Abstract:
:To analyze the association between Eales disease, histocompatibility leukocyte antigen alleles (HLA-A/B, HLA-DRB/DQB) and tuberculosis infection, and to explore susceptible genes and protective genes associated with Eales disease and tuberculosis infection in a population of Han nationals from Zunyi City in Guizhou Province, China. The subjects were analyzed by a case-control study consisting of three groups--Eales disease group (47 cases), pulmonary tuberculosis group (36 cases) and normal control group (100 cases). The Eales disease group was divided into four parts. Part one consisted of 12 patients who had suffered from pulmonary tuberculosis. Part two consisted of 27 patients who had not suffered from pulmonary tuberculosis. Parts three and four consisted of 27 patients with a positive purified protein derivative test and 12 patients with a negative test, respectively. DNA samples from 47 patients with Eales disease, 36 patients with pulmonary tuberculosis and 100 healthy people were detected by polymerase chain reaction with sequence-specific primers. The 59 HLA-A/B and HLA-DRB/DQB alleles from Eales disease were compared with those from tuberculosis and normal control, and a correlativity test of common susceptible genes was performed to analyze the potential relationship between Eales disease and pulmonary tuberculosis. The frequency distribution of HLA-A*02 alleles (OR 9.719, OR 95 % CI 4.377-21.580, P = 0.000) and HLA-B*07 (OR 11.605, OR 95 % CI 2.397-56.191, P = 0.001) in the Eales disease group was higher than in the normal control group, but the HLA-A*11 alleles (OR 0.495, OR 95 % CI 0.245-1.000, P = 0.048) were lower than in the normal control group, showing a significant difference. Compared with parts two and four, the frequency distribution of HLA-A*02, HLA-A*11 and HLA-B*07 alleles in parts one and three showed no significant difference (P > 0.05). HLA-A*A02, HLA-A*24, HLA-B*07 and HLA-DRB*16 alleles between the Eales disease, pulmonary tuberculosis and normal control group showed statistical significance (P < 0.05). HLA-A*24 alleles in the pulmonary tuberculosis group were lower than the Eales disease group (χ(2) 7.289, P = 0.007), but HLA-A*02 alleles showed no significant difference (P > 0.05) between the two groups. The results show that HLA-A*02 and HLA-B*07 may be genetic predisposing genes, but HLA-A*11 alleles may be protective genes of Eales disease, the HLA-A*02 allele may be a common susceptible gene of Eales disease and pulmonary tuberculosis. HLA-A*11 and HLA-A24 alleles are protective genes of Eales disease and pulmonary tuberculosis, respectively. In summary, the frequency distribution of susceptible genes of Eales disease and pulmonary tuberculosis in a population of Han nationals from Zunyi City in Guizhou Province, China showed no significant difference.
journal_name
Int Ophthalmoljournal_title
International ophthalmologyauthors
Cai SJ,Su G,Li H,Xie B,Luo JMdoi
10.1007/s10792-013-9718-6subject
Has Abstractpub_date
2013-10-01 00:00:00pages
475-9issue
5eissn
0165-5701issn
1573-2630journal_volume
33pub_type
杂志文章abstract::Infants have been known occasionally to stare without blinking for almost a minute. This puts great demands on the stability of their tear-film. To verify the stability of infant tears, we performed biophysical experiments on Meibomian gland secretion, which forms the outermost layer of the tear-film. The secretion wa...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/BF00919408
更新日期:1994-01-01 00:00:00
abstract:PURPOSE:To assess posterior inflammation using a fluorescein (FA)/indocyanine-green angiography (ICGA) scoring system, and compare them to the presently recommended outcome measure, the standardization of uveitis nomenclature vitreous haze score (SUN-VH) in stromal choroiditis. METHODS:This was a retrospective study o...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-018-0979-y
更新日期:2019-07-01 00:00:00
abstract:PURPOSE:To evaluate the efficacy of long-tube shunt surgery (LTSS) without valve in uveitic glaucoma (UG) eyes. METHODS:We retrospectively analyzed the data of 45 UG eyes that underwent only LTSS or LTSS combined with trabeculectomy (TLE) (LTSS/TLE). The UG eyes were analyzed by categorizing them into granulomatous/no...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-020-01601-3
更新日期:2020-10-14 00:00:00
abstract::In the original publication, first line of methods under the Abstract section was published incorrectly. ...
journal_title:International ophthalmology
pub_type: 已发布勘误
doi:10.1007/s10792-020-01327-2
更新日期:2020-04-01 00:00:00
abstract::Fifty patients who developed preretinal or papillary neovascularization following tributary vein occlusion were treated by laser photocoagulation. Areas of non-perfused retina within the distribution of the obstructed vein were identified by fluorescein angiography and ablated using moderately intense laser photocoagu...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/BF00130697
更新日期:1981-05-01 00:00:00
abstract:PURPOSE:To evaluate the long-term course of primary angle-closure ocular hypertension and primary open-angle ocular hypertension and possible risk factors for progression to glaucoma. METHODS:A total of 109 eyes of 109 ocular hypertension (OHT) patients with a minimum follow-up period of 5 years having complete ocular...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-018-0872-8
更新日期:2019-04-01 00:00:00
abstract:PURPOSE:Few case reports have described vaso-occlusive retinopathy in systemic lupus erythematosus (SLE) using optical coherence tomography (OCT) angiography. Here we report the clinical features of a patient with SLE, complicated by Kikuchi-Fujimoto disease, who developed vaso-occlusive retinopathy. We then describe t...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-017-0650-z
更新日期:2018-08-01 00:00:00
abstract:PURPOSE:To compare the efficacy of intravitreal injection of ranibizumab, dexamethasone implant and aflibercept for the management of macular edema (ME) related to branch retinal vein occlusion (BRVO). METHODS:This retrospective and comparative study included 62 eyes of 62 patients with BRVO and ME. Patients received ...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-017-0618-z
更新日期:2018-08-01 00:00:00
abstract::To determine the optimal area of retinal photocoagulation required for suppressing active neovascularisation (NVI) associated with diabetic retinopathy. We studied 1 eye each of 4 patients in whom active NVI was ophthalmoscopically shown to have been suppressed by additional photocoagulation. These patients initially ...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-013-9802-y
更新日期:2014-10-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to evaluate the effect retrobulbar and topical anesthesia on optic nerve by measuring retinal nerve fiber layer (RNFL) thickness before and after phacoemulsification cataract surgery using optical coherence tomography (OCT). METHODS:A total of 126 eyes of 108 patients were included ...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-020-01338-z
更新日期:2020-07-01 00:00:00
abstract:INTRODUCTION:We report on a 62-year-old healthy woman who suffered from bilateral predescemetic opacities, where the underlying disorder could not be identified. She had bilateral keratopathy with corneal edema, a diffuse predescemetic avascular haze and deszemetic folds. Because of high hyperopia (right +7.50/left +7....
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1023/b:inte.0000018521.88103.17
更新日期:2004-01-01 00:00:00
abstract::To evaluate the efficacy of golimumab on severe and frequent recurrent anterior uveitis in patients with HLA-B27-positive ankylosing spondylitis. In this study, 15 eyes of 12 HLA-B27-positive AS patients with resistant anterior uveitis who received 50 mg of subcutaneous golimumab (Gol) per month due to frequent uveiti...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-016-0239-y
更新日期:2017-02-01 00:00:00
abstract:PURPOSE:A population-based study was conducted to determine the prevalence of color deficiencies in secondary-school students (ages 12-14) in Tehran. METHODS:A total of 2,058 students (1,136 males, 922 females) were examined with Ishihara pseudoisochromatic color plates. RESULTS:In the study population, 97 cases of d...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/BF00175263
更新日期:1996-01-01 00:00:00
abstract::To evaluate efficacy and safety of same site re-operation in eyes with failed trabeculectomy. A retrospective, noncomparative, interventional case series. We reviewed the medical records of 35 eyes of 35 patients who underwent same-site re-operation for failed trabeculectomy. The surgery involved a fornix-based perito...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-013-9840-5
更新日期:2014-06-01 00:00:00
abstract::Insulin-like growth factor-1 (IGF-1) is altered in several neurodegenerative diseases, the association between serum IGF-1 levels and glaucoma has not been evaluated. This study was designed to evaluate whether serum IGF-1 levels are different in patients with Pseudoexfoliation (PEX) with or without glaucoma. The stud...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-016-0271-y
更新日期:2017-04-01 00:00:00
abstract:PURPOSE:To compare the systemic and ocular characteristics and laboratory findings of patients developing toxic anterior segment syndrome (TASS) after uneventful phaco surgery with unaffected subjects undergoing the same surgery in the same session. DESIGN:A retrospective case-control study. METHODS:The study group c...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-016-0418-x
更新日期:2018-02-01 00:00:00
abstract::Carotid cavernous fistulas (CCFs) can be classified as direct and indirect, depending on their flow rates and their etiology. Both forms can cause the same characteristic ophthalmological symptoms and signs. We analyzed these ocular characteristics and determined the prognostics factors associated with treatment outco...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-012-9550-4
更新日期:2012-04-01 00:00:00
abstract:PURPOSE:Early predictors of diabetic complications may aid in the prevention and/or management of these complications. The aim of this cross-sectional study was to determine the predictive value of retinopathy for the presence of other diabetic complications. METHODS:The population studied comprised 648 patients with ...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1023/a:1014409829614
更新日期:2001-01-01 00:00:00
abstract::Three cases of orbital tuberculosis are presented, two as cold abscess in the orbit and one as a chronic indolent sinus. A simple clinical test like Fine Needle Aspiration Cytology (FNAC) can demonstrate some or all of the characteristic pathological features like caseating necrosis, epitheloid cells and Langhan's gia...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/BF00915963
更新日期:1994-01-01 00:00:00
abstract::In a randomized, double-masked, single drop study the effect of topical isosorbid-mononitrate (ISMO) 0.5% eye drops, the main metabolite of isosorbid-dinitrate, widely used in the treatment of coronary heart diseases, was studied in patients suffering from open angle glaucoma or ocular hypertension. There was no stati...
journal_title:International ophthalmology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF00171028
更新日期:1991-07-01 00:00:00
abstract:PURPOSE:To investigate the characteristics of dynamic visual acuity (DVA) and contrast sensitivity (CS) in pseudophakic patients with posterior capsular opacification (PCO). METHODS:Fifty-four eyes (36 patients) with PCO planned for laser capsulotomy were recruited. They underwent examinations of static visual acuity ...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-020-01536-9
更新日期:2020-12-01 00:00:00
abstract:OBJECTIVE:To assess the comprehensive effects of raloxifene hydrochloride on retinal, choroidal and retrobulbar hemodynamics and on visual function in post-menopausal women. DESIGN:Twenty-four post-menopausal women (age 55 +/- 3.8 years) were recruited for this cross-sectional study: 12 received placebo and 12 receive...
journal_title:International ophthalmology
pub_type: 临床试验,杂志文章
doi:10.1007/s10792-008-9224-4
更新日期:2009-08-01 00:00:00
abstract::Thirty-three cases of aphakic retinal detachment have been treated by pars plana vitrectomy and retinopexy. This procedure allowed us to lower the incidence of postoperative massive periretinal proliferation from 15,4%, in a series that was performed by a classical method, to 6% in the pars plana treated group. ...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/BF00138265
更新日期:1984-01-01 00:00:00
abstract:PURPOSE:Pseudoexfoliation syndrome (PEX) is a late onset disorder of extracellular matrix turnover, associated systemically with cardiovascular and cerebrovascular disease. To evaluate the suggested association of polymorphisms of homocysteine metabolism genes MTHFR (rs1801131, rs1801133) and MTHFD1 (rs8006686) with PE...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-017-0498-2
更新日期:2018-04-01 00:00:00
abstract:PURPOSE:To investigate the diurnal fluctuations of macular vessel density (VD) in primary open-angle glaucoma (POAG) and healthy subjects using optical coherence tomography angiography. METHODS:A total of 22 POAG eyes and 15 healthy eyes were included in this study. Macular VD, intraocular pressure, and blood pressure...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-020-01408-2
更新日期:2020-09-01 00:00:00
abstract:PURPOSE:State Gentamicin antibiotic prophylaxis is contraindicated in 25 gauge Transconjunctival Sutureless Vitrectomy. METHODS:A 75-year-old diabetic woman was affected by glaucoma and mild diabetic retinopathy in both eyes, and epiretinal membrane in the left eye. A 25-gauge Transconjunctival Sutureless Vitrectomy (...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-007-9148-4
更新日期:2008-10-01 00:00:00
abstract::The physiology of the orbital arteries supplying the eye is currently under intensive investigation. However, while the anatomical distribution of these vessels in humans is well known, their normal histology and age-related or other pathologic alterations have hardly been studied. We obtained at autopsy 10 orbits fro...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/BF00918866
更新日期:1993-02-01 00:00:00
abstract::The purpose of this study was to report on two novel missense mutations of the cornea-specific TGFBI gene in one single patient and in two generations of a family diagnosed with unique corneal dystrophy (CD) phenotypes. Ophthalmologic examination, in several cases ocular coherence tomography of the anterior segment (A...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-016-0216-5
更新日期:2016-12-01 00:00:00
abstract:PURPOSE:To compare the outcome of penetrating keratoplasty (PKP) and deep anterior lamellar keratoplasty (DALK) in the surgical management of keratoconus (KC). PATIENT AND METHODS:A retrospective review was conducted of the medical records of all patients treated with PKP or DALK for KC at University of Iowa Hospitals...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-010-9393-9
更新日期:2010-12-01 00:00:00
abstract::The appearance of a hypopyon is an extremely uncommon finding in acute angle-closure glaucoma and only a few cases have been previously reported in the literature. We report a fifty-year-old female who, following a recent bereavement, presented with classical features of acute angle-closure glaucoma and a hypopyon. Th...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/BF00942925
更新日期:1993-06-01 00:00:00