Abstract:
INTRODUCTION:Uveitis encompasses a wide variety of sight-threatening diseases characterized by intraocular inflammation. It is often classified as infectious and non-infectious uveitis. Unlike infectious uveitis, a distinct infectious agent cannot be identified in non-infectious uveitis and disease origin is usually autoimmune, drug related, or idiopathic. THE ISSUE AT HAND:Non-infectious uveitis can often have a relapsing-remitting course, making it difficult to treat, and poses a significant challenge to ophthalmologists. The autoimmune nature of non-infectious uveitis warrants the use of anti-inflammatory and immunomodulatory agents for disease control. However, a subset of patients has persistent or recurrent ocular inflammation despite appropriate treatment, stressing the need for newer therapies aimed at more specific inflammatory targets such as tumour necrosis factor (TNF) alpha agents, anti-interleukin agents, and anti-interleukin receptor agents. OBJECTIVES:This article discusses the various medical options available for the treatment of non-infectious uveitis in the light of the most recent evidence. CONCLUSION:Successful management of non-infectious uveitis requires the clinician carefully balance advantages and disadvantages of each new and old therapy while considering individual circumstances. Counselling regarding the benefits and complications of each therapy can help patients make an informed choice.
journal_name
Int Ophthalmoljournal_title
International ophthalmologyauthors
Shahab MA,Mir TA,Zafar Sdoi
10.1007/s10792-018-0984-1subject
Has Abstractpub_date
2019-07-01 00:00:00pages
1633-1650issue
7eissn
0165-5701issn
1573-2630pii
10.1007/s10792-018-0984-1journal_volume
39pub_type
杂志文章,评审abstract:BACKGROUND:Optic disc drusen (ODD) are acellular deposits in the prelaminar optic nerve head. The most accredited theory is that they are secondary to abnormalities in axonal metabolism and degeneration, but the pathogenesis is not clear to date. CLINICAL MANIFESTATION:Although ODD are often considered a benign condit...
journal_title:International ophthalmology
pub_type: 杂志文章,评审
doi:10.1007/s10792-020-01365-w
更新日期:2020-08-01 00:00:00
abstract:PURPOSE:To demonstrate differences in optic nerve head (ONH), retinal nerve fiber layer (RNFL), and macular thickness in patients with internal carotid artery (ICA) stenosis using spectral domain optical coherence tomography (SD-OCT). METHODS:A case-controlled study was conducted in 31 patients with a diagnosis of uni...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-020-01642-8
更新日期:2020-11-10 00:00:00
abstract:PURPOSE:To investigate the characteristics of dynamic visual acuity (DVA) and contrast sensitivity (CS) in pseudophakic patients with posterior capsular opacification (PCO). METHODS:Fifty-four eyes (36 patients) with PCO planned for laser capsulotomy were recruited. They underwent examinations of static visual acuity ...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-020-01536-9
更新日期:2020-12-01 00:00:00
abstract::Retinal arteriovenous malformations are rare and most are reported to be asymptomatic. We report an 11-year-old boy who attended for blunt trauma to his eye. The first ophthalmologic examination was performed in Nikookari Hospital Eye Emergency Room. Visual acuity was 20/20 and relative afferent pupillary defect was n...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-012-9636-z
更新日期:2013-02-01 00:00:00
abstract:PURPOSE:Recently, the vasodilator relaxin 2 has been introduced as a treatment for acute heart failure. However, its role on vessels of the eye and intraocular pressure (IOP) remains unclear though it has been hypothesized to induce a decrease IOP after intramuscular injection in humans. We aimed to test whether the ho...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-018-0884-4
更新日期:2019-04-01 00:00:00
abstract:BACKGROUND:To determine the inflammatory course and level of visual rehabilitation after cataract extraction and posterior chamber lens implantation in patients with Fuchs' heterochromic iridocyclitis complicated by cataract. METHODS:In a clinical trial, 32 eyes (visual acuity of 20/160 or worse) of 30 patients underw...
journal_title:International ophthalmology
pub_type: 临床试验,杂志文章
doi:10.1023/a:1026490902566
更新日期:1997-01-01 00:00:00
abstract::In a study of 95 patients with intraocular foreign body injuries presenting in the eight year period from 1978-1986 we found the overall visual results to be good with 62% of patients achieving a final visual acuity of 6/18 or better. The factors leading to a poor visual result were a large intraocular foreign body, p...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/BF00137136
更新日期:1988-01-01 00:00:00
abstract::To evaluate subfoveal choroidal thickness of normal eyes with the use of the enhanced depth imaging technique of optical coherence tomography (EDI-OCT) and correlation of choroidal thickness with patient age. A retrospective analysis of 123 healthy eyes was performed. Age, gender, refractive state and spheric equivale...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-013-9787-6
更新日期:2014-02-01 00:00:00
abstract:PURPOSE:To report two cases of ciliochoroidal effusion after the usage of topiramate. CASES:Two middle-aged women experienced sudden onset of acute glaucoma and acquired myopia after taking topiramate. Ultrasound biomicroscopy demonstrated bilateral ciliochoroidal effusion and angle closure. The A-scan ultrasonography...
journal_title:International ophthalmology
pub_type: 杂志文章,评审
doi:10.1007/s10792-017-0740-y
更新日期:2018-12-01 00:00:00
abstract::Thirty strains of Staphylococcus epidermidis, ten each from normal conjunctival sacs, corneal ulcer cases and from those who developed postoperative endophthalmitis, were examined for their dermonecrotic and haemolytic activities. Dermonecrosis was studied on rabbit skin whereas haemolysis was determined against sheep...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/BF00149145
更新日期:1982-11-01 00:00:00
abstract::17 patients with intraretinal magnetic foreign bodies and vitreous hemorrhage are reported. 15 patients underwent a primary surgical repair consisting of a watertight wound closure and removal of the already swelling cataractous lens in 5 cases. All patients had vitrectomy during the second postinjury week. The foreig...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/BF02279868
更新日期:1989-09-01 00:00:00
abstract:PURPOSE:To evaluate the long-term safety and efficacy of Mycophenolate Mofetil (MMF) for the control of cystoid macular oedema (CMO) secondary to noninfectious uveitis (NU). METHODS:The medical records of 19 consecutive patients with inflammatory CMO treated with MMF were retrospectively reviewed. Patient demographics...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-008-9200-z
更新日期:2009-06-01 00:00:00
abstract:PURPOSE:To report a unique case of congenital simple hamartoma of retinal pigment epithelium (CSHRPE) associated with full-thickness macular hole (FTMH). METHODS:A 14-year-old female with a previous diagnosis of simple hamartoma of retinal pigment epithelium in the left eye presented with a 3-week onset of reduced vis...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-017-0676-2
更新日期:2018-10-01 00:00:00
abstract:PURPOSE:To compare the systemic and ocular characteristics and laboratory findings of patients developing toxic anterior segment syndrome (TASS) after uneventful phaco surgery with unaffected subjects undergoing the same surgery in the same session. DESIGN:A retrospective case-control study. METHODS:The study group c...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-016-0418-x
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND:To describe the clinical characteristics of active ocular toxoplasmosis in a large population of Turkish patients. METHODS:A retrospective study of 109 consecutive patients with active ocular toxoplasmosis seen at the Department of Ophthalmology, Istanbul Faculty of Medicine, from 1995 to 2005. RESULTS:Fif...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-007-9047-8
更新日期:2005-12-01 00:00:00
abstract::To investigate the correlation between the perifoveal capillary blood flow velocity (BFV) and the vitreous level of pigment epithelium-derived factor (PEDF) in patients with branch retinal vein occlusion (BRVO) and macular edema. In a retrospective interventional study of patients with BRVO and macular edema, undilute...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-012-9584-7
更新日期:2012-10-01 00:00:00
abstract:PURPOSE:To compare corneal graft survival rates after penetrating keratoplasty (PK) and Descemet's stripping endothelial keratoplasty (DSEK) in patients with a glaucoma drainage device (GDD) or medically managed glaucoma. METHODS:A retrospective chart review was conducted on consecutive patients who underwent primary ...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-017-0451-4
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND:Bevacizumab (Avastin) has been used as off-label treatment for the specific inhibition of the vascular endothelial growth factor (VEGF). Although only intravenous administration of the drug is approved in combination therapy of colorectal carcinoma, promising short-term results have been reported about its i...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-007-9122-1
更新日期:2008-04-01 00:00:00
abstract:PURPOSE:The purpose was to evaluate the angle of the anterior chamber (ACA) and intraocular pressure (IOP) changes following eventless phacoemulsification surgery done for non-glaucomatous Egyptian patients. METHODS:A prospective, interventional study involved 126 cataractous patients undergoing phacoemulsification wi...
journal_title:International ophthalmology
pub_type: 杂志文章,多中心研究
doi:10.1007/s10792-019-01234-1
更新日期:2020-03-01 00:00:00
abstract::A solitary fibrous tumor is a neoplasm generally arising from the mesothelial surfaces of the pleura and mesothelium. In this paper, we describe three cases of rare solitary fibrous tumors arising from the orbit and discuss the management of the tumors, including diagnosis and treatment. All three cases were treated b...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-016-0421-2
更新日期:2018-02-01 00:00:00
abstract::The unifying principle underlying this classification system is: The more posterior the disease and the greater the amount of involved retinal vascular tissue, the more serious the disease. The staging of the disease at any given location expresses the natural history and evolution of events at the border between vasc...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/BF00136454
更新日期:1985-04-01 00:00:00
abstract::We describe the first two cases of diffuse unilateral subacute neuroretinitis (DUSN) in the UK successfully treated with albendazole. Two patients are described who presented with unilateral reduction in vision, with clusters of yellow-white retinal lesions fading and reappearing in new locations of the fundus over a ...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-010-9358-z
更新日期:2010-10-01 00:00:00
abstract:PURPOSE:To report a case of toxic optic neuropathy caused by an ocular bee sting. METHODS:Case report and literature review. RESULTS:A 44-year-old female presented with no light perception vision 2 days after a corneal bee sting in her right eye. She was found to have diffuse cornea edema with overlying epithelial de...
journal_title:International ophthalmology
pub_type: 杂志文章,评审
doi:10.1007/s10792-018-0978-z
更新日期:2019-07-01 00:00:00
abstract::The choroidal vascular bed has many interesting features such as relatively wide but flat capillaries, fenestrated capillary walls and an enormous blood flow. The high flow rate results in a high oxygen tension in the tissue and is also of importance in the temperature control of the eye. The capillary wall is permeab...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/BF00127638
更新日期:1983-02-01 00:00:00
abstract::One hundred cases of clinically acceptable sympathetic ophthalmia (SO) were evaluated histologically to determine the incidence of atypical features and correlate them with the severity of choroidal inflammation. The inflammatory response in the choroid varied from a focal non-granulomatous to a diffuse non-necrotizin...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/BF00161902
更新日期:1982-02-01 00:00:00
abstract:PURPOSE:The objective is to report a rare case of asymptomatic penetrating injury with a copper foreign body found during an examination for cataract surgery. METHOD:A case report. RESULTS:A 73-year-old woman had vision loss. Examination by pupil dilation disclosed a dark-brown metallic mass located under the anterio...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-007-9074-5
更新日期:2007-10-01 00:00:00
abstract::The melanocytoma of the optic disc is a deeply-pigmented tumor located on the optic nerve head. In contrast to malignant melanoma, it appears to occur in equal frequency in whites and non-whites. Histologically, it consists of deeply-pigmented plump nervus cells with benign characteristics. No treatment is usually nec...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/BF00133275
更新日期:1978-09-01 00:00:00
abstract::A case of orbital metastasis of cervical keratinizing squamous cell carcinoma is presented. The patient, in remission from primary cervical and ovarian cancers, presented with complaints of left eye ptosis and pain. Examination revealed the presence of a moderately tender mass along the left supra-temporal orbital rim...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-007-9162-6
更新日期:2009-02-01 00:00:00
abstract:INTRODUCTION:The aim of this prospective study is to verify, in terms of both early postoperative complications and intraocular pressure (IOP) outcomes, the performance of a scleral flap removable suture. MATERIALS AND METHODS:Sixty-six patients that underwent trabeculectomy were randomly divided into two groups: in t...
journal_title:International ophthalmology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s10792-008-9245-z
更新日期:2009-10-01 00:00:00
abstract::The objective of this study is to evaluate the visual prognosis and postoperative course in advanced glaucoma patients who underwent trabeculectomy. The records of 30 patients with advanced visual field (VF) defects undergoing trabeculectomy were retrospectively reviewed. Severe VF defects were defined as those with a...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-011-9494-0
更新日期:2011-12-01 00:00:00