Abstract:
:Clinical trials are often used to evaluate the efficacy of a given treatment. The results of clinical trials however do not always agree with a clinician's experience or intuition. The merits and demerits of Clinical Trials versus Intuition are discussed by using the laser photocoagulation trials of Proliferative Diabetic Retinopathy, Central serous retinopathy, Branch Vein Occlusion (treatment for macular oedema), Senile Macular Degeneration, and Pigment Epithelial Detachment. A model based on Intuition is used to explain the discrepancy between the results of the British and American trials of Branch Vein Occlusion and Senile Macular Degeneration. Proposals on the presentation of Clinical Trials and the place of Intuition are made.
journal_name
Int Ophthalmoljournal_title
International ophthalmologyauthors
Wong D,Blach RKdoi
10.1007/BF00159835subject
Has Abstractpub_date
1986-05-01 00:00:00pages
71-6issue
2-3eissn
0165-5701issn
1573-2630journal_volume
9pub_type
杂志文章abstract:OBJECTIVE:The aim of this study was to evaluate the effect retrobulbar and topical anesthesia on optic nerve by measuring retinal nerve fiber layer (RNFL) thickness before and after phacoemulsification cataract surgery using optical coherence tomography (OCT). METHODS:A total of 126 eyes of 108 patients were included ...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-020-01338-z
更新日期:2020-07-01 00:00:00
abstract::Ectopic cilia are the most rare of cilial anomalies. We report a 27-year-old man who presents with tarsal conjunctival symptomatic ectopic cilia. On slit-lamp examination eversion of the lower eyelid demonstrated that several black-white cilia were protruding from the conjunctiva. ...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-008-9228-0
更新日期:2009-08-01 00:00:00
abstract::The appearance of a hypopyon is an extremely uncommon finding in acute angle-closure glaucoma and only a few cases have been previously reported in the literature. We report a fifty-year-old female who, following a recent bereavement, presented with classical features of acute angle-closure glaucoma and a hypopyon. Th...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/BF00942925
更新日期:1993-06-01 00:00:00
abstract:BACKGROUND:With the increasing prevalence of electronic readers (e-readers) for vocational and professional uses, it is important to discover if there are visual consequences in the use of these products. There are no studies in the literature quantifying the incidence or severity of eyestrain, nor are there clinical c...
journal_title:International ophthalmology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s10792-016-0281-9
更新日期:2017-04-01 00:00:00
abstract:PURPOSE:The aim of the present study was to prospectively examine the effect of two styles of PRP, full- and mild-scatter on central and peripheral visual field in diabetic patients. METHODS:40 eyes with preproliferative or early proliferative diabetic retinopathy of 32 patients underwent visual field testing on the C...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1023/a:1006367029134
更新日期:1998-01-01 00:00:00
abstract:PURPOSE:To evaluate whether retinal arteriolar widths change in normal patients and in different glaucoma types. We measured the arteriolar width at the merge in the optic nerve (MD), at the edge of the optic nerve (ED) and at the peripapillary area (1 disc diameter distance) (disc distance D). HRT software 1.11, Inter...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1023/a:1014417606396
更新日期:2001-01-01 00:00:00
abstract:PURPOSE:To compare the outcome of penetrating keratoplasty (PKP) and deep anterior lamellar keratoplasty (DALK) in the surgical management of keratoconus (KC). PATIENT AND METHODS:A retrospective review was conducted of the medical records of all patients treated with PKP or DALK for KC at University of Iowa Hospitals...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-010-9393-9
更新日期:2010-12-01 00:00:00
abstract::Three cases of orbital tuberculosis are presented, two as cold abscess in the orbit and one as a chronic indolent sinus. A simple clinical test like Fine Needle Aspiration Cytology (FNAC) can demonstrate some or all of the characteristic pathological features like caseating necrosis, epitheloid cells and Langhan's gia...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/BF00915963
更新日期:1994-01-01 00:00:00
abstract::We report a case of transient ectropion associated with corneal ulcer. The corneal ulcer responded well to treatment with fortified gentamicin and cefazolin. As the corneal ulcer healed, the eyelid simultaneously returned to its original position. We suggest that in the presence of involutional eyelid changes, even a ...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1023/a:1006004320762
更新日期:1997-01-01 00:00:00
abstract:PURPOSE:To describe a case of scattered toxicity of indocyanine green on the outer retina and retinal pigment epithelium (RPE) after indocyanine green (ICG) assisted membrane peeling for macular pucker. METHODS:A 61-year-old woman was examined by slit-lamp biomicroscopy, fluorescein angiography (FA), indocyanine green...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-007-9112-3
更新日期:2008-04-01 00:00:00
abstract::To study the efficacy and safety of sutureless amniotic membrane transplantation combined with narrow-strip conjunctival autograft and to investigate the clinical outcomes. Thirty eyes of 30 patients with primary pterygia were treated in this institutional study with excision followed by sutureless amniotic membrane t...
journal_title:International ophthalmology
pub_type: 临床试验,杂志文章
doi:10.1007/s10792-011-9488-y
更新日期:2011-12-01 00:00:00
abstract:PURPOSE:To evaluate the performance of full-thickness (FT) versus partial-thickness (PT) sutures in a full-thickness corneal wound in an animal model. METHODS:This is a prospective, experimental, comparative, longitudinal study. A 6-mm linear, full-thickness corneal incision was performed on the right eye of eight dom...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-020-01585-0
更新日期:2021-01-01 00:00:00
abstract:PURPOSE:To evaluate rotational stability and visual and refractive outcomes of supplementary toric IOLs (Sulcoflex Toric 653T, Rayner Intraocular Lenses Ltd) for residual astigmatic refractive error in pseudophakic eyes. METHODS:A retrospective interventional case series was conducted in a single surgeon practice. Cha...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-018-1027-7
更新日期:2019-09-01 00:00:00
abstract:PURPOSE:Coagulase-negative staphylococci have been reported to be the most frequent cause of bacterial postoperative endophthalmitis. Biofilm formation is the major virulence factor of Staphylococcus epidermidis and is often associated with methicillin resistance. This study aims at evaluating the presence of biofilm-p...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-016-0339-8
更新日期:2017-08-01 00:00:00
abstract:PURPOSE:The Pascal dynamic contour tonometer (DCT) allows measurement of intraocular pressure (IOP) independently of corneal properties. It records, simultaneously, haemodynamic IOP fluctuations and the difference between the systolic and the diastolic IOP corresponding to the ocular pulse amplitude (OPA). The OPA indi...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-007-9161-7
更新日期:2007-12-01 00:00:00
abstract:PURPOSE:To evaluate the efficacy of long-tube shunt surgery (LTSS) without valve in uveitic glaucoma (UG) eyes. METHODS:We retrospectively analyzed the data of 45 UG eyes that underwent only LTSS or LTSS combined with trabeculectomy (TLE) (LTSS/TLE). The UG eyes were analyzed by categorizing them into granulomatous/no...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-020-01601-3
更新日期:2020-10-14 00:00:00
abstract:PURPOSE:The purpose of this study was to evaluate the accuracy of the convolutional neural network (CNN) model in glaucoma identification with three primary colors (red, green, blue; RGB) and split color channels using fundus photographs with a small sample size. METHODS:The dataset was prepared using color fundus pho...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-020-01485-3
更新日期:2020-11-01 00:00:00
abstract:PURPOSE:The objective of this study is to examine the morphometry of the lacrimal drainage system with reference to bony landmarks in the vicinity. METHODS:Twenty midsaggitalized heads obtained from sixteen preserved cadavers were studied. Measurements involved detailed morphometry of anterior and posterior lacrimal c...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-017-0753-6
更新日期:2018-12-01 00:00:00
abstract:UNLABELLED:The purpose of this study is to evaluate the effect of trephination with free scleral auto-implant plug exposed to Mitomycin-C out of the eye, in surgical treatment of primary open-angle glaucoma (POAG), in comparison with efficacy of trabeculectomy with MMC (32 eyes with POAG of patients, younger than 55 ye...
journal_title:International ophthalmology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF00212952
更新日期:1996-01-01 00:00:00
abstract:BACKGROUND:Cyclocryotherapy and transscleral cyclophotocoagulation are commonly used procedures for the treatment of refractory glaucoma, but still with many complications. Ultrasound cyclo plasty (UCP) is a novel technique that determines a selective and more precise coagulation necrosis of the ciliary body to reduce ...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-020-01606-y
更新日期:2020-10-18 00:00:00
abstract:PURPOSE:To report two cases of ciliochoroidal effusion after the usage of topiramate. CASES:Two middle-aged women experienced sudden onset of acute glaucoma and acquired myopia after taking topiramate. Ultrasound biomicroscopy demonstrated bilateral ciliochoroidal effusion and angle closure. The A-scan ultrasonography...
journal_title:International ophthalmology
pub_type: 杂志文章,评审
doi:10.1007/s10792-017-0740-y
更新日期:2018-12-01 00:00:00
abstract:PURPOSE:To assess variability in the coefficient of variation (COV) in cell area estimates when using different numbers of cells for endothelial morphometry. METHODS:Using non-contact specular microscopy images of the corneal endothelium, 4 sets of 20 cases were selected that included 200 cells and had overall (global...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-017-0765-2
更新日期:2018-12-01 00:00:00
abstract:PURPOSE:To evaluate the long-term safety and efficacy of Mycophenolate Mofetil (MMF) for the control of cystoid macular oedema (CMO) secondary to noninfectious uveitis (NU). METHODS:The medical records of 19 consecutive patients with inflammatory CMO treated with MMF were retrospectively reviewed. Patient demographics...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-008-9200-z
更新日期:2009-06-01 00:00:00
abstract:PURPOSE:To explore the protective effect of probucol on human retinal Müller cells cultured in high glucose. METHODS:Primary Müller cells from human retinas were cultured in complete DMEM. Third-generation Müller cells were identified using glutamine synthetase (GS) antibody and randomly divided into three groups: nor...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-019-01130-8
更新日期:2019-12-01 00:00:00
abstract:PURPOSE:To estimate objective visual acuity in subjects suffering from cataract and age-related macular degeneration via the optokinetic response evoked by a non-conventional induction method (oktotype); in addition, to compare such objective outcome with the subjective acuity based on the ETDRS charts. METHODS:Patien...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-018-1001-4
更新日期:2019-08-01 00:00:00
abstract::To evaluate the clinical efficacy of transcutaneous everting sutures for lower eyelid involutional entropion in Chinese patients. A retrospective, non-comparative, interventional case series. This retrospective study consecutively reviewed the medical records of all patients with involutional lower eyelid entropion wh...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-013-9893-5
更新日期:2014-08-01 00:00:00
abstract:PURPOSE:To report a case of resolution of retinal arterial aneurysms in a patient of idiopathic retinal vasculitis, aneurysms and neuroretinitis (IRVAN) treated with oral steroids. METHODS:This study contains case report and review of literature. RESULTS:A 16-year-old girl with stage 2 IRVAN was treated with oral ste...
journal_title:International ophthalmology
pub_type: 杂志文章,评审
doi:10.1007/s10792-018-0913-3
更新日期:2019-05-01 00:00:00
abstract:PURPOSE:The purpose of the study was to assess the reproducibility of ocular biometry using the IOLMaster-700 in a healthy population. METHODS:This is a prospective, cross-sectional, observational reproducibility study. Ocular biometry was performed three times on each of 45 studied eyes. Flattest meridian (Kf) and th...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-016-0380-7
更新日期:2017-10-01 00:00:00
abstract:PURPOSE:Corneal melting with perforation is a severe ophthalmic complication of autoimmune disorders such as rheumatoid arthritis. It requires urgent medical management in order to maintain the integrity of the globe and preserve vision. Treating this complication by penetrating keratoplasty is problematic due to the h...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-017-0545-z
更新日期:2018-06-01 00:00:00
abstract:PURPOSE:To provide normal corneal elevation data for a large Caucasian population and to determine the impacts on these data of age, sex, axial length (AXL) and horizontal white-to-white (WW). SETTING:Centro Internacional de Oftalmología Avanzada, Madrid, Spain. DESIGN:Retrospective, cross-sectional, observational. ...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-018-1028-6
更新日期:2019-09-01 00:00:00