Abstract：
OBJECTIVE:To assess the comprehensive effects of raloxifene hydrochloride on retinal, choroidal and retrobulbar hemodynamics and on visual function in post-menopausal women. DESIGN:Twenty-four post-menopausal women (age 55 +/- 3.8 years) were recruited for this cross-sectional study: 12 received placebo and 12 received raloxifene hydrochloride 60 mg once a day for 3 months. Baseline measurements of both groups included heart rate (HR), blood pressure (BP), visual acuity, contrast sensitivity and intraocular pressure (IOP) for both eyes. A comprehensive ocular blood flow (OBF) assessment was obtained for each patient in a randomly chosen study eye. Retinal blood flow data was obtained using confocal scanning laser Doppler flowmetry [Heidelberg Retinal Flowmeter (HRF)]. Color Doppler imaging (CDI) was used to assess retrobulbar hemodynamics in the ophthalmic, central retinal, short nasal and temporal posterior ciliary arteries. Baseline vision and hemodynamics in post-menopausal subjects were compared using paired Student's t tests, and the percentage change in baseline versus 3-month parameters was analyzed. RESULTS:There were no statistically significant differences between 3 months of raloxifene therapy and placebo in terms of age, HR, arterial or mean BP, visual acuity, contrast sensitivity, IOP or retinal or retrobulbar blood flow. CONCLUSION:Raloxifene therapy at 60 mg/day had no clinically significant impact on BP, IOP or OBF in post-menopausal women.
journal_name
Int Ophthalmoljournal_title
International ophthalmologyauthors
Siesky B,Harris A,Kheradiya N,Ehrlich R,Klaas C,Kaplan B,Catoira Y,McCranor L,Rospigliosi C,Harris Mdoi
10.1007/s10792-008-9224-4subject
Has Abstractpub_date
2009-08-01 00:00:00pages
225-30issue
4eissn
0165-5701issn
1573-2630journal_volume
29pub_type
临床试验,杂志文章abstract：:To report a unusual case of an isolated traumatic stellated tarso-conjunctival laceration located in the upper left eyelid without eyelid margin involvement and with normal ocular examination. A 19 year-old male wounded by a bokken (wooden katana) while practicing a sham duel had an isolated eyelid tarso-conjunctival ...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-012-9573-x
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abstract：:Diabetes mellitus and pregnancy have reciprocal influences between them, therefore diabetes mellitus may complicate the course of pregnancy as well as pregnancy can worsen the performance of diabetes especially at the fundus oculi. Several factors seem to play a role in retinal neovascularization. Actually it's not po...
journal_title：International ophthalmology
pub_type： 杂志文章,评审
doi：10.1007/s10792-014-9906-z
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journal_title：International ophthalmology
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journal_title：International ophthalmology
pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：International ophthalmology
pub_type： 杂志文章
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pub_type： 杂志文章,随机对照试验
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journal_title：International ophthalmology
pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：International ophthalmology
pub_type： 杂志文章
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