Efficacy and safety of extemporaneously prepared miconazole eye drops in Candida albicans-induced keratomycosis.

Abstract:

PURPOSE:Extemporaneously prepared miconazole eye drops (EPMD) are used by some eye care practitioners to manage keratomycosis in Ghana. This study therefore aimed to determine the efficacy and safety of EPMD using in vitro and in vivo experimental models. METHODS:The minimum inhibitory concentration (MIC) of EPMD was determined by the agar-well diffusion method. In vivo, the activity of EPMD on corneal ulcer, neovascularization, clouding, edema, carring and on keratomycotic conjunctivitis and corneal scarring (clinical features) associated with Candida albicans-induced keratomycosis in rabbits was determined by treating them with 0.034-1.08% (weight-in-volume) EPMD for a period of 30 days. The safety of EPMD on the healthy eye was determined by instilling various concentrations into the intact eye of the rabbits. RESULTS:The MIC of EPMD on Candida albicans was 1.08% (zone of inhibition of 13 mm ± 0.578), which resulted in significantly better improvements (p ≤ 0.001) in clinical findings than eyes treated with sterile water (p > 0.05), and showed no significant difference (p > 0.05) compared to eyes treated with 0.3% fluconazole. There were no visible signs of ocular toxicity on instilling it into healthy eyes of rabbits. CONCLUSION:The extemporaneously prepared miconazole eye drops are effective and safe to use in keratomycosis.

journal_name

Int Ophthalmol

authors

Gyanfosu L,Koffuor GA,Kyei S,Ababio-Danso B,Peprah-Donkor K,Nyansah WB,Asare F

doi

10.1007/s10792-017-0707-z

subject

Has Abstract

pub_date

2018-10-01 00:00:00

pages

2089-2100

issue

5

eissn

0165-5701

issn

1573-2630

pii

10.1007/s10792-017-0707-z

journal_volume

38

pub_type

杂志文章
  • The effectiveness of dapiprazole in preventing exercise-induced IOP increase in patients with pigmentary dispersion syndrome.

    abstract:PURPOSE:The authors investigated the use of dapiprazole, an alpha-adrenergic blocking agent, in preventing pigment release and IOP increase after exercise in patients affected with PDS. METHODS:Three young myopic males (31, 34 and 35 years old) affected with pigmentary dispersion syndrome performed 30 minutes of joggi...

    journal_title:International ophthalmology

    pub_type: 杂志文章

    doi:10.1007/BF00130855

    authors: Mastropasqua L,Carpineto P,Ciancaglini M,Gallenga PE

    更新日期:1995-01-01 00:00:00

  • Congenital iris ectropion associated with juvenile glaucoma.

    abstract::Congenital iris ectropion is an uncommon malformation of the anterior segment of the eye. The authors describe a case of bilateral congenital iris ectropion associated with juvenile glaucoma in an otherwise healthy 9-year-old girl. Intra-ocular pressure (IOP) measured by Goldmann applanation tonometry was 40 mmHg in t...

    journal_title:International ophthalmology

    pub_type: 杂志文章

    doi:10.1007/s10792-010-9388-6

    authors: Seymenoğlu G,Başer E

    更新日期:2011-02-01 00:00:00

  • The black lacrimal sac: a clinicopathological correlation of a malignant melanoma with anterior lacrimal crest infiltration.

    abstract::Primary lacrimal sac melanoma is an extremely rare clinical entity with fewer than 25 cases reported in the literature. We present a well-documented case of lacrimal sac melanoma with anterior lacrimal crest infiltration and discuss the clinical, radiological and histopathological features along with surgical challeng...

    journal_title:International ophthalmology

    pub_type: 杂志文章

    doi:10.1007/s10792-013-9743-5

    authors: Pujari A,Ali MJ,Mulay K,Naik MN,Honavar SG

    更新日期:2014-02-01 00:00:00

  • Efficacy of the XEN gel stent on intraocular pressure lowering in East Asian eyes.

    abstract:PURPOSE:This study aims to evaluate the efficacy and safety of XEN45 gel stent (Allergan plc, Dublin, Ireland) in East Asian patients with glaucoma. METHODS:A retrospective study of consecutive XEN45 gel stent implantation surgeries with or without concurrent cataract surgery from May 2017 to August 2018 was performed...

    journal_title:International ophthalmology

    pub_type: 杂志文章

    doi:10.1007/s10792-020-01284-w

    authors: Hu JY,Ang BCH,Yip LW

    更新日期:2020-05-01 00:00:00

  • Visual, refractive and topographic outcomes of progressive thickness intrastromal corneal ring segments for keratoconic eyes.

    abstract:PURPOSE:To evaluate one-year visual, refractive, and topographic outcomes of 58 eyes of 53 keratoconus patients who underwent surgery with a progressive thickness intrastromal corneal ring segment (ICRS). METHODS:This multi-center, retrospective, observational study evaluates the one-year effects of progressive thickn...

    journal_title:International ophthalmology

    pub_type: 杂志文章

    doi:10.1007/s10792-020-01467-5

    authors: Coşkunseven E,Ambrósio R Jr,Smorádková A,Sánchez León F,Sahin O,Kavadarli I,Jankov MR 2nd

    更新日期:2020-11-01 00:00:00

  • Acute onset transient ectropion associated with corneal ulcer.

    abstract::We report a case of transient ectropion associated with corneal ulcer. The corneal ulcer responded well to treatment with fortified gentamicin and cefazolin. As the corneal ulcer healed, the eyelid simultaneously returned to its original position. We suggest that in the presence of involutional eyelid changes, even a ...

    journal_title:International ophthalmology

    pub_type: 杂志文章

    doi:10.1023/a:1006004320762

    authors: Maden A,Söylev MF,Ozkan SB

    更新日期:1997-01-01 00:00:00

  • Macular capillary recovery in systemic lupus erythematosus complicated by Kikuchi-Fujimoto disease.

    abstract:PURPOSE:Few case reports have described vaso-occlusive retinopathy in systemic lupus erythematosus (SLE) using optical coherence tomography (OCT) angiography. Here we report the clinical features of a patient with SLE, complicated by Kikuchi-Fujimoto disease, who developed vaso-occlusive retinopathy. We then describe t...

    journal_title:International ophthalmology

    pub_type: 杂志文章

    doi:10.1007/s10792-017-0650-z

    authors: Kinouchi R,Kinouchi M,Ishibazawa A,Yoshida A

    更新日期:2018-08-01 00:00:00

  • Efficacy of golimumab on recurrent uveitis in HLA-B27-positive ankylosing spondylitis.

    abstract::To evaluate the efficacy of golimumab on severe and frequent recurrent anterior uveitis in patients with HLA-B27-positive ankylosing spondylitis. In this study, 15 eyes of 12 HLA-B27-positive AS patients with resistant anterior uveitis who received 50 mg of subcutaneous golimumab (Gol) per month due to frequent uveiti...

    journal_title:International ophthalmology

    pub_type: 杂志文章

    doi:10.1007/s10792-016-0239-y

    authors: Yazgan S,Celik U,Işık M,Yeşil NK,Baki AE,Şahin H,Gencer E,Doğan İ

    更新日期:2017-02-01 00:00:00

  • Atypical histopathologic features in sympathetic ophthalmia. A study of a hundred cases.

    abstract::One hundred cases of clinically acceptable sympathetic ophthalmia (SO) were evaluated histologically to determine the incidence of atypical features and correlate them with the severity of choroidal inflammation. The inflammatory response in the choroid varied from a focal non-granulomatous to a diffuse non-necrotizin...

    journal_title:International ophthalmology

    pub_type: 杂志文章

    doi:10.1007/BF00161902

    authors: Croxatto JO,Rao NA,McLean IW,Marak GE

    更新日期:1982-02-01 00:00:00

  • Oncocytoma of the peripunctum.

    abstract:BACKGROUND:Oncocytoma is rarely found around the lacrimal punctum. We describe a case of oncocytoma of the peripunctum. METHODS:Case report. RESULTS:An 88-year-old patient presented with a upper peripunctal mass in the left eye. The tumor was completely excised including the lacrimal punctum and part of the canalicul...

    journal_title:International ophthalmology

    pub_type: 杂志文章

    doi:10.1007/s10792-006-9008-7

    authors: Imaizumi M,Nakatsuka K

    更新日期:2005-06-01 00:00:00

  • Regression of optic nerve head neovascularization in proliferative diabetic retinopathy after intravitreal triamcinolone. Regression of diabetic optic disc neovascularization after intravitreal triamcinolone.

    abstract::The aim of this study is to report the clinical outcome of a diabetic patient with optic nerve head neovascularization treated with an intravitreal injection of triamcinolone acetonide. A 52-year-old patient presented with clinically significant diffuse macular edema and optic nerve head neovascularization due to prol...

    journal_title:International ophthalmology

    pub_type: 杂志文章

    doi:10.1023/b:inte.0000031740.85124.78

    authors: Karacorlu M,Ozdemir H,Karacorlu S,Alacali N

    更新日期:2004-03-01 00:00:00

  • Natural history and visual outcome of nonarteritic anterior ischemic optic neuropathy in Southern Taiwan: a pilot study.

    abstract:PURPOSE:To investigate the natural course, visual outcome, and risk factors for visual loss after nonarteritic anterior ischemic optic neuropathy (NAION) attack in Chinese patients from a tertiary medical center in Southern Taiwan. METHODS:This is a longitudinal observational study that included sixty NAION patients, ...

    journal_title:International ophthalmology

    pub_type: 杂志文章

    doi:10.1007/s10792-020-01448-8

    authors: Huang HM,Wu PC,Kuo HK,Chen YJ,Poon LY

    更新日期:2020-10-01 00:00:00

  • Neuroretinitis: a rare feature of tubulointerstitial nephritis and uveitis syndrome.

    abstract::A 17-year-old female presented to our hospital with fatigue, arthralgia and fever associated with non-granulomatous anterior uveitis in the left eye. Blood tests revealed renal failure and a renal biopsy showed acute tubulointerstitial nephritis. Findings were consistent with tubulointerstitial nephritis and uveitis (...

    journal_title:International ophthalmology

    pub_type: 杂志文章

    doi:10.1007/s10792-013-9820-9

    authors: Khochtali S,Harzallah O,Hadhri R,Hamdi C,Zaouali S,Khairallah M

    更新日期:2014-06-01 00:00:00

  • Endothelial keratoplasty in eyes with a retained angle-supported intraocular lens.

    abstract:PURPOSE:To describe the outcomes of endothelial keratoplasty (EK) for bullous keratopathy in eyes with a retained angle-supported anterior chamber intraocular lens (acIOL). METHODS:Among 263 consecutive EK procedures, 7 DMEK and 11 DSAEK procedures were identified in eyes with an acIOL and included in the present retr...

    journal_title:International ophthalmology

    pub_type: 杂志文章

    doi:10.1007/s10792-018-0899-x

    authors: Droutsas K,Lazaridis A,Kymionis G,Chatzistefanou K,Papaconstantinou D,Sekundo W,Koutsandrea C

    更新日期:2019-05-01 00:00:00

  • Evaluating CO2 laser-assisted sclerectomy surgery with mitomycin C combined with or without phacoemulsification in adult Asian glaucoma subjects.

    abstract:PURPOSE:To evaluate and compare outcomes of CO2 laser-assisted sclerectomy surgery (CLASS) with mitomycin C (MMC) combined with or without phacoemulsification in adult Asian glaucoma patients. DESIGN:Retrospective, comparative study. METHODS:Adult Asian glaucoma patients who underwent CLASS alone or combined with pha...

    journal_title:International ophthalmology

    pub_type: 杂志文章

    doi:10.1007/s10792-021-01707-2

    authors: Ho DCW,Perera SA,Hla MH,Ho CL

    更新日期:2021-01-22 00:00:00

  • Safety monitoring in bevacizumab (Avastin) treatment: retinal function assessed by psychophysical (visual fields, colour vision) and electrophysiological (ERG/EOG) tests in two subgroups of patients.

    abstract:BACKGROUND:Bevacizumab (Avastin) has been used as off-label treatment for the specific inhibition of the vascular endothelial growth factor (VEGF). Although only intravenous administration of the drug is approved in combination therapy of colorectal carcinoma, promising short-term results have been reported about its i...

    journal_title:International ophthalmology

    pub_type: 杂志文章

    doi:10.1007/s10792-007-9122-1

    authors: Ziemssen F,Lüke M,Messias A,Beutel J,Tatar O,Zrenner E,Bartz-Schmidt KU,Tuebingen Bevacizumab Study Group.

    更新日期:2008-04-01 00:00:00

  • Immunopathology of ocular sarcoidosis.

    abstract::Sarcoidosis is a multisystem disease characterized by enhanced immune responses at sites of involvement. To elucidate the immunopathogenesis of ophthalmic lesions, cell infiltrates in biopsies from conjunctiva and other tissues involved (lungs, lymph nodes, skin) were studied in 26 patients with active sarcoidosis in ...

    journal_title:International ophthalmology

    pub_type: 杂志文章

    doi:10.1007/BF00131162

    authors: Angi MR,Forattini F,Chilosi M,Cipriani A,De Caro G,Semenzato G

    更新日期:1990-01-01 00:00:00

  • Management of postequatorial magnetic intraretinal foreign bodies.

    abstract::17 patients with intraretinal magnetic foreign bodies and vitreous hemorrhage are reported. 15 patients underwent a primary surgical repair consisting of a watertight wound closure and removal of the already swelling cataractous lens in 5 cases. All patients had vitrectomy during the second postinjury week. The foreig...

    journal_title:International ophthalmology

    pub_type: 杂志文章

    doi:10.1007/BF02279868

    authors: Kuhn F,Kovacs B

    更新日期:1989-09-01 00:00:00

  • Comparison of the efficacy of accelerated corneal cross-linking therapy in different pediatric age groups having progressive keratoconus.

    abstract:PURPOSE:To report a comparison analysis of accelerated corneal cross-linking (A-CXL) treatment for progressive keratoconus patients in different pediatric age groups. STUDY DESIGN:Retrospective, cross-sectional. METHODS:Patients with progressive keratoconus aged ≤ 18 were retrospectively reviewed. Forty-one eyes of 4...

    journal_title:International ophthalmology

    pub_type: 杂志文章

    doi:10.1007/s10792-020-01446-w

    authors: Ozer MD,Batur M,Mesen S,Tekın S,Seven E,Yasar T

    更新日期:2020-10-01 00:00:00

  • Retrobulbarly injecting nerve growth factor attenuates visual impairment in streptozotocin-induced diabetes rats.

    abstract:PURPOSE:To explore whether retrobulbar administration of nerve growth factor (NGF) can restore visual function of streptozotocin-induced diabetes rats. METHODS:A high-sucrose/high-fat diet and single injection of streptozotocin (STZ) were used in modeling diabetes. During week 13-15 after STZ injection, diabetic rats ...

    journal_title:International ophthalmology

    pub_type: 杂志文章

    doi:10.1007/s10792-020-01537-8

    authors: Wang QC,Sheng W,Yi CJ,Lv H,Cheng B

    更新日期:2020-12-01 00:00:00

  • Assessment of measurement methods of posterior inflammation in stromal choroiditis: the value of quantitative outcome measures versus the presently qualitatively based paradigm.

    abstract:PURPOSE:To assess posterior inflammation using a fluorescein (FA)/indocyanine-green angiography (ICGA) scoring system, and compare them to the presently recommended outcome measure, the standardization of uveitis nomenclature vitreous haze score (SUN-VH) in stromal choroiditis. METHODS:This was a retrospective study o...

    journal_title:International ophthalmology

    pub_type: 杂志文章

    doi:10.1007/s10792-018-0979-y

    authors: Gillmann K,El Ameen A,Massy R,Fabro F,Gasc A,Herbort CP Jr

    更新日期:2019-07-01 00:00:00

  • Evaluation of fixation stability using different targets with the MP1 microperimeter.

    abstract::The aim of this study was to evaluate fixation stability using two different fixation targets with the Nidek MP1 microperimeter. Twenty-nine healthy subjects with a mean age of 26.53 ± 7.35 years and visual acuity ≥0.0 logMAR were enrolled in this study. Fifty-eight eyes of 29 patients without ophthalmic and/or system...

    journal_title:International ophthalmology

    pub_type: 杂志文章

    doi:10.1007/s10792-014-9924-x

    authors: Cesareo M,Manca D,Ciuffoletti E,De Giovanni V,Ricci F,Nucci C,Cerulli L

    更新日期:2015-02-01 00:00:00

  • In-vivo confocal microscopy of iridocorneal endothelial syndrome.

    abstract:BACKGROUND:We carried out a study by in-vivo confocal microscopy to investigate the appearance of iridocorneal endothelial (ICE) syndrome, and discuss its diagnostic potential. METHODS:Twelve patients, each with unilateral ICE syndrome, had both their eyes examined by in-vivo confocal microscopy. The images were recor...

    journal_title:International ophthalmology

    pub_type: 杂志文章

    doi:10.1007/s10792-007-9187-x

    authors: Le QH,Sun XH,Xu JJ

    更新日期:2009-02-01 00:00:00

  • 25-Gauge pars plana vitrectomy for ciliary block (malignant) glaucoma.

    abstract::To evaluate the efficacy of 25-ga pars plana vitrectomy (PPV) and 25-ga PPV combined with phacoemulsification surgery for managing ciliary block (malignant) glaucoma. The medical records of 11 eyes, in nine consecutive patients with malignant glaucoma were retrospectively reviewed to determine the efficacy of 25-ga PP...

    journal_title:International ophthalmology

    pub_type: 杂志文章

    doi:10.1007/s10792-014-9974-0

    authors: Meng L,Wei W,Li Y,Hui X,Han X,Shi X

    更新日期:2015-08-01 00:00:00

  • Observation of anterior chamber volume after cataract surgery with swept-source optical coherence tomography.

    abstract:PURPOSE:To investigate the changes in the anterior chamber volume (ACV) with swept-source optical coherence tomography (SS-OCT) after cataract surgery and the factors that influence these ACV changes. METHODS:This was a prospective cohort study. Fifty-one patients who underwent cataract surgery were enrolled. Their AC...

    journal_title:International ophthalmology

    pub_type: 杂志文章

    doi:10.1007/s10792-018-1012-1

    authors: Chen M,Hu H,He W,Lu Y,Zhu X

    更新日期:2019-08-01 00:00:00

  • Refractive predictability using two optical biometers and refraction types for intraocular lens power calculation in cataract surgery.

    abstract:PURPOSE:To evaluate the accuracy of intraocular lens (IOL) power calculation in relation to optical biometry devices and refraction types. METHODS:Patients undergoing cataract phacoemulsification and insertion of the MX60 IOL were enrolled. Optical biometric measurements were performed with both IOLMaster 700 and Lens...

    journal_title:International ophthalmology

    pub_type: 杂志文章

    doi:10.1007/s10792-020-01355-y

    authors: Cheng H,Li J,Cheng B,Wu M

    更新日期:2020-07-01 00:00:00

  • Efficacy and safety of adding ripasudil to existing treatment regimens for reducing intraocular pressure.

    abstract:PURPOSE:Ripasudil accelerates aqueous humour drainage along the trabecular meshwork-Schlemm's canal route and has been approved for clinical use in Japan. We retrospectively investigated the efficacy and safety of adding ripasudil to existing treatment regimens to reduce intraocular pressure (IOP) in patients with glau...

    journal_title:International ophthalmology

    pub_type: 杂志文章

    doi:10.1007/s10792-016-0427-9

    authors: Inoue K,Okayama R,Shiokawa M,Ishida K,Tomita G

    更新日期:2018-02-01 00:00:00

  • Diabetic retinopathy and pregnancy.

    abstract::Diabetes mellitus and pregnancy have reciprocal influences between them, therefore diabetes mellitus may complicate the course of pregnancy as well as pregnancy can worsen the performance of diabetes especially at the fundus oculi. Several factors seem to play a role in retinal neovascularization. Actually it's not po...

    journal_title:International ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1007/s10792-014-9906-z

    authors: Pescosolido N,Campagna O,Barbato A

    更新日期:2014-08-01 00:00:00

  • Full- versus partial-thickness sutures: experimental models of corneal injury repair.

    abstract:PURPOSE:To evaluate the performance of full-thickness (FT) versus partial-thickness (PT) sutures in a full-thickness corneal wound in an animal model. METHODS:This is a prospective, experimental, comparative, longitudinal study. A 6-mm linear, full-thickness corneal incision was performed on the right eye of eight dom...

    journal_title:International ophthalmology

    pub_type: 杂志文章

    doi:10.1007/s10792-020-01585-0

    authors: Dalma-Weiszhausz J,Galván-Chávez M,Guinto-Arcos EB,Miyake-Martínez DY,Rodríguez-Reyes A,Golzarri MF,Sebastián-Arellano C,Dávila-Ávila NM,Ríos-Elizondo CE

    更新日期:2021-01-01 00:00:00

  • Melanocytoma of the optic nerve head: a review.

    abstract::The melanocytoma of the optic disc is a deeply-pigmented tumor located on the optic nerve head. In contrast to malignant melanoma, it appears to occur in equal frequency in whites and non-whites. Histologically, it consists of deeply-pigmented plump nervus cells with benign characteristics. No treatment is usually nec...

    journal_title:International ophthalmology

    pub_type: 杂志文章

    doi:10.1007/BF00133275

    authors: Shields JA

    更新日期:1978-09-01 00:00:00