Abstract：
:To evaluate the efficacy of golimumab on severe and frequent recurrent anterior uveitis in patients with HLA-B27-positive ankylosing spondylitis. In this study, 15 eyes of 12 HLA-B27-positive AS patients with resistant anterior uveitis who received 50 mg of subcutaneous golimumab (Gol) per month due to frequent uveitis recurrences were analyzed retrospectively between May 2013 and October 2015. Assessment criteria were uveitis activity, the number of recurrence of uveitis, visual acuity, systemic corticosteroid, or other drug requirement for maintenance of remission of AU. Twelve patients (15 eyes) with HLA-B27-positive ankylosing spondylitis and anterior uveitis have been treated with golimumab 50 mg/month. Remission of uveitis was observed in 12 eyes out of 15. Malign hypertension developed in one subject after the second dose of golimumab therefore the treatment was stopped and this subject was excluded from the study. Median follow-up time was 11 months (interquartile range: 8-18). No uveitic reaction was seen except in the patient who stopped treatment. No topical or systemic steroid necessity was needed except in two cases with oral 4 mg systemic maintenance. Visual acuity was significantly increased (p = 0.002). Golimumab may be a new and effective choice for maintaining remission and the prevention of recurrences of severe, resistant anterior uveitis in patients with HLA-B27-positive ankylosing spondylitis.
journal_name
Int Ophthalmoljournal_title
International ophthalmologyauthors
Yazgan S,Celik U,Işık M,Yeşil NK,Baki AE,Şahin H,Gencer E,Doğan İdoi
10.1007/s10792-016-0239-ysubject
Has Abstractpub_date
2017-02-01 00:00:00pages
139-145issue
1eissn
0165-5701issn
1573-2630pii
10.1007/s10792-016-0239-yjournal_volume
37pub_type
杂志文章abstract：PURPOSE:To compare the visual and refractive outcomes after FEMTOLASIK with and without iris registration. METHODS:In this randomized, prospective, comparative, contralateral eye study, 118 eyes of 59 patients with myopia and myopic astigmatism underwent LASIK using the Femto LDV femtosecond laser (160 µm) and the MEL...
journal_title：International ophthalmology
pub_type： 杂志文章,随机对照试验
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更新日期：2018-10-01 00:00:00
abstract：:I have developed two protective caps that fit on the viewing windows of the indirect ophthalmoscope. These caps contain filters that absorb the argon laser beam and protect the operator's eyes during endolaser treatment. ...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/BF00225937
更新日期：1986-04-01 00:00:00
abstract：:The beneficial effect of photocoagulation in diabetic retinopathy is now established (2-6, 10). Whereas the capability of providing photocoagulation is widespread, the indications and actual techniques are poorly defined. In this paper, we propose to discuss the principles of photocoagulation. In a following paper the...
journal_title：International ophthalmology
pub_type： 杂志文章
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更新日期：1978-09-01 00:00:00
abstract：OBJECTIVES:To compare the intraocular pressure (IOP)-lowering effects of ripasudil, a rho-kinase inhibitor, and selective laser trabeculoplasty (SLT) as adjuvant therapy in Japanese glaucoma patients and to identify the factors associated with treatment success. METHODS:We performed a retrospective medical chart revie...
journal_title：International ophthalmology
pub_type： 杂志文章
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更新日期：2020-10-20 00:00:00
abstract：PURPOSE:To compare capillaries perfusion in macular areas at different layers and peripapillary region in radial peripapillary capillaries (RPC) between healthy subjects and subjects with obstructive sleep apnea-hypopnea (OSA) using spectral-domain optical coherence tomography angiography (OCTA). METHODS:Totally 16 ey...
journal_title：International ophthalmology
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abstract：PURPOSE:To report the first European case of endogenous endophthalmitis secondary to a liver abscess due to Klebsiella pneumoniae expressing MagA gene. METHODS:A 33-year-old diabetic patient was admitted for fever and right upper quadrant abdominal pain. Abdominal computed tomography and laboratory studies were perfor...
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doi：10.1007/s10792-007-9111-4
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journal_title：International ophthalmology
pub_type： 临床试验,杂志文章
doi：10.1007/s10792-011-9488-y
更新日期：2011-12-01 00:00:00
abstract：BACKGROUND:With the increasing prevalence of electronic readers (e-readers) for vocational and professional uses, it is important to discover if there are visual consequences in the use of these products. There are no studies in the literature quantifying the incidence or severity of eyestrain, nor are there clinical c...
journal_title：International ophthalmology
pub_type： 杂志文章,随机对照试验
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更新日期：2017-04-01 00:00:00
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journal_title：International ophthalmology
pub_type： 杂志文章
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pub_type： 杂志文章
doi：10.1007/s10792-012-9550-4
更新日期：2012-04-01 00:00:00
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journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/BF00159865
更新日期：1990-07-01 00:00:00
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journal_title：International ophthalmology
pub_type： 杂志文章
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更新日期：2017-08-01 00:00:00
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pub_type： 临床试验,杂志文章
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journal_title：International ophthalmology
pub_type： 杂志文章
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更新日期：2009-08-01 00:00:00
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journal_title：International ophthalmology
pub_type： 杂志文章
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更新日期：1988-01-01 00:00:00
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更新日期：1994-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：2018-08-01 00:00:00
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journal_title：International ophthalmology
pub_type： 杂志文章
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更新日期：1998-01-01 00:00:00
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journal_title：International ophthalmology
pub_type： 杂志文章
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更新日期：1987-08-01 00:00:00
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pub_type： 杂志文章
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更新日期：2020-10-14 00:00:00
