Abstract：
PURPOSE:Ripasudil accelerates aqueous humour drainage along the trabecular meshwork-Schlemm's canal route and has been approved for clinical use in Japan. We retrospectively investigated the efficacy and safety of adding ripasudil to existing treatment regimens to reduce intraocular pressure (IOP) in patients with glaucoma. METHODS:A total of 119 eyes from 119 subjects (61 men, 58 women) with primary open-angle glaucoma or ocular hypertension who had ripasudil added to their treatment regimens between December 2014 and June 2015 were included. An average of 3.8 ± 1.0 anti-glaucoma medications was in use before adding ripasudil. Subjects were divided into four groups based on the number of medications included in the original treatment regimen: ≤2, 3, 4, or ≥5 medications. The IOP was compared before and after 1 and 3 months of treatment with ripasudil for all subjects and between groups. Patients for whom ripasudil use was discontinued within 3 months were also examined. RESULTS:The IOP was significantly lower in all patients after 1 month (17.5 ± 4.5 mmHg) and 3 months (16.8 ± 4.2 mmHg) of treatment than it was before (19.8 ± 5.3 mmHg, p < 0.0001). All groups were equivalent in the rate and magnitude of IOP change. Ripasudil administration was discontinued in five patients (4.2%) prior to the end of the study: three were lost to follow-up and two underwent glaucoma surgery. CONCLUSION:Adding ripasudil to existing glaucoma treatment regimens is effective and safe in reducing IOP, regardless of the number of medications in use.
journal_name
Int Ophthalmoljournal_title
International ophthalmologyauthors
Inoue K,Okayama R,Shiokawa M,Ishida K,Tomita Gdoi
10.1007/s10792-016-0427-9subject
Has Abstractpub_date
2018-02-01 00:00:00pages
93-98issue
1eissn
0165-5701issn
1573-2630pii
10.1007/s10792-016-0427-9journal_volume
38pub_type
杂志文章abstract：BACKGROUND:A case report of recurrent unilateral granulomatous iridocyclitis with ocular hypertension without retinitis caused by cytomegalovirus (CMV) in an immunocompetent patient. METHODS:Aqueous humor was analysed by multiplex PCR to detect viral DNA, and real-time PCR was used to evaluate virus copies before and ...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-007-9090-5
更新日期：2007-12-01 00:00:00
abstract：:The ocular surface is exposed to many chronic inflammatory stimuli, and goblet cell hyperplasia of the conjunctiva occurs in many situations. We report two cases of epithelial goblet cell hyperplasia with nonspecific chronic inflammation which occurred on the internal canthus of elderly people. These cases shared the ...
journal_title：International ophthalmology
pub_type： 杂志文章,评审
doi：10.1007/s10792-015-0083-5
更新日期：2015-08-01 00:00:00
abstract：:Glycated proteins formed by the Maillard reaction were measured by furosine determination in human normal lenses and in senile and diabetic cataracts. Furosine, an hydrolysis product of fructose-lysine adduct formed in the early stages of the Maillard reaction, was measured by high performance liquid chromatography (H...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/BF00951795
更新日期：1994-01-01 00:00:00
abstract：:Traumatic expulsive iridodialysis is a rare complication after trauma by a blunt object in eyes with previous small-incision cataract surgery. The presence of an intact lens capsule with an intraocular lens was thought to protect against damage beyond the posterior capsule. We report a case of dehiscence of the catara...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-011-9491-3
更新日期：2011-12-01 00:00:00
abstract：:A case of keratomycosis caused by Alternaria species in a patient with glaucoma is reported. A 55-year-old Japanese man who had been followed for developmental glaucoma presented with corneal ulcer in his right eye, which did not respond to antibacterial agents. There was no history of traumatic episode. Culture on po...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-008-9260-0
更新日期：2009-12-01 00:00:00
abstract：PURPOSE:To report a case of DUSN from the Indian subcontinent and emphasize the importance of immediate photocoagulation. METHOD:Review of case record. RESULT:The referring ophthalmologist had photographed the subretinal worm but had not undertaken laser photocoagulation. On presentation to us the patient had feature...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-007-9045-x
更新日期：2005-12-01 00:00:00
abstract：:Evaluation of brain cluster activation using the functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) was sought in strabismic amblyopes. In this hospital-based case-control cross-sectional study, fMRI and DTI were conducted in strabismic amblyopes before initiation of any therapy and after ...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-015-0159-2
更新日期：2016-08-01 00:00:00
abstract：:We describe a case illustrating a new technique of using intraoperative optical coherence tomography (IOCT) for foreign body removal from the limbus and cornea. In this case, fragments of a fish hook in the temporal limbus and cornea were identified on the OCT. The residual pieces were then removed, assisted by high-r...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-016-0304-6
更新日期：2017-06-01 00:00:00
abstract：:A 37 year old woman presented with a bilateral vitritis. 4 months previously, she had developed in her left eye a necrotizing retinitis compatible with acute retinal necrosis (ARN). A trial of Acyclovir was unsuccessful as were systemic steroids. Over the following 2 months the vitritis worsened. The patient underwent...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/BF00163568
更新日期：1990-10-01 00:00:00
abstract：PURPOSE:To evaluate circular neodymium: YAG laser incision in cases of anterior capsular contraction syndrome (ACCS) by comparing it to radial Neodymium: YAG laser incision as for efficacy and safety. SETTINGS:Ophthalmology Department, Benha University Hospitals. METHODS:The study was done on 74 eyes of 66 patients w...
journal_title：International ophthalmology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s10792-019-01094-9
更新日期：2019-11-01 00:00:00
abstract：:The aim of this study was to evaluate tear osmolarity and ocular comfort with two different types of hydrogel daily disposable lenses. The right eyes of 15 first-time contact lens users were included in this prospective study. All eyes wore hilafilcon B silicone hydrogel contact lenses for 8 h (group 1). After 1 week ...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-012-9556-y
更新日期：2012-06-01 00:00:00
abstract：:Diplopia is a very disturbing condition that has been reported as a complication of several surgical procedures. The following review aims to identify the ocular and nonocular surgical techniques more often associated with this undesirable result. Diplopia is reported as an adverse outcome of some neurosurgical proced...
journal_title：International ophthalmology
pub_type： 杂志文章,评审
doi：10.1007/s10792-014-9927-7
更新日期：2014-08-01 00:00:00
abstract：:Postural behaviour of intraocular pressure (IOP) was studied in 29 glaucomatous eyes before and after argon laser trabeculoplasty (ALT) and compared with that of 60 normal eyes. Although argon laser trabeculoplasty was successful in lowering the IOP below 21 mm Hg, it produced little effect on the postural behaviour o...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/BF00916436
更新日期：1992-05-01 00:00:00
abstract：PURPOSE:To compare the outcome of penetrating keratoplasty (PKP) and deep anterior lamellar keratoplasty (DALK) in the surgical management of keratoconus (KC). PATIENT AND METHODS:A retrospective review was conducted of the medical records of all patients treated with PKP or DALK for KC at University of Iowa Hospitals...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-010-9393-9
更新日期：2010-12-01 00:00:00
abstract：PURPOSE:To investigate complex and different phenotypes in seven Chinese patients diagnosed with Bardet-Biedl syndrome (BBS) and carrying pathogenic mutations. METHODS:Seven unrelated BBS patients were enrolled. Their medical and ophthalmic histories were reviewed, and comprehensive clinical examinations, such as fund...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-020-01415-3
更新日期：2020-09-01 00:00:00
abstract：PURPOSE:To determine whether gene polymorphisms which are associated with age-related macular degeneration (AMD) influence treatments' response and specifically the antioxidant supplementation in dry AMD patients, as well as the anti-vascular endothelial growth factor (anti-VEGF) therapy in neovascular AMD patients. M...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-019-01274-7
更新日期：2020-04-01 00:00:00
abstract：PURPOSE:To assess ophthalmic manifestations in patients with stroke and emphasize the importance of a formal screening for visual problems in stroke patients in hospital and rehabilitation settings. METHODS:This was a cross-sectional study of 50 newly diagnosed patients with stroke with Glasgow Coma Scale (GCS) > 8 ex...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-019-01131-7
更新日期：2019-12-01 00:00:00
abstract：PURPOSE:Ibopamine is used when performing provocative tests, thanks to its pharmacological property of increasing ocular pressure in eyes with outflow system impairment. This study summarizes the latest results that we have achieved with reference to its clinical-diagnostic use. METHODS:175 (250 eyes) POAG patients, 1...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/BF00212962
更新日期：1996-01-01 00:00:00
abstract：PURPOSE:To evaluate and compare outcomes of CO2 laser-assisted sclerectomy surgery (CLASS) with mitomycin C (MMC) combined with or without phacoemulsification in adult Asian glaucoma patients. DESIGN:Retrospective, comparative study. METHODS:Adult Asian glaucoma patients who underwent CLASS alone or combined with pha...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-021-01707-2
更新日期：2021-01-22 00:00:00
abstract：:Lipoid proteinosis is a rare disorder involving multiple organ systems. The ocular manifestations are usually trivial, but greatly aid in the diagnosis. We describe a patient who presented to us with typical moniliform blepharosis. A brief description of relevance to the ophthalmologist and review of the literature fo...
journal_title：International ophthalmology
pub_type： 杂志文章,评审
doi：10.1007/s10792-011-9417-0
更新日期：2011-04-01 00:00:00
abstract：INTRODUCTION AND AIM:To compare intraocular pressure (IOP) measurements obtained with non-contact tonometry (NCT), Icare rebound tonometry (IRT) and Goldmann applanation tonometry (GAT) in pediatric cases and to examine the effect of topical anesthesia on measurements obtained using IRT. MATERIALS AND METHODS:Pediatri...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-020-01375-8
更新日期：2020-08-01 00:00:00
abstract：BACKGROUND:To evaluate the preliminary effects of treating the half of high latent hyperopia on refractive and visual outcomes of femtosecond laser-assisted in situ keratomileusis (LASIK) in young subjects with hyperopia. METHODS:This non-randomized comparative study includes 120 eyes of 60 subjects who underwent femt...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-020-01421-5
更新日期：2020-09-01 00:00:00
abstract：:Primary lacrimal sac melanoma is an extremely rare clinical entity with fewer than 25 cases reported in the literature. We present a well-documented case of lacrimal sac melanoma with anterior lacrimal crest infiltration and discuss the clinical, radiological and histopathological features along with surgical challeng...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-013-9743-5
更新日期：2014-02-01 00:00:00
abstract：:The study aims to determine the progression of gyrate atrophy by measuring the area growth of chorioretinal atrophic lesions using ultra-wide-field images (UWFI). A retrospective, observational, and comparative study was conducted and UWFI (200°) were obtained from two patients with gyrate atrophy at baseline and foll...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-015-0085-3
更新日期：2016-02-01 00:00:00
abstract：:To investigate the efficacy of anti-tuberculous therapy and systemic corticosteroids in patients suffering from active presumed tuberculous choroiditis by the assessment of central retinal sensitivity and fixation characteristics. Six patients (six eyes) with active presumed tuberculous choroiditis were treated with a...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-010-9371-2
更新日期：2010-10-01 00:00:00
abstract：:To compare the efficacy of 5-fluorouracil (5-FU) with mitomycin C (MMC) in preventing pterygium recurrence when used as an adjuvant following pterygium excision with conjunctival autograft. Low-dose MMC combined with conjunctival autograft is an effective treatment for preventing recurrence following pterygium excisio...
journal_title：International ophthalmology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s10792-011-9509-x
更新日期：2012-02-01 00:00:00
abstract：:We report the functional outcome of a patient who had undergone Boston keratoprosthesis type I for extensive ocular surface damage caused by latex of Euphorbia. The milky sap or latex of the Euphorbia plant is highly toxic and an irritant to the skin and eye. Damage to the eye ranges from mild to severe corneal edema,...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-012-9515-7
更新日期：2012-02-01 00:00:00
abstract：PURPOSE:To evaluate whether retrobulbar blood flow and choroidal thickness (CT) are affected in patients with rheumatoid arthritis (RA), and the relationship between these values. METHODS:We evaluated 40 eyes of 20 RA patients and 40 eyes of 20 healthy controls. The enhanced depth imaging optical coherence tomography,...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-017-0656-6
更新日期：2018-10-01 00:00:00
abstract：:Congenital iris ectropion is an uncommon malformation of the anterior segment of the eye. The authors describe a case of bilateral congenital iris ectropion associated with juvenile glaucoma in an otherwise healthy 9-year-old girl. Intra-ocular pressure (IOP) measured by Goldmann applanation tonometry was 40 mmHg in t...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-010-9388-6
更新日期：2011-02-01 00:00:00
abstract：:Infants have been known occasionally to stare without blinking for almost a minute. This puts great demands on the stability of their tear-film. To verify the stability of infant tears, we performed biophysical experiments on Meibomian gland secretion, which forms the outermost layer of the tear-film. The secretion wa...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/BF00919408
更新日期：1994-01-01 00:00:00
