日期：1984-01-01 00:00:00
abstract：:To report the clinical and microbiological characteristics of infectious endophthalmitis after Boston type I keratoprosthesis (B-K-Pro) implantation. Retrospective analysis of 136 eyes that received a B-K-Pro type 1 between 1999 and 2012 was performed. Five eyes with a diagnosis of exogenous endophthalmitis after B-K-...
journal_title：International ophthalmology
pub_type： 杂志文章,评审
doi：10.1007/s10792-014-9994-9
更新日期：2015-10-01 00:00:00
abstract：:The beneficial effect of photocoagulation in diabetic retinopathy is now established (2-6, 10). Whereas the capability of providing photocoagulation is widespread, the indications and actual techniques are poorly defined. In this paper, we propose to discuss the principles of photocoagulation. In a following paper the...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/BF00133274
更新日期：1978-09-01 00:00:00
abstract：:To report a unusual case of an isolated traumatic stellated tarso-conjunctival laceration located in the upper left eyelid without eyelid margin involvement and with normal ocular examination. A 19 year-old male wounded by a bokken (wooden katana) while practicing a sham duel had an isolated eyelid tarso-conjunctival ...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-012-9573-x
更新日期：2012-08-01 00:00:00
abstract：:The aim of this study is to compare a portable spectral domain optical coherence tomography (SD-OCT) device with a non-portable SD-OCT for the identification of anterior chamber angle parameters based on location of Schwalbe's line (SL) and to measure their reproducibility. 99 eyes from 46 normal, healthy participants...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-016-0223-6
更新日期：2017-02-01 00:00:00
abstract：PURPOSE:To report a large, consecutive series of endophthalmitis of all causes managed at a tertiary referral retina center. METHODS:Retrospective chart review of all cases diagnosed with endophthalmitis that received reatment and follow-up between January 2000 and January 2005. RESULTS:A total of 67 patients were di...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-007-9068-3
更新日期：2007-08-01 00:00:00
abstract：PURPOSE:Traditional color vision tests depend on subjective judgments and are not suitable for infant children and subjects with cognitive dysfunction. We aimed to explore an objective and quantitative color vision testing method based on sweep steady-state visual evoked potentials (sweep SSVEPs) and compare the result...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-020-01613-z
更新日期：2020-10-12 00:00:00
abstract：PURPOSE:To evaluate the importance of "en toto" globe submission in the assessment of high-risk pathological findings in retinoblastoma cases, aiming at identifying the additional value from full globe examination of enucleated eyes (including the calottes). METHODS:Retrospective histopathological case series of eight...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-016-0410-5
更新日期：2018-02-01 00:00:00
abstract：:The melanocytoma of the optic disc is a deeply-pigmented tumor located on the optic nerve head. In contrast to malignant melanoma, it appears to occur in equal frequency in whites and non-whites. Histologically, it consists of deeply-pigmented plump nervus cells with benign characteristics. No treatment is usually nec...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/BF00133275
更新日期：1978-09-01 00:00:00
abstract：PURPOSE:To evaluate the effects of epiretinal membrane (ERM) formation on the anatomic and functional results of subjects with diabetic macular edema (DME) who are receiving intravitreal aflibercept injections (IAIs). MATERIALS AND METHODS:This retrospective comparative study includes 29 eyes with DME (Group 1) and 43...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-020-01444-y
更新日期：2020-10-01 00:00:00
abstract：:Out of 49 patients diagnosed as having Stargardt's disease that have been clinically reviewed, 22 of these cases have been followed for a period up to 13 years. The cases have been studied in three subgroups, according to their fundus appearance. Patients from group I were those whose lesions were confined to the macu...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/BF00137651
更新日期：1985-11-01 00:00:00
abstract：:We investigated in normal persons of different ages ranging from 4 months to 85 years the frequency of different ferning types as well as the results of the Schirmer I test, break-up time and tear protein profile. With increasing age, ferning types of higher degree were significantly more frequent. Furthermore, a corr...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/BF00137950
更新日期：1991-11-01 00:00:00
abstract：:The association between HLA-A29 and birdshot chorioretinopathy is the strongest of all associations between HLA and disease. Determination of HLA-A29 is even of diagnostic significance. The association between HLA-B27 and acute anterior uveitis (AAU) is much weaker, but B27 positive AAU may be considered as a distinct...
journal_title：International ophthalmology
pub_type： 杂志文章,评审
doi：10.1007/BF00163552
更新日期：1990-10-01 00:00:00
abstract：PURPOSE:A population-based study was conducted to determine the prevalence of color deficiencies in secondary-school students (ages 12-14) in Tehran. METHODS:A total of 2,058 students (1,136 males, 922 females) were examined with Ishihara pseudoisochromatic color plates. RESULTS:In the study population, 97 cases of d...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/BF00175263
更新日期：1996-01-01 00:00:00
abstract：AIM:To evaluate the whether intravitreal erythropoietin (EPO) administration has any beneficial or adverse effect in patients with late-stage optic neuropathy (ON) or not. METHODS:The study examined 16 eyes of 16 patients who had late-stage ON and ≥1/20 best-corrected visual acuity (BCVA) in their affected eye. There ...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-017-0553-z
更新日期：2018-06-01 00:00:00
abstract：:The unifying principle underlying this classification system is: The more posterior the disease and the greater the amount of involved retinal vascular tissue, the more serious the disease. The staging of the disease at any given location expresses the natural history and evolution of events at the border between vasc...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/BF00136454
更新日期：1985-04-01 00:00:00
abstract：:To investigate long-term clinical outcomes after acute angle closure in the Chinese population. A 10-year retrospective review of primary acute angle closure in Hong Kong Chinese to document patient demographics, treatment, and pre- and post-acute angle closure intraocular pressure (IOP) and visual acuity (VA). The ye...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-013-9806-7
更新日期：2014-04-01 00:00:00
abstract：PURPOSE:Pseudoexfoliation syndrome (PEX) is a late onset disorder of extracellular matrix turnover, associated systemically with cardiovascular and cerebrovascular disease. To evaluate the suggested association of polymorphisms of homocysteine metabolism genes MTHFR (rs1801131, rs1801133) and MTHFD1 (rs8006686) with PE...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-017-0498-2
更新日期：2018-04-01 00:00:00
abstract：:Current theories for macular hole formation implicate antero-posterior and tractional forces at the vitreofoveal interface. It is thought that localized perifoveal defects enlarge from centrifugal forces acting about the axis of ocular rotation. If this is true, eyes with longer axial lengths should have an increased ...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-012-9568-7
更新日期：2012-08-01 00:00:00
abstract：:We report on a patient with an overhanging bleb several years following trabeculectomy surgery with mitomycin C. ...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-011-9477-1
更新日期：2011-10-01 00:00:00
abstract：PURPOSE:To evaluate one-year visual, refractive, and topographic outcomes of 58 eyes of 53 keratoconus patients who underwent surgery with a progressive thickness intrastromal corneal ring segment (ICRS). METHODS:This multi-center, retrospective, observational study evaluates the one-year effects of progressive thickn...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-020-01467-5
更新日期：2020-11-01 00:00:00
abstract：PURPOSE:State Gentamicin antibiotic prophylaxis is contraindicated in 25 gauge Transconjunctival Sutureless Vitrectomy. METHODS:A 75-year-old diabetic woman was affected by glaucoma and mild diabetic retinopathy in both eyes, and epiretinal membrane in the left eye. A 25-gauge Transconjunctival Sutureless Vitrectomy (...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-007-9148-4
更新日期：2008-10-01 00:00:00
abstract：PURPOSE:Regional variations of the preoperative biometry can affect the refractive accuracy of cataract surgery. We aimed to compare the preoperative biometric data for cataract surgery between two domestic institutions. METHODS:We retrospectively reviewed the preoperative biometric data of 673 consecutive eyes underg...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-020-01476-4
更新日期：2020-11-01 00:00:00
abstract：PURPOSE:To gain an insight into the manufacturing and fitting of artificial eyes in children and potential improvements to the process. METHOD:An online qualitative survey was distributed to 39 ocularists/prosthetists in Europe and Canada. Participants were recruited through purposive sampling, specifically maximum va...
journal_title：International ophthalmology
pub_type： 杂志文章,多中心研究
doi：10.1007/s10792-016-0383-4
更新日期：2017-10-01 00:00:00
abstract：:Preliminary results of a larger investigation on correlation between Retinal Nerve Fiber Layer Defects (RNFL) and Automated Perimetry (AP) are presented. A group of ocular hypertensive patients was recruited and a cross-section, randomized study was carried out. The group was composed of 54 eyes from 28 patients; 15 m...
journal_title：International ophthalmology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF00917968
更新日期：1992-09-01 00:00:00
abstract：:The incidence of endophthalmitis after pars plana vitrectomy is low. Silicone oil is a tamponading agent which has anti-microbial activity. Post-operative endophthalmitis following vitrectomy with silicone oil tamponade has been rarely reported. We describe the case of a young male who underwent pars plana vitrectomy ...
journal_title：International ophthalmology
pub_type： 杂志文章,评审
doi：10.1007/s10792-015-0072-8
更新日期：2015-08-01 00:00:00
abstract：:I have developed two protective caps that fit on the viewing windows of the indirect ophthalmoscope. These caps contain filters that absorb the argon laser beam and protect the operator's eyes during endolaser treatment. ...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/BF00225937
更新日期：1986-04-01 00:00:00
abstract：PURPOSE:Numerous studies suggest that reactive oxygen species play a crucial role in the development of glaucoma. Since glaucoma patients exhibit posterior vitreous detachment earlier than controls, it has been suggested that reactive oxygen species-increased in glaucoma-also affect the vitreous. In the present study w...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-019-01268-5
更新日期：2020-04-01 00:00:00
abstract：INTRODUCTION:We report on a 62-year-old healthy woman who suffered from bilateral predescemetic opacities, where the underlying disorder could not be identified. She had bilateral keratopathy with corneal edema, a diffuse predescemetic avascular haze and deszemetic folds. Because of high hyperopia (right +7.50/left +7....
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1023/b:inte.0000018521.88103.17
更新日期：2004-01-01 00:00:00
