Abstract：
UNLABELLED:The purpose of this study is to evaluate the effect of trephination with free scleral auto-implant plug exposed to Mitomycin-C out of the eye, in surgical treatment of primary open-angle glaucoma (POAG), in comparison with efficacy of trabeculectomy with MMC (32 eyes with POAG of patients, younger than 55 years-group 1). Trephination with scleral auto-implant plug with MMC was done on 35 eyes of patients, younger than 55 years, with POAG (group 2). The postoperative follow-up was 28.52 +/- 8.78 months. SURGICAL PROCEDURE:A limbal 1.0 mm diameter trephination is made beneath the limbus-based conjunctival flap, a small iridectomy is performed. From the external layers of the trephine button one third of the corneoscleral thickness, in the form of a thin disc, is excised. The scleral disc, a free auto-implant, is dipped into liquid containing MMC with concentration 0.2 mg/ml for 5 minutes, outside the eye. Afterwards the scleral disc soaked with MMC is carefully irrigated with 150 ml of BSS and placed in the external part of the trephine fistula in primary position and stabilized with two interrupted 10-0 nylon sutures. The operation is ended as a typical trabeculectomy. The final success rate in terms of IOP (IOP < 14 mmHg) was 100%, without or with antiglaucoma medication, in both groups, but the number of postoperative complications was significantly lower in group 2. Trephination with free scleral auto-implant plug soaked with MMC may represent a viable alternative to trabeculectomy with MMC; the scleral plug may be taken out of the eye and exposed to antimetabolite outside the eye to minimize toxicity.
journal_name
Int Ophthalmoljournal_title
International ophthalmologyauthors
Szymanski Adoi
10.1007/BF00212952subject
Has Abstractpub_date
1996-01-01 00:00:00pages
89-94issue
1-3eissn
0165-5701issn
1573-2630journal_volume
20pub_type
临床试验,杂志文章,随机对照试验abstract：PURPOSE:To explore whether retrobulbar administration of nerve growth factor (NGF) can restore visual function of streptozotocin-induced diabetes rats. METHODS:A high-sucrose/high-fat diet and single injection of streptozotocin (STZ) were used in modeling diabetes. During week 13-15 after STZ injection, diabetic rats ...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-020-01537-8
更新日期：2020-12-01 00:00:00
abstract：:A 32-year-old lady presented with bilateral painful proptosis and left infranuclear facial palsy. She was mildly anemic. Ocular examination revealed a firm non-tender mass in the super lateral quadrant of both orbits. Fine-needle aspiration cytology from the orbital mass showed the presence of lymphoplasmacytoid cells...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-007-9037-x
更新日期：2005-12-01 00:00:00
abstract：:Roussel and Fankhauser have proposed contact glasses with a collecting front surface centred on the bundle focus for use with high power lasers. We demonstrate here that the main contribution to the gain in energy density within the focus spot must be attributed to the front surface of the glass. This is at variance w...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/BF00165111
更新日期：1984-06-01 00:00:00
abstract：PURPOSE:To evaluate the effect of metronidazole ophthalmic solutions on corneal neovascularization (CNV) in a rat model. METHODS:A chemical burn was created in the right central cornea of 40 rats. Animals were randomized and distributed into four study groups (n = 10 rats per group) designated Met_0.1%, Met_0.5%, sham...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-018-0922-2
更新日期：2019-05-01 00:00:00
abstract：:The aim of the study was to study the clinical, radiological and histopathological characteristics of orbital schwannomas. It is a retrospective study conducted at a tertiary eye care hospital. A review of histopathological records of the orbital tumors operated between 1993 and 2011 was done. The clinical, imaging an...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-014-9973-1
更新日期：2015-08-01 00:00:00
abstract：:From January 1990 until October 1992, 103 Zimbabwean patients underwent intracapsular cataract extraction by a general medical doctor. Of the first 100 patients operated upon, 50 were traced of which 37 could be assessed adequately. Operative complications and visual acuities after three months show that this is an ef...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/BF00131924
更新日期：1996-01-01 00:00:00
abstract：PURPOSE:The aim of this study was to evaluate the corneal biomechanical parameters in patients with ankylosing spondylitis (AS) and to compare them with the healthy subjects. METHODS:Sixty patients with AS (study group) and 60 healthy subjects (control group) were enrolled in this prospective study. The study group wa...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-016-0368-3
更新日期：2017-08-01 00:00:00
abstract：PURPOSE:To investigate the characteristics of dynamic visual acuity (DVA) and contrast sensitivity (CS) in pseudophakic patients with posterior capsular opacification (PCO). METHODS:Fifty-four eyes (36 patients) with PCO planned for laser capsulotomy were recruited. They underwent examinations of static visual acuity ...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-020-01536-9
更新日期：2020-12-01 00:00:00
abstract：:The effect of therapeutic ultrasound for the treatment of refractory glaucoma was evaluated in 44 patients by comparing average IOP curves measured before and 3-4 months after treatment. The insonification regime was standardized and the glaucoma medication in each individual patient was unchanged during IOP curve mea...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/BF00918000
更新日期：1992-09-01 00:00:00
abstract：:One hundred cases of clinically acceptable sympathetic ophthalmia (SO) were evaluated histologically to determine the incidence of atypical features and correlate them with the severity of choroidal inflammation. The inflammatory response in the choroid varied from a focal non-granulomatous to a diffuse non-necrotizin...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/BF00161902
更新日期：1982-02-01 00:00:00
abstract：:Fifty patients who developed preretinal or papillary neovascularization following tributary vein occlusion were treated by laser photocoagulation. Areas of non-perfused retina within the distribution of the obstructed vein were identified by fluorescein angiography and ablated using moderately intense laser photocoagu...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/BF00130697
更新日期：1981-05-01 00:00:00
abstract：:To compare the efficacy of 5-fluorouracil (5-FU) with mitomycin C (MMC) in preventing pterygium recurrence when used as an adjuvant following pterygium excision with conjunctival autograft. Low-dose MMC combined with conjunctival autograft is an effective treatment for preventing recurrence following pterygium excisio...
journal_title：International ophthalmology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s10792-011-9509-x
更新日期：2012-02-01 00:00:00
abstract：PURPOSE:To examine the retinal layers' changes and alterations in retinal microvasculature in patients with rhegmatogenous retinal detachment (RRD) treated with pars plana vitrectomy (PPV). METHODS:Participants in this study were 103 patients with RRD, 85 macula off and 18 macula on, who were treated with PPV and gas ...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-020-01521-2
更新日期：2020-12-01 00:00:00
abstract：PURPOSE:To introduce a case of ciliary detachment with primary pulmonary hypertension (PPH). METHODS:The clinical manifestations of a case of ciliary detachment with PPH were addressed by comprehensive examination including ultrasound biological microscope (UBM), intraocular pressure, color fundus photographs, fluores...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-017-0443-4
更新日期：2018-02-01 00:00:00
abstract：:After glaucoma filtering surgery subconjunctival injection of human recombinant tissue plasminogen activator may promote the function of glaucoma filter bleb and increase outflow facility. It can also increase postoperative complications, such as corneal damage. The aim of our research was to determine corneal endothe...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/BF00156413
更新日期：1995-01-01 00:00:00
abstract：PURPOSE:To evaluate the importance of "en toto" globe submission in the assessment of high-risk pathological findings in retinoblastoma cases, aiming at identifying the additional value from full globe examination of enucleated eyes (including the calottes). METHODS:Retrospective histopathological case series of eight...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-016-0410-5
更新日期：2018-02-01 00:00:00
abstract：:We report the first case of ischaemic optic neuropathy (ION) linked to chronic myelomonocytic leukaemia (CMML) and its associated vasculitis. We discuss the link between CMML and vasculitis and the evidence suggesting it can cause anterior ischaemic optic neuropathy through a vasculitic process. We highlight the diffi...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-012-9675-5
更新日期：2013-08-01 00:00:00
abstract：PURPOSE:Regional variations of the preoperative biometry can affect the refractive accuracy of cataract surgery. We aimed to compare the preoperative biometric data for cataract surgery between two domestic institutions. METHODS:We retrospectively reviewed the preoperative biometric data of 673 consecutive eyes underg...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-020-01476-4
更新日期：2020-11-01 00:00:00
abstract：:XPERT NCT advanced logic pneumotonometer (Reichert) was studied for its reliability and use in glaucoma screening. The evaluated 2400 NCT measurements on 300 eyes were compared to the results of Goldmann applanation tonometry (GAT) from the same eyes. Repeated NCT tonometry had no significant effect on IOP. Local anes...
journal_title：International ophthalmology
pub_type： 临床试验,杂志文章
doi：10.1007/BF00917978
更新日期：1992-09-01 00:00:00
abstract：:We report on two cases of bilateral chorioretinal colobomas with ocular anomalies in patients with CHARGE syndrome. In the first case, a female infant was born at 36 + 5 weeks gestation. At birth, the patient demonstrated a small left eye. Slit-lamp examination revealed colobomas of both irises. Fundus examination sho...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-013-9817-4
更新日期：2014-06-01 00:00:00
abstract：:A 61-year-old male developed recurrent anterior uveitis over a period of 8 months after an uncomplicated phacoemulsification and posterior chamber intraocular lens implantation surgery. This was subsequently found to be due to a retained lens fragment in the anterior segment, with complete resolution following surgica...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-008-9279-2
更新日期：2010-02-01 00:00:00
abstract：:We encountered two cases of Harada's disease in monozygotic twins, and this is the first such report as far as could be determined. Case 1 was a 32-year-old woman who presented a typical clinical picture of Harada's disease. Seven years later, case 2 (the younger sister), also presented with the disease at 39 years of...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/BF00917073
更新日期：1992-01-01 00:00:00
abstract：:To evaluate the efficacy of golimumab on severe and frequent recurrent anterior uveitis in patients with HLA-B27-positive ankylosing spondylitis. In this study, 15 eyes of 12 HLA-B27-positive AS patients with resistant anterior uveitis who received 50 mg of subcutaneous golimumab (Gol) per month due to frequent uveiti...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-016-0239-y
更新日期：2017-02-01 00:00:00
abstract：:The incidence of endophthalmitis after pars plana vitrectomy is low. Silicone oil is a tamponading agent which has anti-microbial activity. Post-operative endophthalmitis following vitrectomy with silicone oil tamponade has been rarely reported. We describe the case of a young male who underwent pars plana vitrectomy ...
journal_title：International ophthalmology
pub_type： 杂志文章,评审
doi：10.1007/s10792-015-0072-8
更新日期：2015-08-01 00:00:00
abstract：:Diabetes mellitus and pregnancy have reciprocal influences between them, therefore diabetes mellitus may complicate the course of pregnancy as well as pregnancy can worsen the performance of diabetes especially at the fundus oculi. Several factors seem to play a role in retinal neovascularization. Actually it's not po...
journal_title：International ophthalmology
pub_type： 杂志文章,评审
doi：10.1007/s10792-014-9906-z
更新日期：2014-08-01 00:00:00
abstract：PURPOSE:The study aims to evaluate changes in neopterin levels and tryptophan degradation which are induced by Th1-type immune response and nitric oxide metabolism which may be involved in allergic inflammation. METHODS:Serum nitrite, kynurenine, tryptophan and neopterin levels were evaluated in 36 patients with seaso...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-017-0669-1
更新日期：2018-10-01 00:00:00
abstract：:A young patient is described who presented with sudden visual loss in the left eye quickly followed by proliferative retinopathy with retinal detachment and thrombotic glaucoma. He developed similar initial symptoms in the right eye but has now made a complete recovery in that eye on systemic steroids, oral acyclovir,...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/BF00163567
更新日期：1990-10-01 00:00:00
abstract：:We report the immunopathology and histopathology of a patient with Terson syndrome. The design was an observational case-report. Histopathology and immunohistochemical staining for endoglin (CD105) of an eye from a patient with subarachnoid haemorrhage and Terson syndrome was performed. Immunohistology revealed high p...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-010-9343-6
更新日期：2010-08-01 00:00:00
abstract：:The purpose of this study is to evaluate whole lysyl oxidase like 1 (LOXL1) gene by sequence analysis in Turkish patients with exfoliation glaucoma (XFG). A total of 48 (35 male, 13 female) patients with XFG were enrolled. Besides routine ophthalmological examination, peripapillary retinal nerve fibre layer (RNFL) ana...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-016-0174-y
更新日期：2016-10-01 00:00:00
abstract：PURPOSE:To describe the incidence of, and risk factors associated with, diabetic retinopathy in diabetic persons assessed at a Saudi diabetes centre. METHODS:Five hundred and two patients with diabetes mellitus assessed by our service were studied. There were 174 patients (34.7%) with insulin-dependent diabetes mellit...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1023/a:1006240928938
更新日期：1998-01-01 00:00:00
