Abstract:
PURPOSE:To identify risk factors for endogenous endophthalmitis (EE) in hospitalized adults, under 65 years of age, with a history of intravenous opioid use and non-ocular infection. METHODS:The National Inpatient Sample Database was used to identify cases of EE with a recent history of intravenous opioid use disorder with associated non-ocular infection. Systemic and ocular comorbidities were identified using codes from the International Classification of Diseases, Ninth Revision (ICD-9). Descriptive and regression analyses were performed to evaluate the risk factors for EE using IBM SPSS 23. RESULTS:Of the 605,859 inpatients, 21-65 years age, who had a history of recent opioid-IVDU and an associated IVDU-associated systemic infection, 363 (0.1%) had EE. Systemic comorbidities such as diabetes mellitus, mitral valve disease, aortic valve disease, history of cardiac valve transplantation, chronic kidney disease/renal failure, cirrhosis, active or previous radiation therapy, and history of solid organ transplantation were significantly more prevalent in patients with EE. A significantly increased risk of EE in intravenous opioid users was noted if they were of male gender (OR = 1.84), Asian/Pacific Islander ethnicity (OR = 4.41), had history of cirrhosis (OR = 2.33), active or history of radiation therapy (OR = 14.74), history of solid organ transplantation (OR = 5.91), candidemia (OR = 15.22), and infectious endocarditis (OR = 4.83). Conversely, concurrent alcohol use disorder (OR = 0.35) decreased the risk of EE. CONCLUSION:Various demographic variables and systemic comorbidities increased the risk of developing EE in inpatients with a history of intravenous opioid use with associated non-ocular infection.
journal_name
Int Ophthalmoljournal_title
International ophthalmologyauthors
Uppuluri A,Zarbin MA,Bhagat Ndoi
10.1007/s10792-021-01709-0subject
Has Abstractpub_date
2021-01-27 00:00:00eissn
0165-5701issn
1573-2630pii
10.1007/s10792-021-01709-0pub_type
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journal_title:International ophthalmology
pub_type: 杂志文章
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journal_title:International ophthalmology
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1007/s10792-020-01518-x
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pub_type: 杂志文章
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更新日期:1992-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:1983-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s10792-006-9027-4
更新日期:2007-04-01 00:00:00
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journal_title:International ophthalmology
pub_type: 临床试验,杂志文章
doi:10.1007/s10792-016-0428-8
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pub_type: 杂志文章
doi:10.1007/s10792-014-9964-2
更新日期:2014-10-01 00:00:00
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2015-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:2019-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2013-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:2019-09-01 00:00:00
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2010-08-01 00:00:00
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journal_title:International ophthalmology
pub_type: 已发布勘误
doi:10.1007/s10792-020-01327-2
更新日期:2020-04-01 00:00:00