Abstract:
PURPOSE:To compare sub-tenon steroid plus anti-VEGF injection with anti-VEGF injection solely in the treatment of resistant diabetic macular edema (DME). METHOD:Patients who exhibited insufficient anatomic [over 350 μm central macular thickness (CMT)] and less than 3 lines of visual gain at least six anti-VEGF injections, were randomly divided into two groups. In group I, the anti-VEGF injection was performed 10 days after the sub-tenon steroid injection [Triamcinolone acetonide (Sinakort-A®)]. And anti-VEGF was performed when needed during the follow-up period. In group II, treatment was continued with anti-VEGF only. All patients' visual acuity and CMT were followed up for 6 months. RESULTS:The baseline BCVA in group I and group II was 0.51 ± 0.667 logMAR and 0.47 ± 0.60 logMAR, respectively (p = 0.52). In group I and II, at the end of 6-month follow-up, BCVA improved to 0.38 ± 0.60 logMAR (p < 0.001) and 0.43 ± 0.60 logMAR (p = 0.20), respectively. The baseline CMT in group I and group II was 494 ± 118.32 and 438.20 ± 90.99 μm, respectively (p = 0.029). In group I and II, at the end of 6 months, CMT decreased to 302.57 ± 69.89 μm (p < 0.001) and 439.20 ± 107.6 μm (p = 0.96), respectively. CONCLUSION:Adding steroid to routine anti-VEGF treatment is an effective way of treatment method for resistant DME.
journal_name
Int Ophthalmoljournal_title
International ophthalmologyauthors
Eriş E,Perente I,Vural E,Vural A,Seymen Z,Celebi ARC,Erdogan G,Ozkaya A,Artunay Odoi
10.1007/s10792-018-0977-0subject
Has Abstractpub_date
2019-07-01 00:00:00pages
1575-1580issue
7eissn
0165-5701issn
1573-2630pii
10.1007/s10792-018-0977-0journal_volume
39pub_type
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