Abstract:
PURPOSE:Extemporaneously prepared miconazole eye drops (EPMD) are used by some eye care practitioners to manage keratomycosis in Ghana. This study therefore aimed to determine the efficacy and safety of EPMD using in vitro and in vivo experimental models. METHODS:The minimum inhibitory concentration (MIC) of EPMD was determined by the agar-well diffusion method. In vivo, the activity of EPMD on corneal ulcer, neovascularization, clouding, edema, carring and on keratomycotic conjunctivitis and corneal scarring (clinical features) associated with Candida albicans-induced keratomycosis in rabbits was determined by treating them with 0.034-1.08% (weight-in-volume) EPMD for a period of 30 days. The safety of EPMD on the healthy eye was determined by instilling various concentrations into the intact eye of the rabbits. RESULTS:The MIC of EPMD on Candida albicans was 1.08% (zone of inhibition of 13 mm ± 0.578), which resulted in significantly better improvements (p ≤ 0.001) in clinical findings than eyes treated with sterile water (p > 0.05), and showed no significant difference (p > 0.05) compared to eyes treated with 0.3% fluconazole. There were no visible signs of ocular toxicity on instilling it into healthy eyes of rabbits. CONCLUSION:The extemporaneously prepared miconazole eye drops are effective and safe to use in keratomycosis.
journal_name
Int Ophthalmoljournal_title
International ophthalmologyauthors
Gyanfosu L,Koffuor GA,Kyei S,Ababio-Danso B,Peprah-Donkor K,Nyansah WB,Asare Fdoi
10.1007/s10792-017-0707-zsubject
Has Abstractpub_date
2018-10-01 00:00:00pages
2089-2100issue
5eissn
0165-5701issn
1573-2630pii
10.1007/s10792-017-0707-zjournal_volume
38pub_type
杂志文章abstract:PURPOSE:The authors investigated the use of dapiprazole, an alpha-adrenergic blocking agent, in preventing pigment release and IOP increase after exercise in patients affected with PDS. METHODS:Three young myopic males (31, 34 and 35 years old) affected with pigmentary dispersion syndrome performed 30 minutes of joggi...
journal_title:International ophthalmology
pub_type: 杂志文章
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doi:10.1007/s10792-020-01448-8
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更新日期:2014-06-01 00:00:00
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更新日期:2008-04-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1007/s10792-007-9187-x
更新日期:2009-02-01 00:00:00
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更新日期:2015-08-01 00:00:00
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更新日期:2019-08-01 00:00:00
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doi:10.1007/s10792-020-01355-y
更新日期:2020-07-01 00:00:00
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更新日期:2018-02-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2014-08-01 00:00:00
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journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-020-01585-0
更新日期:2021-01-01 00:00:00
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journal_title:International ophthalmology
pub_type: 杂志文章
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更新日期:1978-09-01 00:00:00