Abstract：
PURPOSE:To evaluate the effect of metronidazole ophthalmic solutions on corneal neovascularization (CNV) in a rat model. METHODS:A chemical burn was created in the right central cornea of 40 rats. Animals were randomized and distributed into four study groups (n = 10 rats per group) designated Met_0.1%, Met_0.5%, sham, and untreated groups. Chemical-burned corneas in the Met_0.1% and Met_0.5% groups received ophthalmic solutions of 0.1 and 0.5% metronidazole, respectively. Corneas in the sham group received phosphate-buffered saline (metronidazole diluent). All treated eyes received ophthalmic solution at intervals of 6 h, for up to 30 days. Untreated corneas received no treatment. CNV was evaluated postinjury using corneal photographs at different evaluation time points. The main CNV outcome measures were: burn intensity, index of CNV, and percentage of vascularized corneal area. Five rats from each group were euthanized, on days 15 and 30; the samples were collected for histological analyses. Differences with P < 0.05 were considered significant. RESULTS:CNV was observed in the eyes from day 7 postinjury. However, the indices of CNV for the Met_0.1% and Met_0.5% groups were smaller than those for the sham and untreated groups (P < 0.05). Furthermore, corneas treated with 0.1 or 0.5% metronidazole had smaller vascularized areas compared to control corneas. On histological study, the presence of blood vessels confirmed clinical outcomes. CONCLUSIONS:Regular instillation of 0.1 or 0.5% metronidazole had a significant inhibitory effect for CNV on chemical burns induced in a rat model.
journal_name
Int Ophthalmoljournal_title
International ophthalmologyauthors
Claros-Chacaltana FDY,Aldrovani M,Kobashigawa KK,Padua IRM,Valdetaro GP,de Barros Sobrinho AAF,Abreu TGM,Laus JLdoi
10.1007/s10792-018-0922-2subject
Has Abstractpub_date
2019-05-01 00:00:00pages
1123-1135issue
5eissn
0165-5701issn
1573-2630pii
10.1007/s10792-018-0922-2journal_volume
39pub_type
杂志文章abstract：PURPOSE:To investigate risk factors for choroidal detachment after trabeculectomy. METHODS:We prospectively evaluated 97 patients with open-angle glaucoma who underwent primary trabeculectomy to investigate risk factors for choroidal detachment after trabeculectomy. The primary outcome measure was risk factors for the...
journal_title：International ophthalmology
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更新日期：2020-05-01 00:00:00
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journal_title：International ophthalmology
pub_type： 杂志文章
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更新日期：1989-01-01 00:00:00
abstract：PURPOSE:This study compares outcomes and complications of scleral-fixated intraocular lens implantation between 2 levels of surgeons. METHODS:A retrospective case series of patients undergoing scleral-fixated intraocular lens implantation at Prince of Wales Hospital, Hong Kong, between May 2012 and April 2017 were rev...
journal_title：International ophthalmology
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abstract：BACKGROUND:Only a few studies have investigated structural and functional changes in monocular blind individuals. Our aim in this study was to segmentally investigate the cerebellar structures of subjects with late-onset monocular blindness (LMB) using a Voxel-based volumetric analysis system. METHODS:The segmental vo...
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journal_title：International ophthalmology
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journal_title：International ophthalmology
pub_type： 杂志文章
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journal_title：International ophthalmology
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更新日期：1982-11-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2008-06-01 00:00:00
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更新日期：2016-04-01 00:00:00
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journal_title：International ophthalmology
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更新日期：1978-09-01 00:00:00
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更新日期：2001-01-01 00:00:00
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abstract：:The clinical and pathological presentation of Behçet's disease are discussed. Necrotising arteriolitis and phlebitis with thromboses are demonstrated when a rare enucleation specimen became available for examination in this condition. Immunohistochemical studies show mural IgG, IgA, and C3 deposits in episcleral and s...
journal_title：International ophthalmology
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doi：10.1007/BF00128365
更新日期：1985-03-01 00:00:00
abstract：:A case of orbital metastasis of cervical keratinizing squamous cell carcinoma is presented. The patient, in remission from primary cervical and ovarian cancers, presented with complaints of left eye ptosis and pain. Examination revealed the presence of a moderately tender mass along the left supra-temporal orbital rim...
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abstract：:Glaucoma after penetrating keratoplasty is a frequently observed post-operative complication and is a risk factor for graft failure. Penetrating keratoplasty performed for aphakic and pseudophakic bullous keratopathy and inflammatory conditions are more likely to cause postoperative glaucoma compared with keratoconus ...
journal_title：International ophthalmology
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更新日期：2018-10-01 00:00:00
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journal_title：International ophthalmology
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更新日期：1992-05-01 00:00:00
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pub_type： 杂志文章
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更新日期：2018-08-01 00:00:00
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更新日期：2001-01-01 00:00:00
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journal_title：International ophthalmology
pub_type： 杂志文章,评审
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abstract：:The main visual field indices of Flammer and the analogous ones of Heijl have been compared based on a population of 113 glaucomatous visual fields. It is shown that for the population studied, the differences between the two sets of indices are negligible for Octopus G1 program results and that they may thus be used ...
journal_title：International ophthalmology
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doi：10.1007/BF00128955
更新日期：1991-09-01 00:00:00
