Investigation of genetic base in the treatment of age-related macular degeneration.

Abstract:

PURPOSE:To determine whether gene polymorphisms which are associated with age-related macular degeneration (AMD) influence treatments' response and specifically the antioxidant supplementation in dry AMD patients, as well as the anti-vascular endothelial growth factor (anti-VEGF) therapy in neovascular AMD patients. METHODS:A total of 170 patients with dry AMD and 52 neovascular AMD patients were genotyped for the following single nucleotide polymorphisms (SNPs): rs1061170/Y402H in CFH gene, rs10490924/A69S in ARMS2 gene, rs9332739/E318D and rs547154/IVS10 in C2 gene, and rs4151667/L9H and rs2072633/IVS17 in CFB gene. Treatment response was evaluated by comparing visual acuity and optical coherence tomography between baseline and at the end of the treatment. RESULTS:Τhe CFH/Y402H variant was associated with the response to antioxidants in dry AMD patients. Carriers of one or two CFH risk alleles displayed a lower chance of responding compared to those with no risk allele. No association of antioxidants' response and ARMS2/A69S genotype was identified. The analysis of the C2 and CFB genetic variants (protective SNPs) revealed that antioxidant supplementation was much more effective in protective SNP carriers. In neovascular AMD patients, the analysis indicated that Y402H homozygous patients were less likely to respond to anti-VEGF therapy compared to heterozygous. Regarding the ARMS2/A69S genotype, carriers of the risk variant experienced significantly worse treatment outcome compared to wild-type patients. CONCLUSION:In AMD patients, the efficacy of the antioxidant supplementation and the anti-VEGF therapy appears to differ by genotype. The detection of genetic variants, associated with treatment responsiveness, could lead to improved visual outcomes through genotype-directed therapy.

journal_name

Int Ophthalmol

authors

Gourgouli K,Gourgouli I,Tsaousis G,Spai S,Niskopoulou M,Efthimiopoulos S,Lamnissou K

doi

10.1007/s10792-019-01274-7

subject

Has Abstract

pub_date

2020-04-01 00:00:00

pages

985-997

issue

4

eissn

0165-5701

issn

1573-2630

pii

10.1007/s10792-019-01274-7

journal_volume

40

pub_type

杂志文章
  • External ophthalmomyiasis: a case series.

    abstract::Oestrus ovis or 'sheep botfly' causes common ophthalmomyiasis in warm climates. It is a self-limited infestation with symptoms such as foreign body sensation and/or tearing. The larvae can be observed in the conjunctiva and should be extracted with forceps. The development of larvae beyond the first stage does not occ...

    journal_title:International ophthalmology

    pub_type: 杂志文章

    doi:10.1007/s10792-012-9644-z

    authors: Carrillo I,Zarratea L,Suárez MJ,Izquierdo C,Garde A,Bengoa A

    更新日期:2013-04-01 00:00:00

  • Evaluation of the effect of combined intravitreal ranibizumab injection and sub-tenon steroid injection in the treatment of resistant diabetic macular edema.

    abstract:PURPOSE:To compare sub-tenon steroid plus anti-VEGF injection with anti-VEGF injection solely in the treatment of resistant diabetic macular edema (DME). METHOD:Patients who exhibited insufficient anatomic [over 350 μm central macular thickness (CMT)] and less than 3 lines of visual gain at least six anti-VEGF injecti...

    journal_title:International ophthalmology

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s10792-018-0977-0

    authors: Eriş E,Perente I,Vural E,Vural A,Seymen Z,Celebi ARC,Erdogan G,Ozkaya A,Artunay O

    更新日期:2019-07-01 00:00:00

  • Ru-106 plaque radiotherapy for vasoproliferative tumors of retina: a 15-year single-center experience.

    abstract:PURPOSE:This study evaluates the outcomes of ruthenium-106 (Ru-106) plaque brachytherapy for vasoproliferative tumors (VPTs) of the ocular fundus in a single referral ocular oncology center. METHODS:The clinical charts of all patients diagnosed with VPT who underwent plaque radiotherapy from 2002 to 2017 were reviewed...

    journal_title:International ophthalmology

    pub_type: 杂志文章

    doi:10.1007/s10792-020-01386-5

    authors: Abolfathzadeh N,Naseripour M,Jaberi R,Azma Z,Alemzadeh SA,Arbab M,Sedaghat A

    更新日期:2020-08-01 00:00:00

  • Laser flare photometry: a noninvasive, objective, and quantitative method to measure intraocular inflammation.

    abstract::Aqueous flare and cells are the two inflammatory parameters of anterior chamber inflammation resulting from disruption of the blood-ocular barriers. When examined with the slit lamp, measurement of intraocular inflammation remains subjective with considerable intra- and interobserver variations. Laser flare cell photo...

    journal_title:International ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1007/s10792-009-9310-2

    authors: Tugal-Tutkun I,Herbort CP

    更新日期:2010-10-01 00:00:00

  • Pediatric keratoconus: a review of the literature.

    abstract:PURPOSE:To describe the epidemiology and prevalence, rates of progression, difference between adult and pediatric populations, and therapeutic approaches to pediatric keratoconus from documented literature. METHODS:A literature search was done on PubMed using key words including pediatric keratoconus, children with ke...

    journal_title:International ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1007/s10792-017-0699-8

    authors: Mukhtar S,Ambati BK

    更新日期:2018-10-01 00:00:00

  • Tear ferning and other lacrimal tests in normal persons of different ages.

    abstract::We investigated in normal persons of different ages ranging from 4 months to 85 years the frequency of different ferning types as well as the results of the Schirmer I test, break-up time and tear protein profile. With increasing age, ferning types of higher degree were significantly more frequent. Furthermore, a corr...

    journal_title:International ophthalmology

    pub_type: 杂志文章

    doi:10.1007/BF00137950

    authors: Puderbach S,Stolze HH

    更新日期:1991-11-01 00:00:00

  • Assessment of measurement methods of posterior inflammation in stromal choroiditis: the value of quantitative outcome measures versus the presently qualitatively based paradigm.

    abstract:PURPOSE:To assess posterior inflammation using a fluorescein (FA)/indocyanine-green angiography (ICGA) scoring system, and compare them to the presently recommended outcome measure, the standardization of uveitis nomenclature vitreous haze score (SUN-VH) in stromal choroiditis. METHODS:This was a retrospective study o...

    journal_title:International ophthalmology

    pub_type: 杂志文章

    doi:10.1007/s10792-018-0979-y

    authors: Gillmann K,El Ameen A,Massy R,Fabro F,Gasc A,Herbort CP Jr

    更新日期:2019-07-01 00:00:00

  • Investigating the effects of glaucomatous damage on the multifocal visual evoked potential parameters.

    abstract:PURPOSE:To investigate the effects of glaucomatous damage on the mfVEP parameters of patients suffering from primary open-angle glaucoma (POAG). METHODS:Fifteen healthy subjects and 15 patients with unilateral POAG participated in this study. In addition, routine ophthalmological examinations including visual acuity, ...

    journal_title:International ophthalmology

    pub_type: 杂志文章

    doi:10.1007/s10792-019-01138-0

    authors: Danyaei A,Kasiri A,Latifi SM,Armiun P,Tahmasebi MJ

    更新日期:2019-12-01 00:00:00

  • Indocyanine green angiographic findings in central serous chorioretinopathy.

    abstract::There has been great controversy about the pathogenesis of the focal changes in the retinal pigment epithelium (RPE) causing detachment of the neurosensory retina in central serous chorioretinopathy (CSC). This study was performed to evaluate changes in choroidal perfusion in 15 patients with CSC. Fluorescein and indo...

    journal_title:International ophthalmology

    pub_type: 杂志文章

    doi:10.1007/BF00133176

    authors: Prünte C

    更新日期:1995-01-01 00:00:00

  • Quantitative assessment of the effect of acute anaerobic exercise on macular perfusion via swept-source optical coherence tomography angiography in young football players.

    abstract:AIM:To evaluate the effect of acute anaerobic exercise on macular perfusion measured by swept-source optical coherence tomography angiography (SS-OCTA) in young football players. MATERIALS AND METHODS:Football players with ages between 18 and 20 years were included into the study. After a detailed ophthalmological exa...

    journal_title:International ophthalmology

    pub_type: 杂志文章

    doi:10.1007/s10792-020-01303-w

    authors: Karakucuk Y,Okudan N,Bozkurt B,Belviranlı M,Sezer T,Gorçuyeva S

    更新日期:2020-06-01 00:00:00

  • Angiolymphoid hyperplasia with eosinophilia of the eyelid and orbit: the Western cousin of Kimura's disease?

    abstract::Angiolymphoid hyperplasia with eosinophilia (ALHE) is an uncommon disease most frequently occurring in the head and neck region. It occurs in all races. In spite of a clear distinction between ALHE and Kimura's disease on histological grounds for almost 20 years now, confusion and misdiagnosis still exist to date. Thr...

    journal_title:International ophthalmology

    pub_type: 杂志文章

    doi:10.1007/s10792-013-9741-7

    authors: Cunniffe G,Alonso T,Dinarès C,Medina FJ,Medel R

    更新日期:2014-02-01 00:00:00

  • Intravitreal triamcinolone acetonide for the management of papillophlebitis and associated macular edema.

    abstract:BACKGROUND:To investigate the efficacy of intravitreal injection of triamcinolone acetonide in the management of papillophlebitis and associated cystoid macular edema. METHODS:This study was a retrospective medical records review of four eyes of four patients (three males and one female) who had approximately 2-4 mont...

    journal_title:International ophthalmology

    pub_type: 杂志文章

    doi:10.1007/s10792-007-9128-8

    authors: Chang YC,Wu WC

    更新日期:2008-08-01 00:00:00

  • Retrospective clinicopathological study of 129 cancerous and 18 precancerous lesions of the eyelids in North-Western Greece.

    abstract::This study aimed to present precancerous and cancerous epithelial eyelid lesions, their histopathological features, and possible correlations with clinical parameters. The retrospective study included 147 formalin-fixed, paraffin-embedded samples. We studied precancerous and cancerous epithelial eyelid lesions. Preneo...

    journal_title:International ophthalmology

    pub_type: 杂志文章

    doi:10.1007/s10792-016-0258-8

    authors: Tzoutzos K,Batistatou A,Kitsos G,Liasko R,Stefanou D

    更新日期:2017-02-01 00:00:00

  • Vector analysis of changes in corneal astigmatism following lateral tarsal strip procedure in patients with involutional ectropion or entropion.

    abstract:PURPOSE:To perform vector analysis of changes in corneal astigmatism and evaluate changes in corneal topographic parameters following the lateral tarsal strip (LTS) procedure in patients with involutional ectropion or entropion. METHODS:Nineteen eyes of 15 patients (10 eyes with ectropion and 9 eyes with entropion) we...

    journal_title:International ophthalmology

    pub_type: 杂志文章

    doi:10.1007/s10792-018-0987-y

    authors: Eshraghi B,Jamshidian-Tehrani M,Fadakar K,Ali-Zamani H,Fallah Tafti Z,Ghaffari R

    更新日期:2019-08-01 00:00:00

  • The global burden of trachomatous visual impairment: II. Assessing burden.

    abstract::This paper builds on results of a previous paper on the prevalence of trachomatous visual impairment as the foundation for assessing the global burden of trachomatous blindness and low vision: approximately 2.9 million cases of trachomatous blindness and 3.8 million low visioned corresponding to a global prevalence of...

    journal_title:International ophthalmology

    pub_type: 杂志文章

    doi:10.1007/BF00130921

    authors: Evans TG,Ranson MK

    更新日期:1995-01-01 00:00:00

  • Sutureless amniotic membrane transplantation combined with narrow-strip conjunctival autograft for pterygium.

    abstract::To study the efficacy and safety of sutureless amniotic membrane transplantation combined with narrow-strip conjunctival autograft and to investigate the clinical outcomes. Thirty eyes of 30 patients with primary pterygia were treated in this institutional study with excision followed by sutureless amniotic membrane t...

    journal_title:International ophthalmology

    pub_type: 临床试验,杂志文章

    doi:10.1007/s10792-011-9488-y

    authors: Taylan Sekeroglu H,Erdem E,Dogan NC,Yagmur M,Ersoz R,Dogan A

    更新日期:2011-12-01 00:00:00

  • Biomechanical evaluation of cornea in patients with ankylosing spondylitis.

    abstract:PURPOSE:The aim of this study was to evaluate the corneal biomechanical parameters in patients with ankylosing spondylitis (AS) and to compare them with the healthy subjects. METHODS:Sixty patients with AS (study group) and 60 healthy subjects (control group) were enrolled in this prospective study. The study group wa...

    journal_title:International ophthalmology

    pub_type: 杂志文章

    doi:10.1007/s10792-016-0368-3

    authors: Caglayan M,Sarac O,Kosekahya P,Erten S,Ayan B,Cagil N

    更新日期:2017-08-01 00:00:00

  • Traumatic expulsive iridodialysis with vitreous prolapse.

    abstract::Traumatic expulsive iridodialysis is a rare complication after trauma by a blunt object in eyes with previous small-incision cataract surgery. The presence of an intact lens capsule with an intraocular lens was thought to protect against damage beyond the posterior capsule. We report a case of dehiscence of the catara...

    journal_title:International ophthalmology

    pub_type: 杂志文章

    doi:10.1007/s10792-011-9491-3

    authors: Zurutuza A,Andonegui J,Berástegui L

    更新日期:2011-12-01 00:00:00

  • Glaucomatous optic nerve head changes with scanning laser ophthalmoscopy.

    abstract:PURPOSE:To determine whether there are angiographic differences among normal, preperimetric and advanced glaucoma eyes using indocyanine green angiography with SLO. This method was chosen because of its sensibility to detect peripapillary capillary vessels. METHODS:Scanning laser opthalmoscopy was preformed on normal ...

    journal_title:International ophthalmology

    pub_type: 杂志文章

    doi:10.1023/a:1014431404096

    authors: Marengo J,Ucha RA,Martinez-Cartier M,Sampaolesi JR

    更新日期:2001-01-01 00:00:00

  • Long-term evaluation of refractive changes in eyes of preterm children: a 6-year follow-up study.

    abstract:PURPOSE:To investigate the longitudinal changes in refractive errors in preterm children with and without retinopathy of prematurity (ROP) in the first 6 years of life. METHODS:We included 226 preterm children with a gestational age of ≤34 weeks: 222 eyes with no ROP, 73 eyes with mild ROP and 145 eyes with severe ROP...

    journal_title:International ophthalmology

    pub_type: 杂志文章

    doi:10.1007/s10792-017-0642-z

    authors: Kaya M,Berk AT,Yaman A

    更新日期:2018-08-01 00:00:00

  • Optic disc pallor and visual field defect in exfoliative and non-exfoliative, untreated ocular hypertension.

    abstract::In a prospective study of untreated ocular hypertension 117 eyes were non-exfoliative and 20 eyes exfoliative. The percentage of optic disc pallor was significantly larger in the exfoliative than in the non-exfoliative group, whereas no significant differences were found in IOP or in the visual field. ...

    journal_title:International ophthalmology

    pub_type: 杂志文章

    doi:10.1007/BF02028632

    authors: Linnér E,Schwartz B,Araujo D

    更新日期:1989-01-01 00:00:00

  • Gyrate atrophy of the choroid and retina. Approaches to therapy.

    abstract::Gyrate atrophy of the choroid and retina is caused by deficient activity of ornithine ketoacid aminotransferase, a pyridoxal phosphate dependent enzyme. Besides the typical eye findings, abnormalities have been found on muscle biopsy, electro-encephalography, electromyography and electrocardiography, establishing this...

    journal_title:International ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1007/BF00139577

    authors: Weleber RG,Kennaway NG,Buist NR

    更新日期:1981-08-01 00:00:00

  • Intraoperative clouding of a posterior chamber intraocular lens.

    abstract::The glistening and delayed opacification of intraocular lenses (IOLs) has been reported in literature as a late and permanent change in the acrylic IOL due to temperature change. We report a case in which clouding and opacification of an IOL occurred intraoperatively within a few seconds of implantation into the capsu...

    journal_title:International ophthalmology

    pub_type: 杂志文章

    doi:10.1007/s10792-011-9481-5

    authors: Tyagi P,Shah N,Jabir M

    更新日期:2011-12-01 00:00:00

  • HLA and uveitis.

    abstract::The association between HLA-A29 and birdshot chorioretinopathy is the strongest of all associations between HLA and disease. Determination of HLA-A29 is even of diagnostic significance. The association between HLA-B27 and acute anterior uveitis (AAU) is much weaker, but B27 positive AAU may be considered as a distinct...

    journal_title:International ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1007/BF00163552

    authors: Feltkamp TE

    更新日期:1990-10-01 00:00:00

  • Simultaneous intraocular and bilateral extraocular muscle involvement in a case of disseminated cysticercosis.

    abstract::We report an unusual case of disseminated cysticercosis having simultaneous intraocular and extraocular involvement. This 21-year-old male presented with recent loss of vision in one eye and history of a single seizure. Examination revealed intravitreal cysticercosis with exudative retinal detachment. Computed tomogra...

    journal_title:International ophthalmology

    pub_type: 杂志文章

    doi:10.1007/s10792-005-8248-2

    authors: Chadha V,Pandey PK,Chauhan D,Das S

    更新日期:2005-02-01 00:00:00

  • Toxigenic strains of Staphylococcus epidermidis and their experimental corneal pathogenicity in rabbits.

    abstract::Thirty strains of Staphylococcus epidermidis, ten each from normal conjunctival sacs, corneal ulcer cases and from those who developed postoperative endophthalmitis, were examined for their dermonecrotic and haemolytic activities. Dermonecrosis was studied on rabbit skin whereas haemolysis was determined against sheep...

    journal_title:International ophthalmology

    pub_type: 杂志文章

    doi:10.1007/BF00149145

    authors: Mahajan VM,Reddy TN,Agarwal LP

    更新日期:1982-11-01 00:00:00

  • Ocular biometric parameters are associated with non-contact tonometry measured intraocular pressure in non-pathologic myopic patients.

    abstract:PURPOSES:This research aimed to investigate effects and risk factors on non-contact tonometer (NCT) readings in healthy myopic subjects by employing cross-sectional study design. METHODS:Totally, sixty otherwise healthy myopic volunteers (mean 28.4 years old) with 90% female were recruited in ophthalmic clinic. The ro...

    journal_title:International ophthalmology

    pub_type: 杂志文章

    doi:10.1007/s10792-019-01203-8

    authors: Ma Y,Ma Y,Feng C,Shen M,Yuan Y

    更新日期:2020-02-01 00:00:00

  • Boston keratoprosthesis restoring vision in an unusual case of end-stage limbal stem cell deficiency following exposure to Euphorbia latex.

    abstract::We report the functional outcome of a patient who had undergone Boston keratoprosthesis type I for extensive ocular surface damage caused by latex of Euphorbia. The milky sap or latex of the Euphorbia plant is highly toxic and an irritant to the skin and eye. Damage to the eye ranges from mild to severe corneal edema,...

    journal_title:International ophthalmology

    pub_type: 杂志文章

    doi:10.1007/s10792-012-9515-7

    authors: Dutta J,Mukhopadhyay S,Datta H,Sen S

    更新日期:2012-02-01 00:00:00

  • 'Idiopathic' preretinal macular fibrosis in young individuals.

    abstract::In order to evaluate possible etiological factors and the natural course of 'idiopathic' preretinal fibrosis in young persons, nine consecutive patients with macular pucker diagnosed under the age of 50 years were examined. There were six women and three men with the mean age of 27.2 years (range 15-50) and the mean f...

    journal_title:International ophthalmology

    pub_type: 杂志文章

    doi:10.1007/BF00202776

    authors: Laatikainen L,Punnonen E

    更新日期:1987-02-01 00:00:00

  • Ocular manifestations of rheumatic diseases.

    abstract:PURPOSE:Our aim was to summarize key aspects of the pathomechanism and the ocular involvements of rheumatic and systemic autoimmune diseases. METHODS:Apart from a paper in French (Morax V, Ann Oculist 109:368-370, 1893), all papers referred to in this article were published in English. All the materials were peer-revi...

    journal_title:International ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1007/s10792-019-01183-9

    authors: Kemeny-Beke A,Szodoray P

    更新日期:2020-02-01 00:00:00