Abstract:
PURPOSE:To assess posterior inflammation using a fluorescein (FA)/indocyanine-green angiography (ICGA) scoring system, and compare them to the presently recommended outcome measure, the standardization of uveitis nomenclature vitreous haze score (SUN-VH) in stromal choroiditis. METHODS:This was a retrospective study on patients with a diagnosis of ocular sarcoidosis(OS), ocular tuberculosis(OT), Birdshot retinochoroiditis(BRC) and Vogt-Koyanagi-Harada disease(VKH) seen in the Centre for Ophthalmic Specialized Care, Lausanne, Switzerland. Angiography signs were quantified according to an established FA/ICGA scoring system. Vitritis was assessed using SUN-VH. Results were compared. RESULTS:65 newly diagnosed patients (128 eyes) with stromal choroiditis were included. Angiographic scoring showed variable degrees of choroidal versus retinal involvement (87% for OS, 72% for OT, 62.5% for BRC and 100% for VKH). On the other hand, a mere 22 of 128 eyes (17%) showed a SUN-VH score ≥ 2 necessary for inclusion in clinical trials. Moreover, FA/ICGA values followed a normal distribution curve and presented inter-examiner variations greater than 1-SD in only 8.4% of cases. SUN-VH values' distribution was non-normal and showed inter-examiner discrepancies greater than 1-SD in 51.7% of cases. CONCLUSION:This study highlights the precise measurement of global posterior inflammation achieved by a dual FA/ICGA scoring system in stromal choroiditis. In contrast, SUN-VH scale appears imprecise and inadequate, as only a minute percentage of the studied eyes could have been included in a clinical trial based on this criterion. To evaluate posterior intraocular inflammation meaningfully in stromal choroiditis, the use of dual FA/ICGA is strongly advised and should replace the presently recommended SUN-VH system.
journal_name
Int Ophthalmoljournal_title
International ophthalmologyauthors
Gillmann K,El Ameen A,Massy R,Fabro F,Gasc A,Herbort CP Jrdoi
10.1007/s10792-018-0979-ysubject
Has Abstractpub_date
2019-07-01 00:00:00pages
1567-1574issue
7eissn
0165-5701issn
1573-2630pii
10.1007/s10792-018-0979-yjournal_volume
39pub_type
杂志文章abstract:PURPOSE:To perform vector analysis of changes in corneal astigmatism and evaluate changes in corneal topographic parameters following the lateral tarsal strip (LTS) procedure in patients with involutional ectropion or entropion. METHODS:Nineteen eyes of 15 patients (10 eyes with ectropion and 9 eyes with entropion) we...
journal_title:International ophthalmology
pub_type: 杂志文章
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更新日期:2019-08-01 00:00:00
abstract::After glaucoma filtering surgery subconjunctival injection of human recombinant tissue plasminogen activator may promote the function of glaucoma filter bleb and increase outflow facility. It can also increase postoperative complications, such as corneal damage. The aim of our research was to determine corneal endothe...
journal_title:International ophthalmology
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abstract:PURPOSE:Recently, the vasodilator relaxin 2 has been introduced as a treatment for acute heart failure. However, its role on vessels of the eye and intraocular pressure (IOP) remains unclear though it has been hypothesized to induce a decrease IOP after intramuscular injection in humans. We aimed to test whether the ho...
journal_title:International ophthalmology
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journal_title:International ophthalmology
pub_type: 杂志文章,meta分析,评审
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更新日期:2013-02-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:1995-01-01 00:00:00
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更新日期:2017-12-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2020-12-01 00:00:00
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更新日期:2013-10-01 00:00:00
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更新日期:2009-02-01 00:00:00
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更新日期:2009-02-01 00:00:00
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更新日期:2018-08-01 00:00:00
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更新日期:2015-02-01 00:00:00
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