Abstract:
PURPOSE:To assess variability in the coefficient of variation (COV) in cell area estimates when using different numbers of cells for endothelial morphometry. METHODS:Using non-contact specular microscopy images of the corneal endothelium, 4 sets of 20 cases were selected that included 200 cells and had overall (global) COV values of less than 30 (group 1), 31-40 (group 2), 41-50 (group 3) and over 50% (group 4). Subjects could be normal, or had ophthalmic disease (such as diabetes), a history of rigid or soft contact lens wear or were assessed after cataract surgery. A step-wise analysis was undertaken, 20 cells at a time, of the variability in cell area estimates when using different numbers of cells for the calculations. RESULTS:Variability in the average cell area values was higher if only 20-60 cells were used in the calculations and then tended to decrease. The standard deviation values on these average cell area values and the calculated COV showed the same overall trends and were more than twice as large for endothelia with marked polymegethism. Using more than 100 cells/image in markedly polymegethous endothelia only increased the variability in the calculations. CONCLUSIONS:These analyses indicate that substantial region variability in cell area values can be expected in polymegethous endothelia. The analysis further confirm that using only small numbers of cells (e.g. less than 50/image) in such cases is likely to yield far less reliable estimates of COV.
journal_name
Int Ophthalmoljournal_title
International ophthalmologyauthors
Doughty MJdoi
10.1007/s10792-017-0765-2subject
Has Abstractpub_date
2018-12-01 00:00:00pages
2537-2546issue
6eissn
0165-5701issn
1573-2630pii
10.1007/s10792-017-0765-2journal_volume
38pub_type
杂志文章abstract:PURPOSE:To compare the visual and refractive outcomes after FEMTOLASIK with and without iris registration. METHODS:In this randomized, prospective, comparative, contralateral eye study, 118 eyes of 59 patients with myopia and myopic astigmatism underwent LASIK using the Femto LDV femtosecond laser (160 µm) and the MEL...
journal_title:International ophthalmology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s10792-017-0703-3
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND:Bevacizumab (Avastin) has been used as off-label treatment for the specific inhibition of the vascular endothelial growth factor (VEGF). Although only intravenous administration of the drug is approved in combination therapy of colorectal carcinoma, promising short-term results have been reported about its i...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-007-9122-1
更新日期:2008-04-01 00:00:00
abstract::XPERT NCT advanced logic pneumotonometer (Reichert) was studied for its reliability and use in glaucoma screening. The evaluated 2400 NCT measurements on 300 eyes were compared to the results of Goldmann applanation tonometry (GAT) from the same eyes. Repeated NCT tonometry had no significant effect on IOP. Local anes...
journal_title:International ophthalmology
pub_type: 临床试验,杂志文章
doi:10.1007/BF00917978
更新日期:1992-09-01 00:00:00
abstract:PURPOSE:To compare the efficacy and safety of two intravitreal anti-vascular endothelial growth factor (anti-VEGF) agents, ranibizumab and aflibercept, for the treatment of vascularized pigment epithelium detachment (vPED) due to age-related macular degeneration (AMD) in a follow-up time of 12 months. METHODS:Particip...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-018-0833-2
更新日期:2019-02-01 00:00:00
abstract::The Hermansky-Pudlak Syndrome, a "tyrosinase positive' form of oculocutaneous albinism, is a triad comprising albinism, a hemorrhagic diathesis and ceroid-lipofuscin storage. A pedigree is presented showing consanguinity with a pattern of pseudodominance. Electroretinography in two isolated Hermansky-Pudlak subjects w...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/BF00139585
更新日期:1981-08-01 00:00:00
abstract:PURPOSE:To assess the comparative efficacy and the long-term cost-utility of alternative minimally invasive glaucoma surgeries (MIGSs) when combined with cataract surgery in patients with primary open-angle glaucoma (POAG). METHODS:Treatment effects, as measured by the 1-year reduction in intraocular pressure (IOP), w...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-020-01314-7
更新日期:2020-06-01 00:00:00
abstract::To investigate the correlation between the perifoveal capillary blood flow velocity (BFV) and the vitreous level of pigment epithelium-derived factor (PEDF) in patients with branch retinal vein occlusion (BRVO) and macular edema. In a retrospective interventional study of patients with BRVO and macular edema, undilute...
journal_title:International ophthalmology
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doi:10.1007/s10792-012-9584-7
更新日期:2012-10-01 00:00:00
abstract::Retinal astrocytic hamartomas are benign tumors of the retinal nerve fiber layer (NFL) that may be found in association with tuberous sclerosis (TS). We describe the spectral-domain optical coherence tomography (SD-OCT) features of type 1 astrocytic hamartomas in a child with TS that may aid in the diagnosis and follo...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-012-9586-5
更新日期:2012-10-01 00:00:00
abstract::To report an unusual case of primary paranasal sinus lymphoma associated with intraocular secondary uveal involvement. Retrospective case report emphasizing the histopathologic diagnosis as well as imaging studies, and review of the pertinent literature. The diagnosis of ophthalmologic lymphoma can be difficult due to...
journal_title:International ophthalmology
pub_type: 杂志文章,评审
doi:10.1007/s10792-012-9570-0
更新日期:2012-08-01 00:00:00
abstract::Sensorineural hearing loss is the most common disease associated with systemic retinitis pigmentosa (RP). We have conducted an epidemiological study to assess the correlation of age at onset of visual symptoms and hearing loss associated with RP. Epidemiological data was derived from a questionnaire-based study of pat...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-005-2035-y
更新日期:2004-10-01 00:00:00
abstract::Transvitreal pars plana sclerotomy using the contact Nd:YAG laser with a sapphire probe was performed on a group of rabbit eyes and compared with a similar procedure performed with a Ziegler knife. Although the intraocular pressure (IOP) was lowered in both groups of animals, the reduction was greater and more lasting...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/BF00130620
更新日期:1988-01-01 00:00:00
abstract:PURPOSE:To compare sub-tenon steroid plus anti-VEGF injection with anti-VEGF injection solely in the treatment of resistant diabetic macular edema (DME). METHOD:Patients who exhibited insufficient anatomic [over 350 μm central macular thickness (CMT)] and less than 3 lines of visual gain at least six anti-VEGF injecti...
journal_title:International ophthalmology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s10792-018-0977-0
更新日期:2019-07-01 00:00:00
abstract::The traditional opinion that increased intraocular pressure is the cause of glaucoma is controversial, probably mainly because of the fact that firm evidence for the value of pressure reduction is largely lacking. The present article reviews results from short term studies of visual fields before and after pressure re...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/BF02028651
更新日期:1989-01-01 00:00:00
abstract::We report our experience with three cases of Epstein-Barr virus (EBV)-associated uveitis. These patients had the following common clinical features: 1) a common cold-like prodrome, 2) bilateral involvement, 3) severe acute anterior uveitis with fibrinous exudate, 4) granulomatous anterior uveitis in the chronic stage,...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/BF00163559
更新日期:1990-10-01 00:00:00
abstract::A 71-year-old man presented with a large disciform scar in the right eye and hard (nodular) as well as soft (granular) drusen scattered throughout the posterior pole of the left eye. A large serous pigment epithelial detachment was evident in the drusen area of the left fundus. Six months later a tear of the retinal p...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/BF00139344
更新日期:1987-06-01 00:00:00
abstract:PURPOSE:To assess ophthalmic manifestations in patients with stroke and emphasize the importance of a formal screening for visual problems in stroke patients in hospital and rehabilitation settings. METHODS:This was a cross-sectional study of 50 newly diagnosed patients with stroke with Glasgow Coma Scale (GCS) > 8 ex...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-019-01131-7
更新日期:2019-12-01 00:00:00
abstract::Oximetry may be useful for understanding pathologies of the eye. We use a prototype scanning laser ophthalmoscope capable of simultaneous multiple wavelength imaging to record fundus images. The system is run under non-confocal conditions in using slit apertures with a width of up to 600 microm. The laser lines launch...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1023/a:1014406831412
更新日期:2001-01-01 00:00:00
abstract:PURPOSE:To demonstrate differences in optic nerve head (ONH), retinal nerve fiber layer (RNFL), and macular thickness in patients with internal carotid artery (ICA) stenosis using spectral domain optical coherence tomography (SD-OCT). METHODS:A case-controlled study was conducted in 31 patients with a diagnosis of uni...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-020-01642-8
更新日期:2020-11-10 00:00:00
abstract::There has been great controversy about the pathogenesis of the focal changes in the retinal pigment epithelium (RPE) causing detachment of the neurosensory retina in central serous chorioretinopathy (CSC). This study was performed to evaluate changes in choroidal perfusion in 15 patients with CSC. Fluorescein and indo...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/BF00133176
更新日期:1995-01-01 00:00:00
abstract:BACKGROUND:To evaluate the retinal nerve fiber layer (RNFL) and peripapillary vascular density (VD) changes in the pediatric group with optic disk drusen (ODD). METHODS:Sixty eyes of 30 patients with buried ODD referred by the pediatric or neurology physicians to ophthalmology clinic with a preliminary diagnosis of pa...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-021-01700-9
更新日期:2021-01-18 00:00:00
abstract:PURPOSE:To report a case of resolution of retinal arterial aneurysms in a patient of idiopathic retinal vasculitis, aneurysms and neuroretinitis (IRVAN) treated with oral steroids. METHODS:This study contains case report and review of literature. RESULTS:A 16-year-old girl with stage 2 IRVAN was treated with oral ste...
journal_title:International ophthalmology
pub_type: 杂志文章,评审
doi:10.1007/s10792-018-0913-3
更新日期:2019-05-01 00:00:00
abstract::Three cases of orbital tuberculosis are presented, two as cold abscess in the orbit and one as a chronic indolent sinus. A simple clinical test like Fine Needle Aspiration Cytology (FNAC) can demonstrate some or all of the characteristic pathological features like caseating necrosis, epitheloid cells and Langhan's gia...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/BF00915963
更新日期:1994-01-01 00:00:00
abstract::To describe a congenital retinal macrovessel with macular thickening. This case was investigated using fundus photography, fluorescein angiography, Spectralis optical coherence tomography and a 10-2 visual field test. A 23-year-old man was referred to our clinic with decreased vision in the right eye. Fundus examinati...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-010-9402-z
更新日期:2011-02-01 00:00:00
abstract:PURPOSE:To describe the outcome of a series of Acanthamoeba keratitis treated with a similar regimen. METHODS:All cases diagnosed with Acanthamoeba keratitis in a referral centre from June 1994 through June 1997 were included. Diagnosis of Acanthamoeba keratitis was based in clinical presentation and laboratory result...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1023/a:1006055918101
更新日期:1997-01-01 00:00:00
abstract::Ocular tuberculosis is difficult to diagnose but should be suspected when uveitis fails to respond to inflammation suppressive therapy. Interferon-gamma release assays (IGRAs) represent a substantial help to diagnose suspected ocular tuberculosis especially in non-endemic areas. Indocyanine green angiography (ICGA) is...
journal_title:International ophthalmology
pub_type: 杂志文章,评审
doi:10.1007/s10792-012-9588-3
更新日期:2012-10-01 00:00:00
abstract:BACKGROUND:Cyclocryotherapy and transscleral cyclophotocoagulation are commonly used procedures for the treatment of refractory glaucoma, but still with many complications. Ultrasound cyclo plasty (UCP) is a novel technique that determines a selective and more precise coagulation necrosis of the ciliary body to reduce ...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-020-01606-y
更新日期:2020-10-18 00:00:00
abstract:BACKGROUND:A study of the characteristics and the results obtained in 99 consecutive eyes operated on for rhegmatogenous retinal detachment associated with aphakia or pseudophakia in order to find the predictive factors of poor anatomical and functional results. METHODS:The authors retrospectively reviewed the files o...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/BF00176882
更新日期:1996-01-01 00:00:00
abstract:PURPOSE:To elucidate the role of trabeculectomy in advanced glaucoma. MATERIALS AND METHODS:Only patients with primary open-angle glaucoma were selected. All patients who had cup-disc ratio of 0.9 or a near-total cupping were given a trial of aggressive maximum medical therapy for IOP control for at least 4 weeks. Tar...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-017-0797-7
更新日期:2019-01-01 00:00:00
abstract::We encountered two cases of Harada's disease in monozygotic twins, and this is the first such report as far as could be determined. Case 1 was a 32-year-old woman who presented a typical clinical picture of Harada's disease. Seven years later, case 2 (the younger sister), also presented with the disease at 39 years of...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/BF00917073
更新日期:1992-01-01 00:00:00
abstract::We report on a patient with an overhanging bleb several years following trabeculectomy surgery with mitomycin C. ...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-011-9477-1
更新日期:2011-10-01 00:00:00