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A case of conjunctival MALT lymphoma: successfully treated with solely extended rituximab therapy.

Abstract：

PURPOSE:Primary ocular adnexal lymphomas are cured by radiotherapy; however, complications are frequent and relapses may occur. In this case, we aimed to report the efficacy and safety of extended systemic rituximab (anti-CD 20 monoclonal antibody) therapy of conjunctival mucosa-associated lymphoid tissue (MALT) lymphoma. METHODS:In the standard regimen, rituximab is used as four consecutive weekly infusions of 375 mg/m2 in patients with low-grade lymphomas. We treated a patient who had bilateral conjunctival MALT lymphoma with rituximab 375 mg/m2 intravenously once weekly for 10 weeks as a first-line therapy. RESULTS:During the examination of the sixth week, we observed partial response of the lesions in both eyes. At the end of the tenth cure, complete remission was achieved. No local or systemic adverse effect was observed. The patient has no signs of recurrence during the 22-months follow-up period. CONCLUSION:Extended rituximab therapy may be an effective and well-tolerated first-line treatment option for bilateral conjunctival MALT lymphoma.

journal_name

Int Ophthalmol

journal_title

International ophthalmology

authors

Celiker H,Toker E,Kaygusuz Atagunduz I

doi

10.1007/s10792-018-0844-z

subject

Has Abstract

pub_date

2019-03-01 00:00:00

pages

687-691

issue

3

eissn

0165-5701

issn

1573-2630

pii

10.1007/s10792-018-0844-z

journal_volume

39

pub_type

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